Clinical trials: Post Transplant Diabetes
Islet Cell Transplantation, Type 1 Diabetes
Pancreatic Islet Cell Transplantation After Kidney Transplantation - A Novel Approach to Immunosupression
The purpose of this study is to further test islet cell transplant in patients who have had a kidney transplant. This study will also evaluate the safety and effectiveness of the anti-rejection medications used to prevent…
- Trial name
- NCT03047200
- Testing
- Islet cell transplantation
- Where
- United States
- Sponsor
- Baylor Research Institute
Post-transplant Diabetes Mellitus, Kidney Transplant; Complications
Define Predictors for Posttransplant Diabetes Mellitus Study
The primary aim of this prospective, multicentre study is to develop an accurate and convenient tool to predict the risk of PTDM at 3 months post-transplant, based on information on the day of transplantation (day 0).
- Trial name
- DECODE (NCT06440330)
- Testing
- continuous glucose monitoring
- Where
- Belgium
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Disorder Related to Renal Transplantation, Diabetes
Prevention of Diabetes After Transplantation by Vildagliptin in the Early Post-transplant Period
Post-transplant diabetes affects 15 to 20% of renal transplant patients and contributes to increased morbidity and reduced survival of transplants and patients.
- Trial name
- PRODIG (NCT02849899)
- Testing
- Vildagliptin
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cardiovascular Disease, Chronic Kidney Disease
Vascular Risk After Kidney Transplantation
Hypothesis: Nontraditional risk factors, such as inflammation, vitamin D deficiency, elevated PTH, insulin resistance, homocysteine, or uric acid, contribute to cardiovascular disease progression after kidney transplant.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease, Diabetes, Vitamin D Deficiency
- Trial name
- NCT00374595
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- University of Nebraska
Kidney Transplant; Complications, Diabetes Mellitus, Type 2
CardioRenal Effects of SGLT2 Inhibition in Kidney Transplant Recipients
CREST-KT is a single-center, double-blinded, randomized trial of empagliflozin therapy in 72 kidney transplant recipients with (n=36) and without type 2 diabetes (n=36).
- Trial name
- CREST-KT (NCT04906213)
- Testing
- Empagliflozin10Mg Tab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Chronic Pancreatitis, Diabetes Mellitus
Intra-Portal Alone Versus Intra- and Extra-Portal Transplantation of Pancreatic Islets After Total Pancreatectomy for Chronic Pancreatitis
Randomized pilot trial of patients (n=30) undergoing Total Pancreatectomy and Islet AutoTransplant (TPIAT). Patients with islet harvest of greater than 5000 islet equivalents/kg body weight will be randomized to receive a portion…
- Conditions
- Chronic Pancreatitis, Diabetes Mellitus, Islet Cell Transplantation
- Trial name
- iSite (NCT03779139)
- Testing
- Intrahepatic islets and islets in the omental pouch, Intrahepatic islets alone, Normal Volunteers
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetes Mellitus
Risk Factors for Diabetes After Stem Cell Transplantation
This study is proposed to investigate the incidence of Post Transplant Diabetes Mellitus (PTDM) as well as associated risk factors for the development of PTDM in patients undergoing allogenic stem cell transplantation.
- Trial name
- NCT00539851
- Volunteers
- 87 people
- Sponsor
- Vanderbilt University
Diabetes, Liver Transplant; Complications
Optimal A1c Control in Post Liver or Combined Liver and Kidney Transplant Recipients Who Have Diabetes Mellitus
Major cardiovascular events are greatest in liver transplant recipients with sustained post-transplantation diabetes1. However, the optimal A1c target after transplantation has not been studied.
- Conditions
- Diabetes, Liver Transplant; Complications, Kidney Transplant Failure
- Trial name
- NCT04216303
- Testing
- hemoglobin A1c
- Where
- United States
- Sponsor
- Methodist Health System
Renal Transplantation
Prediction of NODAT After Renal Transplantation
A statistical analysis of the predictive value of OGTT and FPG testing executed as part of standard clinical practice after renal transplantation for the diagosis of new-onset diabetes mellitus after transplantation.
- Trial name
- NCT00442988
- Where
- Belgium
- Volunteers
- 360 people
- Sponsor
- KU Leuven
Diabetes, Renal Failure
MR-Evaluation of Renal Function-After-Pancreas-transplantation
The purpose of this study is to evaluate the beneficial effect of pancreas transplantation for long term kidney function in patients undergoing single-pancreas transplantation.
- Conditions
- Diabetes, Renal Failure, Pancreas Transplantation
- Trial name
- MERFAP (NCT01537445)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University
Type 1 Diabetes (T1D), Islet Transplantation
Extended Follow-Up After Islet Transplantation in T1D
The purpose of this study is to provide patients who have received at least one islet transplant as a previous participant in a Clinical Islet Transplantation Consortium (CIT) clinical trial with maintenance immunosuppressive…
- Trial name
- NCT01369082
- Testing
- Maintenance Immunosuppressive Treatment
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes
Extending Indication for Islet Autotransplantation in Pancreatic Surgery
Islet autotransplantation (IAT) is a therapeutic approach used to prevent pancreatogenic diabetes or to reduce the severity of diabetes after a major pancreatectomy.
- Trial name
- AutoTx (NCT01702051)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Ospedale San Raffaele
Post Coronary Artery Bypass Grafting, Hypertension
"Smart Family Doctor" Assisted Comprehensive Management of Secondary Prevention Among Post Coronary Artery Bypass Graft Patients or Post Percutaneous Coronary Intervention Patients
This study aims to evaluate the effect of an AI-assisted "Smart family doctor" digital health management tool on improving the control rates of hypertension, diabetes, and dyslipidemia in post-CABG (coronary artery bypass…
- Conditions
- Post Coronary Artery Bypass Grafting, Hypertension, Diabetes Mellitus, Hyperlipidemia
- Trial name
- SMART (NCT06615609)
- Testing
- Smart family doctor, Health manager
- Where
- China
- Volunteers
- 536 people
- Sponsor
- China National Center for Cardiovascular Diseases
Graft Failure, Death
European Transplant Registry of Senior Renal Transplant Recipients on Advagraf
SENIOR transplant Registry European transplant registry of senior renal transplant recipients (above the age of 65 years) receiving initial immunosuppression with tacrolimus once daily, mycophenolate and steroids to investigate…
- Conditions
- Graft Failure, Death, Acute Rejection of Renal Transplant, Infections
- Trial name
- SENIOR (NCT02558452)
- Testing
- Tacrolimus once daily (Advagraf)
- Volunteers
- 1,000 people
- Sponsor
- Klemens Budde
Diabetes, Insulin Resistance
Measurement of the Pancreas Function in Patients With More Than One Pancreas After Liver and Small Bowel Transplantation
Under chronic immunosuppressive and corticosteroid therapy, transplant patients have a tendency to develop in the long-term diabetes.
- Conditions
- Diabetes, Insulin Resistance, Liver/Small Bowel Transplant
- Trial name
- NCT01621516
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Kidney Transplant Recipients, Post-transplant Diabetes Mellitus
Efficacy, Mechanisms and Safety of SGLT2 Inhibitors in Kidney Transplant Recipients
This study will be a randomized, double-blind, placebo-controlled clinical trial comparing the SGLT2 inhibitor dapagliflozin to placebo in 52 kidney transplant recipients (KTR) with or without pre-existing type 2 diabetes (T2D)…
- Conditions
- Kidney Transplant Recipients, Post-transplant Diabetes Mellitus, Type 2 Diabetes
- Trial name
- INFINITI2019 (NCT04965935)
- Testing
- Dapagliflozin 10 MG Oral Tablet
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University Health Network, Toronto
Diabetes After Total Pancreatectomy
Autologous Transplantation of Expanded Pancreatic Islet Cells (YD01-2022) in Patients
This study will evaluate the efficacy and safety of autologous transplantation of expanded pancreatic islet cells in patients with diabetes mellitus after total pancreatectomy.
- Trial name
- NCT05990517
- Testing
- YD01-2022
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type 1 Diabetes Mellitus
Efficacy of Islet After Kidney Transplantation
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00468117
- Testing
- Islet transplantation, Antithymocyte Globulin, Daclizumab or Basiliximab
- Where
- 10 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Wound
Evaluation of the Safety and Effectiveness of ALLEVYN Gentle Border
The clinical study will evaluate the safety and effectiveness of the ALLEVYN Gentle Border. The study is a post-market clinical follow-up to assess clinical performance and safety of ALLEVYN Gentle Border with new wound contact…
- Trial name
- NCT03877484
- Testing
- ALLEVYN Gentle border
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 43 people
- Sponsor
- Smith & Nephew Orthopaedics AG
Type 1 Diabetes Mellitus
Islet After Kidney Transplant for Type 1 Diabetes
The purpose of this study is to determine if prolonged administration of the anti TNF (tumor necrosis factor)-Alpha agent etanercept is associated with enhanced graft survival in patients undergoing islet after kidney…
- Trial name
- NCT00784966
- Testing
- etanercept
- Where
- United States
- Sponsor
- Virginia Commonwealth University