Clinical trials: Positive End-expiratory Pressure (PEEP)
Respiratory Insufficiency
Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation
The purpose of the study is to evaluate variation of BNP in non invasive mechanical ventilated patients with severe acute respiratory failure.
- Trial name
- NCT00453726
- Testing
- Non invasive mechanical ventilation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale S. Giovanni Bosco
Intracranial Hypertension, Critical Illness
Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure
The purpose of this study is to collect physiologic data from patients with severe brain injury who require mechanical ventilation in order to describe the impact of ventilation, specifically positive end expiratory pressure…
- Conditions
- Intracranial Hypertension, Critical Illness, Brain Injuries, Lung Injury
- Trial name
- NCT02680704
- Testing
- PEEP titrated mechanical ventilation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Respiratory Distress Syndrome
A Comparison of Optimal PEEP Determination Guided by EIT and G5 Device in Moderate and Severe ARDS Patients
To Select the Optimal Positive End-expiratory Pressure in Moderate and Severe Acute Respiratory Distress Syndrome Patients by Using: 1. the novel Non-invasive Electrical Impedance Tomography Guided Method 2.
- Trial name
- NCT03112512
- Testing
- optimal PEEP guided by EIT, optimal PEEP guided by G5 ventilator
- Where
- Taiwan
- Volunteers
- 88 people
- Sponsor
- Mei-Yun Chang
Critical Illness, ARDS
Assessment of Lung Recruitablity of Acute Respiratory Distress Syndrome With SARS-CoV-2 Pneumonia by Electrical Impedance Tomography
Novel coronavirus (SARS-CoV-2: severe acute respiratory coronavirus 2) pneumonia often develop the acute respiratory distress syndrome (ARDS).
- Trial name
- NCT04473300
- Where
- Japan
- Volunteers
- 43 people
- Sponsor
- Osaka University
Chronic Obstructive Pulmonary Disease
Intrinsic PEEP and Laryngeal Aperture in COPD
In this study the investigators aim to investigate the extent to which in patients with chronic obstructive pulmonary disease narrowing of the vocal cords causes a positive pressure within the airways thus improving airflow and…
- Trial name
- NCT02437630
- Testing
- Oesophageal balloon to measure intra-thoracic pressure, Fibre-optic laryngoscopy, standard lung function tests
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Oxygenation
Obesity, PEEP and Postoperative Oxygenation
A study on overweight patients undergoing anesthesia for laparoscopic surgery. evaluation of positive end-expiratory pressure versus zero positive end-expiratory pressure during awakening on oxygenation in the early postoperative…
- Trial name
- ZAPPAII (NCT04150276)
- Testing
- ZEEP during awakening, PEEP during awakening
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Västmanland
Complication, Postoperative, Cardiac Complication
Acute Effect of Positive Expiratory Pressure Versus Breath Stacking Technique After Cardiac Surgery
This study evaluates the efficacy and safety of a single session of positive expiratory pressure and of breath stacking technique in patients after cardiac surgery.
- Trial name
- NCT04013360
- Testing
- Breath Stacking, Expiratory Positive Airway Pressure
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Universidade Federal de Santa Maria
Blood Pressure
Arterial Waveform Analysis Applying Different Positive End-Expiratory Pressure (PEEP) Levels in Healthy Volunteers
Population in study will be selected from students and staff of the University of Pisa. Right carotid artery contour wave analysis will be performed during the application of different PEEP levels (from 0 cmH2O to 10 cmH2O) with…
- Trial name
- NCT03294928
- Testing
- progressive increasing of PEEP level.
- Where
- Italy
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Hypoxia
Efficacy and Safety of Using Noninvasive Ventilation Associated With Recruitment Maneuver in Cardiac Surgery.
Cardiac surgery can evolve with complications in the postoperative period, atelectasis and hypoxemia are the major pulmonary dysfunctions.
- Trial name
- NCT02913391
- Testing
- recruitment group (RG), control group (CG)
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Mieko Cláudia Miura
Acute Respiratory Distress Syndrome
ELASTANCE: Prospective Physiological Study of Lung Elastance in Recruitment and Derecruitment in Early Onset Mechanically Ventilated ARDS Patients
The recruitment strategy in Acute respiratory distress syndrome (ARDS) patients mechanically ventilated combines recruitment maneuvers and positive end expiratory pressure (PEEP).
- Trial name
- ELASTANCE (NCT01899560)
- Testing
- Measure lung and chest wall elastance with esophageal catheter, non-invasive method for measuring the lung elastance
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Chronic Respiratory Failure
Impact of Patient Controlled Positive End-expiratory Pressure on Speech in Tracheostomized Ventilated Patients
Adequate communication is a major part of the quality of life of tracheostomized ventilator dependent patients. Maintaining speech is therefore major goal in the management of these patients.
- Trial name
- OptiPEP (NCT01479959)
- Testing
- Eole 3 ventilator - Resmed
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University of Versailles
Mechanical Ventilation Complication, Respiratory Failure
Effect of PEEP on Lung Regional Ventilation and Perfusion
Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT
- Conditions
- Mechanical Ventilation Complication, Respiratory Failure, Hypoxia
- Trial name
- PEEP (NCT04081155)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Yun Long
Acute Brain Injuries
Effect of Increased Positive End-expiratory Pressure on Intracranial Pressure in Different Respiratory Mechanic in Acute Respiratory Distress Syndrome
There are concerns that the use of positive end-expiratory pressure (PEEP) for the treatment of pulmonary complications in patients with brain injury may potentially elevate intracranial pressure (ICP), and deteriorate…
- Trial name
- NCT02670733
- Testing
- Positive end-expiratory pressure
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Acute Hypoxemic Respiratory Failure, Post-cardiac Surgery
Automated Analysis of EIT Data for PEEP Setting
First: to develop a computerized algorithm for automated analysis of the electrical impedance tomography (EIT) data. The algorithm calculates the "optimal" positive end-expiratory pressure (PEEP) and inspiratory pressure defined…
- Trial name
- NCT03653806
- Testing
- computerized algorithm for automated analysis
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Lung Injury, Acute
Lung Atelectasis Improvement Through Positive End Expiratory Pressure During Anesthetic Induction
Anesthetic induction could lead to lung atelectasis, increase intrapulmonary shunt, and potentially impair oxygenation. The study aimed to validate that a positive end-expiratory pressure (PEEP) of 10 cmH2O could reduce lung…
- Trial name
- NCT06900426
- Testing
- 10 PEEP, ZEEP, 5PEEP
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fudan University
Pulmonary Resection Surgery, One Lung Ventillation (OLV)
BMI-Adjusted PEEP During One-Lung Ventilation in Thoracic Surgery
One-lung ventilation (OLV) is required during many thoracic surgical procedures and is associated with reduced functional residual capacity, atelectasis, ventilation-perfusion mismatch, hypoxemia, and potentially…
- Conditions
- Pulmonary Resection Surgery, One Lung Ventillation (OLV), General Anesthetic
- Trial name
- SIMPLE-PEEP (NCT07851740)
- Testing
- Fixed PEEP, BMI-adjusted PEEP
- Where
- 4 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Jesús Manuel Nieves Alonso
Respiratory Insufficiency
Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency
The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.
- Trial name
- dARICUPEEP (NCT01376518)
- Testing
- positive end-expiratory pressure
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Johannes Gutenberg University Mainz
Noninvasive Ventilation, Pneumonia
High PEEP in Noninvasive Ventilation Patients With Pneumonia or ARDS
Noninvasive ventilation is commonly employed in patients with pneumonia or acute respiratory distress syndrome (ARDS) and has been shown to reduce the need for intubation and invasive mechanical ventilation.
- Conditions
- Noninvasive Ventilation, Pneumonia, ARDS
- Trial name
- NCT07298889
- Testing
- The level of PEEP during noninvasive ventilation
- Where
- China
- Volunteers
- 706 people
- Sponsor
- Chongqing Medical University
Airway Management, Tracheal Extubation
Interest of Tracheal Extubation in Positive Pressure on Postoperative Oxygenation in Adult Digestive Surgery
Evaluation of a postoperative tracheal extubation protocol under positive pressure in accordance with international recommendations.
- Conditions
- Airway Management, Tracheal Extubation, Postoperative Respiratory Complications, Postoperative Hypoxemia
- Trial name
- ExPress (NCT04381949)
- Testing
- positive pressure extubation
- Where
- France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Rouen
Atelectasis
Peroperative Use of Positive End-expiratory Pressure Prevents Formation of Atelectasis as Studied by Computerised Tomography at End of Surgery
Atelectasis is common during and after general anaesthesia and a number of interventions have been suggested in order to prevent their formation.
- Trial name
- NCT02548416
- Testing
- Positive end-expiratory pressure, Control group, zero PEEP
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Region Västmanland