Clinical trials: Post-COVID Condition, open to volunteers
Schizophrenia, Bipolar Disorder
Approaches For ThE pRioritization of Patients in priMAry Care Post-COVID To Reduce Health Inequities (AFTERMATH)
The COVID-19 pandemic significantly impacted primary care across Canada. Inequities in prevention activities and chronic disease management likely increased but the extent is unknown.
- Trial name
- AFTERMATH (NCT05823805)
- Testing
- Community Health Worker
- Volunteers
- 520 people
- Sponsor
- Unity Health Toronto
Long COVID, Post-COVID-19 Condition
Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients
Mitochondria are structures inside cells that are responsible for producing energy from nutrients through a series of steps, using oxygen.
- Trial name
- MitoLoCo (NCT07134673)
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Post COVID Condition
RECLAIM Adaptive Platform Trial for PCC Treatments
RECLAIM is a Phase III, multi-domain, randomized, controlled, adaptive platform trial, designed to evaluate efficacy and safety of repurposed medications in patients with post-COVID condition (PCC).
- Trial name
- RECLAIM (NCT07280572)
- Testing
- Metformin, colchicine
- Where
- Netherlands
- Volunteers
- 1,250 people
- Sponsor
- Janneke van de Wijgert
Post COVID-19 Condition
Post COVID-19 Syndrome Treatment With Variable Pulse Transcranial Magnetic Stimulation
The purpose of this study is to test if Variable Pulse TMS (Transcranial Magnetic Stimulation) can result in objective improvements in patients with Post COVID Syndrome (PCS).
- Trial name
- NCT06865222
- Testing
- Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) - 2 weeks, Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) - 4 weeks
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Long COVID, Major Depressive Disorder
Presynaptic Imaging in Major Depressive Episodes After COVID-19
The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP).
- Conditions
- Long COVID, Major Depressive Disorder, Major Depressive Episode
- Trial name
- PCOV (NCT06086366)
- Testing
- [11C]DTBZ PET scan, [18F]SDM8 PET scan, MRI scan
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Post-acute Sequelae of SARS-CoV-2 Infection
Cognitive-Sensorimotor Function in Long-COVID
Growing evidence indicates that many people who have chronic post-acute sequelae of SARS-CoV-2 infection (PASC) will experience ongoing neurological and musculoskeletal impairment that can affect gait and balance.
- Trial name
- NCT06850350
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post COVID Condition
Sonlicromanol in Post-COVID
The aim of this randomized, double-blind, placebo-controlled, phase II trial, is to study the effect of sonlicromanol on fatigue in patients with post-COVID who experience post-exertional malaise (PEM).
- Trial name
- SON4PEM (NCT07298005)
- Testing
- Sonlicromanol
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Michele van Vugt
Long COVID
Fatigue in Long COVID
Long COVID affects about 6 in 100 people after a COVID-19 infection. It can cause ongoing problems like ongoing tiredness, muscle pain, and "brain fog." We know very little about which treatments might be helpful for long COVID.
- Trial name
- FALCON (NCT07697261)
- Testing
- Lightning Process, Activity Pacing
- Volunteers
- 100 people
- Sponsor
- McMaster University
Long-COVID
Long-term COVID and Rehabilitation
The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress…
- Trial name
- NCT05373043
- Testing
- Mitoquinone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Long COVID, PASC Post Acute Sequelae of COVID 19
Brain Stimulation in Long COVID
Cognitive problems and severe fatigue are two frequently occurring symptoms in long COVID, also known as Post-Covid Condition or Post-Acute Sequelae of COVID-19 (PASC), and their causes are currently unknown.
- Conditions
- Long COVID, PASC Post Acute Sequelae of COVID 19, Post COVID-19 Condition (PCC)
- Trial name
- MALIBU (NCT07278206)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Amsterdam UMC, location VUmc
Long COVID
Water-based Activity to Enhance Recovery in Long COVID-19
This two-year study will evaluate the feasibility and safety of an exercise + cognitive training program to improve neurological symptoms of long-COVID.
- Trial name
- NCT06142253
- Testing
- WATER+CT, Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Post-Acute COVID-19 Syndrome
Second Prospective Cohort of Patients Entering the Multidisciplinary Care Pathway for Post-Covid Syndromes - SyPoCo2 Cohort
The study aims to identify clinical profiles of long-COVID patients and correlate them with immunological and molecular data in order to identify prognostic biomarkers and potential therapeutic targets.
- Trial name
- SYPOCO 2 (NCT07356570)
- Testing
- Blood sample collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Long COVID-19 Syndrome, Long COVID Symptoms
Epigenetic Changes in Long COVID Patients
The goal of this observational study is to improve the understanding of the biological mechanisms underlying long COVID and to identify molecular biomarkers that may support its diagnosis, prognosis, and future precision medicine…
- Trial name
- ECLIPSE (NCT07757620)
- Where
- 3 sites in Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Long COVID
Sauna for Long Covid
Research suggests that Whole Body Hyperthermia in a sauna-like environment can reduce symptoms related to post-acute sequelae of SARS-CoV-2 (PASC), or Long Covid.
- Trial name
- NCT05931497
- Testing
- whole body hyperthermia
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Long COVID
PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID
Some people who had COVID-19 continue to have symptoms for weeks, months, or even years after their infection. This is often called "Long COVID" or Post-Acute Sequelae of SARS-CoV-2 (PASC).
- Trial name
- NCT07661862
- Testing
- PERCEIVE-Outreach Disease Management Program
- Where
- 2 sites in Australia
- Volunteers
- 577 people
- Sponsor
- University of Tasmania
Long COVID, Postural Orthostatic Tachycardia Syndrome
The Long COVID-19 Wearable Device Study
To further characterize Long COVID-19 by collecting data from individuals who already own wearable devices or are provided with a wearable device along with basic and enhanced educational materials to determine if both can…
- Conditions
- Long COVID, Postural Orthostatic Tachycardia Syndrome, Dysautonomia, Myalgic Encephalomyelitis
- Trial name
- NCT05741112
- Testing
- Wearable device
- Where
- United States
- Volunteers
- 100,500 people
- Sponsor
- Scripps Translational Science Institute
COVID Long-Haul
Covid-19 Long Immunité IMagerie (CLIIM)
Covid-long pathology affects a large number of patients, and represents a major medical, economic and societal challenge. To date, we have no objective criterion for a definitive diagnosis, nor any predictive tool for monitoring…
- Trial name
- CLIIM (NCT06528171)
- Testing
- Brain MRI, Specific blood samples
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Long COVID, Long COVID Syndrome
A Study to Examine Anktiva for the Treatment of COVID-19.
This study will examine the safety and effectiveness of Anktiva in treating patients with Long COVID-19 which is defined as persistent symptoms of a COVID-19 infection that remain after the infection is over.
- Conditions
- Long COVID, Long COVID Syndrome, Long Covid 19
- Trial name
- NCT07123727
- Testing
- Anktiva
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- ImmunityBio, Inc.
Pediatric Respiratory Diseases, COVID
COVID-19 in Hospitalised Norwegian Children - Risk Factors, Outcomes and Immunology
Prospective cohort study of COVID-19 infection among children in Norway.
- Conditions
- Pediatric Respiratory Diseases, COVID, Fatigue Post Viral
- Trial name
- NCT04335773
- Where
- Norway
- Volunteers
- 350 people
- Sponsor
- University Hospital, Akershus
Long Covid
The Effect of Acupuncture Treatment on Cognitive Functions and Brain Networks for Long COVID
Background of study: Long COVID(LC) is a prevalent sequalae of SARS-CoV-2 infection and can affect multiple organ systems. Cognitive dysfunction is one of the most common symptoms in LC with 22% prevalence.
- Trial name
- NCT07355751
- Testing
- Acupuncture
- Where
- 2 sites in China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Tingting Luo