Clinical trials: Post Lung Transplantation
Acute Pain
Paravertebral Catheter for Lung Transplant
This is a prospective observational trial of patient undergoing lung transplantation who have a thoracic paravertebral catheter(s) placed for postoperative pain control.
- Trial name
- NCT02380417
- Testing
- paravertebral catheter placement, 0.2% ropivacaine, Elastomeric pump
- Volunteers
- 33 people
- Sponsor
- University of Minnesota
SARS-CoV-2 Infection, Active Immunization
Saxon SARS-CoV-2 Infection and Vaccination Study in Dialysis Patients, Solid Organ Recipients and Staff
To investigate short- (3 and 8 weeks) and long-term (6, 9, 12, and 18 months) immune protection or response at the humoral and cellular levels before and after SARS-CoV-2 infection or vaccination in patients with moderately…
- Conditions
- SARS-CoV-2 Infection, Active Immunization, Immune Response, Immunosuppression
- Trial name
- DIA-Vacc (NCT04799808)
- Where
- Germany
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Lung Transplantation
Physical Activities in Daily Life After Lung Transplantation
The purpose of this study is to compare participation in physical activities in daily life and functional outcomes of lung transplant recipients attending a six-month multicomponent rehabilitation program including exercise…
- Trial name
- NCT00395889
- Testing
- Rehabilitation including structured exercise training, Physical Activity Counseling
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- KU Leuven
Disorder Related to Lung Transplantation
Peri-operative Azithromycin to Improve Early Allograft Function and Outcome After Lung Transplantation
This study investigates possible beneficial effects of peri-operative treatment (i.e. pre-transplant initiation and prompt post-transplant continuation) with azithromycin in lung transplantation.
- Trial name
- AZI003 (NCT01915082)
- Testing
- Azithromycin, Ora-Plus
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Immunocompromised, Hematologic Malignancy
Low-Flow vs. High-Flow Nasal Cannula for Hypoxemic Immunocompromised Patients During Diagnostic Bronchoscopy
Pneumonia is a lung infection. Fiberoptic bronchoscopy is a test to diagnose the type of lung infection. While this procedure is being performed, a small amount of oxygen is delivered into the nose (low flow nasal cannula).
- Conditions
- Immunocompromised, Hematologic Malignancy, Post Hematopoietic Stem Cell Transplant, Hypoxia
- Trial name
- NCT03168815
- Testing
- High Flow Nasal Cannula or Low Flow Nasal Cannula
- Where
- Canada
- Volunteers
- 98 people
- Sponsor
- Mount Sinai Hospital, Canada
Lung Transplant, CMV
Letermovir for CMV Prevention After Lung Transplantation
This is an interventional, open-label, single center, pilot study with historical controls to test the efficacy of letermovir (LET) for the prevention of CMV infection and disease in adult lung transplant recipients (LTRs) with…
- Trial name
- NCT05041426
- Testing
- Letermovir, Valganciclovir
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Fernanda P Silveira, MD, MS
Lung Transplant Rejection, Primary Graft Dysfunction
Exhaled Breath Particles in Lung Transplantation
Lung transplantation (LTx) is the only effective treatment for patients with end stage lung disease. Of the major organs transplanted, survival following LTx is the lowest with a mean of 5 years.
- Conditions
- Lung Transplant Rejection, Primary Graft Dysfunction, Chronic Rejection of Lung Transplant
- Trial name
- NCT05375149
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Lund University Hospital
Lung Transplant Rejection
Adipose Derived Mesenchymal Cell Treatment in Lungtransplantation
To investigate safety of treatment with allogeneic adipose tissue-derived mesenchymal stromal cells (ASCs) in patients undergoing lung transplantation, to evaluate whether the treatment can reduce host immunological reaction…
- Trial name
- NCT04714801
- Testing
- adipose derived mesenchymal stromal cells, Saline
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hepatopulmonary Syndrome, Liver Cirrhosis
Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study
Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 < 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations.
- Trial name
- HPS (NCT03092401)
- Volunteers
- 142 people
- Sponsor
- Hospices Civils de Lyon
Disorder Related to Lung Transplantation, Bronchiolitis Obliterans
Aerosol Liposomal Cyclosporine for Chronic Rejection in Lung Transplant Recipients
This is a single-center pilot study to investigate the efficacy and safety of aerosolized liposomal cyclosporine A in the treatment of chronic rejection in lung transplant recipients with bronchiolitis obliterans syndrome (BOS).
- Conditions
- Disorder Related to Lung Transplantation, Bronchiolitis Obliterans, Decreased Immunologic Activity, Chronic Rejection of Lung Transplant
- Trial name
- NCT01650545
- Testing
- Liposomal aerosol cyclosporine, standard immune suppression, oral
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Maryland, Baltimore
Pulmonary Mortality, Acute GVH Disease
Skin Disease and Pulmonary Mortality After Transplantation
Predictors for pulmonary mortality was determined in a cohort of 79 patients with acute-GVHD of the skin. The acute-GVHD treatment was corticosteroids and photochemotherapy (Photosensitization with oral 8-methoxysalen and…
- Trial name
- NCT03320928
- Testing
- Photochemotherapy
- Volunteers
- 79 people
- Sponsor
- Karolinska University Hospital
Cystic Fibrosis, Asthma
Multi Breath Nitrogen Washout (MBNW) as a Measure of Small Airway Function in Patients With Respiratory Disease
The researchers are investigating a novel technique, the multi breath nitrogen washout technique, to measure airway changes in various respiratory diseases.
- Conditions
- Cystic Fibrosis, Asthma, Bronchiolitis Obliterans, Lung Transplantation
- Trial name
- NCT00163696
- Where
- Australia
- Volunteers
- 90 people
- Sponsor
- Bayside Health
Cytomegalovirus Infections
Comparison of Oral Valganciclovir and Placebo for the Prevention of Cytomegalovirus (CMV) After Lung Transplantation
The study evaluated the efficacy and safety of a prolonged, continuous course of Valganciclovir (Valgan) in the prevention of CMV by comparing 3 months of Vaglanciclovir, the standard of care upon initiation of the study, to 12…
- Trial name
- Valgan (NCT00227370)
- Testing
- valganciclovir
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Duke University
Lung Transplant Rejection
Cell-free DNA as a Biomarker After Lung Transplantation
The purpose of this investigation is to determine the association of the fraction of donor-derived cell-free DNA in plasma and lung fluid samples with acute rejection as proven by biopsy in lung transplant recipients.
- Trial name
- NCT04271267
- Testing
- No Intervention
- Volunteers
- 126 people
- Sponsor
- Duke University
Hematological Malignancies
Rituximab for Prevention of Chronic GVHD
The purpose of this trial is to determine if administration of rituximab after allogeneic stem cell transplantation can reduce the incidence of chronic GVHD.
- Trial name
- NCT00379587
- Testing
- Rituximab, 375 mg/m2 RRituximab
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Dana-Farber Cancer Institute
Intrahepatic Cholangiocarcinoma (Icc)
Liver Transplantation for Unresectable Intrahepatic Colangiocarcinoma After Sustained Response to Neoadjuvant Treatments
This is single-arm, observational, academic, investigator-driven study investigating the efficacy of liver transplantation after successful and sustained downstaging/tumor control of liver-limited unresectable intrahepatic…
- Trial name
- iCOLA (NCT06862934)
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Disorder Related to Lung Transplantation
Copenhagen Acute Renal Complications After Transplantations Study Group
Lung transplanted patients experience marked decrease in renal function post transplant mainly due to cyclosporine induced renal changes.
- Trial name
- CARCATS (NCT02744872)
- Testing
- Felodipine
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Antibody Mediated Rejection of Lung Transplant
A Phase 1 Clinical Trial of Siltuximab for the Treatment of Antibody-Mediated Rejection After Lung Transplantation
Antibody-mediated rejection after lung transplantation commonly results in allograft failure and death in spite of current therapeutic regimens.
- Trial name
- Siltux-AMR (NCT06990711)
- Testing
- Siltuximab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Lung Transplantation, Bronchiolitis Obliterable Syndrome
Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant Recipients
Bronchiolitis obliterable syndrome (BOS) is the most common cause of death in long-term survivors after lung transplantation and refractory to most interventions.
- Trial name
- NCT01394835
- Testing
- Alpha -1 Antitrypsin, Alpha-1 Antitrypsin, AAT
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Lung Transplant; Complications
RENAL: TNF-alpha Inhibitor for Improving Renal Dysfunction and Primary Graft Dysfunction After Lung Transplant
The purpose of this study is to assess whether TNFa antibody use before lung transplant can prevent kidney injury after lung transplant.
- Trial name
- NCT05950724
- Testing
- Etanercept Injection [Enbrel]
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University