Clinical trials: Post Traumatic Stress Disorders
PTSD, Pain, Chronic
Feasibility of Remote Tai Chi
In the proposed trial, the investigators plan to refine interventions, then conduct a small randomized trial to provide critical information to inform a future large-scale randomized efficacy trial of Tai Chi for Post Traumatic…
- Trial name
- NCT05693805
- Testing
- Tai Chi, Wellness program
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Boston University
PostTraumatic Stress Disorder
Effects of Delta-9 Tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R61 Study
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT03008005
- Testing
- Dronabinol Cap 5 milligrams (MG), Dronabinol Cap 10 milligrams (MG)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Wayne State University
PTSD
A Phase 3 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Participants With PTSD
This is a 12-week, multicenter, randomized, double-blind, placebo-controlled, fixed-dose study that will investigate the efficacy and safety of TNX-102 SL 5.6 mg (2 x 2.8 mg tablets) - a sublingual formulation of cyclobenzaprine.
- Trial name
- RECOVERY (NCT03841773)
- Testing
- TNX-102 SL
- Where
- 30 sites in United States
- Volunteers
- 192 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Stress Disorders, Post Traumatic, Trust
Neuroimaging the Impact of Treatment on Neural Substrates of Trust in Post-Traumatic Stress Disorder (PTSD)
Traumatic experiences can have a profound negative effect on the lives and well-being of both the people who experience them and their loved ones.
- Trial name
- NCT01244477
- Testing
- Group CPT-C
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- VA Office of Research and Development
Stress Disorder - Post-traumatic (Acute)
Prevention of Post-traumatic Stress Disorder by Telephone Based Cognitive Behavioral Therapy
This is a randomized controlled study comparing telephone-based cognitive behavioral therapy (CBT) for recent survivors of traumatic events with Acute Stress Disorder (ASD) or acute PTSD with a waitlist control group.
- Trial name
- NCT00889005
- Testing
- Telephone Based Cognitive Behavioral Therapy
- Where
- Israel
- Volunteers
- 139 people
- Sponsor
- Hadassah Medical Organization
Stress Disorders, Post-Traumatic, Smoking
CPT and Smoking Cessation
Posttraumatic stress disorder (PTSD) and cigarette smoking are both associated with significant impairment in Veterans and cost to the Veterans' Affairs (VA) system.
- Trial name
- NCT01901848
- Testing
- Cognitive Processing Therapy (CPT), Bupropion, nicotine replacement therapy (NRT)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Women's Post Traumatic Stress Disorder (PTSD) Research Study
The purpose of this study is to examine the relationship between trauma and startle. The investigators are also looking at the effect of menstrual phase on this relationship.
- Trial name
- NCT01304940
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Tobacco Use Cessation, Post Traumatic Stress Disorders
Tobacco Cessation for Veterans With Post Traumatic Stress Disorder (PTSD)
The goal of this study is to improve the effectiveness of tobacco cessation treatment for veterans with Post Traumatic Stress Disorder (PTSD) through ongoing, integrated care management approach using telehealth and motivational…
- Trial name
- NCT00908882
- Testing
- Motivation Interviewing Counseling
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- US Department of Veterans Affairs
Post Traumatic Stress Disorder
Service Dog Training Program for Military Veterans With PTSD
Post-traumatic stress disorder (PTSD), an invisible wound of war, affects approximately 20%1 of the 18.5 million U.S. veterans and places them at higher risk for impaired biopsychosocial functioning.
- Trial name
- NCT03777020
- Testing
- Service Dog Training Program, Dog Training Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
PTSD
Effects of Mindfulness-Based Cognitive-Behavioral Conjoint Therapy on PTSD and Relationship Function
The purpose of this study is to first adapt Cognitive Behavioral Conjoint Therapy for PTSD for Operation Enduring Freedom and Operation Iraqi Freedom (OEF-OIF) Veterans diagnosed with PTSD and their intimate partners by (1)…
- Trial name
- NCT01035788
- Testing
- Mindfulness Based Cognitive Behavioral Conjoint Therapy, CBCT for PTSD - Communication Skills
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury
Remediation of Impaired Self-Regulation in Patients With Mild TBI
The ability to regulate impulses enables us to plan for the future, to maintain focus in the face of distractions (i.e. to encode memories), and to manage emotions.
- Trial name
- NCT02260570
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Post-Traumatic Stress Disorder
Effectiveness of Three Different Psychotherapies for Chronic Post-Traumatic Stress Disorder
This study will examine whether interpersonal psychotherapy is as effective in treating post-traumatic stress disorder as the established therapies of prolonged exposure and relaxation.
- Trial name
- NCT00739765
- Testing
- Interpersonal Psychotherapy, Prolonged Exposure Therapy, Relaxation Therapy
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Anxiety, PTSD
A Placebo-Controlled Study of Mirtazapine for PTSD
Objective: To study the efficacy and tolerability of mirtazapine (Remeron) in the treatment of PTSD. Research Design: This is an 8-week randomized, double-blind, placebo-controlled treatment trial of mirtazapine for the treatment…
- Trial name
- NCT00302107
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
PTSD
Trauma-informed Collaborative Care for Low-income African Americans With PTSD
The purpose of this study is to optimize, culturally adapt, implement, and pilot test a trauma-informed collaborative care intervention for low-income African Americans who receive care in Federally Qualified Health Centers…
- Trial name
- NCT03591107
- Testing
- PTSD Care Management (PCM), Minimally Enhanced Usual Care (MEU)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- RAND
Insomnia, Depression
Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)
There is a strong association between sleep disturbance and suicidal thoughts and behaviors. Sleep disturbance is also highly comorbid with other common conditions associated with suicide such as depression and posttraumatic…
- Conditions
- Insomnia, Depression, Posttraumatic Stress Disorder, Suicidal Ideation
- Trial name
- NCT02248675
- Testing
- CBT-I, TAU
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
PTSD, Depression
National Guard Outreach and Linkage to Treatment
This project will add an evaluation/research component to an existing peer outreach program, now implemented for over 1100 soldiers in the Michigan Army National Guard. Preliminary work will be completed in three areas.
- Conditions
- PTSD, Depression, Reintegration, Veterans Health
- Trial name
- NCT01020981
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Posttraumatic Stress Disorder, Depression
Study Testing if Fast or Slow rTMS is Better for the Treatment of Posttraumatic Stress Disorder (PTSD)
Objectives: The primary objective is to test whether right prefrontal cortex low frequency 1 Hz rTMS versus right prefrontal high frequency 10 Hz rTMS provides a significantly greater improvement in function as measured by IPF…
- Trial name
- NCT02158663
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- James A. Haley Veterans Administration Hospital
Stress Disorders, Post-Traumatic
Secondary Prevention With Paroxetine vs. Placebo in Subthreshold Posttraumatic Stress Disorder (PTSD)
The purpose of this study is: 1) To document the effectiveness and tolerability of paroxetine for the treatment of subthreshold posttraumatic stress disorder (PTSD) in veterans in the early post-deployment period; and 2) To…
- Trial name
- NCT00560612
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Durham VA Medical Center
Depression, Anxiety
Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Childhood trauma is remarkably prevalent, and it has long lasting impact on mental health and neural development. This trial aims to see whether the 8-week mindfulness based intervention can reduce stress related psychological…
- Conditions
- Depression, Anxiety, PTSD, Trauma, Psychological
- Trial name
- NCT02447744
- Testing
- Mindfulness based intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital