Clinical trials: Post Lung Transplantation
Breast Cancer, Metastatic Cancer
Cellular Adoptive Immunotherapy in Treating a Patient Who Has Undergone a Donor Stem Cell Transplant for Breast Cancer That Has Spread to the Lung
RATIONALE: Biological therapy, such as cellular adoptive immunotherapy, may stimulate the immune system in different ways and stop tumor cells from growing.
- Trial name
- NCT00301730
- Testing
- aldesleukin, therapeutic tumor infiltrating lymphocytes, trastuzumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Arterial Hypertension
Ventricular Reversed Remodeling After LTX in PAH Patients
The investigators will evaluate ventricular reversed remodelling after double lung transplantation (LTX) in patients with pulmonary arterial hypertension (PAH), measured with cardiac magnetic resonance imaging (MRI).
- Trial name
- PAH-LTX (NCT02391441)
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- University Medical Center Groningen
Bronchiolitis Obliterans, Bone Marrow Transplantation
Effectiveness of Azithromycin Therapy in Improvement of Symptoms and Lung Function in Patients With Bronchiolitis Obliterans After Bone Marrow Transplantation
Bronchiolitis obliterans syndrome (BOS), an obstructive airway disease as a result of chronic rejection, is one of the major causes of morbidity and mortality in long-term survivors of allogeneic bone marrow transplantation…
- Trial name
- NCT00563251
- Testing
- Azithromycin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hospital Authority, Hong Kong
Sinusoidal Obstruction Syndrome, Veno-occlusive Disease
Defibrotide Dose-escalation for SOS Post-HSCT
This research study is being done to determine the safety and tolerability of increasing doses of defibrotide within a single patient with sinusoidal obstructive syndrome (SOS)/veno-occlusive disease (VOD) after hematopoietic…
- Trial name
- NCT05987124
- Testing
- Defibrotide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York Medical College
COPD
Muscle Function After Lung Transplantation in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of the project is to investigate changes in the quadriceps muscle and cardiovascular regulation during exercise in relation to improved lung function after lung transplantation in patients with COPD.
- Trial name
- COPD (NCT03548857)
- Testing
- Lung transplantation
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Graft Versus Host Disease, Leukemia
Donor Lymphocyte Infusion After Stem Cell Transplant in Treating Patients With Haematological Cancers
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and melphalan, before a donor stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma, Myeloma
- Trial name
- ProT4 (NCT01240525)
- Testing
- CD4 DLI, No DLI
- Where
- 11 sites in United Kingdom
- Volunteers
- 114 people
- Sponsor
- University College, London
Bronchiolitis Obliterans Syndrome, Hematopoietic and Lymphoid Cell Neoplasm
The Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Cell Transplantation (The RV-BOS Study)
This observational trial studies whether respiratory viruses are the cause of lung disease (bronchiolitis obliterans syndrome [BOS] or graft-versus-host disease of the lung) and changes in lung function in patients who have…
- Trial name
- NCT05250037
- Testing
- Home spirometry, Biospecimen Collection, Questionnaire Administration
- Where
- 4 sites in United States
- Volunteers
- 261 people
- Sponsor
- Fred Hutchinson Cancer Center
Lung Transplantation, Cystic Fibrosis
Predictive Value of PIIINP Urinary for the Development of Chronic Renal Failure in Patients With Cystic Fibrosis After Lung Transplantation (MUCO-IRC)
Chronic renal failure is a serious complication of lung transplantation especially in patients with cystic fibrosis. Their medical history prior to the Lung Transplantation has already exposed to kidney damage.
- Conditions
- Lung Transplantation, Cystic Fibrosis, Renal Failure
- Trial name
- MUCO-IRC (NCT01572194)
- Testing
- Urinary levels of PIIINP as a marker of changes in renal function
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Nantes University Hospital
Lung Transplant Rejection
Macitentan in the Treatment of Organ Rejection After Lung Transplantation
Potential therapy with MACITENTAN in the treatment of Chronic Lung Allograft Dysfunction (CLAD) after Lung Transplantation. Pilot Study, Double-blind, "ADD-ON Therapy" with MACITENTAN to "usual standard of care immunosuppressive…
- Trial name
- NCT02893176
- Testing
- macitentan
- Where
- United States
- Sponsor
- University of California, Los Angeles
Post Single or Double Lung Transplant
Lung Transplant Subjects Using 19F MRI
The goal of this study is to evaluate the utilization of conventional 'thermally' polarized perfluorinated gases mixed with oxygen as inhaled inert contrast agents to image the airway spaces in subjects who have undergone single…
- Trial name
- DIAL1001005 (NCT02019251)
- Testing
- perfluorinated gas/oxygen mixture, MRI
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Hal C Charles
Pancreatitis, Chronic; Diabetes; Transplant
Anti-inflammatory Therapy to Improve Outcomes After TPIAT
Patients with severe chronic pancreatitis may be candidates to have their pancreas removed and their islets transplanted into the liver to reduce the risk of diabetes mellitus, a procedure called total pancreatectomy with islet…
- Trial name
- NCT02713997
- Testing
- etanercept, Alpha 1-Antitrypsin
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Bronchiolitis Obliterans
Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation
Investigation of photopheresis as new therapy regimen in patients with bronchiolitis obliterans syndrome after lung transplantation in a controlled, randomized study
- Trial name
- NCT00502554
- Testing
- photopheresis
- Where
- 2 sites in Germany
- Volunteers
- 12 people
- Sponsor
- Hannover Medical School
Pulmonary Infection
Massively Parallel Sequencing to Identify Microbiological Organisms in Bronchoalveolar Lavage Fluid
Patients who are post hematopoietic stem cell transplantation who require a bronchoalveolar lavage (BAL) for standard clinical car will have extra fluid collected and sent for massively parallel sequencing to see if it is as…
- Trial name
- NCT03995030
- Testing
- massively paralleled sequencing
- Volunteers
- 10 people
- Sponsor
- New York Medical College
Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2)
The objective of this trial was to assess the efficacy and safety of aerosolized liposomal cyclosporine A (L-CsA) as add-on therapy to standard of care (SoC) as compared to SoC alone in double lung transplant (DLT) recipients…
- Conditions
- Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant, Lung Transplant Rejection, Lung Transplant; Complications
- Trial name
- BOSTON-2 (NCT03656926)
- Testing
- Liposomal Cyclosporine A, Standard of Care
- Where
- 40 sites in United States, Austria and 7 more
- Volunteers
- 169 people
- Sponsor
- Zambon SpA
Parenthood Status, Transplant Lung
Access to Parenthood and Gynecological Follow-up After Organ Transplantation
Solid organ transplants affect subjects of all ages, including young women of childbearing age. The improvement in the management of young female transplant patients makes it possible to consider pregnancies, about which the…
- Conditions
- Parenthood Status, Transplant Lung, Transplant Kidney
- Trial name
- FerGyTransplan (NCT05610670)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Hopital Foch
Chronic Graft vs Host Disease, Chronic Graft-Versus-Host Disease
Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
Background: Chronic graft versus host disease (cGVHD) can affect people who had a hematopoietic stem cell transplant using donor cells. It is often fatal. It is usually treated with high doses of steroids.
- Trial name
- NCT02759731
- Testing
- Baricitinib
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Lung Transplant; Complications
An Evaluation of Remote Care (Questionnaire+Hybrid) in Patients Who Are Post-lung Transplant
Lung transplantation is used to treat patients with lung damage when there is no other treatment option. Patients require close monitoring following their transplant, with hospital check-ups every 3-4 months usually lasting all…
- Trial name
- NCT05916495
- Testing
- Hybrid care arm, Standard of care arm
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- University of Manchester
Covid19, SARS-CoV Infection
RECOVAC - Long Term Efficacy and Safety of COVID-19 (SARS-CoV-2) Vaccination in Kidney Disease Patients
Rationale: COVID-19 is associated with severely increased morbidity and mortality in patients with chronic kidney disease stage G4-G5 and patients on dialysis or after kidney transplantation.
- Conditions
- Covid19, SARS-CoV Infection, Chronic Kidney Diseases
- Trial name
- LESS CoV-2 (NCT04841785)
- Testing
- mailer-based finger-prick
- Where
- Netherlands
- Volunteers
- 4,868 people
- Sponsor
- University Medical Center Groningen
Post Lung Transplantation
Voriconazole Prophylaxis Against Aspergillosis in Lung Transplant Recipients
A fixed dosage regimen of voriconazole is routinely used for prophylaxis of aspergillosis in lung transplant patients at our institution.
- Trial name
- NCT00177827
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Pittsburgh
Kidney Failure, Chronic, Covid19
Assessment of Immune Response After Vaccination Against COVID-19 in Patients Treated With Renal Replacement Therapy
Chronically dialyzed patients and kidney transplant recipients have been identified as particularly vulnerable to SARS-CoV-2 infection due to unavoidable exposure.
- Conditions
- Kidney Failure, Chronic, Covid19, Vaccine Reaction, Vaccine Adverse Reaction
- Trial name
- COViNEPH-1 (NCT04905862)
- Testing
- Immune response, Solicited common and expected adverse reactions shortly following vaccination (reactogenicity), use of antipyretic or pain medications and unsolicited adverse events and serious adverse events
- Where
- 4 sites in Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Gdansk