Clinical trials: Post-Operative Confusion, open to volunteers
Emergence Delirium, Anesthesia
Comparing the Efficacy of Propofol and Dexmedetomidine in Prevention of Emergence Agitation After Sevoflurane Anesthesia in Children
This is a clinical study for comparing the efficacy of two drugs i.e propofol and dexmedetomidine in prevention of a group of post operative abnormal behaviours that can occur after sevoflurane anesthesia in children and we will…
- Trial name
- NCT07799311
- Testing
- propofol 1mg/kg, Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Pediatric, Neurosurgery
Remimazolam and Emergence Delirium in Pediatrics
Emergence delirium is a common complication in pediatrics undergoing neurosurgery. Previous study showed that a single bolus of remimazolam was associated with lower incidence of postoperative agitation.
- Conditions
- Pediatric, Neurosurgery, Sevoflurane Anesthesia, Remimazolam
- Trial name
- NCT07046364
- Testing
- Remimazolam, Normal Saline
- Where
- 2 sites in China
- Volunteers
- 248 people
- Sponsor
- Peking University First Hospital
Postoperative Delirium (POD), Sex Differences
Sex-Dependent Risk of Postoperative Delirium and Mediating Effects of Family Visits
Postoperative delirium is a common and serious complication after surgery, affecting 10-40% of older patients undergoing non-cardiac procedures.
- Trial name
- NCT07502391
- Where
- Switzerland
- Volunteers
- 471 people
- Sponsor
- Julian Rössler
Lumbar Disc Herniation, Emergence Agitation
Magnesium Sulfate for Prevention of Emergence Agitation in Lumbar Disc Surgery
In this retrospective study, the effect of intraoperative magnesium sulfate infusion on the incidence of postoperative emergence agitation was evaluated in adult patients who underwent elective lumbar microdiscectomy under…
- Conditions
- Lumbar Disc Herniation, Emergence Agitation, Magnesium Sulfate
- Trial name
- NCT07139847
- Testing
- Magnesium Sulfate Infusion, 0.9% Saline Infusion
- Volunteers
- 70 people
- Sponsor
- Ondokuz Mayıs University
Postoperative Delirium (POD), Peripheral Arterial Disease
Effect of Preoperative Ultrasound-Guided Stellate Ganglion Block on Postoperative Delirium in Older Adults Undergoing Elective Peripheral Endovascular Intervention
This randomized controlled trial will evaluate whether preoperative ultrasound-guided stellate ganglion block reduces the incidence of postoperative delirium in adults aged 60 years or older undergoing elective peripheral…
- Trial name
- NCT07848113
- Testing
- ropivacaine
- Volunteers
- 168 people
- Sponsor
- Assiut University
Gastroesophageal Cancer (GC), Postoperative Delirium (POD)
Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer
The primary objective of this observational study is to investigate the incidence of Post Operative Delirium (POD) after gastroesophageal cancer surgery.
- Conditions
- Gastroesophageal Cancer (GC), Postoperative Delirium (POD), Quality of Life (QOL), Frailty
- Trial name
- CASE (NCT06687291)
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Karolinska Institutet
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Intervention on Postoperative Delirium in Infants and Toddlers Undergoing Congenital Heart Surgery
This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered infants…
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06861998
- Testing
- Message-based bedtime routine, sleep hygiene education
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Yan Fuxia
Preoperative Stress, Postoperative Cognitive Dysfunction
Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients.
Patients undergoing cardiac surgery often complain of anxiety before a major operation and the resulting stress. This circumstance is a risk factor for mental problems that may occur after the operation (e.g., delirium or memory…
- Conditions
- Preoperative Stress, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- DESTRESS-SURG (NCT05036538)
- Testing
- Intervention with natural sounds administered via headphones, Intervention with natural sounds and binaural beats administered via headphones, Intervention with natural sounds and virtual reality administered via headphones and head mounted display
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- Heart and Brain Research Group, Germany
Postoperative Delirium, Postoperative Cognitive Dysfunction
Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool
This observational cohort study is designed to validate the CogCheck application as a risk prediction tool for postoperative delirium in patients undergoing cardiac surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- CogCheck-Valid (NCT03360838)
- Testing
- CogCheck
- Where
- Switzerland
- Volunteers
- 475 people
- Sponsor
- University Hospital, Basel, Switzerland
Emergence Agitation
Auricular Acupressure for Reducing Postoperative Emergence Agitation in Preschool Children
This study investigates whether auricular acupressure can reduce postoperative emergence agitation among preschool children following adenoidectomy.
- Trial name
- NCT07472764
- Testing
- Auricular acupressure
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Beijing Tongren Hospital
POCD - Postoperative Cognitive Dysfunction, Recovery Time
The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy
In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity.
- Conditions
- POCD - Postoperative Cognitive Dysfunction, Recovery Time, Postoperative Neurocognitive Disorder, Postoperative Delirium
- Trial name
- NCT07637357
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Postoperative Delirium
Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors
Neurosurgery is a risk factor for delirium. Dexmedetomidine might reduce delirium by reducing neuroinflammation, improving postoperative analgesia and sleep quality.
- Trial name
- NCT06164314
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Delirium
The Role of Emotional and Orientation Support in Prevention of Postoperative Delirium Among Elderly Surgical Patients
Postoperative delirium is common and associated with significant adverse outcomes. Its etiology is unknown, and little is known about associated risk factors.
- Trial name
- NCT05140993
- Testing
- extended emotional and orientation support
- Where
- Israel
- Volunteers
- 2,000 people
- Sponsor
- Barak Cohen, MD
Tonsil Hypertrophy
Effect of the Combination of Dexamethasone and BIS Monitoring on Reducing Postoperative Nausea and Vomiting in Children
This study will investigate the impact of combining dexamethasone and bispectral index (BIS) monitoring on the incidence of postoperative nausea and vomiting, emergence delirium and recovery trajectories in children undergoing…
- Trial name
- BISDEX (NCT07299435)
- Testing
- BIS monitoring
- Where
- 5 sites in Czechia
- Volunteers
- 1,508 people
- Sponsor
- University Hospital Ostrava
Emergence Agitation, Emergence Delirium
Transcutaneous Auricular Vagus Nerve Stimulation for Prevention of Emergence Agitation and Delirium in Children Undergoing Tonsillectomy and Adenoidectomy
Brief Summary This study is designed to find out whether transcutaneous auricular vagus nerve stimulation (taVNS) can safely reduce restlessness and confusion when children wake up from anesthesia after tonsillectomy and…
- Trial name
- NCT07394647
- Testing
- Active taVNS Group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Neurosurgery, Delirium - Postoperative
Electroencephalogram Predicts Post-operative Delirium
The goal of this observational study is to investigate the predictive value of sub-hairline electroencephalography (EEG) during anesthesia recovery for postoperative delirium (POD).
- Conditions
- Neurosurgery, Delirium - Postoperative, Brain Tumor Adult
- Trial name
- EPOD (NCT06894238)
- Testing
- Sub-hairline EEG Monitoring
- Where
- 2 sites in China
- Volunteers
- 137 people
- Sponsor
- Beijing Sanbo Brain Hospital
Carotid Stenosis, Carotid Artery Diseases
Cerebral Oximetry During Awake Carotid Endarterectomy
Surgery to remove plaque from the carotid artery in the neck requires the artery to be clamped for a period of time. In some patients this reduces blood flow to the brain enough to cause temporary symptoms, and a temporary…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Brain Ischemia, Carotid Endarterectomy
- Trial name
- COACE (NCT07816081)
- Testing
- Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- Nguyen Toan Thang
Postoperative Delirium, Postoperative Neurocognitive Disorder
Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms
This is a prospective cohort study to explore the differences of serum indicators between elderly gastrointestinal neoplasms patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative…
- Conditions
- Postoperative Delirium, Postoperative Neurocognitive Disorder, Gastrointestinal Surgery
- Trial name
- NCT06466096
- Testing
- no intervention
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Xuanwu Hospital, Beijing
Brain Neoplasms, Delirium - Postoperative
Ciprofol, Propofol and Sevoflurane for Postoperative Delirium in Elderly Brain Tumor Patients
This study will compare three anesthesia medicines used to put people into a deep sleep during surgery: ciprofol, propofol, and sevoflurane. All three are commonly used for general anesthesia, but they work in different ways.
- Trial name
- NCT07799623
- Testing
- Ciprofol, Propofol, Sevoflurane
- Where
- China
- Volunteers
- 381 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Intensive Care Unit Delirium
Dexmedetomidinine in the Prevention of Postoperative Delirium in the Intensive Care Unit After Cardiac Surgery
This is a prospective, randomized, single blinded, controlled clinical trial designed to compare the clinical effects of sedation with dexmedetomidine versus propofol in patients undergoing cardiac surgery.
- Trial name
- NCT05849597
- Testing
- Dexmedetomidine, Propofol
- Where
- Serbia
- Volunteers
- 200 people
- Sponsor
- University of Novi Sad