Clinical trials: Post Transplant Diabetes
Type 1 Diabetes (T1D), Islet Transplantation
Extended Follow-Up After Islet Transplantation in T1D
The purpose of this study is to provide patients who have received at least one islet transplant as a previous participant in a Clinical Islet Transplantation Consortium (CIT) clinical trial with maintenance immunosuppressive…
- Trial name
- NCT01369082
- Testing
- Maintenance Immunosuppressive Treatment
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type I
Study of Islet Transplantation in Type 1 Diabetic Kidney Transplant Recipients
The purpose of the study is to learn if islet transplantation is an effective treatment for Type 1 diabetes in people who have had a kidney transplant.
- Trial name
- NCT00888628
- Testing
- Purified Pancreatic Islets, Etanercept
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus
Effectiveness Study of Pramlintide to Treat Post-Transplant Diabetes Mellitus
Post-transplant diabetes mellitus (PTDM) develops in up to 30% of patients undergoing solid organ transplantation. This disease is difficult to treat as the levels of glycemia fluctuate in response to variations in doses of…
- Trial name
- NCT01165944
- Testing
- Pramlintide
- Where
- United States
- Sponsor
- University of Colorado, Denver
New Onset Diabetes Mellitus After Renal Transplantation
Improving Secretion of Insulin in New Onset Diabetes After Renal Transplantation
New onset diabetes after transplantation (NODAT) is a frequent and feared complication after kidney transplantation and leads to an increase in cardiovascular complications as well as in the rate of graft loss.
- Trial name
- ISINODAT (NCT01268995)
- Testing
- Cyclosporine A, Tacrolimus
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Vienna
New Onset Diabetes After Transplant, Kidney Transplantation
Comparison of NODAT in Kidney Transplant Patients Receiving Belatacept Versus Standard Immunosuppression
This study is being conducted to determine if belatacept is an appropriate alternative immunosuppressive medication (reducing the immune system's effect) when a kidney transplant patient develops new onset diabetes after…
- Trial name
- NCT01875224
- Testing
- Belatacept, Tacrolimus
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arizona
Diabetes Mellitus
Vildagliptin in New Onset Diabetes After Transplantation
The purpose of this study is to determine whether monotherapy with Vildagliptin improve glycemic control in kidney transplanted patients with newly diagnosed New Onset Diabetes after Transplantation (NODAT).
- Trial name
- VINODAT (NCT00980356)
- Testing
- Vildagliptin
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Vienna
Diabetes Mellitus, Adult-Onset
Optimum Immunosuppression in Renal Transplant Recipients.New Onset Diabetes After Transplantation
New onset diabetes after renal transplantation (NODAT) is a common and severe complication negatively influencing graft and patient survival. Cyclosporine (CsA) and Tacrolimus are the basis of modern immunosuppression.
- Trial name
- 01-DMPT (NCT01002339)
- Testing
- Tacrolimus with rapid steroid withdrawal, Tacrolimus with steroids minimization, CsA with steroid minimization
- Where
- 10 sites in Spain
- Volunteers
- 134 people
- Sponsor
- Armando Torres Ramírez
Kidney Transplantation, Pancreas Transplantation
PK Study in Diabetic Transplant récipients : From Twice-daily Tacrolimus to Once-daily Extended-release Tacrolimus
The investigators believe that the pharmacological properties of Envarsus®, well studied in kidney transplantation, may be also suitable after simultaneous kidney and pancreas transplantation than Prograf.
- Conditions
- Kidney Transplantation, Pancreas Transplantation, Diabetes
- Trial name
- SPK-PK (NCT04496401)
- Testing
- Tacrolimus and Tacrolimus Extended Release Oral Tablet [Envarsus]
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Diabetes Mellitus
Exercise, Prediabetes and Diabetes After Renal Transplantation.
This study is designed to evaluate the feasibility of exercise to reverse prediabetes after transplantation to prevent Posttransplantation Diabetes Mellitus (PTDM).
- Trial name
- EXPRED (NCT04489043)
- Testing
- Exercise and healthy lifestyle recommendations
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario de Canarias
Type 1 Diabetes Mellitus
Efficacy of Islet After Kidney Transplantation
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00468117
- Testing
- Islet transplantation, Antithymocyte Globulin, Daclizumab or Basiliximab
- Where
- 10 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
de Novo Kidney Transplantation
Study to Evaluate the Safety and Efficacy of Advagraf vs Prograf in Kidney Transplantation Patients 1 Month After the Transplantation
To investigate the efficacy, safety, and drug compliance of Advagraf® (Extended Release Tacrolimus) by comparing the Advagraf® + steroid + Mycophenolate Mofetil combined therapy and the Prograf® + steroid + Mycophenolate Mofetil…
- Trial name
- AdProCISE (NCT01742624)
- Testing
- Advagraf, Prograf, Corticosteroid
- Where
- 3 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Astellas Pharma Korea, Inc.
Post-transplant Diabetes Mellitus, Kidney Transplant; Complications
Define Predictors for Posttransplant Diabetes Mellitus Study
The primary aim of this prospective, multicentre study is to develop an accurate and convenient tool to predict the risk of PTDM at 3 months post-transplant, based on information on the day of transplantation (day 0).
- Trial name
- DECODE (NCT06440330)
- Testing
- continuous glucose monitoring
- Where
- Belgium
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Diabetes Mellitus
Post-operative Complications and Graft Survival With Conventional Versus Continuous Glucose Monitoring in Patients With Diabetes Mellitus Undergoing Renal Transplantation
This will be a prospective, randomized, single-blinded controlled trial in which the investigators evaluate post-operative serum glucose control using conventional point-of-care glucose monitoring in the morning and before meals…
- Trial name
- NCT04742023
- Testing
- Continuous Glucose Monitor Application, Finger Stick Glucose Measurement, Insulin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Cardiovascular Disease, Chronic Kidney Disease
Vascular Risk After Kidney Transplantation
Hypothesis: Nontraditional risk factors, such as inflammation, vitamin D deficiency, elevated PTH, insulin resistance, homocysteine, or uric acid, contribute to cardiovascular disease progression after kidney transplant.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease, Diabetes, Vitamin D Deficiency
- Trial name
- NCT00374595
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- University of Nebraska
Islets of Langerhans Transplantation, Diabetes Mellitus
Arginine-stimulated Indication of Early Outcome After Islet Transplantation
Through islet transplantation, functional β-cell mass can be restored. Allogeneic islet transplantation is a treatment modality for a select group of patients with complicated type 1 diabetes mellitus.
- Conditions
- Islets of Langerhans Transplantation, Diabetes Mellitus, Chronic Pancreatitis
- Trial name
- ALADDIN (NCT05540197)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Immunodeficiency Secondary to Organ Transplantation
Evolution of Interleukin 7, Fat Mass and Metabolic Profile Before and After Transplantation
Three different white adipose tissue-related disorders, whether due to its excess (obesity), absence (lipoatrophies) or aberrant distribution (lipodystrophies), are paradoxically able to induce metabolic insulin resistance…
- Trial name
- IL-7tran (NCT01414660)
- Testing
- transplantation
- Where
- 5 sites in France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Lille
Pre Diabetes
Assess the Efficacy and Safety of Exenatide SR for the Prevention of Diabetes After Kidney Transplantation
Researchers are trying to determine if an anti-diabetes medication, called Exenatide SR, is well tolerated in kidney transplant patients with elevated blood glucose levels, and if it's effective in preventing diabetes.
- Trial name
- NCT03961256
- Testing
- Exenatide SR
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes Mellitus
Visualizing Beta Cells After Islet Transplantation
In patients with type 1 diabetes (T1D) that have undergone islet of Langerhans transplantation or are on the waiting list for transplantation, Ga-68-exendin PET imaging is performed to study the visualization of transplanted…
- Trial name
- GLP1-transpl (NCT03785236)
- Testing
- 68Ga-NODAGA-exendin PET/CT
- Where
- 2 sites in Netherlands, Sweden
- Volunteers
- 13 people
- Sponsor
- Radboud University Medical Center
Posttransplant Diabetes Mellitus
Efficacy Study of Sitagliptin to Prevent New-onset Diabetes After Kidney Transplant
The purpose of this study is to determine whether sitagliptin is effective in preventing the development of new-onset diabetes after kidney transplant (NODAT).
- Trial name
- NCT01928199
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Washington University School of Medicine
Diabetes After Total Pancreatectomy
Autologous Transplantation of Expanded Pancreatic Islet Cells (YD01-2022) in Patients
This study will evaluate the efficacy and safety of autologous transplantation of expanded pancreatic islet cells in patients with diabetes mellitus after total pancreatectomy.
- Trial name
- NCT05990517
- Testing
- YD01-2022
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine