Clinical trials: Post Traumatic Stress
Chronic Low Back Pain, Posttraumatic Stress Disorder
Exercise Maintenance in Chronic Pain and PTSD
The primary purpose of the R21 is using an experimental medicine research approach to study whether a chronic, progressive-based exercise program will help Veterans suffering from chronic low back pain (cLBP) and PTSD achieve…
- Trial name
- NCT03644927
- Testing
- Progressive exercise training, Waitlist Control
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston University
Tobacco Dependence, PTSD
Behavioral Activation for Smoking Cessation in PTSD
The purpose of this study is to examine whether behavioral activation as an adjuvant to standard smoking cessation treatment improves smoking cessation outcomes among veterans with PTSD relative to a comparably intense…
- Trial name
- NCT01995123
- Testing
- Behavioral Activation Therapy, Health and Smoking Education, Standard Smoking Cessation Therapy
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD
Group Treatment for PTSD: A Randomized Clinical Trial With Veterans
The purpose of this study is to examine whether group cognitive behavioral treatment (GCBT) is efficacious in the treatment of PTSD in a sample of male Veterans.
- Trial name
- GCBT (NCT01544088)
- Testing
- Group Cognitive Behavioral Treatment (GCBT), Present Centered Group Treatment
- Where
- 2 sites in United States
- Volunteers
- 198 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence, Posttraumatic Stress Disorder
Mechanisms of Change, Motivation, and Treatment Outcome in Alcohol Dependence - Posttraumatic Stress Disorder
The purpose of this study is to test if provision of an effective psychotherapy for Post-traumatic Stress Disorder (PTSD), prolonged exposure, can be tolerated in alcohol dependent patients with PTSD and if it is associated with…
- Trial name
- NCT01409707
- Testing
- Trauma-focused exposure therapy, Motivational enhancement + trauma-focused exposure therapy, Healthy lifestyles sessions
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Mississippi Medical Center
Stress Disorders, Post-Traumatic, Anxiety Disorders
Peer Social Support During In Vivo Exposure for PTSD
Veterans who have prematurely dropped out of exposure therapy for PTSD will be contacted and offered the opportunity to return to treatment, this time with the assistance of an in vivo exposure therapy 'workout buddy'.
- Conditions
- Stress Disorders, Post-Traumatic, Anxiety Disorders, Mental Disorder, Traumatic Disorder
- Trial name
- PEP (NCT03485391)
- Testing
- Prolonged Exposure
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Medical University of South Carolina
PTSD
PTSD Coach App Evaluation
PTSD Coach is a mobile application (app) that aims to teach individuals self-management strategies for symptoms of Post-traumatic Stress Disorder (PTSD). PTSD is a major public health concern.
- Trial name
- NCT02445196
- Testing
- PTSD Coach, Smartphone
- Volunteers
- 120 people
- Sponsor
- Craig Barr Taylor
TBI, Anxiety
Cranial Electrotherapy Stimulation (CES) Therapy
The primary aim of this proposed study is to gather preliminary data for CES use in treating PTSD and anxiety symptoms in OEF/OIF Veterans with PTSD and a history of TBI.
- Conditions
- TBI, Anxiety, PTSD, Depression
- Trial name
- CES (NCT02453347)
- Testing
- CES Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Brain Injury, Chronic
Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
The purpose of this study is to determine if hyperbaric oxygen therapy (HBOT) improves the cognitive function of OIF/OEF individuals who have chronic mild to moderate traumatic brain injury (TBI).
- Trial name
- NCT00810615
- Testing
- Hyperbaric oxygen @ 2.4 ATA
- Volunteers
- 50 people
- Sponsor
- San Antonio Military Medical Center
Acute Pain, Wound Care
RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain
The Ketamine for Acute Pain in Burns study is a randomized, double-blind, parallel group trial (RCT) with active control (usual care) contrasting the efficacy and safety of "Ketamine Plus Opiate-based usual care" (O+K) with the…
- Conditions
- Acute Pain, Wound Care, Posttraumatic Stress Disorder
- Trial name
- NCT03305055
- Testing
- ketamine, Fentanyl
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Traumatic Brain Injury, Chronic Pain
One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change
Mild traumatic brain injury (mTBI) is the signature wound of Veterans returning from the operations in Iraq and Afghanistan (i.e., OIF/OEF/OND), with up to 20 percent experiencing persistent post-concussive symptoms.
- Conditions
- Traumatic Brain Injury, Chronic Pain, Post Traumatic Stress Disorder, Depression
- Trial name
- NCT04143243
- Testing
- ACT on Life, Education, Resources, and Support
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence, Posttraumatic Stress Disorder (PTSD)
A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD
The goal of this project is to improve the treatment of veterans with co-occurring alcohol dependence and posttraumatic stress disorder (PTSD).
- Trial name
- TAP2 (NCT01749215)
- Testing
- Topiramate, Medical Management
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- University of California, San Francisco
Posttraumatic Headache, Combat Disorders
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
The purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members…
- Conditions
- Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache
- Trial name
- NCT02266329
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- VA Office of Research and Development
PTSD, Overweight
MOVE!+UP: Testing a Tailored Weight Management Program for Veterans With PTSD
Posttraumatic Stress Disorder (PTSD) is common among Veterans and results in poor psychological functioning, quality of life, and physical health.
- Conditions
- PTSD, Overweight, Obesity
- Trial name
- NCT04563741
- Testing
- MOVE!+UP, MOVE!
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
PTSD
Clinical Trial Intelligent Biometrics for PTSD - Clinical Trial
Posttraumatic stress disorder (PTSD) is a debilitating mental health condition that increases suicide risk and affects up to 20% of military veterans and 8% of the general population.
- Trial name
- NCT04471207
- Testing
- Therapist Guided Prolonged Exposure with BioWare Device, Record Only Prolonged Exposure with BioWare Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, Post Traumatic Stress Disorder
Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma
The U.S. Deaf community - more than 500,000 Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure as compared to the…
- Trial name
- NCT03845985
- Testing
- Seeking Safety + Signs of Safety toolkit
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Stress Disorder, Post Traumatic
D-cycloserine and Virtual Reality Exposure to Treat Iraq War Veterans With PTSD
This study will determine whether a combination of virtual reality exposure therapy and D-cycloserine will reduce post-traumatic stress disorder symptoms in Iraq war veterans.
- Trial name
- NCT00356278
- Testing
- D-Cycloserine, Alprazolam, Virtual Reality Exposure Therapy
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Emory University
Sleep Initiation and Maintenance Disorders, Anxiety
HIRREM Developmental Study
The purpose of this study is to explore the functional and physiological effects associated with the use of High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), as supplemental care, for symptoms of…
- Conditions
- Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes
- Trial name
- NCT02709369
- Testing
- HIRREM
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD)
Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD
The wars in Iraq and Afghanistan are creating a new generation of Veterans, including an increasing number of women Veterans, who present with comorbid PTSD and chronic pain conditions from recent deployment-related physical…
- Conditions
- Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD), Mild or Moderate Traumatic Brain Injury
- Trial name
- EXCPPTSD (NCT03283163)
- Testing
- Exercise Testing and Training
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post-Traumatic Stress Disorder
Orvepitant (GW823296) in Adult Post Traumatic Stress Disorder
This is a 12-week, randomized, multicenter, double-blind, placebo controlled, fixed-dose parallel group study to assess the efficacy and safety of orvepitant (60 mg/day) versus placebo in subjects with a diagnosis of…
- Trial name
- NCT01000493
- Testing
- orvepitant
- Where
- 26 sites in United States
- Volunteers
- 132 people
- Sponsor
- GlaxoSmithKline
Brain Concussion
Enhanced Problem-Solving Training
Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom.
- Trial name
- E-PST (NCT03759223)
- Testing
- Enhanced Problem-Solving Training (E-PST), Healthy Living Messages (HLM), Enhanced Problem-Solving Training (E-PST) (non-randomized)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development