Clinical trials: Post-Acute COVID19 Syndrome
Post-acute COVID-19 Syndrome
The Study of Brave-LC LDN Treatment Trial
This is a randomized, double-blind, placebo-controlled Phase 3 trial evaluating the efficacy and safety of a 16-week course of low-dose naltrexone (LDN) in approximately 1,300 participants aged 6 to 25 years with fatigue…
- Trial name
- NCT07916259
- Testing
- naltrexone
- Where
- 13 sites in United States
- Volunteers
- 1,300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Long COVID
Reliability (Test-retest) of 30 Seconds Sit-to-stand and Timed Up and Go in Adults With Long Covid
The goal of this study is to test the reliability (with a test-retest process) of 30 seconds Sit to Stand and Timed Up and Go in an adult population with long-covid, hospitalised in a rehabilitation center.
- Trial name
- NCT05886842
- Testing
- Test-retest
- Where
- Cyprus
- Volunteers
- 19 people
- Sponsor
- European University Cyprus
Triphala Capsule Supplementation, High-intensity Interval Training
Triphala Supplementation and High-intensity Interval Exercise and Immune System Function and Oxidative Stress
One hundred and forty-one male and female participants aged 18-59 years were randomly divided into 4 groups: 1) control group: neither received exercise program nor supplement but received placebo capsule for 8 weeks 2)…
- Trial name
- NCT06208761
- Testing
- Triphala capsule supplementation and high-intensity interval training
- Where
- Thailand
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Burapha University
Long Covid, Post-treatment Lyme Disease Syndrome
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: Long Covid (LC) Post-treatment Lyme disease syndrome (PTLDS) Myalgic…
- Conditions
- Long Covid, Post-treatment Lyme Disease Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
- Trial name
- NCT06511050
- Testing
- Lumbrokinase
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Long COVID
Exercise for Health in Patients With Post-acute Sequelae of COVID-19
Background: Many patients with COVID-19 present the so-called post-acute sequelae of COVID-19 such as fatigue, post-stress discomfort, dyspnea, headache, pain mental impairment, incapacity to perform daily physical tasks ant…
- Trial name
- EJerSA-COVID (NCT05848518)
- Testing
- Rehabilitation program
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Campus docent Sant Joan de Déu-Universitat de Barcelona
Post-COVID, POST-Covid 19
sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19
Fatigue, cognitive problems, post-exertional malaise (PEM) and postural orthostatic tachycardia syndrome (POTS) are common and debilitating symptoms after COVID-19.
- Conditions
- Post-COVID, POST-Covid 19, Post-COVID Conditions
- Trial name
- ESPRIT (NCT07359482)
- Testing
- Fluvoxamine
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Rehabilitation, Post-Acute COVID-19 Syndrome
RCT Long COVID-19 Rehabilitation
The Coronavirus 2019 (COVID-19) pandemic has resulted in at least four million infections in Norway. The vast majority of cases are diagnosed and followed up in the community, but some with extensive symptoms and large degree of…
- Conditions
- Rehabilitation, Post-Acute COVID-19 Syndrome, Post-Infectious Disorders
- Trial name
- NCT06085911
- Testing
- One day course, Individual follow-ups
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Long COVID, Post-Acute COVID-19 Syndrome
Effectiveness and Safety of Mesenchymal Stem Cell Therapy in Long COVID Patients
The goal of this clinical trial is to evaluate the effectiveness and safety of mesenchymal stem cell therapy in long-COVID patients.
- Trial name
- NCT06492798
- Testing
- umbilical cord mesenchymal stem cell
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Changhai Hospital
Post-COVID-19 Syndrome
Lung Function in Post-COVID-19 Nursing Home Residents
The coronavirus disease 2019 (COVID-19) took a toll in institutionalised older adults, who represent a vulnerable population in European countries.
- Trial name
- NCT05866211
- Testing
- Previous exposure to SARS-CoV-2
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- University of Vic - Central University of Catalonia
Post COVID-19 Condition, Post-COVID-19 Syndrome
The COPE Study: Pilot Intervention to Improve Symptom Self-management and Coping in Adults With Post COVID-19
This project is a randomized controlled pilot trial using mixed methods to examine the feasibility, acceptability, and initial effects of a telemedicine group-based intervention designed to improve symptom management and coping…
- Trial name
- NCT05658536
- Testing
- 6-Week Self-Management Group
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Washington
Long Covid19, COVID-19 Pneumonia
Clinical Characteristics and Long Term Impact on Pediatric COVID-19 in Taiwan
This project will study severe COVID-19 related factors, host genes, biomarkers, and prognosis of severe encephalitis in children, and conduct: 1.
- Conditions
- Long Covid19, COVID-19 Pneumonia, Multisystem Inflammatory Syndrome in Children
- Trial name
- NCT05582512
- Testing
- sequelae tracking
- Where
- Taiwan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Post COVID-19 Condition, Long COVID Syndrome
Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC)
The study aims to prove that plitidepsin could be an efficacious, safe, and well-tolerated therapy for PCC. To this end, we will perform a randomized, double-blind study comparing the clinical and laboratory benefits of…
- Conditions
- Post COVID-19 Condition, Long COVID Syndrome, Persistent COVID-19, Persistent COVID Condition
- Trial name
- THALASSA (NCT06766825)
- Testing
- Plitidepsin 1.5 mg/day
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
COVID-19 Pandemic, ICU
Chronic Pain in COVID-19 Patients Discharged From Intensive Care Unit
More than six million French were affected by SARS-COV2 epidemic. About 20% of infected peoples were hospitalized, and about 5% were admitted to the intensive care units (ICU) for severe SARS-COV2 acute respiratory distress…
- Conditions
- COVID-19 Pandemic, ICU, Pain, Chronic, Post Intensive Care Unit Syndrome
- Trial name
- NCT04940208
- Testing
- Pain and neuropsychological questionnaires, Quantitative Sensory testing
- Where
- 3 sites in France
- Volunteers
- 143 people
- Sponsor
- Mikhail Dziadzko, MD, PhD
Post-Acute COVID-19 Syndrome
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from an acute COVID-19 infection may continue to have symptoms that persist for months or years.
- Trial name
- NCT07388550
- Testing
- Keytruda
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Long COVID-19 Syndrome, Long COVID Symptoms
Epigenetic Changes in Long COVID Patients
The goal of this observational study is to improve the understanding of the biological mechanisms underlying long COVID and to identify molecular biomarkers that may support its diagnosis, prognosis, and future precision medicine…
- Trial name
- ECLIPSE (NCT07757620)
- Where
- 3 sites in Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
SARS-CoV2 Infection
Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals who will enter the cohort with and without SARS-CoV-2 infection and at varying stages before and after infection.
- Trial name
- NCT05172024
- Where
- 86 sites in United States, Puerto Rico
- Volunteers
- 15,172 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Post-acute Corona Virus 19 (COVID-19) (Long COVID)
Phase 2 Study of RSLV-132 in Subjects With Long COVID
The purpose of this study is to assess the efficacy (decrease in profound fatigue), safety and pharmacokinetics of RSLV-132 in subjects with long Corona Virus (COVID) syndome
- Trial name
- NCT04944121
- Testing
- RSLV-132, Sodium Chloride 0.9%
- Where
- 5 sites in United States
- Volunteers
- 112 people
- Sponsor
- Resolve Therapeutics
Post COVID-19 Condition (PCC)
Basel Long COVID-19 Cohort Study and Digital Long COVID Substudy
The Basel Long COVID Cohort Study (BALCoS) is a registry-based cohort study that focuses on the patients' present health status, symptoms, the course of these symptoms, and potential mechanisms involved.
- Trial name
- BALCoS/DiLCoS (NCT05781893)
- Testing
- Digital intervention (DiLCoS), Data collection
- Where
- Switzerland
- Volunteers
- 196 people
- Sponsor
- University Hospital, Basel, Switzerland
Postacute Sequelae of Sars-CoV-2, Post-Acute COVID-19 Syndrome
Transcutaneous Electrical Nerve Stimulation (TENS) in Patients With Postacute Sequelae of Sars-CoV-2
The purpose of the pilot study is to examine acceptability and proof of concept effectiveness of a wireless TENS technology to address PASC associated FM.
- Conditions
- Postacute Sequelae of Sars-CoV-2, Post-Acute COVID-19 Syndrome, Widespread Chronic Pain, Fatigue Syndrome, Chronic
- Trial name
- NCT05200858
- Testing
- TENS - high-dose, TENS - low-dose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine