Clinical trials: Post-Operative Complications
Vasoplegia Syndrome
Effects of Vitamin C on Shock Duration and Microcirculation in Patients With Vasoplegia Syndrome After Cardiac Surgery
This pilot study intends to observe the effect of intravenous vitamin C on the prognosis and sublingual microcirculation in patients with vasoplegia syndrome after cardiac surgery through a prospective randomized controlled study…
- Trial name
- NCT06723626
- Testing
- Vit C, Standard Preparation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Pain, Pain, Postoperative
Peter Hess® Sound Massage for Reducing Anxiety and Pain in Cardiac Surgery
Cardiac surgery patients often undergo anxiousness and pain. Before surgery, anxiety is often caused by the idea of sternotomy, extracorporeal circulation, fear of post-operative pain, and even death.
- Conditions
- Pain, Pain, Postoperative, Pain, Chest, Anxiety
- Trial name
- MuSoCa (NCT05204043)
- Testing
- Peter Hess® sound massage, Music relaxation Music Care®, Questionnaires
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Bra, Breast Cancer Surgery
OptiBra Study, Optimal Postoperative Bra After Breastcancer Surgery
This study evaluates how two different types of postoperative bra 1) standard bra, soft VS 2) compression bra compression after breast cancer surgery affect pain, seroma, other symptoms and complications, and the womans…
- Conditions
- Bra, Breast Cancer Surgery, Complication, Compression
- Trial name
- NCT04059835
- Testing
- OptiBra study
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital
Postoperative Pain
Evaluation of the Efficacy and Safety of HTX-011 for Postoperative Analgesia Following Abdominoplasty Surgery
A Phase 2, Randomized, Controlled Evaluation of the Efficacy and Safety of HTX-011 or HTX-002 for Post-Operative Analgesia Following Abdominoplasty Surgery
- Trial name
- NCT02689258
- Testing
- HTX-011B, HTX-011A, HTX-002
- Where
- 8 sites in United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Heron Therapeutics
Bacterial Infections
BAYQ3939, 1000 mg Tablet in Transrectal Needle Biopsies of the Prostate (TRNBP) - Infection Prophylaxis
The primary purpose of this clinical trial is to compare in a double-blind randomized trial, the efficacy and safety of ciprofloxacin MR 1000 mg tablets given as a single-dose or as a multiple-dose regimen for the prevention of…
- Trial name
- NCT00670215
- Testing
- Ciprofloxacin single dose, Ciprofloxacin triple dose
- Where
- 51 sites in United States, Brazil and 4 more
- Volunteers
- 497 people
- Sponsor
- Bayer
Peritonitis, Primary Closure
Outcome of Primary vs Delayed Primary Closure of Laparotomy in Dirty Abdominal Wounds
This randomized controlled trial is designed to evaluate and compare two different wound management strategies-primary closure (PC) and delayed primary closure (DPC)-in patients undergoing emergency laparotomy for peritonitis The…
- Conditions
- Peritonitis, Primary Closure, Delayed Primary Closure
- Trial name
- NCT07531576
- Testing
- Delayed Primary Laparotomy wound Closure, Primary Abdominal Closure
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Ayub Teaching Hospital
Surgical Site Infection
Colorectal Surgical Site Infection
Surgical site infection (SSI) is one of the most common postoperative complications in surgery, with high morbidity. In the tertiary-center that the investigators evaluated they had a significant rate of surgical site infection.
- Trial name
- NCT05355376
- Testing
- Bundle of measures to decreased SSI
- Volunteers
- 1,139 people
- Sponsor
- Centro Hospitalar Universitário Lisboa Norte
Myocardial Reperfusion Injury, Hypoxia
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases.
- Conditions
- Myocardial Reperfusion Injury, Hypoxia, Hyperoxia, Coronary Artery Disease
- Trial name
- NCT05354648
- Testing
- Hypoxic-hyperoxic preconditioning
- Volunteers
- 120 people
- Sponsor
- Alexander Averyanov
Postoperative Pain
Comparison of the Effects of Erector Spinae Area (ESP) Block and Thoracic Paravertebral Block (TPVB) on Acute Pain, Postoperative Persistent Pain and Neuropathic Pain in Video-Assisted Thoracoscopic Surgery
VATS is a minimally invasive approach that allows the introduction of a video camera and surgical instruments into the thoracic cavity through small incisions made in the chest wall.
- Trial name
- NCT06672848
- Testing
- Numeretic rating scale (NRS), Brief Pain Inventory (BPI), The S-LANSS Pain Score
- Volunteers
- 118 people
- Sponsor
- Aydin Adnan Menderes University
Oral Cancer
Defining Mechanisms of Surgical Site Infection After Oral Cancer Surgery
The study design is an observational cohort study of patients undergoing standard of care oral cavity reconstruction. An observational study is required to prospectively evaluate microbial and antibiotic mechanisms underlying…
- Trial name
- NCT06681935
- Testing
- Oral Cavity Reconstruction
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Postoperative Pain
Analgesic Efficacy of Transversus Thoracic Muscle Plane Block on Post-sternotomy Pain
Patients were randomly allocated to either Tansversus group (T group) and general anesthesia (N group).Patient demographic data, preoperative medical status, left ventricular function, and operative data (total ischemic time…
- Trial name
- NCT04872192
- Testing
- transversus thoracic muscle plane block, general anaesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Esophagectomy
Prediction of Anastomotic Leak/Stricture After Esophagectomy With Gastric Pull-up by Venous Blood Gas
Esophageal resection becomes a routine surgical procedure in many medical centers. Usually reconstruction after esophagectomy is achieved by gastric pull-up with cervical or intrathoracic anastomosis.
- Trial name
- NCT02546687
- Testing
- Venous blood sampling
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma
Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery
This phase II trial compares the effect of adding a Live Biotherapeutic Product called CBM588 to pembrolizumab versus pembrolizumab alone in preventing return of disease (recurrence) after surgery for patients with renal cell…
- Conditions
- Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Stage II Renal Cell Cancer AJCC v8, Stage III Renal Cell Cancer AJCC v8
- Trial name
- NCT07037004
- Testing
- Biospecimen Collection, Clostridium butyricum CBM588 Strain, Computed Tomography
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- City of Hope Medical Center
Postoperative Nausea and Vomiting
Intraoperative Electronic Reminder Module to Enhance Postoperative Nausea and Vomiting Prophylaxis
This project intends to develop and implement an electronic reminder for post-operative nausea and vomiting (PONV) prophylaxis into the Anesthesia Record Keeping System.
- Trial name
- NCT02830412
- Testing
- Postoperative nausea and vomiting (PONV) reminder
- Sponsor
- The Cleveland Clinic
Endometrial Cancer
Postoperative Hypofractionated Intensity-modulated Radiotherapy Endometrial Cancer
To investigate the non-inferiority of disease-free survival in women who received hypofractionated intensity-modulated whole pelvic radiation therapy (2.5 Gy x 16 fractions) after curative surgery for stage III endometrial cancer.
- Trial name
- NCT05876130
- Testing
- POHIM_EM
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Samsung Medical Center
Thoracic Surgery, Cardiopulmonary Bypass
Variations of the Lung Compliance During Extracorporeal Circulation and Post Operative Pulmonary Complications
the decrease in thoracopulmonary compliance after cardiac surgery is well known . The investigators hypothesize that the major factor determining pulmonary outcome after cardiac surgery is the alteration of pulmonary compliance…
- Trial name
- COMPLI (NCT02654600)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Post-operative Pain
Effectiveness of Pre-emptive Analgesics on Post-Operative Pain After Stainless Steel Crown Placement On Primary Molars
The aim of this study is to evaluate the effectiveness of pre-emptive analgesia using ibuprofen and paracetamol on reducing post-operative pain following the placement of stainless steel crowns on primary molars compared to…
- Trial name
- NCT05602064
- Testing
- Ibuprofen, Paracetamol
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Postoperative Pain
Erector Spinae Plan Block for Postoperative Analgesia
Laparoscopic cholecystectomy is a widely employed procedure in ambulatory surgery. Pain after laparoscopic cholecystectomy arises significantly from port site incisions in the anterior abdominal wall.
- Trial name
- NCT03398564
- Testing
- Erector Spinae Plan Block, Oblique subcostal TAP
- Where
- Saudi Arabia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Al Jedaani Hospital
Rectal Cancer
Multi-Technology Integrated Total Mesorectal Excision Versus Conventional Total Mesorectal Excision for the Treatment of Middle and Distal Rectal Cancer.
A multicenter, prospective, randomized, controlled clinical trial of multi-technology integration total mesorectal excision (MTI-TME) versus conventional total mesorectal excision (C-TME) for the treatment of middle and distal…
- Trial name
- NCT06613399
- Testing
- MTI-TME, C-TME
- Volunteers
- 324 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
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