Clinical trials: Post-COVID Syndrome
Long COVID, Long Covid19
RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM))
This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06404073
- Testing
- Structured Pacing, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Long COVID
Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study
The Long-Covid (LC)-Revitalize clinical study is testing repurposed drug treatments for Long Covid, involving adult participants from Brazil, Canada, Italy, South Africa, Uganda, the United States, and Zambia.
- Trial name
- NCT06928272
- Testing
- Pirfenidone, Upadacitinib
- Where
- 10 sites in United States, Brazil and 5 more
- Volunteers
- 348 people
- Sponsor
- Douglas D. Fraser
Long COVID
PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID
Some people who had COVID-19 continue to have symptoms for weeks, months, or even years after their infection. This is often called "Long COVID" or Post-Acute Sequelae of SARS-CoV-2 (PASC).
- Trial name
- NCT07661862
- Testing
- PERCEIVE-Outreach Disease Management Program
- Where
- 2 sites in Australia
- Volunteers
- 577 people
- Sponsor
- University of Tasmania
Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome
The Precision Mito- Mito Map COMPASS Study
Mito Map is a research tool that produces an Energy Score from information provided by a participant. This remote observational study has an initial enrollment target of 400 adults across seven prespecified cohorts: healthy…
- Conditions
- Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome, Post-COVID-19 Condition, Postural Orthostatic Tachycardia Syndrome
- Trial name
- COMPASS (NCT07856121)
- Testing
- Mito Map Energy Score and Home Functional Assessments
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- AI Agent Vault, Inc. d/b/a Precision Mito
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI
The overarching goal of this study is to develop PET/MR techniques for the diagnosis of neuropsychiatric post-acute sequelae (PASC) of SARS-CoV-2.
- Trial name
- NCT05615415
- Testing
- PET Tracer, MRI Tracer, 3T PET/MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Post-COVID / Long-COVID
SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID)
This placebo-controlled, randomized, blinded, two-arm phase II study will test the safety and potential efficacy of the targeted mAb, Sipavibart (formerly AZD3152) in patients with Long COVID.
- Trial name
- Monoclonal (NCT07021794)
- Testing
- Sipavibart
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nancy Klimas
Long COVID Syndrome, Post-Acute COVID-19 Syndrome
Diaphragmatic Breathing Exercises With KOTS Currents in Patients With Long COVID
This study will evaluate the effects of diaphragmatic breathing exercises combined with diaphragmatic electrostimulation using KOTS currents in patients with Long COVID.
- Trial name
- KOTS-LC (NCT07621588)
- Testing
- Diaphragmatic Electrostimulation Using KOTS Currents, Diaphragmatic Breathing Exercises
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Universidad Pontificia de Salamanca
Long COVID
Heat thErapy And mobiLity in COVID-19 Survivors
Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and…
- Trial name
- HEAL (NCT06928116)
- Testing
- Heat therapy, Walking
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Nebraska
SARS CoV-2 Post-Acute Sequelae
Long-Term Study of COVID-19 Infection and Long COVID
This study will examine how common Long COVID is and how symptoms may persist over time in people who have previously had COVID-19.
- Trial name
- PASC (NCT07781501)
- Testing
- This study is observational. Only patients who have previously tested positive for SARS-CoV-2 infection or are experiencing ongoing symptoms.
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of North Carolina, Chapel Hill
Long COVID, POTS - Postural Orthostatic Tachycardia Syndrome
Long COVID Immune Profiling
Parasympathetic nervous system (PNS) is part of the body's autonomic nervous system(PNS) protects body against inflammation. Study shows that reduced PNS function activity is associated with persistent inflammation.
- Conditions
- Long COVID, POTS - Postural Orthostatic Tachycardia Syndrome, Autonomic Dysfunction
- Trial name
- NCT06027255
- Testing
- IL-6, cytokines (IL-17, and IFN-ɣ), Compass 31
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Long COVID, Sars-CoV-2 Infection
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of…
- Conditions
- Long COVID, Sars-CoV-2 Infection, Coronavirus Infections, COVID-19
- Trial name
- REVERSE-LC (NCT06631287)
- Testing
- Baricitinib
- Where
- 17 sites in United States
- Volunteers
- 550 people
- Sponsor
- Wes Ely
Post-Acute COVID-19 Syndrome, Long COVID
QEEG-NEUROFEEDBACK FOR COGNITIVE REHABILITATION IN LONG COVID-19 SURVIVORS WITH BRAIN FOG
The pandemic has highlighted social, economic, educational, and political issues that have affected the health and quality of life of millions of Brazilians.
- Conditions
- Post-Acute COVID-19 Syndrome, Long COVID, Brain Fog
- Trial name
- QEEG-NFT (NCT07005921)
- Testing
- qEEG-neurofeedback
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jade Carvalho Da Silva
Long COVID, Long COVID Syndrome
A Study to Examine Anktiva for the Treatment of COVID-19.
This study will examine the safety and effectiveness of Anktiva in treating patients with Long COVID-19 which is defined as persistent symptoms of a COVID-19 infection that remain after the infection is over.
- Conditions
- Long COVID, Long COVID Syndrome, Long Covid 19
- Trial name
- NCT07123727
- Testing
- Anktiva
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- ImmunityBio, Inc.
Chronic Cough, Long COVID
Etiology Analysis of Chronic Cough After COVID-19 Infection and Research on the Efficacy of ICS or ICS/LABA
In this real-world study, we retrospectively classified the causes of chronic cough in patients, analyzed the prevalence of cough-variant asthma, and prospectively evaluated and compared the improvement of cough symptoms and…
- Trial name
- NCT06503939
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Xiangya Hospital of Central South University
Long COVID
NE3107 in Adults With Neurological Symptoms of Long COVID
Long COVID is a condition where debilitating symptoms can persist for months after a COVID-19 infection. This study aims to evaluate the effects of NE3107 on several neurological symptoms reported in people with Long COVID…
- Trial name
- ADDRESS-LC (NCT06847191)
- Testing
- NE3107
- Where
- 20 sites in United States
- Volunteers
- 203 people
- Sponsor
- BioVie Inc.
Chronic Fatigue Syndrome (CFS), Post-COVID ME/CFS
RCT of Efficacy and Safety of CP003 on CFS/ME or Post COVID-19 Fatigue
The goal of this clinical trial is to test if a Lingzhi supplement (CP003) helps people with chronic fatigue or post-COVID fatigue feel better. It will also check if the supplement is safe to use.
- Trial name
- NCT06739720
- Testing
- LingZhi capsule
- Where
- Hong Kong
- Volunteers
- 130 people
- Sponsor
- The University of Hong Kong
Multiple Sclerosis, Clinically Isolated Syndrome
Autoimmune Intervention Mastery Course Study
The goal of this project is to critically evaluate the effectiveness of using an online program to improve diet and self-care in patients with multiple sclerosis (MS), clinically isolated syndrome (CIS), fibromyalgia, post acute…
- Conditions
- Multiple Sclerosis, Clinically Isolated Syndrome, Fibromyalgia, Post Acute Sequelae of COVID-19
- Trial name
- AIM (NCT05057676)
- Testing
- Immediate Autoimmune Intervention Mastery Course (AIM), Immediate Question and Answer sessions. (AIM Q and A sessions), Delayed Autoimmune Intervention Mastery Course (delayed AIM course)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Terry L. Wahls
Long COVID
Taurine Supplementation in Long COVID
The COVID-19 pandemic has swept across the globe, affecting millions of individuals with varying degrees of severity. While many individuals recover from the acute phase of the infection, a significant proportion continue to…
- Trial name
- NCT06721949
- Testing
- Taurine
- Where
- 5 sites in Canada
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Long COVID
Evaluating the Neuromodulatory Effect of Ketamine in Long COVID-19
Plain Language Summary: This study is a clinical trial to see if ketamine can help treat symptoms of Long COVID, especially fatigue and problems with thinking clearly (often called "brain fog").
- Trial name
- NCT06821087
- Testing
- Ketamine only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas at Austin
PASC Post Acute Sequelae of COVID-19
Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have symptoms that last long after the active infection ends.
- Trial name
- NCT06577467
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)