Clinical trials: Post Partum Haemorrhage
Postpartum Hemorrhage
Controlled Cord Traction During Third Stage of Labor
Of the estimated number of 529,000 maternal deaths for the year 2000, 132,000 (25%) were caused by postpartum hemorrhage (PPH); 99% of these deaths occurred in low-income countries.
- Trial name
- CCT (NCT00781066)
- Testing
- Controlled cord traction, No controlled cord traction
- Where
- 2 sites in Uruguay
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidad de la Republica
Postpartum Hemorrhage
Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section
Cesarean section (CS) is one of the most frequently performed operative interventions worldwide [1]. Cesarean section rates increase each year throughout the world.
- Trial name
- NCT06765473
- Testing
- Misoprostol
- Volunteers
- 400 people
- Sponsor
- Assiut University
Labor Complication
Comparison of Routine Versus Restrictive Episiotomy in Primigravida Women at Term.
The ongoing debate over routine versus selective episiotomy in primiparous term women underscores the necessity for updated local data.
- Trial name
- NCT07796685
- Testing
- Routine Episiotomy, Restrictive Episiotomy
- Where
- Pakistan
- Volunteers
- 466 people
- Sponsor
- Muhammad Aamir Latif
Postpartum Hemorrhage, Systemic Autoimmune Diseases
Prophylactic Tranexamic Acid Reduces Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the most significant leading cause of pregnancy-related mortality in high-risk cesarean delivery women.
- Trial name
- NCT06754371
- Testing
- tranexamic acid, normal saline
- Where
- China
- Volunteers
- 276 people
- Sponsor
- RenJi Hospital
Pregnancy Complications
Validating a New Method to Assess Estimated Blood Loss in the Obstetric Population
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality in low-income countries and the primary cause of nearly one quarter of all maternal deaths globally.
- Trial name
- NCT03404375
- Testing
- Gauss Triton system
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Post Partum Hemorrhage
Carbetocin Versus Syntometrine in Obese Women Undergoing Elective Cesarean
to compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of Postpartum hemorrhage after cesarean section
- Trial name
- NCT03693599
- Testing
- carbetocin, Syntometrine
- Where
- Egypt
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postpartum Hemorrhage
Comparison of Inhaled Oxytocin (IH) With Intramuscular (IM) Oxytocin in Pregnant Women and With Intravenous (IV) Oxytocin in Healthy Non-pregnant Women
The study will evaluate a stable, dry-powder formulation of oxytocin, with the goal of reducing post-partum hemorrhage morbidity and mortality in resource poor settings.
- Trial name
- NCT02999100
- Testing
- IH Oxytocin, IM Oxytocin, IV Oxytocin
- Where
- 3 sites in Australia, United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Postpartum Hemorrhage
Early Usage of Bakri Ballon in Managing Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the top reason for maternal deaths in China. The four major causes of PPH include uterine atony, genital tract laceration, placenta factors and systemic medical disorders (including inherited and…
- Trial name
- NCT02861482
- Testing
- Bakri Balloon, Oxytocin, Hemabate
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Dongyu Wang
Adverse Effect of Oxytocic Drugs
Carbetocin Versus Syntocinon for Prevention of Postpartum Hemorrhage in Cardiac Patients Undergoing Caesarean Section
Postpartum hemorrhage (PPH) is the primary cause of nearly one quarter of all maternal deaths globally. Management of uterine tone after delivery involves giving a prophylactic uterotonic and the use of controlled cord traction…
- Trial name
- NCT05110482
- Testing
- Syntocinon, Carbetocin
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Cairo University
Maternal Sepsis During Labor, Hemorrhage, Postpartum
Scaling Up an Integrated Approach to Improve Delivery Care in North Guatemala With Stepped Wedge Design
"¡Que Vivan las Madres!: Venga a tener su parto al CAP" (QVLM) is a guatemalan quasi-experimental study that has been performed from January 2014 to January 2017 by the Epidemiological Research Center in Sexual and Reproductive…
- Conditions
- Maternal Sepsis During Labor, Hemorrhage, Postpartum, Eclampsia; Complicating Pregnancy, Pre-Eclampsia
- Trial name
- QVLM (NCT03151070)
- Testing
- QVLM Intervention package
- Volunteers
- 32,000 people
- Sponsor
- Hospital San Juan de Dios Guatemala
Postpartum Hemorrhage
The Use of the Bakri Postpartum Balloon in the Management of Postpartum Hemorrhage Refractory to Conservative Measures
The broad objective of the study is to determine if the Bakri Postpartum Balloon is effective in preventing morbidity and mortality from postpartum hemorrhage (PPH) as part of a standardized management algorithm.
- Trial name
- NCT01844089
- Where
- 2 sites in Kenya
- Volunteers
- 57 people
- Sponsor
- Duke University
Postpartum Hemorrhage
A Study of Self-administered Misoprostol to Prevent Bleeding After Childbirth in the Community (MamaMiso)
Postpartum hemorrhage (PPH) is a major cause of maternal death in the developing world. An important strategy in the prevention of deaths is the use of uterotonic drugs for PPH prophylaxis.
- Trial name
- NCT01510574
- Testing
- Misoprostol
- Where
- 4 sites in Uganda
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Healthy Participants
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Tranexamic acid is a well-established treatment for post-partum hemorrhage. This study aims to examine the effect of tranexamic acid administration rates on blood pressure changes over 1 minute compared to 10 minutes in healthy…
- Trial name
- RateTXA (NCT06356948)
- Testing
- Tranexamic Acid (TXA)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Postpartum Hemorrhage
Misoprostol for Preventing Postpartum Hemorrhage
This hospital-based, multicenter, randomized, placebo-controlled trial will assess the effects of misoprostol as part of active management of the third stage of labor on postpartum blood loss, complications, and side effects.
- Trial name
- NCT00124540
- Testing
- misoprostol
- Where
- 5 sites in Nigeria, South Africa and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Anemia
Well Being of Obstetric Patients on Minimal Blood Transfusions
Postpartum haemorrhage (PPH) is one of the top five causes of maternal mortality in developed and developing countries. The most important treatment of PPH is red blood cell (RBC) transfusion.
- Trial name
- WOMB (NCT00335023)
- Testing
- Red blood cell transfusion
- Where
- Netherlands
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sanquin Research & Blood Bank Divisions
Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage
Patient Blood Management for Massive Obstetric Hemorrhage
Obstetric Hemorrhage continues to be the first cause of maternal morbidity and mortality around the world especially in middle to low income countriesThe blood components are high value resources; however, its use has been shown…
- Conditions
- Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage, Fibrinogen; Deficiency, Acquired, Massive Hemorrhage
- Trial name
- NCT03784794
- Testing
- Thromboelastometry, Standard Coagulation Test, Fibrinogen Concentrate Human
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Angel Augusto Perez Calatayud
Primary Postpartum Haemorrhage
Comparative Study on the Effects of Sublingual Misoprostol in Addition to Standard AMTSL in Low Risk Parturients in LASUTH, Ikeja.
Postpartum haemorrhage is the leading cause of maternal haemorrhage globally. With active management of labour 3 to 16.5% of parturients still experience postpartum haemorrhage.
- Trial name
- NCT02424201
- Testing
- Misoprostol, vitamin c
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Lagos State University
Postpartum Hemorrhage
Study of Predictors of Failure of Sulprostone Treatment in Postpartum Hemorrhage
The investigators wish to identify potential factors predicting failure of second-line drug treatment (sulproston (Nalador®)): risk factors and factors linked to a failure to take initial care for PPH.
- Trial name
- NALAPOST (NCT06164236)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
No Placental Abruption, No Hemorrhage
Proof of Concept Study of a Sucker Hemostatic Intra Uterine in Postpartum Hemorrhage After Abruptio Placenta Assisted
The postpartum hemorrhage (PPH) is the major complication of the delivery. In clinical practice, if after giving birth, the placenta is not expelled naturally, an active management should be triggered.
- Trial name
- HEMOGYN (NCT01589744)
- Testing
- Suction cup Hemostatic Intra-Uterine, device not marked CE (not marketed)
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- AdministrateurCIC
Postpartum Hemorrhage
Oxytocin, Carbetocin and Misopristol for Treatment of Postpartum Hemorrhage: A Multicentric Randomized Trial
Postpartum hemorrhage (PPH) is the leading cause of maternal death worldwide, with an estimated mortality of 140 000 per year. Uterine atony is one of the most important causes of PPH.
- Trial name
- NCT01600612
- Testing
- carbetocin, misopristol, oxytocin
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Sohag University