Clinical trials: Post Lung Transplantation
End-stage Lung Disease
Perioperative Recovery Outcomes With a Spontaneous Breathing Strategy in Older Lung Transplant Recipients
The goal of this prospective, multicenter, single-arm cohort study is to learn whether a lung transplantation approach that preserves patients' spontaneous breathing during surgery can improve early recovery in adults aged 70…
- Trial name
- NCT07384507
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Transplant Rejection
Histological Profiles of Lung Allograft Transbronchial Biopsies and Clinical Outcomes After Lung Transplantation
Lung transplantation is the only curative treatment for individuals with end-stage lung disease. Understanding the lung allograft's histological lesions, which is key for the patient management, remains difficult because of the…
- Trial name
- LANDSCAPE (NCT05655208)
- Volunteers
- 498 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Lung Transplantation, Bronchoscopy
Anastomotic Airway Complications After Lung Transplantation
Retrospective analysis of data concerning anastomotic airway complications after lung transplantation.
- Trial name
- NCT02265835
- Testing
- no intervention
- Volunteers
- 432 people
- Sponsor
- KU Leuven
Rejection, Lung Transplantation
Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation
In patients with acute rejection after lung transplantation the peptide profile in broncho-alveolar lavage (BAL) and urine should be compared in order to identify a paradigm that allows an non-invasive rejection therapy.
- Trial name
- NCT00558597
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Hannover Medical School
Allogeneic Hematopoietic Cell Transplant Recipients
Prospective Phase II Study for Assessment of Regulatory Immune Cell Populations After Allogeneic HSCT
Allogeneic hematopoietic cell transplantation offers high cure rates for patients with hematological and oncological diseases. Graft-versus-host disease (attack of donor's white blood cells on patient's tissues) is a serious…
- Trial name
- NCT00587574
- Where
- 2 sites in Austria, Czechia
- Volunteers
- 150 people
- Sponsor
- Medical University of Vienna
Chronic Graft-Versus-Host Disease (cGVHD)
A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)
The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD.
- Trial name
- NCT06619561
- Testing
- Vimseltinib
- Where
- 26 sites in United States
- Volunteers
- 48 people
- Sponsor
- Deciphera Pharmaceuticals, LLC
Ocular Graft-versus-host Disease
Allogeneic Platelet Lysate Eye Drops for the Treatment of Severe Chronic Ocular Graft-versus-host Disease
The study evaluates the efficacy and safety of allogeneic platelet lysate eye drops in patients with severe ocular graft versus host disease refractory to conventional systemic and local treatments.
- Trial name
- NCT05311514
- Testing
- Allogeneic platelet lysate eye drops
- Where
- Russia
- Volunteers
- 38 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Metabolic Syndrome
Feasibility of a Home Exercise Program to Manage Post-transplant Metabolic Syndrome
Post-transplant metabolic syndrome (PTMS) affects about 50% liver transplant (OLT) and 25% lung transplant (LTx) recipients at 12-18 months post-transplant.
- Trial name
- NCT04965142
- Testing
- Exercise Training
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University Health Network, Toronto
Chronic Graft-Versus-Host Disease, Graft vs Host Disease
A Prospective Study of Madecassoside Tablets in Sclerotic Chronic Graft-versus-Host Disease After Allo-HSCT
Sclerotic chronic graft-versus-host disease (scl-cGVHD) is a severe subtype of chronic GVHD after allogeneic hematopoietic stem cell transplantation (allo-HSCT), characterized by skin sclerosis, fascial involvement, and…
- Trial name
- NCT07606703
- Testing
- Madecassoside Tablets, Standard Therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- WeiShi
Lung Transplantation
Biodegradable Stents in Lung Transplantation
A prospective observational trial involving 10 patients is planned. Intervention "SX-ELLA Stent Degradable DV Bronchial (DV Stent)" will be implanted in the target lesion in general anesthesia under fluoroscopy or by direct…
- Trial name
- NCT00929942
- Testing
- SX-ELLA Stent Degradable DV Bronchial (DV Stent)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Hannover Medical School
Chronic Rejection of Lung Transplant
Noninvasive Early Detection of Lung Allograft Dysfunction After Lung Transplantation With Multiple Breath Washout Test
Chronic rejection, more commonly called bronchiolitis obliterans syndrome (BOS), is the leading cause of death beyond the first year post lung transplantation.
- Trial name
- NCT05586906
- Testing
- Multiple Breath Washout (MBW) tests
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Post-Acute COVID19 Syndrome, COVID-19
FMT for Post-acute COVID-19 Syndrome
In recovered COVID-19 patients, emerging global data have reported the presence of long COVID, that is, at least one symptom that an alternative diagnosis cannot explain has been persistent for four or more weeks after the…
- Trial name
- FMT-PACS (NCT05556733)
- Testing
- Faecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Allograft Rejection, Lung Transplantation
Vitamin D in Bronchiolitis Obliterans Syndrome
Vitamin D deficiency occurs in around 50% of our transplant population. Preventive treatment with Vitamin D (D-cure) can reduce the prevalence of Bronchiolitis Obliterans Syndrome after lung transplantation
- Conditions
- Allograft Rejection, Lung Transplantation, Bronchiolitis Obliterans
- Trial name
- VIT001 (NCT01212406)
- Testing
- Vitamin D
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lung Transplant, Diaphragmatic Function
Evaluation of Diaphragmatic Function After Bi-pulmonary Transplantation
A current complication after lung transplantation is diaphragmatic dysfunction. These dysfunction result to several factors: duration of mechanical ventilation, chest tube, atelectasis, denutrition, phrenic nerve injury during…
- Trial name
- DIATRIB (NCT03977597)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Chronic Graft-Versus-Host Disease
Treatment of Refractory Acute Graft-Versus-Host Disease by Sequential Infusion of Allogenic Mesenchymal Stem Cell.
The purpose of this study is to determine the safety and efficacy of sequential infusion of allogenic mesenchymal stem cells (MSC) expanded "in vitro" in treating patients with acute graft-versus-host disease refractory to…
- Trial name
- CSM/EICH2010 (NCT01956903)
- Testing
- Allogenic Mesenchymal Stem Cell
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Grupo Espanol de trasplantes hematopoyeticos y terapia celular
Primary Graft Dysfunction, Lung Transplant; Complications
Perioperative Vitamin C Lung Transplant
This study is being done to determine if parenterally administered ascorbic acid (Vitamin C) given at the time of lung transplant is safe. Vitamin C may be an effective intervention towards primary graft dysfunction (PGD).
- Trial name
- NCT04505878
- Testing
- Vitamin C
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Lung Transplantation, Donor-specific Anti-human Leukocyte Antigen(HLA) Antibodies
Monitoring of Donor-specific Antibodies After Treatment With Immunoglobulins, Plasmapheresis and Rituximab in Lung Transplantation
Single-arm, prospective observational study
- Trial name
- NCT03798860
- Testing
- blood samples
- Where
- Germany
- Volunteers
- 340 people
- Sponsor
- Hannover Medical School
Airway Complication Which Require Any Intervention
Early Endoscopic Indicators for OACs After Lung Transplantation: Development of a Novel Mucosal Healing Score
Airway complications are a significant cause of morbidity after lung transplantation (LTx). Bronchoscopic evaluation may help to identify risk factors for requiring interventions later.
- Trial name
- OAC (NCT00940147)
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Thomas Fuehner
Lung Transplant Rejection
LAMBDA 002 (Lung Registry) Study
The LAMBDA 002 registry study is an observational, longitudinal, multi-center study observing patients undergoing lung transplant.
- Trial name
- NCT05170425
- Testing
- Prospera
- Where
- 11 sites in United States
- Volunteers
- 154 people
- Sponsor
- Natera, Inc.
Lung Cancer, Lymphoma
AMG 706 and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: AMG 706 may stop the growth of cancer cells by blocking blood flow to the cancer or by blocking some of the enzymes needed for cell growth.
- Conditions
- Lung Cancer, Lymphoma, Lymphoproliferative Disorder, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00324597
- Testing
- gemcitabine hydrochloride, motesanib diphosphate, pharmacological study
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Jonsson Comprehensive Cancer Center