Clinical trials: Positive-Pressure Respiration, Intrinsic
Obstructive Sleep Apnea
Testing Settings of NovaResp's cMAP® Software During Home PAP Therapy
The goal of this clinical trial is to identify which settings of proactive therapy work best in OSA patients who regularly adhere to PAP therapy at home.
- Trial name
- NCT07898254
- Testing
- Dynamic cMAP, Direct cMAP
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- NovaResp Technologies Inc
Stroke, Sleep Apnea, Obstructive
Stroke and CPAP Outcome Study: A Sham-controlled Trial of CPAP Among Stroke Rehabilitation Patients
The purpose of this study is to assess the effect of continuous positive airway pressure (CPAP) on functional outcome in patients with acute stroke, the investigators conducted a sham-controlled, double-blind pilot trial during…
- Trial name
- SCOUTS (NCT02551757)
- Testing
- Auto-titrating CPAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Sleep Apnea, Dyslipidaemia
Effect of Nasal CPAP on Lipid Profile in Patients With Dyslipidaemia and Sleep Apnea
OBJECTIVES Main objective: To assess if six months of treatment with CPAP, associated with conventional treatment, improves the lipid profile of patients with dyslipidemia and mild-moderate apnea-hypopnea syndrome (OSA).
- Trial name
- NCT02557412
- Testing
- Continuous positive airway pressure, Intensive lifestyle intervention, Conventional treatment
- Where
- Spain
- Sponsor
- Hospital Universitario La Paz
Interface, Mask, Continuous Positive Airway Pressure (CPAP)
CPAP and NIV Interfaces : Side-effects in Home Care Patients
Home ventilation techniques consist mainly of two techniques, Continuous Positive Airway Pressure or CPAP and Non Invasive Ventilation or NIV. Whether for CPAP or NIV, pressures are delivered to the patient via an interface.
- Conditions
- Interface, Mask, Continuous Positive Airway Pressure (CPAP), Non Invasive Ventilation (NIV), Hyperventilation Anxiety
- Trial name
- InterfaceVent (NCT03013283)
- Testing
- self questionnaire
- Where
- 2 sites in France
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Montpellier
Obstructive Sleep Apnea, Hypertension
Antihypertensive and PAP Treatment in Obstructive Sleep Apnea Patients With Hypertension (AHPAP)
The investigators will perform a long term registry based prospective analysis on incidence of major cardiovascular events or death in hypertensive patients with obstructive sleep apnea .
- Conditions
- Obstructive Sleep Apnea, Hypertension, Death, Cardiac, Treatment Compliance
- Trial name
- AHPAP (NCT05115994)
- Testing
- Continous positive airway pressure
- Where
- Sweden
- Volunteers
- 10,000 people
- Sponsor
- Vastra Gotaland Region
Obstructive Sleep Apnea
Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness
Millions of Americans suffer from high blood pressure, diabetes, strokes and motor vehicle accidents due to ineffective treatment of obstructive sleep apnea (OSA).
- Trial name
- NICEPAP (NCT05067088)
- Testing
- CPAP (all patients receive CPAP as part of routine clinical care)
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- Yale University
Obstructive Sleep Apnea
Performance of the Tasman Continuous Positive Airway Pressure (CPAP) System
Assessment of the performance of the Tasman CPAP system in treating obstructive sleep apnea. The purpose of this study is to (1) evaluate the performance of this system in the efficacy of the treatment in comparison to S8 Escape…
- Trial name
- NCT01171066
- Testing
- Tasman CPAP system
- Where
- Australia
- Volunteers
- 57 people
- Sponsor
- ResMed
Sleep Apnea, Obstructive
Effect of Liraglutide vs CPAP on Cardiometabolic Outcomes in Obstructive Sleep Apnea
This is an explorative, proof-of-concept study exploring the potential therapeutic role of a Liraglutide-based weight loss regimen versus standard CPAP or the combination of both on metabolic parameters, blood pressure…
- Trial name
- NCT04186494
- Testing
- Liraglutide (Saxenda) 6Mg/Ml Inj Pen 3Ml, Continuous positive airway pressure treatment, Liraglutide and CPAP
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- St Vincent's University Hospital, Ireland
Sleep Apnea, Obstructive
Effectiveness of Auto-adjusted Continuous Positive Airway Pressure for Long-term Treatment of Sleep Apnea
Hypothesis: Computer controlled continuous positive airway pressure (autoCPAP) is equally effective in improving obstructive sleep apnea syndrome symptoms, breathing disturbances, objective vigilance, and it is cost-effective…
- Trial name
- NCT00280800
- Testing
- constant CPAP devices, automatic CPAP devices
- Where
- Switzerland
- Volunteers
- 208 people
- Sponsor
- Konrad E. Bloch
Obstructive Sleep Apnea
The Impact of Daily Sinus Irrigation on Nasal Symptoms in Continuous Positive Airway Pressure (CPAP) Users - A Pilot Study
Continuous positive airway pressure (CPAP) is the most commonly used treatment for obstructive sleep apnea. Nasal symptoms such as dryness, itching and congestion are common in CPAP users.
- Trial name
- NCT01121445
- Testing
- NeilMed nose and sinus irrigation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Bridgeport Hospital
Obstructive Sleep Apnea
TPAP for Comfort in OSA
TheraPAP is a prototype device (with full documented electrical and isolation safety) being developed by SleepRes for the treatment of obstructive sleep apnea (OSA) that can deliver either standard CPAP at a set pressure or what…
- Trial name
- NCT06264128
- Testing
- TPAP, CPAP
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- SleepRes Inc.
Obstructive Sleep Apnea of Adult
Effect of Continuous Positive Airway Pressure on Chronotype, Dietary Intake, and Cardiovascular Risk Markers
In this study the investigators will evaluate chronotype, food intake pattern, and cardiovascular risk markers of elder individuals with OSA, in use of CPAP, when submitted to two weeks of CPAP withdrawal.
- Trial name
- NCT04262960
- Testing
- Device: active CPAP
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Dysphagia, OSA
Obstructive Sleep Apnea (OSA), Oral Frailty, Dysphagia, Continuous Positive Airway Pressure (CPAP)
The purpose of this study is to evaluate the effects of the CPAP treatment on oral frailty and dysphagia among OSA patients.
- Conditions
- Dysphagia, OSA, CPAP
- Trial name
- NCT05977296
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Early Onset Alzheimer Disease, Alzheimer Disease
Sleep Apnea in Early to Mid-Stage Alzheimer's Disease
Obstructive sleep apnea (OSA) is much more common in the elderly than in the young; the latest studies show prevalence between 45% and 62% in individuals over 60.
- Conditions
- Early Onset Alzheimer Disease, Alzheimer Disease, Obstructive Sleep Apnea Syndromes
- Trial name
- AZAP (NCT01400542)
- Testing
- CPAP Treatment, No treatment
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sleep Apnea, Dyslipidemias
CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep Apnea
Clinical Trial Phase IV Indication: Moderate-severe obstructive sleep apnea and dyslipidemia. Objectives: Main objective: To test whether 12 months of CPAP treatment associated with conventional pharmacological treatment improves…
- Conditions
- Sleep Apnea, Dyslipidemias, Hyperuricemia
- Trial name
- CPAPLIP (NCT06463561)
- Testing
- Continuous positive airway pressure, Hygienic-dietary recommendations and daily physical activity promotion
- Where
- Spain
- Volunteers
- 220 people
- Sponsor
- Hospital Universitario La Paz
Sleep Apnea, Stroke
Usefulness of Nasal Continuous Positive Airway Pressure (CPAP) Treatment in Patients With a First Ever Stroke and Sleep Apnea Syndrome
MAIN AIMS: to analyze the efficacy of nasal CPAP treatment in patients with ischemic first-ever stroke and Sleep Apnea Syndrome (SAS) in terms of: early neurological outcome, functional recovery, quality of life influence, stroke…
- Conditions
- Sleep Apnea, Stroke, Cardiovascular Disease
- Trial name
- NCT00202501
- Testing
- Nasal CPAP (Continuous Positive Airway Pressure)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Obstructive Sleep Apnea
Postoperative Nasal High Flow Versus Oxygen for Positive Airway Pressure Non-Compliance Sleep Apnea Patients
The study aims to compare the efficacy of Nasal High Flow Therapy (NHF) with low-flow oxygen supplementation in improving postoperative intermittent desaturations.
- Trial name
- NCT02485236
- Testing
- Low flow oxygen via nasal cannula, Humidified Nasal High Flow Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea of Adult
Impact of Intermittent Hypoxia on the Function of the Phagocytes
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA.
- Trial name
- NCT03618719
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Obstructive Sleep Apnea, Obesity
Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial
The purpose of this study is to assess the feasibility of conducting a comparative effectiveness study comparing a medical versus surgical approach to the initial management of obstructive sleep apnea (OSA) in the setting of…
- Trial name
- ABC (NCT01187771)
- Testing
- Laparoscopic Gastric Banding, Continuous Positive Airway Pressure
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- University of Pittsburgh
COPD (Chronic Obstructive Pulmonary Disease)
End-Inspiratory Pause in COPD Patients During Controlled Ventilation
In patients with airflow obstruction receiving mechanical ventilation, an important objective is to reduce lung hyperinflation often using controlled hypoventilation.
- Trial name
- PYE (NCT07207967)
- Testing
- END INSPIRATORY PAUSE DURING CONTROLLED VENTILATION, NO PAUSE VENTILATION
- Where
- Argentina
- Volunteers
- 14 people
- Sponsor
- Sanatorio Anchorena San Martin