Clinical trials: Post Operative Complications
Cognitive Disorders, Delirium
The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction
Ketamine is a commonly used anesthetic medication which is used for induction of anesthesia as well as as an analgesic. It has been shown to have anti-inflammatory properties which may decrease post-operative complications…
- Conditions
- Cognitive Disorders, Delirium, Acute Kidney Injury
- Trial name
- NCT02554253
- Testing
- Ketamine, Propofol
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic
Postoperative Pain
RADA16 for Adult Tonsillectomy
The purpose of the research is to determine if RADA16 (also known as PuraStat®, PuraGel®, or PuraSinus®) improves patient outcomes following tonsillectomy procedures.
- Trial name
- NCT07060495
- Testing
- RADA16 hydrogel
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Rutgers, The State University of New Jersey
Agitation, Emergence
Single Bolus Dose of Ketodex Versus Ketofol For Prevention Of Emergence Agitation In Adults Undergoing Nasal Surgeries
emergence agitation is seen in around 68% after nasal surgeries. Agitated patients needs more staff and nurses to control their abnormal movement which leads to self extubation , removal of catheters and bruises in the…
- Trial name
- NCT04018157
- Testing
- "Ketamine" and "dexmedetomidine" and "propofol" and "0.9%saline"
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Gastric Cancer, Postoperative Complications
Comparative Study of Antiperistaltic vs Isoperistaltic Billroth II + Braun Anastomosis for Postoperative Reflux
Postoperative gastroesophageal reflux is one of the most common complications of distal gastrectomy. With more attention paid on it by surgeons, several new operation methods have been practised.
- Trial name
- NCT03372681
- Testing
- Isoperistaltic Billroth II + Braun anastomosis, Antiperistaltic Billroth II + Braun anastomosis
- Volunteers
- 214 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Analgesia, Surgery
Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS
This protocol investigates the effect of a high dose dexamethasone regimen in the treatment of postoperative pain following Transoral Robotic Surgery (TORS). The protocol consists of three substudies. 1.
- Conditions
- Analgesia, Surgery, Cancer of Head and Neck, Oropharyngeal Cancer
- Trial name
- NCT04189107
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Total Intravenous Anesthesia, Desflurane
TIVA Versus Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery
Many factors during laparascopic surgery leads to PONV (postoperative nausea and vomiting), such as C02 insufflations causing peritoneal stretch and irritation and type of anaesthesia given during surgery.
- Conditions
- Total Intravenous Anesthesia, Desflurane, Obesity, Pain, Postoperative
- Trial name
- NCT03727607
- Testing
- Desflurane
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Postoperative Pain, Anterior Cruciate Ligament Reconstruction
Comparison of Two Techniques for Placement of Perineural Femoral Catheters.
The purpose of this study is to assess the efficacy of the hydrolocalization technique for placement of femoral perineural catheters in comparison with stimulating catheters. A non inferiority trial.
- Trial name
- HLOCSTIM2 (NCT01726192)
- Testing
- Placement of a femoral catheter with the hydrolocalization technique, Placement of a femoral neurostimulating catheter
- Where
- 2 sites in Greece, Italy
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Pain, Postoperative, Analgesics, Opioid
Evaluation of Abdominal Wall Block With Liposomal Bupivacaine for Post-Operative Analgesia in Donor Nephrectomy
A blinded randomized control trial in living kidney donors. The study group will receive a liposomal bupivacaine Trans Quadratus Lumborum (TQL) block after the induction of general anesthesia.
- Conditions
- Pain, Postoperative, Analgesics, Opioid, Analgesics, Non-Narcotic, Physiological Effects of Drugs
- Trial name
- NCT03294109
- Testing
- Abdominal wall block with liposomal bupivicaine
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Lymphedema, Perioperative/Postoperative Complications
Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva
RATIONALE: Fibrin sealant may decrease lymphedema following surgery to remove lymph nodes in the groin by helping to seal the lymphatic vessels.
- Conditions
- Lymphedema, Perioperative/Postoperative Complications, Vulvar Cancer
- Trial name
- NCT00028951
- Testing
- fibrin sealant, surgical wound closure
- Where
- 49 sites in United States
- Sponsor
- Gynecologic Oncology Group
Surgical Site Infections
St. Barbara Specialised Regional Hospital No. 5: Surveillance of Healthcare-Associated Infections
Retrospective laboratory-based data collection study of surgical site infections: Surveillance of Healthcare-Associated Infections in Orthopaedic and Trauma Surgery Unit in Sosnowiec, Poland;
- Trial name
- NCT03686553
- Testing
- laboratory-based data collection
- Volunteers
- 5,239 people
- Sponsor
- Polskie Towarzystwo Zakażeń Szpitalnych
Parkinson's Disease, Deep Brain Stimulation
Predicting Cognition After DBS for Parkinson's Disease
The aim of the study is to improve estimation of cognitive outcome after STN-DBS in PD in order to avoid risk factors by optimizing peri- and intraoperative management personalize therapeutic strategies for optimal long-term…
- Conditions
- Parkinson's Disease, Deep Brain Stimulation, Postoperativeneurocognitive Deficit, Postoperative Delirium
- Trial name
- NCT03982953
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Knee Prosthesis
Effect of Normothermia Care Bundle in Knee Replacement Surgery
Osteoarthritis is a disease characterized by disruption of the integrity of articular cartilage as a result of erosion of articular cartilage.
- Trial name
- NCT06454877
- Testing
- active heating, pasive heating
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Neuropathic Pain, Amputation, Traumatic
Postamputation Pain: Peripheral Mechanisms
Stump and phantom pain after amputation are common, but the responsible mechanisms are still not clarified. It has been suggested that phantom limb pain can be reduced by regional anaesthesia and in several recent studies, pain…
- Conditions
- Neuropathic Pain, Amputation, Traumatic, Nerve Block, Phantom Limb Pain
- Trial name
- NCT03317600
- Testing
- Lidocaine
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Pain Research Center
Postoperative Pulmonary Complications, Cardiac Surgery
Diaphragmatic Inspiratory Amplitude as a Prognosticator for Postoperative Pulmonary Complications After Cardiac Surgery
Cardiac surgery is a critical intervention for a variety of cardiovascular conditions, yet it can frequently results in a spectrum of postoperative complications.
- Trial name
- NCT06396767
- Testing
- DIA measured via Ultrasonography
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pancreatic Cancer
Standard Versus Prolonged Antibiotic Prophylaxis After Pancreatoduodenectomy (SPARROW)
The goal of this multicenter randomized controlled trial is to evaluate the additional value of pre-emptive antibiotic treatment on clinically relevant organ/space surgical site infections (OSIs) in patients undergoing…
- Trial name
- SPARROW (NCT05784311)
- Testing
- Cefuroxime, Metronidazole
- Where
- 11 sites in Netherlands
- Volunteers
- 344 people
- Sponsor
- Leiden University Medical Center
Patient Safety, Intraoperative Complications
Validation Study of ClassIntra®
Whereas there are several validated systems for reporting postoperative complications, there are only a few and not prospectively validated systems for reporting intraoperative complications.
- Conditions
- Patient Safety, Intraoperative Complications, Postoperative Complications, Risk Management
- Trial name
- ClassIntra® (NCT03009929)
- Testing
- Observational study
- Where
- 18 sites in United States, Australia and 10 more
- Volunteers
- 2,500 people
- Sponsor
- University Hospital, Basel, Switzerland
Post-Op Complication
Delayed Rewarming for Neuroprotection in Infants Following Cardiopulmonary Bypass Surgery
This is an unblinded, single center, randomized study of infants with congenital heart disease undergoing cardiopulmonary bypass surgery, randomized to either the delayed rewarming intervention or to the standard of care (strict…
- Trial name
- NCT03036072
- Testing
- Strict normothermia, Delayed Rewarming
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Alexa Craig
Laparotomy, Incisional Hernia
Clinical Performance and Safety of Suture-TOOL
The goal of this single arm intervention study is to investigate the safety and performance of a suturing device for closure of the midline incision after open abdominal surgery.
- Conditions
- Laparotomy, Incisional Hernia, Wound Infection, Closure Technique
- Trial name
- NCT05695157
- Testing
- Suture-TOOL
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Suturion AB
Back Pain, Failed Back Surgery Syndrome
Epidural Pulsed Radiofrequency Treatment in Failed Back Surgery Syndrome
Low back pain can persist in some patients with history of back surgery. In some cases, an increase in pain may even occur, and chronic pain may make treatment more difficult.
- Conditions
- Back Pain, Failed Back Surgery Syndrome, Neuropathic Pain
- Trial name
- NCT06239857
- Testing
- Epidural pulsed radiofrequency
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Hip Fracture, Anemia
Study of the Effect of Tranexamic Acid Administered to Patients With Hip Fractures. Can Blood Loss be Reduced?
The effect of Tranexamic acid on blood loss, hemoglobin and transfusions in patients with pertrochanteric hip fractures. Tranexamic acid is a well known drug used in many types of surgery.
- Trial name
- NCT01535781
- Testing
- Tranexamic Acid
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Hvidovre University Hospital
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