Clinical trials: Post Traumatic Stress, open to volunteers
Spinal Cord Injuries, PTSD
Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury
This study will examine the use brief prolonged exposure (Brief PE) therapy compared to standard clinical care to reduce posttraumatic distress among people who have had a spinal cord injury and are receiving rehabilitation in an…
- Conditions
- Spinal Cord Injuries, PTSD, Post-Traumatic Stress Disorder
- Trial name
- NCT05233111
- Testing
- Brief Prolonged Exposure Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor Research Institute
Insomnia, PTSD
The Effects of Orexin Antagonism on Fear Extinction in PTSD
PTSD affects approximately 22% of Veterans who have served in Iraq and Afghanistan. Symptoms of PTSD may include re-experiencing, avoidance of trauma reminders, negative thoughts or feelings, and hyperarousal, such as increased…
- Trial name
- NCT06788522
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 40,120 people
- Sponsor
- VA Office of Research and Development
PTSD - Post Traumatic Stress Disorder, PTSD
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
The Redefine Study (COMP202) is testing COMP360 to see if it may reduce post-traumatic stress disorder (PTSD) symptoms when administered alongside monitoring and support from a trained study team.
- Conditions
- PTSD - Post Traumatic Stress Disorder, PTSD, PTSD Symptoms, PTSD, Post Traumatic Stress Disorder
- Trial name
- Redefine (NCT07570654)
- Testing
- COMP360 psilocybin
- Where
- 17 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- COMPASS Pathways
PTSD - Post Traumatic Stress Disorder
Advancing Skills Through Consultation, Education, and Novel Technologies
This research study tests strategies to train behavioral health providers in Written Exposure Therapy (WET), an evidence-based treatment for posttraumatic stress disorder (PTSD).
- Trial name
- ASCENT (NCT07707102)
- Testing
- Live workshop, AI-enhanced Web-based training, Consultation video calls
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Depression Disorder, Post Traumatic Stress Disorder PTSD
The Effects of Extreme Prematurity on Parenting
In France, perinatal mental health has become a major public health issue. Maternal mental health conditions can have serious consequences, including death by suicide.
- Trial name
- PREMA-PSY (NCT07918365)
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
PTSD - Post Traumatic Stress Disorder, Depression
Feasibility of a Web-based Single-session Intervention Combined With Ecological Momentary Assessment and Intervention for Patients With Complex Posttraumatic Stress Disorder Awaiting Inpatient Treatment
This clinical trial examines whether a self-administered web-based single-session intervention named AWARE OUT, combined with Ecological Momentary Assessments (EMA) and Ecological Momentary Interventions (EMI), can be feasibly…
- Conditions
- PTSD - Post Traumatic Stress Disorder, Depression, Anxiety, Complex Post-Traumatic Stress Disorder (CPTSD)
- Trial name
- NCT07920107
- Testing
- Digital self-administered web-based single-session intervention, While Waiting application: Ecological momentary assessments and interventions
- Volunteers
- 30 people
- Sponsor
- University of Oslo
Depression - Major Depressive Disorder, Anxiety
Deaf CBT-TS to Reduce Suicide Risk
The goal of this clinical trial is to learn if a short, Zoom-based intervention, Cognitive Behavioral Therapy for Treatment-Seeking for Deaf Individuals (Deaf CBT-TS) can change beliefs about mental health treatment and increase…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, PTSD - Post Traumatic Stress Disorder, Insomnia
- Trial name
- NCT07279363
- Testing
- Deaf CBT-TS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Rochester
PTSD, Post-traumatic Stress Disorder
Deep Brain Reorienting in Post-traumatic Stress Disorder
This study will evaluate the efficacy of a therapeutic treatment, Deep Brain Reorienting (DBR), for PTSD (Post-traumatic Stress Disorder). Participants will be randomized to either the DBR treatment, or wait-list condition.
- Trial name
- NCT04317820
- Testing
- Deep Brain Reorienting (DBR)
- Where
- Canada
- Volunteers
- 234 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
PTSD, Post Traumatic Stress Disorder, Moral Injury
Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational and Hyperarousal-Related Neural Reactivity Mechanisms in Veterans With PTSD and Moral Injury
Despite being exposed to a high level of potentially traumatic experiences due to exposure to combat, military veterans have poor response rates to traditional PTSD treatments, in some reports, just 1/3 of veterans recover using…
- Trial name
- NCT06394284
- Testing
- MDMA-AT, SEA-IT
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Herzog Hospital
Insomnia, Nightmares Associated With Trauma and Stress
Restorative Early Sleep Treatment After the Emergency Department
The goal of this randomized controlled trial is to pilot the virtual delivery of cognitive behavioral therapy for insomnia (CBT-I) and nightmares (CBT-I\&N) via telehealth as an early intervention for treating posttraumatic sleep…
- Conditions
- Insomnia, Nightmares Associated With Trauma and Stress, Nightmares, PTSD - Post Traumatic Stress Disorder
- Trial name
- RESTED (NCT07121270)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Cognitive Behavioral Therapy for Insomnia and Nightmares, Sleep Education
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Henry Ford Health System
Post Traumatic Stress Disorder
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD
This study is evaluating the safety and efficacy of TSND-201 in adults with PTSD. Eligible participants will enter a 4-week Treatment Period where they will be randomized 1:1:1 to receive one of two doses of TSND-201 or placebo…
- Trial name
- EMPOWER-2 (NCT07836647)
- Testing
- TSND-201
- Where
- 9 sites in United States
- Volunteers
- 300 people
- Sponsor
- Transcend Therapeutics
PTSD - Post Traumatic Stress Disorder
Virtual Reality Assisted Trauma Focused CBT
Virtual Reality (VR) is becoming an increasingly important tool in mental healthcare, offering new ways to enhance patient treatment.
- Trial name
- NCT07914634
- Testing
- VR Photoscan, Trauma-Focused Cognitive Behavioural Therapy (TF-CBT)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen's University, Belfast
Alcohol Problems, Post-Traumatic Stress Disorder
The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veterans
Veterans seeking to improve their romantic relationships when high conflict and unhealthy dynamics (e.g., aggression) are present remain underserved within the VHA with few treatment options.
- Trial name
- ACT-SHARE (NCT06746727)
- Testing
- Acceptance and Commitment Therapy for Social Health, Achievement, and Relationship Effectiveness (ACT-SHARE)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Transdiagnostic, Depression - Major Depressive Disorder
Open-Label Psilocybin Study in Transdiagnostic Population
The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms.
- Conditions
- Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms
- Trial name
- NCT06442423
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
PTSD, PTSD - Post Traumatic Stress Disorder
Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies
PRE-EMPT will assemble a cohort of 150 participants from three populations (low risk, intermediate risk, and high risk for self-harm).
- Conditions
- PTSD, PTSD - Post Traumatic Stress Disorder, Major Depression, Suicidality
- Trial name
- PRE-EMPT (NCT07745569)
- Testing
- Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback
- Volunteers
- 150 people
- Sponsor
- University of New Mexico
Post-traumatic Stress Disorder
Recovering Sleep After Trauma
The main objective of this pilot trial is to assess the feasibility and preliminary efficacy of telehealth-delivered behavioral therapy to reduce the development of posttraumatic stress and depressive symptoms following motor…
- Trial name
- REST (NCT07196332)
- Testing
- Brief Behavioral Treatment for Insomnia (BBTI), Progressive Muscle Relaxation Training (PMRT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Written Exposure Therapy, Breathing Techniques
Early Intervention for Postpartum PTSD: Comparing Written Exposure and Capnometry-Guided Breathing Therapy
The purpose of this study is to examine two early interventions, Written Exposure Therapy and Capnometry Guided Breathing, to reduce post-traumatic stress disorder (PTSD) symptoms in women after childbirth as compared to usual…
- Conditions
- Written Exposure Therapy, Breathing Techniques, PTSD (Childbirth-Related), Postpartum Care
- Trial name
- NCT07342530
- Testing
- Written Exposure Therapy (WET), Capnometry-Guided Breathing Intervention (CGRI)
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Stanford University
Stress Disorders, Post-Traumatic, Substance-Related Disorders
RISE for PTSD and Substance Use Disorder in Veterans
Veterans with co-occurring posttraumatic stress disorder (PTSD) and substance use disorder (SUD) experience significant impairment and worse treatment outcomes compared to those with either condition alone, including higher rates…
- Trial name
- RISE (NCT07903753)
- Testing
- Written Exposure Therapy, Cognitive Behavioral Therapy for Substance Use Disorders (skill components), Cognitive Behavioral Therapy for Substance Use Disorders
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder PTSD, Hazardous Alcohol Use
Multimodal Intervention for Individuals With Posttraumatic Stress Disorder (PTSD) and Hazardous Alcohol Use
This project will test the effectiveness of a stepped-care talk therapy model for patients with PTSD and Hazardous Alcohol use (HAU).
- Trial name
- NCT07903974
- Testing
- Written Exposure Therapy (WET), Clinician Supported PTSD Coach App (CS-PTSD), Phone follow up
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
PTSD - Post Traumatic Stress Disorder
Written Exposure Therapy Plus Adjunctive Methylphenidate Treatment for Veterans With PTSD
Many Veterans with post-traumatic stress disorder (PTSD) do not fully benefit from the best current treatments, some of which focus on helping the brain regulate trauma memories.
- Trial name
- WET+MPH (NCT07904000)
- Testing
- Written Exposure Therapy (WET), methylphenidate (MPH)
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- VA Office of Research and Development