Clinical trials: Post Lung Transplantation
Kidney Transplantation
Pilot Study on the Use of Sirolimus to Treat Chronic Allograft Nephropathy in Children After Kidney Transplant
The purpose of this study is to determine whether treatment with sirolimus, in combination with low-dose tacrolimus and prednisone, is effective for the treatment of chronic allograft nephropathy (progressive scarring) in…
- Trial name
- NCT00188955
- Testing
- sirolimus
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Gastroparesis, Lung Transplant; Complications
HR-EGG in Medically Refractory Gastroparesis
The goal of this observational study is to utilize a novel high resolution electrogastrography device to gauge if identification of gastric dysarrythmias can reliably identify patients that will respond to or will require…
- Trial name
- NCT05789511
- Testing
- High Resolution Electrogastography
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Chronic Thrombo-embolic Pulmonary Hypertension and Pulmonary Arterial Hypertension
Determinants of Right Heart Remodeling in Patients With CTEPH or PAH
Right heart failure is the main cause of morbi-mortality in patients with pulmonary hypertension (PH), including patients of chronic thrombo-embolic pulmonary hypertension (CTEPH) or pulmonary arterial hypertension (PAH)…
- Trial name
- PRINCEPT (NCT03205085)
- Testing
- magnetic resonance imaging, 2D and 3D trans-thoracic echocardiography, Blood samples
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Chronic Graft-Versus-Host Disease (cGVHD)
A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)
The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD.
- Trial name
- NCT06619561
- Testing
- Vimseltinib
- Where
- 26 sites in United States
- Volunteers
- 48 people
- Sponsor
- Deciphera Pharmaceuticals, LLC
Lymphocytic Bronchi(Oli)Tis Post-lung Transplantation
Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation
This study investigates the role of azithromycin treatment for lymphocytic bronchitis/bronchiolitis after lung transplantation.
- Trial name
- AZI002 (NCT01109160)
- Testing
- Azithromycin Dihydrate
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- KU Leuven
Lung Transplantation
Impact of the Age Difference Between the Donor and Recipient on the Morbidity and Mortality After Lung Transplantation. Study on a National Multicenter Cohort (COLT)
It is commonly accepted that the characteristics of the organ donor impact on the future post transplant. In lung transplantation (LP), the defining characteristics of the "ideal" donor includes an age less than 55 years.
- Trial name
- NCT02855372
- Testing
- Lung transplantation
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Gastroesophageal Reflux
GI Reflux in Lung Transplant and Its Relationship to Chronic Rejection
Recent data has suggested that GER (gastric reflux) may worsen after lung transplantation and potentially increase the risk of chronic rejection (CR) after lung transplantation.
- Trial name
- LTXGERD (NCT00455078)
- Testing
- esophagogastroduodenoscopy, Standard GER questionnaire (RDQ), Scintigraphic evaluation of solid gastric emptying
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Lung Cancer
High-Dose Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003284
- Testing
- filgrastim, carboplatin, etoposide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Herbert Irving Comprehensive Cancer Center
Lung Transplantation
Activity Coaching in Patients Post Lung Transplantation
Lung transplantation is an ultimate, effective treatment option for selected patients with end stage lung disease, improving quality of life and extending survival.
- Trial name
- NCT04122768
- Testing
- Multi-component physical activity tele coaching intervention, Light coaching intervention
- Where
- Belgium
- Volunteers
- 108 people
- Sponsor
- KU Leuven
Post-Acute COVID19 Syndrome, COVID-19
FMT for Post-acute COVID-19 Syndrome
In recovered COVID-19 patients, emerging global data have reported the presence of long COVID, that is, at least one symptom that an alternative diagnosis cannot explain has been persistent for four or more weeks after the…
- Trial name
- FMT-PACS (NCT05556733)
- Testing
- Faecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Malignant Hematological Diseases
Efficacy of Azithromycin to Prevent Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation
The occurrence of bronchiolitis obliterans syndrome (SBO) after allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be a chronic pulmonary graft versus host disease (GVHD) that is associated with…
- Trial name
- ALLOZITHRO (NCT01959100)
- Testing
- Azithromycin
- Where
- France
- Volunteers
- 480 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplant Infection, Covid19
Humoral Immunity Against SARS-CoV-2 in Liver Transplanted Patients After COVID-19 in Comparison With Immunocompetent Patients
This is a prospective study analyzing the development of humoral immune response against SARS-Cov-2 in patients with previous Covid19: the aim is to compare the incidence, titration and evolution of IgG an IgM in a prospective…
- Conditions
- Liver Transplant Infection, Covid19, Mortality, Immune Response
- Trial name
- NCT04410471
- Testing
- CLIA of IgG and IgM against SARS-Cov-2
- Where
- 2 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Magdalena Salcedo
Disorder Related to Lung Transplantation, Chronic Lung Allograft Dysfunction
Studying the Treatment Effect of Pirfenidone in Chronic Lung Allograft Dysfunction (STOP-CLAD)
Greater than 50% of lung transplant recipients show signs of chronic lung allograft dysfunction (CLAD) by 5 years post-transplantation.Therapies to prevent or slow CLAD are lacking.
- Trial name
- NCT03473340
- Testing
- Pirfenidone Capsule
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Rejection, Lung Transplantation
Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation
In patients with acute rejection after lung transplantation the peptide profile in broncho-alveolar lavage (BAL) and urine should be compared in order to identify a paradigm that allows an non-invasive rejection therapy.
- Trial name
- NCT00558597
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Hannover Medical School
Hepatopulmonary Syndrome, Liver Cirrhosis
Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study
Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 < 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations.
- Trial name
- HPS (NCT03092401)
- Volunteers
- 142 people
- Sponsor
- Hospices Civils de Lyon
Lung Transplantation, Chronic Lung Disease
Inspiratory Muscle Training Immediately After Lung Transplantation
Following lung transplantation (LTX), patients may exhibit respiratory and skeletal muscle weakness that will affect exercise capacity, increase dyspnea and fatigue, limit activities of daily living (ADL) and decrease quality of…
- Conditions
- Lung Transplantation, Chronic Lung Disease, Muscle Weakness, Rehabilitation
- Trial name
- NCT05309551
- Testing
- IMT- Intervention group
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Post-Transplant Infections, Post-Transplant Renal Insufficiency
Study of the Complications Associated With Certain Stem Cell Transplants
Background: The National Institutes of Health (NIH) performs up to 100 allogenic stem cell transplants (allo-HSCT) each year. Many studies already look at different problems that can follow a transplant.
- Conditions
- Post-Transplant Infections, Post-Transplant Renal Insufficiency, Post-Transplant Pulmonary Complications
- Trial name
- NCT01919099
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bronchiolitis Obliterans
Itacitinib for the Treatment of Bronchiolitis Obliterans Syndrome After Donor Hematopoietic Cell Transplant
This phase I trial studies how well itacitinib works for the treatment of bronchiolitis obliterans syndrome after donor hematopoietic cell transplant.
- Trial name
- NCT04239989
- Testing
- Itacitinib, Itacitinib Adipate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Transplant, Rehabilitation
Post-operative, Inpatient Rehabilitation After Lung Transplant Evaluation
This randomized, feasibility trial (n=40) will compare the effects of an intensive, twice daily inpatient physical rehabilitation program against standard care (once daily) following double lung transplantation.
- Trial name
- PIRATE (NCT03095859)
- Testing
- Physical rehabilitation.
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- The Alfred
Kidney Transplantation, Delayed Graft Function
Bioimpedance and Multiparametric Ultrasound-Guided Fluid Management After Kidney Transplantation
After a kidney transplant, the amount of fluid in the body must be carefully balanced. Too much fluid can accumulate in the lungs, the tissues and the new kidney itself and may delay its recovery; too little fluid can also damage…
- Conditions
- Kidney Transplantation, Delayed Graft Function, Fluid Overload
- Trial name
- VLMM-MC (NCT07905963)
- Testing
- Multiparametric assessment, Structured usual care
- Volunteers
- 650 people
- Sponsor
- Hospital Universitario Ramon y Cajal