Clinical trials: Post-Mastectomy
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Phase III Study of 5tx vs 15tx of RT (X-rays or Protons) Including RNI in Breast Cancer Patients
This phase III trial compares the rate of complications of x-ray therapy versus proton beam radiation therapy after breast conserving surgery or mastectomy in treating patients with breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT04443413
- Testing
- Proton Beam Radiation Therapy, Questionnaire Administration, X-ray Therapy
- Where
- 3 sites in United States
- Volunteers
- 146 people
- Sponsor
- Mayo Clinic
Sports, Therapy
Myofascial Versus Conventional Physiotherapy
A total of 61 patients who underwent total mastectomy for breast cancer with axillar lymph dissection and adjuvant radiotherapy were enrolled in this trial.
- Trial name
- MYONAMASTE (NCT04369079)
- Testing
- manual myofascial techniques, conventional therapy consisting of exercise and massage.
- Where
- Poland
- Volunteers
- 61 people
- Sponsor
- The Greater Poland Cancer Centre
Breast Reconstruction After Mastectomy
National, Multicenter PMS Study "Patient Reported Outcome" in Breast Reconstruction Following Mastectomy With TiLOOP Bra
This multicentre, non-randomised, observational clinical device investigation will be performed to obtain postmarketing information on the TiLOOP® Bra and in particular on the improvement of the patients' quality of life as well…
- Trial name
- PRO-BRA (NCT01885572)
- Testing
- TiLOOP Bra
- Where
- 8 sites in Germany
- Volunteers
- 267 people
- Sponsor
- Pfm Medical Mepro Gmbh
Chronic Postsurgical Pain
Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain
The study utilizes a 3-arm placebo-controlled RCT to study the effectiveness of ketamine in reducing chronic post-mastectomy pain.
- Trial name
- KALPAS (NCT05037123)
- Testing
- Continuous ketamine infusion, Ketamine + Saline
- Where
- 14 sites in United States
- Volunteers
- 765 people
- Sponsor
- NYU Langone Health
Amantadine, Duloxetine
Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome
This study aims to evaluate the additive effect of Amantadine or Duloxetine to Pregabalin on development of post mastectomy pain syndrome
- Conditions
- Amantadine, Duloxetine, Pregabalin, Mastectomy
- Trial name
- NCT07421427
- Testing
- Pregabalin, Pregabalin + Amantadine, Pregabalin + Duloxetine
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Post-mastectomy Pain Syndrome
Effects of Intraoperative Esmolol on Post-mastectomy Pain Syndrome
Chronic postoperative pain is an entity that is usually neglected by anesthetists, but several studies show that the choice of anesthetic technique may interfere with this prevalence.
- Trial name
- NCT03965442
- Testing
- Control, Esmolol
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Hospital de Base
Breast Cancer, Post Mastectomy
Breast Fractionation Study - Standard Versus Investigational Fractionation Trial - Nodal Radiation
The purpose of this study is to investigate the difference in fatigue, quality of life and radiation morbidity between hypofractionated and conventional radiation to the breast, chest wall and regional lymph nodes post mastectomy…
- Trial name
- NCT04909125
- Testing
- Hypofractionated radiotherapy VS Standard/Conventional fractionation radiotherapy
- Where
- Australia
- Volunteers
- 132 people
- Sponsor
- Royal North Shore Hospital
Free Flap Post Mastectomy
Goal Directed Fluid Therapy in Free Flap Patients
Fluid management of surgical patients has changed dramatically in recent years. Recent studies have shown that so called 'restrictive' fluid strategies can improve outcomes such as length of stay and time to fitness for…
- Trial name
- NCT00869297
- Testing
- Goal Directed Fluid Administration, Control
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Breast Cancer, Mastectomy
Effect of Dexmedetomidine on the Duration of Pain Control in ESP Block for Breast Surgery
Patients undergoing Partial or total mastectomy with axillary LN dissection will receive prior to induction of general anaesthesia ESP block at T4 level at the same side of the surgery.
- Conditions
- Breast Cancer, Mastectomy, Axillary Lymph Node Dissection, Pain, Postoperative
- Trial name
- NCT04029467
- Testing
- Dexmedetomidine
- Where
- Lebanon
- Volunteers
- 44 people
- Sponsor
- Lebanese American University
Lymphedema, Exercise
Effects of Scapulathoracic Stabilization Exercises Plus Complex Decongestive Therapy in Women With Lymphedema
The aim of the study is to investigate the effects of scapulathoracic stabilization exercises additionally applied to complex decongestive therapy after mastectomy on posture, balance and quality of life.
- Trial name
- NCT04421807
- Testing
- Scapulatoracic stabilization exercises, Complex decongestive therapy (CDT)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ataturk Training and Research Hospital
EFFECT OF TOPICAL APPLICATION OF TRANEXAMIC ACID ON WOUND DRAINAGE POST MODIFIED RADICAL MASTECTOMY
EFFECT OF TOPICAL APPLICATION OF TRANEXAMIC ACID ON WOUND DRAINAGE POST MODIFIED RADICAL MASTECTOMY
Objective: To compare efficacy of topical tranexamic acid versus standard postop care in reducing wound drainage following modified radical mastectomy (MRM). Study Design: Randomized controlled trial.
- Trial name
- NCT07800832
- Testing
- Tranexamic Acid (Topical Application in Mastectomy Wound)
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Gulab Devi Hospital
Breast Cancer
Localization of Intercostal Perforating Vessels Reduces Wound Complications From Nipple Sparing Mastectomy
Approximately 100 women scheduled for NSM will be consented pre-operatively to participate in the study. US will be performed after induction of general anesthesia, prior to surgery using Sonosite™ portable US, 5-12mHz transducer…
- Trial name
- NCT02938390
- Testing
- Ultrasound for localizing intercostal perforating vessels
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Amita Health
Post-mastectomy Pain Syndrome
Adding Magnesium Sulphate to Combined Pectointercostal Plane and Erector Spinae Plane Blocks for Acute and Chronic Post-Mastectomy Pain
Given the burden of chronic postmastectomy pain and the need for effective, opioid-sparing analgesia, the propose of the randomized controlled trial is to evaluate the safety and efficacy of adding magnesium sulphate to the…
- Trial name
- NCT07438366
- Testing
- Pectointercostal Plane Block (PIPB), Erector Spinae Plane Block (ESPB), Magnesium sulfate
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
Breast Neoplasms
Combined Intra-articular Shoulder Injection and Stellate Ganglion Block in Chronic Post-mastectomy Shoulder Pain
Background and Purpose: Adhesive capsulitis of the shoulder is commonly found in patients after breast cancer treatment. We aimed to determine the effectiveness of combined shoulder joint intra-articular injection of platelet…
- Trial name
- NCT03586154
- Testing
- Platelet rich plasma, ketamine and bupivacaine injection
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Postoperative Pain
Efficacy of Dexmedetomidine on Postoperative Analgesia
This prospective, randomized, double-blind study is designed to evaluate the postoperative analgesic efficacy of dexmedetomidine as an adjunct to ropivacaine in erector spinae block in patients undergoing radical mastectomy.
- Trial name
- EDPARMRCT (NCT05110339)
- Testing
- Ropivacaine plus dexmedetomidine, Ropivacaine
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- Universidad Autónoma de Tamaulipas
Female Breast Cancer
Female Sexual Dysfunction in Breast Cancer Patients
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females world wide. breast cancer alone accounts for 25% of all cancer cases and 15% of all cancer deaths among females.
- Trial name
- NCT03153631
- Volunteers
- 75 people
- Sponsor
- Assiut University
Persistent Pain After Breast Cancer Surgery
Ultrasound Guided Pectoral Nerves Blockade for Persistent Pain After Breast Cancer Surgery
This is a pilot study of the pectoral nerves block (PECS) in patients with persistent pain after breast cancer surgery.
- Trial name
- PPBCS (NCT02349581)
- Testing
- PECS block, Bupivacaine
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Reconstruction, Deep Inferior Epigastric Perforator
Synthetic Electrospun Fiber Matrix in Abdominal Wall Donor Sites for Breast Reconstruction
This prospective single-arm pilot study will evaluate the application of meshed 5 × 7 cm Restrata® sheets to the abdominal wall donor site following deep inferior epigastric perforator (DIEP) or abdominal wall autologous free…
- Conditions
- Breast Reconstruction, Deep Inferior Epigastric Perforator, Breast Reconstruction After Mastectomy
- Trial name
- NCT07851415
- Testing
- Restrata®
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Post Operative Pain
Ketamine Versus Neostigmine as Adjuvants to Bupivacaine During Ultrasound-guided Serratus Anterior Block
This study is designed to investigate the analgesic efficacy of ketamine compared to neostigmine as adjuvants to LA in ultrasound guided Serratus Anterior Plane Block (SAPB) in patients undergoing Modified Radical Mastectomy.
- Trial name
- NCT05802979
- Testing
- Adjuvants, Anesthesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
MASTECTOMY
Erector Spina Plane Block Versus Deep Serratus Anterior Plane Block for Post Mastectomy Analgesia
Breast cancer surgery like Mastectomy and modified radical mastectomy are associated with significant postoperative pain, and management depends largely on patient controlled analgesia with intravenous Morphine or other opioids…
- Trial name
- NCT04108715
- Testing
- Erector spina plain block for mastectomy analgesia, Deep serratus anterior plane block
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Saud University