Clinical trials: Post-Mastectomy
Seroma Complicating A Procedure, Hematoma Postoperative
SEroma Reduction pOst MAstectomy "SEROMA Study"
This is a pilot study to evaluate the feasibility of conducting a larger trial to determine if the use of intraoperative topical tranexamic acid (TXA) decreases the rate of post-operative hematomas and seromas in breast cancer…
- Conditions
- Seroma Complicating A Procedure, Hematoma Postoperative, Breast Cancer
- Trial name
- SEROMA (NCT03738527)
- Testing
- Tranexamic Acid 100mg/mL, 20mL topical, Normal Saline Flush, 0.9%, 20mL topical
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Mastectomy, Breast Cancer Female
Efficacy of Enhanced Recovery After Surgery Pathway for Total Mastectomy
Retrospective analysis of pre and post-Enhanced Recovery after Surgery for Total mastectomy pathway implementation.
- Trial name
- ERAS_Breast (NCT03181139)
- Testing
- ERAS pathway for Total Mastectomy
- Volunteers
- 386 people
- Sponsor
- Monica Harbell
Post-operative Pain
Postoperative Pain and Morphine Consumption After Mastectomy - Lyrica
This study will compare the effects of oral pregabalin with placebo on postoperative pain and morphine usage after mastectomy. Pregabalin is an anticonvulsant agent approved by the United States Food and Drug Administration (FDA)…
- Trial name
- NCT01391858
- Testing
- lyrica
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Texas Southwestern Medical Center
BREAST-Q
Validity and Reliability of Arabic Version of Breast Questionnaire
To test validity and reliability of the translated Arabic version of breast questionnaire .
- Trial name
- NCT05415033
- Testing
- BREAST-Q
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer
Comparison of MRI and CEDM to Evaluate Treatment Response Before Surgery
The purpose of this study is to compare the diagnostic accuracy of breast magnetic resonance imaging (MRI) and contrast enhanced digital mammography (CEDM) in assessing the residual disease extent in patients who have completed…
- Trial name
- NCT03070340
- Testing
- Breast Magnetic Resonance Imaging (MRI), Contrast Enhanced Mammography (CEDM)
- Where
- 5 sites in United States
- Volunteers
- 125 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pain, Breast Cancer
Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy
Prevalence of chronic pain after mastectomy is beyond 50% 3 months after surgery. This pain is related to a sensitization of the central nervous system through N-methyl-D-asparate (NMDA) receptors.
- Trial name
- NCT00129597
- Testing
- ketalar
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Breast Reconstruction After Mastectomy
A Comparative Study of Delayed Endoscopic DTI and Autologous Flap Reconstruction Post-Mastectomy
In China, low breast-conserving surgery rates and historically minimal immediate reconstruction following mastectomy have resulted in a significant population of women living without a breast, often leading to long-term…
- Trial name
- DEDIA (NCT07602868)
- Volunteers
- 263 people
- Sponsor
- West China Hospital
Mastectomy, Carpal Tunnel Syndrome (CTS)
Ultra Phonophoresis With a Hyaluronic Acid-Containing Gel on Carpal Tunnel Syndrome Post Mastectomy.
In this study, 60 patients will be randomly assigned into two equal groups (30 patients for each group): 1. Group A: This group will include 30 patients who will receive Ultra Phonophoresis with a hyaluronic acid-containing gel 5…
- Trial name
- NCT06538818
- Testing
- Ultra Phonophoresis
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Neuropathic Pain
Memantine and Post-mastectomy Neuropathic Pain
The aim of this study is to evaluate if memantine administered for four weeks starting two weeks before surgery induces a decrease in pain intensity at 3 months post-mastectomy.
- Trial name
- CLEMANTINE (NCT03686774)
- Testing
- Memantine, no memantine
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Breast Cancer
TAP vs QL for Postoperative Analgesia After DIEP Free Flap Breast Reconstruction
The purpose of this study is to compare the efficacy of Transversus abdominus plane (TAP) block and Quadratus Lumborum (QL) block on the quality of recovery after breast reconstruction with deep inferior epigastric perforator…
- Trial name
- NCT05301595
- Testing
- TAP block, QL Block
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Oncologic Complications, Exercise Therapy
Impact of Scapular Mobilization And Strengthening Exercises on Shoulder Function Post Mastectomy
The most common complications following mastectomy are pain, lymphedema of the upper limb ipsilateral to surgery, decreased range of motion (ROM), limited to 90° of flexion, abduction, and external rotation to 40° of the…
- Conditions
- Oncologic Complications, Exercise Therapy, Shoulder Pain, Shoulder Syndrome
- Trial name
- NCT05529680
- Testing
- Scapular mobilization and Scapular strengthening exercises, Conventional physical therapy program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Breast Cancer
Targeted Pain Coping Skills Training (PCST) for Prevention and Treatment of Persistent Post-Mastectomy Pain
This study looks at whether a coping skills training program can help women manage pain and stress after breast surgery, and lower the risk of developing chronic pain.
- Trial name
- NCT02439437
- Testing
- Psychosocial Intervention
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Breast Cancer
Radiation Therapy or Standard Therapy in Treating Women With Stage II Breast Cancer Who Have Undergone Mastectomy
RATIONALE: Radiation therapy uses high-energy x-rays or other types of radiation to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.
- Trial name
- NCT00966888
- Testing
- standard follow-up care, radiation therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 3,500 people
- Sponsor
- Medical Research Council
Breast Cancer
Radiation Therapy After Surgery in Treating Women With Early Stage Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which regimen of radiation therapy is more effective following surgery for breast cancer.
- Trial name
- NCT00005588
- Testing
- radiation therapy
- Where
- 32 sites in United Kingdom
- Sponsor
- Medical Research Council
Breast Cancer
Radiotherapy After Mastectomy for Breast Cancer Patients at Increased Risk of Local Recurrence
STUDY DESCRIPTION: This is a single-arm study to assess the feasibility, toxicity and cosmetic outcome of partial radiotherapy of the chest wall in breast cancer patients at increased risk of local relapse submitted to…
- Trial name
- NCT03101683
- Testing
- Partial chest wall radiation therapy
- Volunteers
- 28 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Breast Cancer, Breast Reconstruction
NIR Device for Assessment of Skin Flap Perfusion in Breast Surgery: A Pilot Interventional Study
The goal of this single-center, nonrandomized, interventional non-profit pilot study is to evaluate the feasibility and clinical utility of a non-invasive near-infrared spectroscopy (NIRS) imaging device for assessing skin-flap…
- Conditions
- Breast Cancer, Breast Reconstruction, Mastectomy
- Trial name
- ADisIRast (NCT07680296)
- Testing
- Snapshot NIR V3.0
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- National Research Council, Institute of Clinical Physiology, Italy
Breast Reconstruction, Breast Cancer
Successful Microsurgical Breast Reconstruction in Minimally Invasive Mastectomy
A retrospective chart review will be conducted to identify patients who received breast reconstruction surgery with DIEP flaps by a single plastic surgeon in one medical center between November 2018 and July 2022.
- Trial name
- NCT05943873
- Where
- Taiwan
- Volunteers
- 63 people
- Sponsor
- Chang Gung Memorial Hospital
Breast Cancer, Radiotherapy; Complications
Hypo Versus Conventional Fractionation in Reconstructed-Breast Cancer Mastectomy Patients
This randomized Phase III study aims to show major complication rate of hypofractionation radiation therapy is not inferior, compared to conventional fractionation radiation therapy in breast cancer patients undergoing mastectomy…
- Trial name
- NCT05253170
- Testing
- Hypofractionation, Conventional Fractionation
- Volunteers
- 622 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Breast Reconstruction
Reconstruction Outcomes in Immediate Post-mastectomy Breast Reconstruction With ADM
Evaluation and comparison of clinical and aesthetic outcomes associated with the use of two allograft dermal matrices (ADMs) currently in use for tissue assisted immediate post-mastectomy breast reconstruction.
- Trial name
- NCT03145337
- Testing
- FlexHD ADM (Cohort A), AlloDerm RTU ADM (Cohort B)
- Where
- 7 sites in United States
- Volunteers
- 224 people
- Sponsor
- Musculoskeletal Transplant Foundation
Breast Cancer
Optimizing Decision Making About Breast Reconstruction After Mastectomy: A Patient-Centered Approach
Although clinical decision tools (CDTs) exist for a variety of treatments, CDTs designed to support personalized breast reconstruction decisions, particularly about type and timing of reconstruction, are lacking.
- Trial name
- NCT03346161
- Testing
- Usual care American Society of Plastic Surgeons booklet "Breast Reconstruction", Decision tool, Usual Care Group - Outcome Measures
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Washington University School of Medicine