Clinical trials: Post-Acute COVID19 Syndrome
Long COVID
Investigation of the Use of a Probiotic Supplement in People With Long COVID
This study is a double-blinded randomised trial to assess the efficacy of a probiotic supplement in alleviating symptoms in people with Long COVID.
- Trial name
- NCT05975034
- Testing
- Probiotic
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- Sheffield Hallam University
Long COVID, PASC Post Acute Sequelae of COVID 19
Brain Stimulation in Long COVID
Cognitive problems and severe fatigue are two frequently occurring symptoms in long COVID, also known as Post-Covid Condition or Post-Acute Sequelae of COVID-19 (PASC), and their causes are currently unknown.
- Conditions
- Long COVID, PASC Post Acute Sequelae of COVID 19, Post COVID-19 Condition (PCC)
- Trial name
- MALIBU (NCT07278206)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Amsterdam UMC, location VUmc
Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections.
- Conditions
- Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), Long COVID, SARS CoV 2 Infection
- Trial name
- NCT05421208
- Testing
- Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls, Levels of inflammatory cytokine ( IL-6) in controls, Effect on inflammation after chronic PNS stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Long COVID
Acupuncture and Chinese Herbal Medicine for Long COVID
List of the Hypothesis: Primary hypothesis: A flexible acupuncture and Chinese herbal medicine protocol will be feasible, acceptable, and useful for the treatment of long COVID.
- Trial name
- ACUCM-LC (NCT07285707)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Southern California University of Health Sciences
Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS
Long COVID is defined by a range of symptoms affecting multiple organs that persist for more than three months following an acute SARS-CoV-2 infection.
- Conditions
- Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), SARS CoV 2 Infection, Long COVID19
- Trial name
- NCT07189936
- Testing
- To Measure levels of circulating monocyte/ T cell doublets at Baseline, To measure levels of circulating monocyte/ T cell doublets after 28 days of 2 HOBA treatment, To Measure Splanchnic venous capacitance after 28 days of Treatment with 2HOBA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Long COVID-19
Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19
The study is conducted in New York, New York at The Cohen Center for Recovery from Complex Chronic Illness at Mount Sinai. This is an IND-exempt, off-label, multi-ascending, randomized, placebo-controlled clinical trial of…
- Trial name
- NCT06960928
- Testing
- Low-dose sirolimus
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Post-COVID-19 Syndrome, Long COVID
Assessment of Functional Capacity in Long-COVID
A paucity of prognostic studies in patients with post-COVID-19 syndrome (long-COVID) shows the need to identify the main effects on functional capacity in the short and medium term.
- Trial name
- NCT05967039
- Testing
- Physiotherapy
- Where
- 2 sites in Brazil
- Volunteers
- 65 people
- Sponsor
- Centro Universitário Augusto Motta
Reproductive Disorder, Neurodegeneration
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome.
- Conditions
- Reproductive Disorder, Neurodegeneration, SARS-CoV 2, Long COVID
- Trial name
- NCT07224490
- Testing
- Kisspeptin 112-121
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stephanie B. Seminara, MD
COVID-19, Long COVID
A Six-Month Follow-Up Study of Participants With Coronavirus Disease 2019 (COVID-19) Previously Enrolled in a RO7496998 (AT-527) Study
This study will evaluate the long-term sequelae of COVID-19 in patients diagnosed with COVID-19 who previously enrolled in a RO7496998 (AT-527) study (i.e.
- Trial name
- MEADOWSPRING (NCT05059080)
- Where
- 35 sites in Argentina, Belgium and 8 more
- Volunteers
- 72 people
- Sponsor
- Hoffmann-La Roche
Neurogenic Dysphagia, Traumatic Brain Injury
Register Study: Implementation of Pharyngeal Electrostimulation Therapy for the Treatment of Acute Neurogenic Dysphagia
Neurogenic dysphagia occurs with disruption of neurological systems or processes involved in the execution of coordinated and safe swallowing.
- Conditions
- Neurogenic Dysphagia, Traumatic Brain Injury, Stroke, Dysphagia
- Trial name
- R:IphEst (NCT05190718)
- Testing
- Pharyngeal electrostimulation
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Karl Landsteiner University of Health Sciences
Long COVID
A Cross-sectional, Observational Study to Characterise Long COVID-19 in an Urban Sample of South African Adults
"Long-COVID'' (also known as post-COVID-19 syndrome, post-acute sequelae of COVID-19, or chronic COVID syndrome, used here as 'Long-COVID' for brevity), is a complex array of postconvalescence symptoms following SARS-CoV-2…
- Trial name
- ChaLOC (NCT05445713)
- Where
- 2 sites in South Africa
- Volunteers
- 400 people
- Sponsor
- University of Witwatersrand, South Africa
Long COVID, Long COVID Syndrome
A Study to Examine Anktiva for the Treatment of COVID-19.
This study will examine the safety and effectiveness of Anktiva in treating patients with Long COVID-19 which is defined as persistent symptoms of a COVID-19 infection that remain after the infection is over.
- Conditions
- Long COVID, Long COVID Syndrome, Long Covid 19
- Trial name
- NCT07123727
- Testing
- Anktiva
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- ImmunityBio, Inc.
PASC Post Acute Sequelae of COVID-19
Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC)
This study uses total-body [¹⁸F]F-AraG PET/CT imaging to investigate immune activation and vascular changes in individuals with post-acute sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID.
- Trial name
- NCT07076862
- Testing
- A.1 - [¹⁸F]F-AraG PET/CT (90-min dynamic + 4-h static), A.2 - [¹⁸F]F-AraG PET/CT (60-min dynamic only), B.1 - [¹⁸F]F-AraG PET/CT (90-min dynamic + 4-h static)
- Where
- 2 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
COVID-19
COVID-19 Infection Control Using H2O2 Mouth Wash and Nasal Spray
Hydrogen peroxide is produced physiologically by oral bacteria and plays a significant role in the balance of oral microecology since it is an important antimicrobial agent.
- Trial name
- NCT04878042
- Testing
- Hydrogen peroxide
- Where
- Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- EPISTATA
Robotic Exoskeleton, Post-acute Covid-19 Syndrome
Robotic Assisted Hand Rehabilitation Outcomes in Adults After COVID-19
Prolonged hospitalization in severe COVID-19 cases can lead to substantial muscle loss and functional deterioration. While rehabilitation is vital, conventional approaches encounter capacity constraints.
- Conditions
- Robotic Exoskeleton, Post-acute Covid-19 Syndrome, Rehabilitation Outcome, Physical And Rehabilitation Medicine
- Trial name
- NCT06137716
- Testing
- Training with a Robotic Hand Exoskeleton
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- University of Valladolid
COVID-19
A Study to Understand How the Use of Paxlovid Affected Healthcare Use in People With Pre-existing Conditions.
This is a cohort study that will include Paxlovid (nirmatrelvir-ritonavir) treatment eligible for people with a positive SARS-CoV-2 diagnostic test and at least one COVID-19 symptom.
- Trial name
- NCT07090486
- Testing
- nirmatrelvir-ritonavir
- Where
- United States
- Volunteers
- 14,000 people
- Sponsor
- Pfizer
Long Covid19, Autonomic Dysfunction
Autonomic Nervous System Affection Due to Post Covid Syndrome
Post-Covid syndrome is defined as symptoms that develop in addition to respiratory symptoms in individuals who have had Covid-19 infection for more than 12 weeks.
- Trial name
- NCT05502094
- Testing
- Heart Rate Variability Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Post-COVID-19 Syndrome
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS)
This clinical trial aims to learn about the therapeutic value of Methylprednisolone, a well-known immunosuppressant, on cognitive deficits in patients with post-COVID-19 syndrome (PCS).
- Trial name
- NCT05986422
- Testing
- Methylprednisolone
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Charite University, Berlin, Germany
COVID-19
Trial of Auricular Vagus Nerve Stimulation in Painful Covid Long
Patients infected with Covid 19 suffer from frequent pain (headache, migraines, joint pain, muscle pain) in the acute phase which may persist after a stay in intensive care or in an intensive care unit, in the event of…
- Trial name
- COLOSAT (NCT05205577)
- Testing
- Tens Eco Plus
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Long COVID, Long Covid19
Understanding the Long-term Impact of COVID-19 in Adults
Long COVID (LC) affects an estimated 5-10% of individuals with SARS-CoV-2 causing a persistent physical, cognitive, and functional impairment with potentially severe socioeconomic consequences.
- Trial name
- NCT07498504
- Where
- United States
- Volunteers
- 5,205 people
- Sponsor
- NYU Langone Health