Clinical trials: Post-Acute Sequelae of SARS-CoV-2 Infection
Long COVID
Optimising General Practice Long COVID Care - an Educational Intervention.
This trial will evaluate the feasibility of a pilot educational intervention for GPs that aims to enhance care and care outcomes among patients with long COVID at six general practices in the Ireland East region.
- Trial name
- GP-COV-ED (NCT06765421)
- Testing
- Intervention Group
- Volunteers
- 72 people
- Sponsor
- University College Dublin
Post-Acute COVID-19 Syndrome
A Study of Positive Emotions With Long COVID-19
This study is testing a new brief mindfulness practice for people suffering from long COVID-19 symptoms. People suffering from long COVID are particularly vulnerable to negative emotions, as they must also cope with the long-term…
- Trial name
- NCT05676008
- Testing
- Microdosing of mindfulness
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of California, Davis
Long COVID
Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19
The Primary objective of this study is to determine, using unblinded samples, if it is possible to develop an algorithm for the classification of specific blood RNA from patients with long COVID together and separately from the…
- Trial name
- NCT06311435
- Testing
- RNA Biomarker Blood Test
- Where
- 3 sites in United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- MaxWell Clinic, PLC
Multiple Sclerosis, Clinically Isolated Syndrome
Autoimmune Intervention Mastery Course Study
The goal of this project is to critically evaluate the effectiveness of using an online program to improve diet and self-care in patients with multiple sclerosis (MS), clinically isolated syndrome (CIS), fibromyalgia, post acute…
- Conditions
- Multiple Sclerosis, Clinically Isolated Syndrome, Fibromyalgia, Post Acute Sequelae of COVID-19
- Trial name
- AIM (NCT05057676)
- Testing
- Immediate Autoimmune Intervention Mastery Course (AIM), Immediate Question and Answer sessions. (AIM Q and A sessions), Delayed Autoimmune Intervention Mastery Course (delayed AIM course)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Terry L. Wahls
Long COVID, Chronic Pain
Characterization of Long Covid Pain in Primary Care
Justification: among the sequelae of Covid-19 in clinical practice we frequently find persistent neuromusculoskeletal pain. Prevalence data and the underlying mechanisms of such pain are very limited in the scientific literature.
- Conditions
- Long COVID, Chronic Pain, Musculoskeletal Pain
- Trial name
- NCT05894642
- Testing
- 0
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Valladolid
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
RCT of Mind-body in Long COVID and Myalgic Encephalomyelitis
We are studying the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC).
- Trial name
- MILES (NCT06933173)
- Testing
- Dynamic neural retraining system
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- University of Alberta
COVID-19, Long Haul
Digital Cognition Study During Long-COVID
The persistence of the COVID-19 disease symptoms, such as extreme fatigue, shortness of breath, cardiovascular complications, depression and anxiety, pain, brain fog, loss of taste/smell, headaches as well as loss of memory has…
- Trial name
- DIGICOG (NCT06391970)
- Testing
- Cognitive screening
- Where
- Luxembourg
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Post-COVID Condition, Fatigue Symptom
Study to Investigate the Efficacy of Abrocitinib in Adult Participants With Severe Fatigue From Post COVID Condition/Long COVID
The primary purpose of this phase 2a study is to compare the efficacy of abrocitinib to placebo in improving severe fatigue in non-hospitalized adults with symptomatic Post-COVID Condition (PCC) (also called Long COVID).
- Trial name
- CLEAR-LC (NCT06597396)
- Testing
- Abrocitinib
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Beth Israel Deaconess Medical Center
Myalgic Encephalomyelitis, Post-acute COVID-19 Syndrome
Inspiratory Muscle Training in ME/CFS and COVID-19 Survivors
Coronavirus-2019 (COVID-19) is a viral disease leading to respiratory dysfunction, but it may also affect the brain and result in the development of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
- Trial name
- Inspire ME (NCT05196529)
- Testing
- Inspiratory muscle training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- York University
Long COVID Syndrome, Post-Acute COVID-19 Syndrome
Diaphragmatic Breathing Exercises With KOTS Currents in Patients With Long COVID
This study will evaluate the effects of diaphragmatic breathing exercises combined with diaphragmatic electrostimulation using KOTS currents in patients with Long COVID.
- Trial name
- KOTS-LC (NCT07621588)
- Testing
- Diaphragmatic Electrostimulation Using KOTS Currents, Diaphragmatic Breathing Exercises
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Universidad Pontificia de Salamanca
Post-Acute COVID-19 Syndrome
A Study of Apabetalone in Subjects With Long -COVID
This is an open label, multicentre, phase II clinical trial that aims to assess the efficacy and safety of oral Apabetalone with background dapagliflozin for up to 12 weeks in T2DM patients with a history of probable or confirmed…
- Trial name
- NCT06590324
- Testing
- Apabetalone
- Where
- 3 sites in Jordan, Saudi Arabia and 1 more
- Volunteers
- 200 people
- Sponsor
- Resverlogix Corp
Post-COVID-19 Syndrome, Post-COVID Syndrome
Post-COVID-19 Chronic Fatigue Syndrome
Fatigue is recognized as one of the most commonly presented long-term complaints in individuals previously infected with SARS-CoV-2.
- Trial name
- NCT05642923
- Testing
- Synthetic Vitamin B1
- Where
- Egypt
- Volunteers
- 528 people
- Sponsor
- ClinAmygate
Long COVID
Tele-exercise Training Program for Long COVID
Patients with long coronavirus disease (COVID-19) experience multisystem symptoms and reduced quality of life (QOL). Proactive interventions are needed to enhance health outcomes.To investigate the effects of a 12-week…
- Trial name
- NCT07553897
- Testing
- Telehealth exercise training program, Education and self-exercise
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Post-Acute COVID-19, Long COVID
Personalized Computerized Training Program for Cognitive Dysfunction After COVID-19
This before-and-after study aims to evaluate the usefulness and efficacy of a personalized computerized cognitive training (CCT) to improve cognitive function among people with post-acute sequelae of COVID-19 (PASC).
- Trial name
- NCT05571852
- Testing
- CogniFit's CCT Post COVID-19
- Where
- Spain
- Volunteers
- 73 people
- Sponsor
- Universidad Antonio de Nebrija
Multicausal Fatigue, Fatigue
Micro-choice-based Intervention for Multicausal Fatigue
This proof-of-concept study aims to evaluate the feasibility, acceptability, and potential benefits of a novel multimodal approach: the micro-choice-based intervention.
- Conditions
- Multicausal Fatigue, Fatigue, Post COVID Condition, Long COVID Syndrome
- Trial name
- CHOOSE-POC (NCT07726082)
- Testing
- Micro-choice-based intervention
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
COVID-19 Acute Respiratory Distress Syndrome
Telerehabilitation Program and Detraining in Patients With Post-COVID-19 Sequelae
The primary objective of this study is to evaluate the effects of a 15-week home telerehabilitation program and a detraining period on cardiorespiratory fitness and muscular efficiency in patients with post-COVID-19 sequelae…
- Trial name
- NCT05866224
- Testing
- Telerehabilitation program
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Campus docent Sant Joan de Déu-Universitat de Barcelona
Long COVID
Characterization of the Immunometabolic Signature in Long COVID-19.
The primary objective of this study is to identify immunometabolic signatures associated with Long COVID in plasma and peripheral blood mononuclear cells (PBMC).
- Trial name
- LoCo-ImMet (NCT05758480)
- Testing
- Blood sample (at inclusion and 6 months later), Patient questionnaires (at inclusion and 6 months later)
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Long Covid
Antiviral Clinical Trial for Long Covid-19
The trial will test if two repurposed HIV antivirals can reduce symptom burden in adult participants with Long Covid compared to placebo. Viral infection and viral reactivation have been documented in Long Covid.
- Trial name
- NCT06511063
- Testing
- tenofovir disoproxil/emtricitabine, Selzentry
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Stroke, Mild Cognitive Impairment (MCI)
Telerehabilitation Decision Support System: Pilot Testing Protocol
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment (MCI), Vestibular Disease, Long Covid-19
- Trial name
- TeleRehab DSS (NCT07079787)
- Testing
- TeleRehab DSS Pilot Test
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 30 people
- Sponsor
- University College, London
Covid19
Efficacy of Adaptogens in Patients With Long COVID-19
The aim of this clinical trial of a fixed combination of standardized extracts from Rhodiola rosea roots, Schisandra chinensis berry and Eleutherococcus senticosus root (ADAPT-232) in COVID-19 patients is to demonstrate possible…
- Trial name
- NCT04795557
- Testing
- ADAPT-232 oral solution
- Where
- Georgia
- Volunteers
- 100 people
- Sponsor
- Swedish Herbal Institute AB