Clinical trials: Positive Pressure Ventilation
Mechanical Ventilation Pressure High
Mask Leak With Nasal Cannula in Noninvasive Positive Pressure Ventilation
This is a prospective randomized cross over study of healthy volunteers undergoing continuous positive airway pressure ventilation via a noninvasive ventilation (NIV) mask with and without the addition of nasal cannulas.
- Trial name
- NCT02743936
- Testing
- Nasal cannula, Non-invasive positive pressure ventilation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
High-Frequency Ventilation, Intermittent Positive-Pressure Ventilation
Nasal HFOV Versus Nasal SIPPV in Neonate Following Extubation: RCT Crossover Study
Mechanical ventilation was introduced to treat respiratory failure in preterm infants or sick neonates then improvements in survival (1,2).
- Conditions
- High-Frequency Ventilation, Intermittent Positive-Pressure Ventilation, Newborn Morbidity, Noninvasive Ventilation
- Trial name
- nHFOnSIPPV (NCT04323397)
- Testing
- Non-invasive ventilation
- Where
- Thailand
- Volunteers
- 133 people
- Sponsor
- Prince of Songkla University
Cerebral Ischemia
Total Shoulder Arthroplasty Near-infrared Spectroscopy
The purpose of this study is to measure cerebral oxygenation and cardiac output of total shoulder replacement patients undergoing general anesthesia (GA) and positive-pressure ventilation (PPV).
- Trial name
- TSA NIRS (NCT02198183)
- Testing
- Casmed Fore-Sight Elite, Non-invasive Cardiac Output Monitor (NICOM)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Hospital for Special Surgery, New York
Interstitial Lung Disease, Obstructive Sleep Apnea
Assessment of Continuous Positive Airway Pressure Therapy in OSA and ILD
The purpose of this study is to evaluate whether biomarkers of lung epithelial and endothelial injury are associated with obstructive sleep apnea (OSA) and interstitial lung disease (ILD).
- Trial name
- NCT03901534
- Testing
- Continuous positive airway pressure (CPAP) therapy, Nox A1 Recorder
- Where
- 2 sites in United States
- Volunteers
- 2,021 people
- Sponsor
- Columbia University
Postoperative Pulmonary Atelectasis, Surgery
Prophylactic nCPAP Following Bowel Surgery (Bio-REB File 11-27)
The purpose of this study is to determine whether prophylactic nasal continuous positive airway pressure (nCPAP) in the post-anaesthesia care unit (PACU) improves post-operative pulmonary function following elective bowel…
- Trial name
- NCT01316575
- Testing
- nCPAP, Low Flow Oxygen
- Volunteers
- 40 people
- Sponsor
- University of Saskatchewan
Sleep Apnea, Obstructive, Delirium
Effect of CPAP on Postoperative Delirium
Patients with a medical condition known as obstructive sleep apnea may be at increased risk of delirium following surgery. This study loans autotitrating CPAP machines to randomly-selected patients who are at high-risk for…
- Trial name
- NCT01816685
- Testing
- CPAP
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Duke University
Obstructive Sleep Apnea, Obesity
Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial
The purpose of this study is to assess the feasibility of conducting a comparative effectiveness study comparing a medical versus surgical approach to the initial management of obstructive sleep apnea (OSA) in the setting of…
- Trial name
- ABC (NCT01187771)
- Testing
- Laparoscopic Gastric Banding, Continuous Positive Airway Pressure
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- University of Pittsburgh
Bronchopulmonary Dysplasia
Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants
This phase 3, multi-center, double blind, placebo-controlled, randomized clinical trial will attempt to demonstrate if preterm infants who require mechanical ventilation and/or positive pressure support at any point during days 5…
- Trial name
- NCT00931632
- Testing
- Inhaled Nitric Oxide
- Where
- 33 sites in United States, Canada
- Volunteers
- 451 people
- Sponsor
- Mallinckrodt
CO2 Clearance, Mask Comfort
Noninvasive Ventilation Masks Carbon Dioxide Clearance in Normal Volunteers
This study will be a randomized crossover trial that will be conducted at Rush University. The study will be conducted with 20 healthy volunteers who will be placed on ICU ventilator operating in the NIPPV mode.
- Conditions
- CO2 Clearance, Mask Comfort, Rebreathing Exhaled Gas
- Trial name
- NCT03882723
- Testing
- Evaluated 4 masks used for NIV with mechanical ventilators
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Sleep Apnea Syndromes
Effect of Self-Management on Improving Sleep Apnea Outcomes
Obstructive sleep apnea syndrome (OSA) is a common sleep disorder that is associated with serious medical and psychological complications.
- Trial name
- NCT00310310
- Testing
- Sleep Apnea Self-Management Program, Usual care
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea, Stroke
Sleep Apnea Treatment After Stroke (SATS)
The purpose of this study is to determine if treating stroke patients who have obstructive sleep apnea with continuous positive airway pressure will improve symptoms caused by the stroke.
- Trial name
- NCT00282815
- Testing
- continuous positive airway pressure or CPAP
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan
Respiratory Distress Syndrome
Early CPAP And Large Volume Minimally Invasive Surfactant (ECALMIST) in Preterm Infants With RDS
Modification of Minimally Invasive Surfactant Therapy (MIST) to a new technique called ECALMIST (Early CPAP And Large volume Minimal Invasive Surfactant).
- Trial name
- ECALMIST (NCT01553292)
- Testing
- ECALMIST
- Where
- 3 sites in Canada
- Volunteers
- 21 people
- Sponsor
- University of Manitoba
Non Alcoholic Fatty Liver Disease, Obstructive Sleep Apnea
The Sleep, Liver Evaluation and Effective Pressure Study
This research is being done to examine: 1) how common obstructive sleep apnea (OSA) is in patients with non-alcoholic fatty liver disease (NAFLD), 2) whether the severity of OSA is related to the severity of NAFLD, and 3) whether…
- Trial name
- SLEEP (NCT01482065)
- Testing
- CPAP (ResMed S9 autoset CPAP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Sleep Apnea, Obstructive, Primary Open-angle Glaucoma
IOP Fluctuations in Patients With Sleep Apnea With or Without Primary Open Angle Glaucoma Using Positive Airway Pressure
Sleep apnea is characterized by repetitive episodes of decreased or interrupted airflow in the upper airways during sleep. Obstructive sleep apnea syndrome (OSAS) is the most common sleep-related breathing disorder and is…
- Trial name
- NCT01560975
- Testing
- SENSIMED Triggerfish®
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sensimed AG
Sleep Apnea - Obstructive, Cost Effectiveness
Remote Diagnosis and Management of Obstructive Sleep Apnea
Although obstructive sleep apnea, a breathing disorder during sleep, is prevalent and recognized as a major public health concern, most Veterans with this disorder are undiagnosed and therefore untreated.
- Conditions
- Sleep Apnea - Obstructive, Cost Effectiveness, Telemedicine
- Trial name
- NCT03007745
- Testing
- autoadjusting continuous positive airway pressure
- Where
- 3 sites in United States
- Volunteers
- 435 people
- Sponsor
- VA Office of Research and Development
Bronchopulmonary Dysplasia
Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator
Very premature infants often cannot breathe on their own and require assistance with a respirator. Conventional respirators deliver air or oxygen via a breathing tube placed through the mouth to the airway (endotracheal tube).
- Trial name
- NCT01440647
- Testing
- Extubation to NIPPV, Extubation to CPAP
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Women and Infants Hospital of Rhode Island
to Test the Hypothesis That NHFOV is More Effective Than nCPAP in the Treatment of Respiratory Distress Syndrome (RDS) in Verypreterm Neonates
NHFOV as Primary Support in Very Preterm Infants With RDS
This will be a prospective, multi-center, two-arms,parallel, randomized, controlled trial with a superiority design,conducted in China.
- Trial name
- NCT05141435
- Testing
- infants receive primary non-invasive respiratory support by mean of nCPAP, infants receive primary non-invasive respiratory support by mean of NHFOV
- Where
- 3 sites in China
- Volunteers
- 360 people
- Sponsor
- Jiulongpo No.1 People's Hospital
Sleep Apnea, Obstructive, Patient Compliance
Tailored Intervention to Promote Positive Airway Pressure Adherence
The purpose of this study is to examine the feasibility of a tailored (i.e., individualized) intervention to promote adherence to continuous positive airway pressure therapy (CPAP) in adults with newly-diagnosed, CPAP treated…
- Trial name
- SCIP-PA (NCT01454830)
- Testing
- Tailored, Usual care
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Milton S. Hershey Medical Center
Obstructive Sleep Apnea
Improving the Frequency and Quality of Sleep Apnea Care Management
OSA is a major chronic condition affecting the quality of life of millions of Americans. Per the Institute of Medicine new treatment adherence strategies are needed to help improve the quality of care, reduce social and economic…
- Trial name
- NCT01916655
- Testing
- Self-Management Care, Self-Management Mobile Care, Usual Care
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Respiratory Insufficiency, Sleep Disordered Breathing
Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm
The aim of the study is to test the hypothesis that an automated algorithm for desired mask pressure improves breathing pattern and sleep quality in patients with hypercapnic ventilatory failure.
- Trial name
- NCT01403584
- Testing
- AutoVPAP with addition of AutoEPAP, AutoVPAP with EPAP manually selected
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- ResMed