Clinical trials: Post Lung Transplantation
Lung Transplant Infection
Evaluation of Tolsura When Used as Prophylaxis After Lung Transplantation
This is a single-center, observational study of Tolsura PK sampling in lung transplant recipients
- Trial name
- Tolsura (NCT04652050)
- Testing
- Tolsura
- Where
- United States
- Sponsor
- Hong Nguyen
Graft-versus-host Disease (GVHD)
A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)
The purpose of this study is to assess Tacrolimus/Methotrexate/Ruxolitinib versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood…
- Trial name
- NCT06615050
- Testing
- Tacrolimus (Tac), Methotrexate (MTX), Ruxolitinib (Rux)
- Where
- 30 sites in United States
- Volunteers
- 572 people
- Sponsor
- Incyte Corporation
Patients Following Lung Transplantation (Single and Double)
Effects of a Whole Body Vibration Training in Patients After Lung Transplantation
Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients following lung transplantation.
- Trial name
- NCT01480960
- Testing
- Pulmonary rehabilitation + whole body vibration training
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Schön Klinik Berchtesgadener Land
End-stage Lung Disease
BREATHE Study: Spontaneous Breathing-Preserved Anesthesia and Surgical Strategy for Hospital Recovery in Lung Transplantation
The goal of this study is to learn whether a spontaneous-breathing ("tubeless") anesthesia and surgery strategy can improve early recovery and remain safe for adults who receive a lung transplant.
- Trial name
- BREATHE-LTx (NCT07384546)
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 110 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Transplantation
Patient Education After Lung Transplantation Via Tablet Computers Versus Conventional Education
Experimental intervention: Patient education after lung transplantation via Tablet computers. An electronic patient questionnaire via tablet computer will be collected in addition.
- Trial name
- NCT01398488
- Testing
- Patient education
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Hannover Medical School
Kidney Transplantation
Pilot Study on the Use of Sirolimus to Treat Chronic Allograft Nephropathy in Children After Kidney Transplant
The purpose of this study is to determine whether treatment with sirolimus, in combination with low-dose tacrolimus and prednisone, is effective for the treatment of chronic allograft nephropathy (progressive scarring) in…
- Trial name
- NCT00188955
- Testing
- sirolimus
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Transplantation Lung
Viral Load Guided Immunosuppression After Lung Transplantation
The VIGILung study is an open-label, randomized, multicenter trial in lung transplant recipients to investigate the safety and efficacy of personalized immunosuppression guided by DNA monitoring of Torque-Teno-Virus (TTV).
- Trial name
- VIGILung (NCT04198506)
- Testing
- Tailored tacrolimus dosing, Conventional tacrolimus dosing
- Where
- 2 sites in Austria, Germany
- Volunteers
- 146 people
- Sponsor
- Philipps University Marburg
Influenza
Influenza Vaccine in Lung Transplant Patients - Seroprotection
This a sub-study of a 5-year study designed to investigate how antibody and T cell responses following influenza vaccine compare among lung transplant patients, patients waiting for lung transplantation, and healthy individuals.
- Trial name
- NCT04531657
- Testing
- Influenza vaccine
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Respiratory Disease
Study of Variations of Pleural and Esophageal Pressures Under Mechanical Ventilation After Lung Transplantation
The primary objective of the study is to determine the correlation between mean pleural pressure and oesophageal pressure in the immediate aftermath of bi-pulmonary transplantation.
- Trial name
- NCT03179644
- Testing
- Measurement of oesophageal pressure and pleural pressure
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Lung Diseases
Multi-Omics-Based Prediction of Allograft Dysfunction After Lung Transplantation
By establishing a prospective, multicenter lung transplantation clinical cohort, this study aims to systematically evaluate the utility of cfDNA fragmentomics, peripheral blood single-cell sequencing, and proteomics in monitoring…
- Trial name
- NCT07243964
- Testing
- longitudinal changes in multi-omics profiling of peripheral blood
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Chang Chen
Bronchiolitis Obliterans Syndrome, Hematologic Malignancy
Ruxolitinib for Newly Diagnosed Bronchiolitis Obliterans Syndrome
Lung is one of the target organs in chronic graft versus host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Trial name
- NCT05413356
- Testing
- Ruxolitinib
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Post Hematopoietic Stem Cell Transplantation
Pulmonary Disease in Patients Undergoing Hematopoietic Stem Cell Transplantation
This will be a retrospective study and analysis of subjects who have undergone a hematopoietic stem transplant (either at OSUMC or external location) and were seen at OSUMC at any time between 01Jan2000 and 30Jun2011.
- Trial name
- NCT01420172
- Testing
- Data Collection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Karen Wood
Diaphragm, Diaphragm Disease
Diaphragmatic Ultrasound and Weaning After Lung Transplant.
The prevalence and adverse effect of diaphragm dysfunction (DD) after bilateral-lung transplant (LT) are still unclear, despite a well-known negative impact on weaning and outcome in other cohorts of critically ill and surgical…
- Conditions
- Diaphragm, Diaphragm Disease, Diaphragm Issues, Weakness, Muscle
- Trial name
- NCT05670327
- Testing
- Diaphragmatic ultrasound assessment
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- University of Padova
SARS-CoV2 Infection, SARS-CoV2 Antibodies
Determinants of the Level of Anti-SARS-CoV-2 IgG ANTibodiEs After Vaccination Study in Patients After Organ Transplantation
Great expectations to control the pandemic are placed in vaccines against COVID-19. Currently, the four COVID-19 vaccines approved in the European Union.
- Trial name
- DANTE-SIRIO 8 (NCT05162456)
- Testing
- assessment of the anti-SARS-CoV-2 IgG antibody titer in 3-dose schedule, assessment of the anti-SARS-CoV-2 IgG antibody titer in 2-dose schedule
- Where
- Poland
- Volunteers
- 250 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Lung Transplantation, Rejection
Long-Term Study On Home Spirometry After Lung Transplantation
Prospective cohort, mono-center study included electronic data of home spirometry (HS, lung function) of lung transplant recipients
- Conditions
- Lung Transplantation, Rejection, Death, Bronchiolitis Obliterans
- Trial name
- NCT00743171
- Where
- Germany
- Volunteers
- 152 people
- Sponsor
- Hannover Medical School
Infection
Voriconazole as Prophylactic Therapy in Lung Transplant Recipients
The purpose of this study is to compare the safety and efficacy of Voriconazole with Itraconazole following lung transplantation.
- Trial name
- VORI (NCT00455364)
- Testing
- Voriconazole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Lung Transplant Recipients, Muscle Weakness
Efficacy of Early Inspiratory Muscle Training in Lung Transplanted Patients
Lung transplantation is an effective therapeutic option in the end-stage of chronic respiratory diseases. Lung transplantation improves lung function in terms of capacity and volume.
- Conditions
- Lung Transplant Recipients, Muscle Weakness, Respiratory Insufficiency, Pulmonary Rehabilitation
- Trial name
- NCT05271019
- Testing
- Threshold load device
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Puerta de Hierro University Hospital
Bronchiolitis Obliterans Syndrome
Forced Oscillation Versus Spirometry in Diagnosing Post Pulmonary Transplant Bronchiolitis Obliterans Syndrome
A study to evaluate the role of forced oscillation in precocious diagnosis of bronchiolitis obliterans syndrome in patients with pulmonary transplant (time difference in detecting distal airways functional impairment by forced…
- Trial name
- OSCILLOPOUMON (NCT01807975)
- Testing
- Forced oscillation
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Hopital Foch
Lung Transplantation
Ex-Vivo Lung Reconditioning
Only about 15% of the potential candidates for lung donation are considered suitable for transplantation. Thus, a strategy that could improve the quality and precision of assessment of nonacceptable donor lungs could have a major…
- Trial name
- ExVivo (NCT02906436)
- Testing
- Xvivo Chamber
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Hopital Foch
End Stage Liver DIsease, Liver Transplant; Complications
Association Between the Use of Pulmonary Artery Catheter and Clinical Outcomes After Liver Transplantation
The investigators attempted to evaluate whether the use of PAC is associated with better clinical outcomes after liver transplantation compared with the case without PAC.
- Conditions
- End Stage Liver DIsease, Liver Transplant; Complications, Liver Cirrhosis, Liver Diseases
- Trial name
- NCT05457114
- Testing
- Pulmonary artery catheter (Edward Lifesciences, Irvine, California, USA), FloTrac Vigileo system (EV1000 clinical platform, Edward Lifesciences, Irvine, California, USA)
- Where
- South Korea
- Volunteers
- 1,970 people
- Sponsor
- Seoul National University Hospital