Clinical trials: Post-Concussive Symptom
Post Concussion Syndrome
Effects of Vestibular Rehabilitation and Routine Physical Therapy in Athletes With Post Concussion Syndrome
This randomized controlled trial with a parallel design was conducted over six months at Ghurki Trust Teaching Hospital to compare the effects of Vestibular Rehabilitation and Routine Physical Therapy on stability, kinesiophobia…
- Trial name
- PCS BESS IPRRS (NCT07401706)
- Testing
- Intervention 1, Control Arm (Conventional Therapy)
- Volunteers
- 34 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Chronic Traumatic Encephalopathy
Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study
to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre…
- Trial name
- NCT03218332
- Testing
- Biomarkers for detecting possible CTE invivo
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Hyperbaric Oxygen Therapy, Traumatic Brain Injury
Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children
Due its high incidence, mTBI and its consequences of PPCS are a major public health issue. There is no consensus regarding the treatment of PPCS in pediatrics.
- Conditions
- Hyperbaric Oxygen Therapy, Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- TBIPED (NCT03339037)
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Assaf-Harofeh Medical Center
Concussions, PCS
Predicting Persistent Postconcussive Problems in Pediatrics (5P)
Concussion, a mild traumatic injury common in children and adolescents, is a complex pathophysiological process affecting the brain.
- Trial name
- 5P (NCT01873287)
- Where
- 9 sites in Canada
- Volunteers
- 3,063 people
- Sponsor
- Children's Hospital of Eastern Ontario
Post-Traumatic Headache, Mild Traumatic Brain Injury
Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache
An exploratory open-label study of PPTH patients to study the efficacy and tolerability of erenumab in the prophylactic treatment of persistent headache attributed to mild traumatic injury to the head.
- Conditions
- Post-Traumatic Headache, Mild Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- NCT03974360
- Testing
- AMG 334
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Headache Center
Persistent Post-concussive Symptoms
Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms
Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity.
- Trial name
- taVNS-PPCS (NCT07017257)
- Testing
- Active taVNS
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University of Liege
Post-Concussion Symptoms, Distorted; Balance
Comparing the Effect of Osteopathic Manipulative Medicine (OMM) Versus Counseling in the Treatment of Concussion
Concussion or mild traumatic brain injury (TBI) is a challenging injury for physicians to manage and is among the most serious disabling neurological disorders.
- Trial name
- NCT02750566
- Testing
- Osteopathic Manipulative Treatment, Counseling
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- New York Institute of Technology
Mild Traumatic Brain Injury
Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)
A two site, 2-arm, Phase III randomized pragmatic clinical trial evaluating the effectiveness of quetiapine monotherapy in comparison to Treatment As Usual (TAU) medication management for symptoms experienced by veterans…
- Trial name
- NCT06333990
- Testing
- Quetiapine Fumarate, TAU
- Where
- 2 sites in United States
- Volunteers
- 146 people
- Sponsor
- Foundation for Advancing Veterans' Health Research
Cerebral Concussion, Brain Injuries
The Effects of Head Trauma on Collegiate Athletes
Recently, researchers and clinicians have examined many different forms of concussion testing aimed to assess if a brain injury has occurred and to what degree it affects the individual being tested.
- Trial name
- NCT02354469
- Where
- United States
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
TBI (Traumatic Brain Injury)
Evaluation of Military Service and Family Members for Post Concussive and Posttraumatic Stress Symptoms
This protocol is designed to facilitate the recruitment, screening and registry of Military Service Members (SMs) and individuals eligible for care in the Department of Defense (DoD) healthcare system.
- Trial name
- MRP (NCT03191357)
- Testing
- n/a observational
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Post Concussive Syndrome, Chronic, Post Concussion Symptoms
Accelerated Transcranial Magnetic Stimulation Intervention for Post-Concussion Syndrome
This study looks at the effects of accelerated intermittent theta burst stimulation (aiTBS) on patients with chronic and acute post-concussion syndrome.
- Conditions
- Post Concussive Syndrome, Chronic, Post Concussion Symptoms, Post Concussive Syndrome, Post Concussion Syndrome
- Trial name
- NCT07211919
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cognitive FX
Post-Concussion Syndrome, Post-Traumatic Headache
Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology
The purpose of this study is to compare a 4-week, moderately intensive, lab and home-based aerobic exercise program versus exercise plus cognitive training.
- Conditions
- Post-Concussion Syndrome, Post-Traumatic Headache, Post-Concussive Syndrome, Chronic, Head Injury
- Trial name
- NCT03674398
- Testing
- Exercise+CT, Exercise only
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Concussion (Diagnosis), Concussion Post Syndrome
Female Concussion Head Cooling
This research is being done to examine the benefits of a 28 day head cooling intervention on cognition, inflammation of the brain, sleep quality, menstrual symptom interaction, and mood in acutely concussed females.
- Conditions
- Concussion (Diagnosis), Concussion Post Syndrome, Concussion, Mild
- Trial name
- NCT07303933
- Testing
- Brain Cooling
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Penn State University
Brain Concussion, Mild Traumatic Brain Injury
Utilizing Electronic Clinical Decision Support to Enhance mTBI Care at the Primary Care Point of Entry
Six primary care practices within a large Philadelphia pediatric care network will use an electronic Clinical Decision Support (eCDS) tool as standard care for concussion evaluation.
- Trial name
- NCT06693778
- Testing
- electronic Clinical Decision Support tool for risk stratification of pediatric patients with mTBI
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Children's Hospital of Philadelphia
Brain Injuries, Post-Concussive Symptom
Metacognitive Therapy for Post-concussive Symptoms After Mild Traumatic Brain Injury
The purpose of this open trial is to investigate the feasibility, acceptability, and effect of metacognitive therapy in patients with prolonged post-concussive symptoms after mild traumatic brain injury.
- Conditions
- Brain Injuries, Post-Concussive Symptom, Post-Concussive Syndrome
- Trial name
- NCT02690584
- Testing
- Metacognitive therapy
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- Norwegian University of Science and Technology
Post-Concussive Syndrome, Chronic
The Immediate Effects of Dry Needling on Post-concussion Syndrome
In about 15% of adult concussion cases, symptoms last longer than 2 weeks and can largely impact the individual's ability to work, be physically active and participate in everyday life.
- Trial name
- NCT03949998
- Testing
- Dry Needling, Manual Therapy
- Where
- 3 sites in Canada
- Sponsor
- University of Guelph
Mild Concussion, Post Concussion Syndrome
Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool
The iDETECT (Integrated Display Enhanced Testing for Concussion and mild traumatic brain injury) system is a novel portable, open access platform that enables immediate and rapid assessment of multimodal neurologic function.
- Conditions
- Mild Concussion, Post Concussion Syndrome, Vestibular Neuritis
- Trial name
- NCT02171312
- Testing
- iDETECT Assessment, Routine Balance and Vestibular Testing
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Emory University
Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms
Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study
The goal of this study is to examine changes in blood biomarkers following hyperbaric oxygen therapy (HBOT) in military veterans with traumatic brain injury and persistent post-concussive symptoms.
- Conditions
- Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms, PTSD
- Trial name
- NCT07849465
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Summit Hyperbarics and Wellness
Persistent Post-concussive Symptoms, Convergence Insufficiency
Persistent Post-Concussion Symptoms With Convergence Insufficiency
Our successful R01 discovered 1) the neural mechanistic difference between typically occurring convergence insufficiency (TYP-CI) and binocularly normal controls and 2) the underlying mechanism of office-based vergence and…
- Conditions
- Persistent Post-concussive Symptoms, Convergence Insufficiency, Mild Traumatic Brain Injury, Concussion, Mild
- Trial name
- PPCS-CI (NCT05262361)
- Testing
- Office-based Vergence and Accommodative Therapy
- Where
- 2 sites in United States
- Volunteers
- 112 people
- Sponsor
- New Jersey Institute of Technology
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine