Clinical trials: Post Traumatic Stress Disorder PTSD
Post-Traumatic Stress Disorder
Comparison of Two Treatments for Post-Traumatic Stress Disorder
This study will compare the short- and long-term effectiveness of two different treatments for people with post-traumatic stress disorder.
- Trial name
- NCT00127673
- Testing
- Sertraline, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Western Reserve University
PTSD
Treatment of PTSD in Residents of Battered Women's Shelters
This is a study comparing a new treatment (HOPE) to supportive therapy in the treatment of PTSD in residents of battered women's shelters.
- Trial name
- HOPE (NCT02398227)
- Testing
- HOPE, PCT
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- The University of Akron
PTSD
Prolonged Exposure (PE) for Post Traumatic Stress Disorder (PTSD): Telemedicine Versus In Person
The present proposal is to study whether Prolonged Exposure (PE) delivered via Telemedicine is as effective as PE delivered In Person for Operation Iraqi Freedom (OIF), Operation Enduring Freedom (OEF) Veterans and Veterans of…
- Trial name
- NCT01102764
- Testing
- Telemedicine, In Person
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence, PTSD
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.
- Trial name
- NCT01055171
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Anxiety Disorders, Post Traumatic Stress Disorder
Increasing Treatment Efficacy Using SMART Methods for Personalizing Care
The proposed study will determine the feasibility, tolerability, and acceptability of a study that tests: 1) personalized treatment delivery (i.e., module sequencing and treatment discontinuation timing) aimed at increasing the…
- Conditions
- Anxiety Disorders, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT04642898
- Testing
- Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shannon E. Sauer-Zavala
Substance Use Disorders, Posttraumatic Stress Disorder
SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)
This study proposes a prospective program of research that will identify feasible and inexpensive methods to detect and treat comorbid PTSD among VA SUD patients, thereby improving substance abuse treatment outcomes.
- Trial name
- NCT00265564
- Testing
- Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- VA Office of Research and Development
Nightmares, Stress Disorders, Post-Traumatic
Understanding Trauma Nightmares Using In-Home Measurement
Trauma-related nightmares in Veterans are associated with poor clinical outcomes, greater substance use, and increased risk of suicide.
- Conditions
- Nightmares, Stress Disorders, Post-Traumatic, Actigraphy, Respiratory Sinus Arrhythmia
- Trial name
- NCT03974503
- Testing
- Exposure, Relaxation, and Rescripting Therapy, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, PTSD
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
The objective of the proposed study is to test if a single IV dose of ketamine (0.5 mg/kg) decreases symptoms of PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, PTSD, Depression, Anxiety Disorder
- Trial name
- KetPTSD (NCT00749203)
- Testing
- Midazolam, Ketamine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Dennis Charney
Posttraumatic Stress Disorder
The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking oxytocin. Oxytocin is a hormone made naturally in the body.
- Trial name
- NCT01466127
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Post Traumatic Stress Disorder
Transcranial Direct Current Stimulation (tDCS) in Human Subjects With PTSD Receiving an Exposure-based, Behavioral Therapy
The primary objective of this study is to evaluate the safety, feasibility, and psychological and physiological treatment benefits of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, when…
- Trial name
- NCT05419999
- Testing
- Soterix 1x1 tDCS mini CT, Written Exposure Therapy (WET)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Post-traumatic Stress Disorder (PTSD)
Transcranial Infrared Laser Stimulation (TILS) of Prefrontal Cognition in Post-traumatic Stress Disorder (PTSD)
This study evaluates the effects of transcranial infrared laser stimulation (TILS) on prefrontal metabolism and hemodynamics in veterans with post-traumatic stress disorder (PTSD).
- Trial name
- NCT03209882
- Testing
- TILS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas at Arlington
Combat Disorders, Stress Disorders, Post-Traumatic
A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD
The primary aim of this project is to examine whether administration of D-Cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) receptor agonist that has been shown to facilitate fear extinction, enhances the therapeutic…
- Trial name
- NCT00371176
- Testing
- Exposure therapy, D-Cycloserine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- US Department of Veterans Affairs
Posttraumatic Stress Disorder
Family Involvement in Treatment for PTSD
Post-traumatic stress disorder (PTSD), prevalent among returning OEF/OIF/OND Veterans, has a powerful impact on family functioning.
- Trial name
- NCT00893152
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- US Department of Veterans Affairs
Low Back Pain, PTSD
Care Outcomes for Chiropractic Outpatient Veterans
The primary objectives of this pilot trial are to evaluate the feasibility, safety and acceptability of an integrative care pathway that includes chiropractic care, for the coordinated care for Veterans Administration (VA)…
- Conditions
- Low Back Pain, PTSD, Depression, Anxiety
- Trial name
- COCOV (NCT03254719)
- Testing
- Study assessments
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Palmer College of Chiropractic
PTSD
Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder
The purpose of this study was to assess the effects of the medication paroxetine on symptoms of posttraumatic stress disorder (PTSD) and the brain in women with a history of PTSD related to childhood abuse.
- Trial name
- NCT01681849
- Testing
- Paroxetine, Positron Emission Tomography (PET) Imaging
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Emory University
Posttraumatic Stress Disorder, Depression
Loving-Kindness Meditation for PTSD
This randomized controlled trial will assess whether a novel complementary and alternative medicines (CAM) intervention, Loving-kindness Meditation (LKM), is not meaningfully inferior to another group-based PTSD treatment …
- Trial name
- NCT01962714
- Testing
- Loving-Kindness Meditation, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- VA Office of Research and Development
Hospitalism in Children, Post Traumatic Stress Disorder
Pilot Testing of an Equity Focused and Trauma-informed Communication Intervention During Family-centered Rounds
Development and pilot testing of a clinician coaching communication intervention to improve communication between medical teams and caregivers (parents, family members) of children in the hospital.
- Trial name
- EFTI (NCT05618652)
- Testing
- Equity Focused and Trauma-Informed Communication Intervention
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Duke University
Posttraumatic Stress Disorder
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective in people with at least severe PTSD. The main question it aims to answer is: Do three sessions of MDMA-assisted therapy reduce PTSD…
- Trial name
- NCT03537014
- Testing
- Therapy, midomafetamine HCl
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- Resilient Pharmaceuticals
Posttraumatic Stress Disorder
Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD
This pilot study gathered preliminary evidence of the safety and efficacy of four potencies of smoked cannabis to manage chronic, treatment-resistant PTSD among veterans: (1) High THC/ Low CBD (High THC), (2) Low THC/High CBD…
- Trial name
- NCT02759185
- Testing
- High THC cannabis, High CBD cannabis, THC/CBD cannabis
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Multidisciplinary Association for Psychedelic Studies
Post-Traumatic Stress Disorders
Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder
The purpose of this study is to obtain data investigating the safety and efficacy of eszopiclone for the treatment of post-traumatic stress disorder (PTSD)-related sleep disturbance and the impact of improved sleep with…
- Trial name
- NCT00120250
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital