Clinical trials: Positive-Pressure Respiration
Critical Illness, Hypoxemia
Preoxygenation Using NIV in Hypoxemic Patients
Critically ill patients are predisposed to oxyhaemoglobin desaturation during intubation. For the intubation of hypoxemic patients, preoxygenation using non invasive ventilation (NIV) is more effective at reducing arterial…
- Trial name
- PREOXY (NCT00472160)
- Testing
- Non Invasive Ventilation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea, Respiratory Failure
Healthcare Renunciation in Respiratory Chronic Disease and Treatment Compliance (OBSERVE)
Health care renunciation is a factor that can alter patients' health status and increase the costs of its support. To date, there is no national data on the renunciation of care.
- Trial name
- OBSERVE (NCT03591250)
- Where
- 3 sites in France
- Volunteers
- 1,083 people
- Sponsor
- University Hospital, Grenoble
Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure
The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of…
- Conditions
- Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Mechanical Ventilation, Electrical Impedance Tomography (EIT)
- Trial name
- PEEP (NCT06733168)
- Testing
- electrical impedance tomography, Non-EIT
- Where
- Vietnam
- Volunteers
- 76 people
- Sponsor
- Vietnam Military Medical University
Satisfaction, Personal
Use of 3D Printing High-fidelity Craniofacial Manikin to Teach Noninvasive Positive Pressure Ventilation
The aim of this study is to enhance the learning efficiency and ability of problem-solving for student of Department of Respiratory Therapy with the innovative 3D printing high-fidelity manikin.
- Trial name
- NCT06171035
- Testing
- 3D-printed high-fidelity craniofacial manikin model education, Traditional model education
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University
Sleep Apnea, Obstructive
Study to Predict the Need for Humidification Use and Comparison of the Effect of ThermoSmart™ and no Humidification on Adherence
Despite the effectiveness of continuous positive airway pressure (CPAP) in abolishing upper airway obstruction, acceptance of and adherence with therapy has been sub-optimal.
- Trial name
- NCT01517750
- Testing
- ICON Auto CPAP™ with Thermosmart heated tube, ICON Auto CPAP™ without Thermosmart heated tube
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep Apnea, Obstructive
Comparison of Breathing Events Detected by the SleepStyle 200 Auto Continuous Positive Airway Pressure (CPAP) Device to Attended Polysomnography
Obstructive Sleep Apnoea (OSA) is a common sleep-breathing disorder affecting around 2-4% of the population and is characterised by loud snoring, periodic collapse of the upper airway particular to sleep, sleep fragmentation, and…
- Trial name
- NCT00697424
- Testing
- SleepStyle 200 Auto Series CPAP Humidifier
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Orofacial Myofunctional Therapy and Positive Airway Pressure-CPAP Trial for Mild-to-Moderate Obstructive Sleep Apnea
The goal of this clinical trial is to evaluate the isolated and combined effects of orofacial myofunctional therapy (OMT) and continuous positive airway pressure (CPAP) in adults with mild-to-moderate obstructive sleep apnea.
- Trial name
- OMPACT-OSA (NCT07539870)
- Testing
- Orofacial Myofunctional Therapy, Continuous Positive Airway Pressure, Standard of Care Sleep-Hygiene and Lifestyle Counseling
- Volunteers
- 168 people
- Sponsor
- Saint-Joseph University
Surgery, Anesthesia Intubation Complication
MAsk VEntilation With Paratracheal Pressure In Children. Para Tracheal Compression to Prevent Gastric Insufflation in Children
The use of cricoid pressure to prevent gastric aspiration or regurgitation in case of "full stomach" situation or emergency is still controversial in the adult population.
- Trial name
- MAVEPPIC (NCT05279170)
- Testing
- MAVEPPIC: MAsk VEntilation with Paratracheal Pressure In Children
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Lille
Interface, Mask, Continuous Positive Airway Pressure (CPAP)
CPAP and NIV Interfaces : Side-effects in Home Care Patients
Home ventilation techniques consist mainly of two techniques, Continuous Positive Airway Pressure or CPAP and Non Invasive Ventilation or NIV. Whether for CPAP or NIV, pressures are delivered to the patient via an interface.
- Conditions
- Interface, Mask, Continuous Positive Airway Pressure (CPAP), Non Invasive Ventilation (NIV), Hyperventilation Anxiety
- Trial name
- InterfaceVent (NCT03013283)
- Testing
- self questionnaire
- Where
- 2 sites in France
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Montpellier
Postoperative Complications, Surgery
Driving Pressure During General Anesthesia for Minimally Invasive Abdominal Surgery (GENERATOR)
The purpose of this international multicenter, patient and outcome-assessor blinded randomized controlled trial is to determine whether the application of an individualized high Positive End Expiratory Pressure (PEEP) strategy…
- Trial name
- GENERATOR (NCT06101511)
- Testing
- Intraoperative ventilation with individualized high PEEP titrated to the lowest ΔP with RMs
- Where
- Netherlands
- Volunteers
- 1,806 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Obstructive Sleep Apnea, Positive Airway Pressure
Big Data Analysis of OSA Patients on Positive Airway Pressure (PAP) Treatment: Real-life Monitoring
The present study aims to determine to what extent remote monitoring of PAP related to patients' clinical parameters is able to provide relevant data on predictors of compliance, subgroups of patients who may benefit from this…
- Trial name
- TeleVAL (NCT05495347)
- Testing
- patients diagnosed with OSA
- Where
- Spain
- Volunteers
- 2,500 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
COPD, Sleep Apnea Syndromes
Noninvasive Positive Pressure Ventilation in Overlap Syndrome
Chronic obstructive pulmonary diseases (COPD) coexisting with obstructive sleep apnea is called overlap syndrome (OS). Patients with OS seem to have worse prognosis than patients with only one disorder.
- Conditions
- COPD, Sleep Apnea Syndromes, Non-invasive Positive Pressure Ventilation
- Trial name
- NCT03184714
- Testing
- NIPPV
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Obstructive Sleep Apnoea
Antioxidant Carbocysteine Treatment in Obstructive Sleep Apnoea Syndrome
Obstructive sleep apnoea syndrome (OSAS) is characterised by repeated episodes of upper airway occlusion during sleep.It can cause cycles of hypoxia reoxygenation.
- Trial name
- NCT02015598
- Testing
- Carbocysteine, Continuous Positive Airway Pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Sleep Apnea
Health Coaching for Positive Airway Pressure Adherence
This study tested a low-resource, brief telephonic health coaching intervention to improve adherence to positive airway pressure therapy for treatment of sleep apnea.
- Trial name
- NCT04067128
- Testing
- Health coaching
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Interstitial Lung Disease, Obstructive Sleep Apnea
Assessment of Continuous Positive Airway Pressure Therapy in OSA and ILD
The purpose of this study is to evaluate whether biomarkers of lung epithelial and endothelial injury are associated with obstructive sleep apnea (OSA) and interstitial lung disease (ILD).
- Trial name
- NCT03901534
- Testing
- Continuous positive airway pressure (CPAP) therapy, Nox A1 Recorder
- Where
- 2 sites in United States
- Volunteers
- 2,021 people
- Sponsor
- Columbia University
Obstructive Sleep Apnea
Assessment of the Effect of PAP on Energy and Vitality in Mild OSA Patients: The Merge Study
The investigators wish to prospectively determine the response to CPAP in patients presenting with mild OSA. In many healthcare systems, patients with mild OSA (AHI 5-15) are not reimbursed for treatment.
- Trial name
- NCT02699463
- Testing
- Continous Positive Airway Pressure, Control Group
- Where
- 11 sites in United Kingdom
- Volunteers
- 301 people
- Sponsor
- ResMed
Hypertension, Obstructive Sleep Apnea
Prospective National Multi-center Registry of Obstructive Sleep Apnea Syndrome in Hypertensive Patients in China
Study name: Screening, Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome in Hypertensive Patients in China: A Prospective National Multi-center Registry.
- Trial name
- NCT05735444
- Testing
- Continuous positive airway pressure
- Where
- China
- Volunteers
- 633 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Acute Hypoxemic Respiratory Failure
Noninvasive Positive Pressure Ventilation for Early Extubation of Acute Hypoxemic Respiratory Failure
Acute hypoxaemic respiratory failure (AHRF) refers to pathological states in which arterial blood oxygenation is severely impaired，and which need invasive positive pressure ventilation (IPPV) as respiratory support technique in…
- Trial name
- NPPV (NCT01151501)
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Sponsor
- Beijing Chao Yang Hospital
Acute Cardiogenic Pulmonary Edema
Helmet CPAP vs Facemask CPAP in ACPE (hCPAP vs fCPAP)
This study objectively held to compare the physiological outcomes in the non-invasive (NIV) treatment of Acute Cardiogenic Pulmonary Edema (ACPE) patients in the Emergency Department (ED) delivered by helmet CPAP (hCPAP) and…
- Trial name
- NCT04014088
- Testing
- hCPAP vs fCPAP
- Volunteers
- 164 people
- Sponsor
- Hospital Raja Permaisuri Bainun
Positive End Expiratory Pressure
Efficacy Evaluation of Positive End-expiratory Pressure in Children Undergoing Mechanical Ventilation Using Supraglottic Airway Device
The aim of this study is to determine whether application of positive end-expiratory pressure (PEEP) improves respiratory data including respiratory compliance in children who receive positive pressure ventilation using…
- Trial name
- NCT05275283
- Testing
- PEEP
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital