Clinical trials: Post Traumatic Stress Disorder, open to volunteers
Fear, GAD
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments.
- Conditions
- Fear, GAD, Emotional Memory, PTSD
- Trial name
- NCT05120635
- Testing
- Deep Brain Stimulation, Virtual and augmented reality tasks
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University
Post Traumatic Stress Disorder
A Brief Intervention for PTSD - BWRT
The purpose of this study is to investigate if a novel brief intervention for Posttraumatic stress disorder (PTSD) is comparable to other traditional clinical interventions for symptom reduction.
- Trial name
- BWRT (NCT07460817)
- Testing
- BrainWorking Recursive Therapy, Treatment as usual
- Where
- Norway
- Volunteers
- 82 people
- Sponsor
- University of Bergen
PTSD, Chronic Pain
Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Although most people recover from acute pain (such as pain caused by injury, surgery, repetitive motion, or unknown causes), many people do not fully recover and will experience chronic pain.
- Trial name
- NCT05700279
- Testing
- Stellate Ganglion Block, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- Rush University Medical Center
Sexual Abuse, Posttraumatic Stress Symptom
Voices of Transformation: A Deep Dive Into the Struggles and Successes of Reclaiming Sexuality After Sexual Trauma
This study aims to gain insight into the experiences of participants in the "Take Your Sexuality Back" intervention groups, evaluate the intervention's acceptability, and identify necessary modifications.
- Conditions
- Sexual Abuse, Posttraumatic Stress Symptom, Sexual Trauma
- Trial name
- NCT07165834
- Testing
- Treatment group. "Take your sexuality back"
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Sykehuset Telemark
Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD)
Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental Disorders
The World Health Organization Composite International Diagnostic Interview (CIDI) is a fully structured diagnostic tool designed for lay interviewers to assess the prevalence of mental and substance use disorders.
- Conditions
- Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Posttraumatic Stress Disorder (PTSD)
- Trial name
- NCT07604753
- Testing
- CIDI-5
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Post-traumatic Stress Disorder
Recovering Sleep After Trauma
The main objective of this pilot trial is to assess the feasibility and preliminary efficacy of telehealth-delivered behavioral therapy to reduce the development of posttraumatic stress and depressive symptoms following motor…
- Trial name
- REST (NCT07196332)
- Testing
- Brief Behavioral Treatment for Insomnia (BBTI), Progressive Muscle Relaxation Training (PMRT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Post-Traumatic Stress Disorders, Stress Disorders, Traumatic
Cognitive Control Training for Extinction in PTSD
The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD).
- Conditions
- Post-Traumatic Stress Disorders, Stress Disorders, Traumatic, Post Traumatic Stress Disorder, PTSD
- Trial name
- NCT06629064
- Testing
- Working Memory Training
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Stroke, Stress, Psychological
Stroke Rehabilitation Utilizing Therapeutical Methods Designed for Nature Environments
Outpatient participants with a recent stroke diagnoses receive complimentary rehabilitation. The nature interventions include ergo- and physiotherapeutic and neurocognitive tasks with the support of an psychotherapeutic frame…
- Conditions
- Stroke, Stress, Psychological, Post Traumatic Stress Disorder, Depression, Anxiety
- Trial name
- NCT06633146
- Testing
- Therapies in nature
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
PTSD - Post Traumatic Stress Disorder, Trauma-related Nightmares
Validation of an Algorithm for Predicting Awakenings Associated With Trauma-related Nightmares, Based on the Analysis of Physiological Patterns in Military and Former Military Patients Suffering From Post-traumatic Stress Disorder
The goal of this clinical trial is to validate an artificial intelligence algorithm called CAUD-PIN (CAUchemar Detection on INdividualized Parameters) to predict nightmare-related awakenings in military personnel and veterans…
- Trial name
- CAUD-PIN (NCT07851480)
- Testing
- CAUD-PIN (CAUchemar Detection on INdividualized Parameters) - AI-based predictive algorithm forTrauma-related nightmare awakenings
- Where
- 3 sites in France
- Volunteers
- 27 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Depression, Anxiety, Post-traumatic Stress Symptoms
Predictors and Process Moderators of EMDR Therapy for Depressive Symptoms
The goal of this clinical trial is to evaluate which factors influence the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy for depressive symptoms in real-world settings in Italy.
- Conditions
- Depression, Anxiety, Post-traumatic Stress Symptoms, Dissociation, Psychotherapy Research and Outcome Measures
- Trial name
- PROCESS-EMDR (NCT07033741)
- Testing
- EMDR
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
PTSD, Depression Disorders
Patient Engagement in PTSD Treatment (PEP)
The goal of this clinical study is to improve the outcome of outpatient PTSD treatment at two clinics treating majority ethnic Danes and refugees with PTSD respectively.
- Conditions
- PTSD, Depression Disorders, Patient Engagement
- Trial name
- PEP (NCT06755710)
- Testing
- Introductory PTSD module, Shared Decision Making, Treatment as Usual
- Where
- Denmark
- Volunteers
- 427 people
- Sponsor
- Herlev and Gentofte Hospital
Cardiovascular Diseases, Overweight
Enhancing Mental and Physical Health of Women Veterans 3.0
Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that…
- Conditions
- Cardiovascular Diseases, Overweight, Obesity, Hypertension
- Trial name
- EMPOWER (NCT07356479)
- Testing
- EBQI Booster (EBQI/B), EBQI Booster + External Facilitation (EBQI/B+EF)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
PTSD, Alcohol; Use, Problem
Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma
The U.S. Deaf community - a group of more than one million Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure…
- Trial name
- NCT06278922
- Testing
- Seeking Safety + Signs of Safety toolkit, Treatment as usual
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Massachusetts, Worcester
Stress Disorders, Post-Traumatic
Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication
The purpose of this clinical trial is to learn whether existing treatments for posttraumatic stress disorder (PTSD) can be improved.
- Trial name
- AWARE (NCT06088303)
- Testing
- Adjunctive writing to amplify response and engagement (AWARE), Cognitive processing therapy (CPT), Prolonged exposure (PE)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Boston University
Post Traumatic Stress Disorder
Brief SEE FAR CBT Intervention Compared With Treatment as Usual for Adults With PTSD
This clinical intervention study evaluates a newly developed Brief SEE FAR CBT protocol for adults aged 18 years and older with posttraumatic stress disorder (PTSD), compared with dynamic psychotherapy treatment as usual.
- Trial name
- NCT07710573
- Testing
- Brief SEE FAR CBT Intervention, Dynamic Psychotherapy Treatment as Usual
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Community Stress Prevention Center
PTSD - Post Traumatic Stress Disorder, Intrusive Memories of Traumatic Event(s)
Neuromodulation of the Hippocampus to Reduce Intrusive Re-Experiencing in PTSD: A Randomized Controlled Trial
The goal of this clinical trial is to learn if non-invasive neurostimulation of memory-related brain areas works to treat intrusive memory symptoms in adults patients with posttraumatic stress disorder (PTSD).
- Trial name
- NCT06639061
- Testing
- Hippocampal stimulation using repetitive transcranial magnetic stimulation (rTMS)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel Aviv University
HIV Infections
Intervention Development for Syndemics Among PWH in SA
In South Africa, the country with the highest HIV prevalence (19%), co-occurring problems such as depression, post-traumatic stress, and food insecurity interact to enhance one another (i.e., syndemic problems) and are associated…
- Trial name
- NCT06152003
- Testing
- Cognitive Behavioral Therapy for Syndemics and Adherence (CBT-SA)
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder, Cannabis Use Disorder
Mitigating PTSD-CUD After Sexual Assault
683,000 women are sexually assaulted annually in the United States, half of whom develop chronic posttraumatic stress disorder (PTSD) and thus have markedly increased risk for cannabis use disorder (CUD).
- Trial name
- RISE-C (NCT05989841)
- Testing
- RISE Guide, Relaxation Control
- Where
- 6 sites in United States
- Volunteers
- 68 people
- Sponsor
- University of Nevada, Las Vegas
Complex Post-Traumatic Stress Disorder (CPTSD)
RECONNECT - Treatments for Complex PTSD
Complex PTSD (CPTSD) is a new diagnosis for which no established gold-standard treatment(s) yet exists. In this trial, three psychotherapies, Prolonged Exposure (PE), Eye Movement Desensitization and Reprocessing (EMDR), and…
- Trial name
- NCT07863089
- Testing
- Prolonged Exposure, EMDR, ESTAIR
- Volunteers
- 225 people
- Sponsor
- University of Copenhagen
Physical Activity, Sedentary Behavior
Exploring Virtual Reality Adventure Training Exergaming
The current project aims to design and implement an 8-week Virtual Reality Adventure Therapy Exergaming (V-RATE) intervention focused on women veterans.
- Conditions
- Physical Activity, Sedentary Behavior, Depression, Cognitive Function
- Trial name
- V-RATE (NCT05563805)
- Testing
- Virtual Reality-based physical activity intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington