Clinical trials: Post-ERCP Pancreatitis
Post-ERCP Pancreatitis, Pancreatitis, Acute Necrotizing
The Efficacy of Pancreatic Duct Stenting With Rectal Indomethacin in Preventing Post-ERCP Pancreatitis
With the development of endoscopic technology, ERCP has been widely used in the diagnosis and treatment of pancreatobiliary diseases, and has become the first treatment for most of the biliary and pancreatic diseases.
- Trial name
- NCT03643900
- Testing
- pancreatic duct stenting, rectal indomethacin
- Where
- China
- Volunteers
- 618 people
- Sponsor
- First People's Hospital of Hangzhou
Pancreatitis, Acute
Epinephrine Sprayed on the Papilla Versus Sterile Water Sprayed on the Papilla for Preventing Pancreatitis After Endoscopic Retrograde Cholangiopancreatography
This multicentre randomised controlled trial included patients aged >18 years with an indication for ERCP and naive major papilla.
- Trial name
- NCT02959112
- Testing
- Epinephrine, Sterile water, Indomethacin Rectal Suppository
- Where
- Mexico
- Volunteers
- 548 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Pancreatitis, Acute, Gastrointestinal Disease
Oral Resveratrol to Prevent Post-ERCP Pancreatitis
Acute pancreatitis is the most common and feared complication of ERCP, occurring after 1% to 30% of procedures. Since 2012, a multicenter RCT was published in NEJM, indomethacin use in high risk patients was considered a…
- Trial name
- NCT02947932
- Testing
- Resveratrol, Indomethacin
- Volunteers
- 2,700 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Post-ERCP Acute Pancreatitis
Trial of Aggressive Hydration Versus Rectal Indomethacin for Prevention of Post-ERCP Pancreatitis
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a commonly performed endoscopic procedure used to treat pancreato-biliary pathology.
- Trial name
- AHRI-PEP (NCT03629600)
- Testing
- Lactated Ringer, Rectal Form Indometacin
- Where
- India
- Volunteers
- 352 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Bile Duct Diseases, Biliary Tract Diseases
Safety and Efficacy Study of IL-10 (Tenovil TM) in the Prevention of Post-ERCP Acute Pancreatitis (Study P02580)(TERMINATED)
The purpose of this study is to determine if a single dose of IL-10 compared to placebo is safe and effective in reducing the incidence of post-ERCP acute pancreatitis for subjects with increased risk.
- Conditions
- Bile Duct Diseases, Biliary Tract Diseases, Gallbladder Diseases, Pancreatitis
- Trial name
- NCT00040131
- Testing
- IL-10
- Volunteers
- 316 people
- Sponsor
- Merck Sharp & Dohme LLC
Post-ERCP Pancreatitis
Rectal Indomethacin in the Prevention of Post-ERCP Pancreatitis
It is now established that indomethacin, a non-steroidal anti-inflammatory drug, at a dose of 100 mg, is effective in reducing the frequency and severity of pancreatitis (inflammation of the pancreas) after endoscopic retrograde…
- Trial name
- NCT01912716
- Testing
- high dose indomethacin, standard dose indomethacin
- Where
- 6 sites in United States
- Volunteers
- 1,037 people
- Sponsor
- Indiana University
Post-ERCP Acute Pancreatitis
PAN-PROMISE to Detect Post-ERCP Pancreatitis Symptoms
The aim of this study is to use a validated patient-reported outcome measure to evaluate how many patients have symptoms of pancreatitis after ERCP and how it correlates with their quality of life and productivity.
- Trial name
- PAN-PROMISE (NCT05310409)
- Where
- 2 sites in United States
- Volunteers
- 700 people
- Sponsor
- University of Pennsylvania
Post-ERCP Acute Pancreatitis
Rectal Indomethacin Versus Rectal Indomethacin and Sublingual Nitrate for PEP Prevention
Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) are at risk for post-ERCP pancreatitis (PEP), which is associated with adverse outcomes.
- Trial name
- NCT04425993
- Testing
- Isosorbide Dinitrate 5 MG, Indomethacin 100 MG
- Where
- 4 sites in China
- Volunteers
- 2,700 people
- Sponsor
- Air Force Military Medical University, China
Post-ERCP Acute Pancreatitis
Post-ERCP Pancreatitis Prevention by Stent Insertion
The presented study is designed to analyze the efficacy of pancreatic stent insertion in patients undergoing ERCP with accidental cannulation of the pancreatic duct.
- Trial name
- PEPSI (NCT01673763)
- Testing
- Stent insertion into the main pancreatic duct
- Where
- 4 sites in Belgium, Germany and 2 more
- Volunteers
- 169 people
- Sponsor
- Technical University of Munich
Endoscopic Retrograde Cholangiopancreatography (ERCP), Choledocholithiasis
Role of Prophylactic Aggressive Hydration to Prevent Post-ERCP Pancreatitis
Endoscopic Retrograde Cholangiopancreatography, also called ERCP, is a procedure used to diagnose and treat disorders of the bile ducts and pancreas.
- Conditions
- Endoscopic Retrograde Cholangiopancreatography (ERCP), Choledocholithiasis, Bile Duct Disorder, Biliary Obstruction
- Trial name
- NCT07417020
- Testing
- Aggressive intravenous hydration with lactated Ringer's solution, Standard intravenous hydration with lactated Ringer's solution
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Lahore General Hospital
Post-ERCP Pancreatitis
Frequency and Predictors of Post-ERCP Pancreatitis in a South Asian Tertiary Care Center
This study was conducted at the Department of Gastroenterology, Lady Reading Hospital, Peshawar, Pakistan, from January 2023 to December 2023.
- Trial name
- NCT07125014
- Testing
- Observational study
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- Nangarhar University
Post-ERCP Acute Pancreatitis
Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis
The purpose of this study is to compare the incidence of post-ERCP pancreatitis (PEP) in chronic pancreatitis (CP) patients to that in biliary disease patients, to determine whether CP patients in early clinical stage have a…
- Trial name
- NCT02781987
- Testing
- chronic pancreatitis
- Volunteers
- 2,028 people
- Sponsor
- Changhai Hospital
Post-ERCP Acute Pancreatitis
Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) has been a well-recognized complication with significant morbidity and even mortality.
- Trial name
- NCT02839356
- Testing
- epinephrine, normal saline
- Where
- China
- Volunteers
- 670 people
- Sponsor
- Anhui Provincial Hospital
Pancreatitis, Acute
COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis
Acute pancreatitis is the most common and feared complication of ERCP, occurring after 1% to 30% of procedures. Since 2012, a multicenter RCT was published in NEJM, indomethacin use in high risk patients was considered a…
- Trial name
- NCT02964403
- Testing
- Cox-2, Indomethacin
- Volunteers
- 2,700 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pancreatitis
A Trial of Aprepitant For Prevention of Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis
The purpose of this study is to determine if giving Aprepitant 4 hours before and for two days after ERCP decreases the risk of developing pancreatitis after ERCP.
- Trial name
- NCT00736073
- Testing
- aprepitant
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Duke University
ERCP, Choledocholithiasis
Pre-cut Versus Intentional Double Guidewire for ERCP Cannulation: Prospective, Randomized Controlled Trial
Endoscopic retrograde cholangiopancreatography (ERCP) is an indispensable therapeutic procedure in the management of a wide spectrum of pancreaticobiliary disorders, including choledocholithiasis, benign and malignant biliary…
- Conditions
- ERCP, Choledocholithiasis, Biliary Drainage, Biliary Strictures Caused by Malignant Neoplasms
- Trial name
- PRIDE (NCT07329803)
- Testing
- Precut Sphincterotomy, Double Guidewire Technique
- Volunteers
- 840 people
- Sponsor
- Asian Institute of Gastroenterology, India
Post-ERCP Acute Pancreatitis, Pancreatic Duct Stricture
Short Term Pancreatic Stenting Registry
The purpose of this study is to document clinical utility and distribution of indications for short term pancreatic stenting, and stent type preference by indication at tertiary referral centers with expertise in pancreatic…
- Conditions
- Post-ERCP Acute Pancreatitis, Pancreatic Duct Stricture, Pancreatic Duct Stones, Pancreatic Duct Leakage
- Trial name
- NCT02262845
- Testing
- The Advanix™ Pancreatic Stent and NaviFlex RX Pancreatic Delivery System and Pushers
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 246 people
- Sponsor
- Boston Scientific Corporation
Post-ERCP Acute Pancreatitis
Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis
Post-ERCP pancreatitis is a well-known and sometimes life-threatening complication of ERCP. Both LR and rectal indomethacin have shown benefit in preventing post-ERCP pancreatitis.
- Trial name
- IND+LRPEP (NCT02641561)
- Testing
- Indomethacin, Lactated Ringer's Solution, Normal Saline
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Pancreatitis
3°C Saline Injection at the Duodenal Papilla to Prevent Post-ERCP Pancreatitis
Endoscopic retrograde cholangiopancreatography (ERCP) is an endoscopic procedure used to diagnose and treat problems in the bile ducts and pancreas. One of its most common complications is post-ERCP pancreatitis.
- Trial name
- NCT07381478
- Testing
- Topical Cold Sterile Saline Irrigation of the Duodenal Papilla (3°C), Standard ERCP (Usual Care)
- Where
- Colombia
- Volunteers
- 900 people
- Sponsor
- Universidad Nacional de Colombia
Pancreatitis
Randomized Trial of Aggressive Fluid Hydration to Prevent Post ERCP Pancreatitis
1. ERCP is a commonly performed endoscopic procedure used to treat stones and blockages of the bile duct as well as to manage leaks which occurs following laparoscopic gallbladder removal. 2.
- Trial name
- NCT01758549
- Testing
- Aggressive Intravenous Hydration Group, Standard Fluids Arm
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Southern California