Clinical trials: Post-Operative Complications
Pregnancy Related, Cesarean Section
Fascial Closure and Post-caesarean Pain
This study will evaluate post-operative pain in patients undergoing elective caesarean sections based on the method of fascial closure.
- Conditions
- Pregnancy Related, Cesarean Section, Post-operative Pain, Fascial Closure
- Trial name
- NCT04999670
- Testing
- Fascial closure method during caesarean section via pfannenstiel incision.
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Short Bowel Syndrome, Intestinal Fistula
Intralipid Versus SMOFlipid in HPN Patients
This study will randomize all patients who are new to the Mayo Clinic HPN team to either standard lipid emulsion (Intralipid) or SMOFLipid.
- Conditions
- Short Bowel Syndrome, Intestinal Fistula, Crohn Disease, Intestinal Obstruction
- Trial name
- NCT03773237
- Testing
- SMOFLipid, Intralipid
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Pain, Postoperative
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) [celecoxib plus placebo] to an NSAID combination [celecoxib plus acetaminophen] administered…
- Trial name
- NCT04790812
- Testing
- Celecoxib, Acetaminophen
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Pain, Anesthesia
Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia
To explore and compare antihyperalgesic effects of Dexmedetomidine,Nalmefene,and a combination of both received before anesthesia induction.
- Trial name
- NCT03096730
- Testing
- Normal saline, Remifentanil, Sufentanil
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tianjin Medical University General Hospital
Pain, Postoperative, Anesthesia
Effectiveness of Ultrasound-guided Scalp Block for Supratentorial Craniotomy
Pain management in patients undergoing neurosurgery is a very important issue. The effectiveness of USG-guided scalp blocks for pain management in craniotomy surgery is currently not known.
- Trial name
- NCT06127628
- Testing
- Ultrasound-guided scalp block with ropivacaine 0.375%
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak
Post Operative Pain
Erector Spinae Plane Block Versus Rectus Sheath Block for Postoperative Analgesia After Supraumbilical Surgery
Objectives: To compare the effectiveness of erector spinae plane block (ESPB) and rectus sheath block (RSB) in providing postoperative analgesia after supraumbilical surgery in adult patients and their impact on the patient's…
- Trial name
- NCT05179928
- Testing
- Erector Spinae Plane Block (ESPB), Rectus Sheath Block (RSB)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Delirium, Postoperative Delirium
Projection of Visual Material on Postoperative Delirium in Patients Undergoing Cardiac Surgery
The aim is to evaluate the impact of visual projection of images of relatives or loved ones in patients undergoing cardiac surgery in the immediate postoperative period, and its influence on the incidence and development of…
- Conditions
- Delirium, Postoperative Delirium, Cardiac Surgery
- Trial name
- VisualMaterial (NCT05932394)
- Testing
- Projection of Visual Material on Postoperative Delirium in Patients Undergoing Cardiac Surgery, the usual unit treatment
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- University of Huelva
Postoperative Pain, Ultrasound Guided Nerve Block
Analgesic Efficacy of Trans-muscular Quadratus Lumborum Block After Unilateral Inguinal Hernia Repair
A significant component of pain experienced after abdominal surgery is related to incision of the abdominal wall and adequate analgesia can be a challenge.
- Trial name
- NCT03526731
- Testing
- ultrasound guided quadratus lumborum block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Pain, Postoperative, Anterior Cruciate Ligament Injuries
IPACK on Early Pain Scores After ACL Reconstruction
The goal of this clinical trial is to learn whether using an anesthetic technique called IPACK block will control pain after ACL reconstruction surgery.
- Conditions
- Pain, Postoperative, Anterior Cruciate Ligament Injuries, Analgesics, Opioid
- Trial name
- NCT05985629
- Testing
- IPACK
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Loyola University
Appendicitis (Diagnosis)
Precision Antibiotic Dosing for Appendectomy
This research is studying a drug called cefoxitin already approved by the Food and Drug Administration (FDA) to reduce the risk of infection after surgery to remove an appendix.
- Trial name
- PANDA (NCT06860802)
- Testing
- Cefoxitin
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Michigan
Postoperative Complications
Influence of Arrangement of Small Intestine Order on the Recovery of Bowel Function After Laparoscopic Colorectal Surgery
The method of arranging and restoring the position of the small intestine under laparoscopy is used to determine whether it can promote the recovery of intestinal function after colorectal surgery.
- Trial name
- NCT05485857
- Testing
- Arrangement of small intestine order before close the abdomen
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Changhai Hospital
Thyroid Nodule, Thyroid Dysfunction
Postoperative Hypocalcemia After Thyroidectomy
This retrospective cohort study investigates predictors of postoperative hypocalcemia following thyroidectomy procedures at Minia University Hospital over a 10-year period (2014-2024).
- Conditions
- Thyroid Nodule, Thyroid Dysfunction, Hypocalcemia, Thyroid Cancer
- Trial name
- NCT07428057
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Minia University
Breast Cancer Surgery, Breast Conserving Surgery
Erector Spinae Plane Block vs. PECS I-II Blocks After Breast-conserving Surgery
The goal of this study is to compare the analgesic effects of ESPB and PECS II blocks in patients undergoing BCS. The main question it aims to answer is: Whether these two different block procedures will create a difference in…
- Conditions
- Breast Cancer Surgery, Breast Conserving Surgery, Erector Spinae Plane Block, Pectoral Nerve (PECS) Block
- Trial name
- NCT06758765
- Testing
- Erector Spinae Plane Block, Pectoral Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Istanbul Saglik Bilimleri University
Laparoscopic Cholecystectomy, Postoperative Pain
Transversus Abdominis Plane Block and Postoperative Pain After Laparoscopic Cholecystectomy
Transversus abdominis plane (TAP) block has gained popularity for the control of postoperative pain in various surgeries. Three studies showed inconsistent result on pain control after TAP block in laparoscopic cholecystectomy.
- Conditions
- Laparoscopic Cholecystectomy, Postoperative Pain, Abdominal Muscles, Nerve Block
- Trial name
- NCT01595165
- Testing
- Ultrasound guided subcostal TAP block
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Soonchunhyang University Hospital
Rejection Acute Hepatic, Transplant; Failure, Liver
Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients
A lot of different early and late complications may occur after liver transplantation. They could be related to surgical procedure, to infectious diseases or immuno-mediated diseases (acute cellular rejection, ACR).
- Conditions
- Rejection Acute Hepatic, Transplant; Failure, Liver, Liver Dysfunction
- Trial name
- ElastOLT (NCT05793203)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obstructive Sleep Apnea, Delayed Emergence From Anesthesia
Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea
The purpose of this study is to determine whether modafinil use in patients with obstructive sleep apnea will improve postoperative delayed emergence after general anesthesia.
- Trial name
- ModOSA (NCT02494102)
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Milton S. Hershey Medical Center
Kidney Transplant; Complications, Physical Activity
Increasing Activity Post-Kidney Transplant With SystemCHANGE
Inactivity is a common problem among older kidney transplant recipients (KTRs) and is associated with their high incidence of obesity and cardiovascular problems which are the leading cause of death for KTRs.
- Conditions
- Kidney Transplant; Complications, Physical Activity, Cardiorenal; Change, Cardiovascular Diseases
- Trial name
- CHANGE (NCT03191630)
- Testing
- Fitbit (Control), SystemCHANGE and Fitbit (Intervention)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Postoperative Pulmonary Complications
An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study
Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality in surgical patients. National estimates suggest 1,062,000 PPCs per year, with 46,200 deaths, and 4.8 million additional days of…
- Trial name
- PRIME-AIR (NCT04108130)
- Testing
- Preoperative Education, Intraoperative PEEP (Positive End-Expiratory Pressure) Individualization, Individualization of Neuromuscular Blockade
- Where
- 16 sites in United States
- Volunteers
- 794 people
- Sponsor
- Columbia University
Prostate Cancer
Outpatient Laparoscopic Radical Prostatectomy
The purpose of the study is to evaluate the incidence of surgery-related complications between Day 0 and Day 30.
- Trial name
- LORP (NCT05975775)
- Testing
- Laparoscopic radical prostatectomy
- Where
- France
- Volunteers
- 64 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Chronic Pain, Wound Dehiscence
Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure
This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy.
- Conditions
- Chronic Pain, Wound Dehiscence, Surgical Site Infection (SSI), Incisional Hernia
- Trial name
- PolySuture (NCT07280975)
- Testing
- Polyglactin 910 (Vicryl) Suture, Polypropylene (Prolene) Suture
- Where
- Pakistan
- Volunteers
- 156 people
- Sponsor
- Lady Reading Hospital, Pakistan
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