Clinical trials: Post Traumatic Stress Disorder PTSD, open to volunteers
Traumatic Brain Injuries, TBI (Traumatic Brain Injury)
Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)
The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI.
- Conditions
- Traumatic Brain Injuries, TBI (Traumatic Brain Injury), MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- ReVIVE (NCT07890337)
- Testing
- Virtual Reality, Standard Psychotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
PTSD - Post Traumatic Stress Disorder, PTSD
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
The Redefine Study (COMP202) is testing COMP360 to see if it may reduce post-traumatic stress disorder (PTSD) symptoms when administered alongside monitoring and support from a trained study team.
- Conditions
- PTSD - Post Traumatic Stress Disorder, PTSD, PTSD Symptoms, PTSD, Post Traumatic Stress Disorder
- Trial name
- Redefine (NCT07570654)
- Testing
- COMP360 psilocybin
- Where
- 10 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- COMPASS Pathways
Insomnia, Depression - Major Depressive Disorder
Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI)
The goal of this pilot clinical trial is to evaluate the effectiveness and delivery method of a CBTI self-managed digital mobile application in service members. The main questions it aims to answer are: RQ1.
- Conditions
- Insomnia, Depression - Major Depressive Disorder, PTSD
- Trial name
- NCT07335276
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Volunteers
- 144 people
- Sponsor
- Madigan Army Medical Center
PTSD
Exercise and Emotional Learning in Posttraumatic Stress Disorder
The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions.
- Trial name
- NCT06127342
- Testing
- Moderate Intensity Exercise, Low Intensity Exercise
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Christal L Badour
PTSD, Suicidal Thoughts and Behaviors
Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study
This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD.
- Conditions
- PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
- Trial name
- CNS (NCT07222306)
- Testing
- 1-(2-[+F]fluoroethyl)-L-tryptophan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wayne State University
Post Traumatic Stress Disorder PTSD, Suicidal Ideation
Deep TMS for PTSD With Suicidal Ideation
The goal of this clinical trial is to evaluate whether deep transcranial magnetic stimulation (DTMS) using the H1-coil can safely and effectively reduce suicidal ideation in adults diagnosed with post-traumatic stress disorder…
- Trial name
- DTMS-PTSD-SI (NCT07880340)
- Testing
- Deep Transcranial Magnetic Stimulation (DTMS)
- Where
- Israel
- Volunteers
- 72 people
- Sponsor
- D.R. Rut Zaks OHAYON
Postpartum Complication, Postpartum
Postpartum Care in the NICU Multi-Site Breastfeeding
Parents of infants in the neonatal intensive care unit (NICU) face unique barriers to long-term breastfeeding and lactation. The physical and emotional demands of having a critically ill or premature newborn combined with the…
- Conditions
- Postpartum Complication, Postpartum, PTSD, PTSD (Childbirth-Related)
- Trial name
- PeliCaN (NCT07881731)
- Testing
- NICU-informed postpartum doula support
- Where
- 11 sites in United States
- Volunteers
- 640 people
- Sponsor
- Children's Hospital of Philadelphia
Spinal Cord Injuries, PTSD
Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury
This study will examine the use brief prolonged exposure (Brief PE) therapy compared to standard clinical care to reduce posttraumatic distress among people who have had a spinal cord injury and are receiving rehabilitation in an…
- Conditions
- Spinal Cord Injuries, PTSD, Post-Traumatic Stress Disorder
- Trial name
- NCT05233111
- Testing
- Brief Prolonged Exposure Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor Research Institute
Traumatic Injury, PTSD
Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center
The purpose of this research is to determine if a brief treatment method is effective for preventing posttraumatic stress disorder (PTSD) and a number of other concerns following injury.
- Conditions
- Traumatic Injury, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT06210711
- Testing
- Treatment as Usual, Brief Prolonged Exposure Therapy
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Baylor Research Institute
Post-traumatic Stress Disorder (PTSD), Intrusive Memories of Traumatic Event(s)
Eye Movement Intervention With Different Memory Reactivation Procedures for Intrusive Traumatic Memories
Post-Traumatic Stress Disorder (PTSD) and trauma-related symptoms are often characterized by recurrent intrusive memories that cause distress and interfere with daily functioning.
- Trial name
- NCT07767396
- Testing
- Unconscious Trauma Reactivation plus Eye Movements, Active Trauma Memory Reactivation plus Eye Movements, Neutral Memory Reactivation plus Eye Movements
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Shaanxi Normal University
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Suvorexant for Treatment of AUD and PTSD
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD), Insomnia
- Trial name
- SUV (NCT06679062)
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Posttraumatic Stress Disorder (PTSD)
EEG and Actigraphy Biomarkers of Written Exposure Therapy for Posttraumatic Stress Disorder
Posttraumatic stress disorder, or PTSD, can affect emotional health, sleep, daily functioning, and quality of life. Written Exposure Therapy is a brief trauma-focused psychotherapy in which participants complete structured…
- Trial name
- TREAT (NCT07766798)
- Testing
- Written Exposure Therapy, Neutral Writing Condition
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mclean Hospital
Awareness, Mechanical Ventilation
The ED-AWARENESS-2 Trial
The investigators will screen all mechanically ventilated ED patients for study eligibility and will enroll all consecutive patients satisfying inclusion and exclusion criteria.
- Conditions
- Awareness, Mechanical Ventilation, Intubation Complication, PTSD
- Trial name
- ED-AWARENES II (NCT05534243)
- Testing
- Standard neuromuscular blocker practices, Education
- Where
- 4 sites in United States
- Volunteers
- 3,212 people
- Sponsor
- Washington University School of Medicine
Anxiety and Fear, PTSD
K08 VR Fear Conditioning
The goal of this clinical trial is to learn how people respond to fear-related experiences in a virtual reality (VR) environment.
- Conditions
- Anxiety and Fear, PTSD, Veteran
- Trial name
- NCT07216222
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Post-Traumatic Stress Disorders, Stress Disorders, Traumatic
Cognitive Control Training for Extinction in PTSD
The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD).
- Conditions
- Post-Traumatic Stress Disorders, Stress Disorders, Traumatic, Post Traumatic Stress Disorder, PTSD
- Trial name
- NCT06629064
- Testing
- Working Memory Training
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder (PTSD), Trauma Exposure
Predictors & Mechanisms of Adolescent PTSD
This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to…
- Trial name
- NCT07537764
- Testing
- Repeated imaginal exposure: Script Driven Imagery (SDI) task
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Medical University of South Carolina
Chronic Musculoskeletal Pain, Sexual Assault
Post-traumatic Estradiol Administration and Care Evaluation (PEACE)
This pilot randomized, double-blind, placebo-controlled trial evaluates the feasibility, acceptability, and tolerability of administering a single 6 mg oral dose of 17β-estradiol (E2) to individuals assigned female at birth who…
- Conditions
- Chronic Musculoskeletal Pain, Sexual Assault, Posttraumatic Stress Disorder (PTSD)
- Trial name
- PEACE (NCT07868536)
- Testing
- 17β-estradiol
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Post-traumatic Stress Disorder (PTSD), Cardiovascular Diseases
NightWare and Cardiovascular Health in Veterans With PTSD
The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD).
- Conditions
- Post-traumatic Stress Disorder (PTSD), Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT06419959
- Testing
- NightWare
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD, Post Traumatic Stress Disorder PTSD
Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)
The goal of this clinical trial is to evaluate the safety and effectiveness of the gammaCore non-invasive vagus nerve stimulation (nVNS) device as an additional treatment for symptoms of post-traumatic stress disorder (PTSD) in…
- Conditions
- PTSD, Post Traumatic Stress Disorder PTSD, PTSD - Post Traumatic Stress Disorder, Post Traumatic Stress Disorder
- Trial name
- NCT07523685
- Testing
- non-invasive vagus nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Acacia Clinics
Post Traumatic Stress Disorder PTSD
The Effects of Stellate Ganglion Block Sleep in U.S. Active Duty Service Members and Veterans Receiving Prolonged Exposure Therapy for PTSD
Participants in this study will have already been enrolled in another research study: Combining Stellate Ganglion Block with Prolonged Exposure for PTSD, NCT05889741.
- Trial name
- NCT07667309
- Testing
- Sleep Profiler Headband
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio