Clinical trials: Positive-Pressure Respiration, Intrinsic
Obstructive Sleep Apnea
Upper Airway Stimulation Versus Continuous Positive Airway Pressure
Standard therapy in patients with obstructive sleep apnea (OSA) is continuous positive airway pressure (CPAP). 30% to 50% are not adherent to this therapy and need an alternative treatment.
- Trial name
- NCT03756805
- Testing
- upper airway stimulation, continuous positive airway pressure
- Where
- Germany
- Volunteers
- 227 people
- Sponsor
- Technical University of Munich
Obstructive Sleep Apnea (OSA)
Development of Advanced Leak Detection Technologies for Positive Airway Pressure Devices Therapies
This study will take between 1-2 months (with first patient first visit to last patient last visit). Each participant will use the supplied PAP device and mask for a period of up to 14 nights.
- Trial name
- NCT04741854
- Testing
- Positive Airway Pressure (PAP) Therapy
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- ResMed
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome
Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise testing in patients with OSA.
- Trial name
- NCT01033266
- Testing
- CPET
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Oklahoma
Obstructive Sleep Apnea
First Line Obstructive Sleep Apnea Treatment Study
The main objective is to evaluate the overall effectiveness of MAD therapy as a first line treatment, including both efficacy in terms of reduction in OSA severity as well as objective compliance, in patients recently diagnosed…
- Trial name
- FLOSAT (NCT05393531)
- Testing
- Mandibular advancement device (MAD), Continuous positive airway pressure (CPAP)
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Peer-Driven Intervention for Sleep Apnea
Fragmentation of care can lead to poor treatment adherence in patients with chronic medical conditions which can, in turn, lead to adverse health consequences, poor quality of life, and patient dissatisfaction.
- Trial name
- PCORI (NCT02056002)
- Testing
- Usual Care, Peer-Buddy System
- Where
- United States
- Volunteers
- 362 people
- Sponsor
- University of Arizona
Sleep Apnea, Atrial Fibrillation
Atrial Fibrillation Recurrence in Sleep Apnea
This randomized, controlled trial is designed to test whether treatment of sleep disordered breathing (SDB) with positive airway pressure (PAP) therapy alters the natural history of atrial fibrillation (AF).
- Trial name
- NCT00263757
- Testing
- Adaptive Servo-Ventilation, Usual Care
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea Syndrome
Phonoaudiologic Therapy Adjunct to Treatment on Patients With Obstructive Sleep Apnea
Objective: to evaluate the effects of a speech therapy exercises program in the treatment of Obstructive Sleep Apna Syndrome (OSAS) patients based on the clinical and polysomnography (PSG) parameters.
- Trial name
- NCT01289405
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Obstructive Apnea
Comparison of a Demand Oxygen Delivery
Conducting a randomized control trial of oxygen in children with Down syndrome to treat moderate to severe obstructive sleep apnea.
- Trial name
- DOSA (NCT06609694)
- Testing
- Portable oxygen concentrator Inogen G5 model
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Adherence to CPAP in Obstructive Sleep Apnea
Evaluating Behavioral Treatments to Improve Adherence to CPAP in People With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a serious sleep disorder in which a person repeatedly stops breathing or experiences shallow breathing for short periods of time during sleep.
- Trial name
- BREATHE (NCT00939601)
- Testing
- Motivational Enhancement Therapy, Educational Counseling
- Sponsor
- Brown University
Apnea Syndrome, Obstructive Sleep Apnea
Analysis of Mandibular Movements in Ventilated Children With Sleep Apnea Syndrome
Obstructive Sleep Apnea is a common medical condition in children. Diagnosis is based on polysomnography . We conducted an open prospective non randomised clinical trial to assess the efficacy of a new medical device called…
- Trial name
- AMANDA (NCT05908188)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Sleep Apnea, Obstructive
Auto Continuous Positive Airway Pressure (CPAP) Based Energy Spectrum Analysis of Flow for Treatment of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)
Nasal Continuous Positive Airway Pressure (CPAP) is the standard therapy for obstructive sleep apnea hypopnea syndrome (OSAHS). This is most commonly administered as a single positive pressure that has been individualized for the…
- Trial name
- NCT00750165
- Testing
- SleepStyle 200 Auto Series CPAP Humidifier
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Treatment Adherence and Outcomes in Three Modalities of Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea
The purpose of this study is to compare the treatment adherence and effects in three modalities of Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea.
- Trial name
- NCT00873977
- Testing
- CPAP (REMstar (Respironics))
- Where
- Japan
- Volunteers
- 93 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Obstructive Sleep Apnea
The Effect of CPAP Treatment on Cognitive Functions, Anxiety, and Affective Symptoms
Long term, prospective study of continuous positive airway pressure treatment influence on cognitive functions in patients with obstructive sleep apnea syndrome.
- Trial name
- NCT03866161
- Testing
- Continuous positive airway pressure
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Olomouc
Sleep Apnea, Obstructive
NPA-OSA Device Tolerability, Usability and Acclimation Clinical Study in Adult Obstructive Sleep Apnea (OSA) Patients
This pilot study is being done to determine if the nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device can be used in the treatment of OSA in adults.
- Trial name
- NCT06677151
- Testing
- nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea (OSA), Suspected Obstructive Sleep Apnea
Empirical CPAP Therapy for Suspected Obstructive Sleep Apnea in a Resource-Limited Setting
Obstructive sleep apnea (OSA) is a condition where a person's airway repeatedly collapses during sleep, causing them to stop breathing briefly and disrupting their rest.
- Conditions
- Obstructive Sleep Apnea (OSA), Suspected Obstructive Sleep Apnea, Sleep Apnea Syndromes
- Trial name
- NCT07693101
- Volunteers
- 80 people
- Sponsor
- Assiut University
Obstructive Sleep Apnea
Improving 24-hour Blood Pressure in Obstructive Sleep Apnea
This study examines the combined effects of an angiotensin receptor blocker (ARB), antioxidant supplementation, and continuous positive airway pressure (CPAP) therapy on the lowering of 24-hour blood pressure in persons with…
- Trial name
- NCT04021550
- Testing
- Continuous Positive Airway Pressure CPAP, Telmisartan 80mg, Alpha-Lipoic Acid 600mg
- Sponsor
- University of British Columbia
Coronary Artery Disease, Obstructive Sleep Apnea
Continuous Positive Airway Pressure (CPAP) Treatment in Coronary Artery Disease and Sleep Apnea
Obstructive sleep apnea (OSA) worsens the prognosis in patients with coronary artery disease (CAD). Many of these subjects do not report daytime sleepiness, and therefore, are not considered for OSA treatment with continuous…
- Trial name
- RICCADSA (NCT00519597)
- Testing
- ResMed S8 (Auto-CPAP)
- Where
- Sweden
- Volunteers
- 511 people
- Sponsor
- Skaraborg Hospital
Sleep Apnea, Chronic Pain Syndrome
Sleep and Pain Sensitivity
This project will assess patients with diagnosed obstructive sleep apnea, to investigate the impact of poor sleep on central pain mechanisms.
- Trial name
- NCT04246294
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Aalborg University
Sleep Apnea, Obstructive, Craniofacial Abnormalities
3D-Printed CPAP Masks for Children With Obstructive Sleep Apnea
The purpose of this study is to determine whether patient-specific computer-aided design (CAD) and three-dimensional (3D) printing can be utilized to produce personalized, effective continuous positive airway pressure (CPAP)…
- Conditions
- Sleep Apnea, Obstructive, Craniofacial Abnormalities, Pediatric Disorder
- Trial name
- NCT02261857
- Testing
- Personalized continuous positive airway pressure (CPAP) mask
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Glenn Green
Sleep Apnea, Obstructive
Adherence to Continuous Positive Airway Pressure Among Obstructive Sleep Apnoea Patients.
Prospective study designed to identify factors that would predict patient adherence to CPAP (Continuous Positive Airway Pressure) therapy.
- Trial name
- NCT02055027
- Testing
- Comparison between groups
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Astes