Clinical trials: Post-Operative Nausea and Vomiting (PONV)
Postoperative Nausea
Entral Feeding in Acute Severe Pancreatitis
A total of 60 patients admitted to King Abdulaziz Specialists Hospital between June 2018 and April 2020 with both a clinical and biochemical presentation of acute pancreatitis with the following inclusion criteria: Abdominal pain…
- Trial name
- NCT04406506
- Testing
- nasogastric, nasojejunal, (erythromycin 250 mg IV bolus)
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Abdul Aziz Specialist Hospital
Postoperative Complications, Respiratory Depression
Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
This study aims to evaluate the efficacy and safety of Remimazolam, either used alone or in combination with Propofol, for moderate sedation anesthesia during endoscopic therapies or examinations.
- Conditions
- Postoperative Complications, Respiratory Depression, Postoperative Nausea, Vomiting
- Trial name
- Remimazolam (NCT06777758)
- Testing
- Remimazolam, Propofol
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Pain, Postoperative, Postoperative Nausea and Vomiting
Single Port Versus Four Ports Laparoscopic Cholecystectomy and Early Postoperative Pain
This is a trial to evaluate if single port laparoscopic cholecystectomy causes less pain than conventional laparoscopic cholecystectomy.
- Conditions
- Pain, Postoperative, Postoperative Nausea and Vomiting, Postoperative Complications
- Trial name
- UMBI-CHOL (NCT01268748)
- Testing
- Conventional laparoscopic procedure, Experimental laparoscopic procedure
- Where
- 3 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Bispebjerg Hospital
Acute Pain, Chronic Pain
ERECTOR SPINE PLANE BLOCK VERSUS LOCAL INFILTRATION ANAESTHESIA FOR TRANSFORAMINAL PERCUTANEOUS ENDOSCOPIC DISCECTOMY
The main aim of our study was to test the hypothesis that Erector spine plane block (ESP) with sedation will provide the similar employment of fentanyl and propofol during surgery as an infiltrative local anaesthesia with…
- Conditions
- Acute Pain, Chronic Pain, Postoperative Pain, Anesthesia
- Trial name
- NCT05483647
- Testing
- Local infiltrative anaesthesia, Erector spine plane block
- Where
- Ukraine
- Volunteers
- 52 people
- Sponsor
- Lviv National Medical University
Postoperative Nausea and Vomiting
Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Vitrectomy Under Local Anesthesia
Vitreoretinal surgery is associated with a considerable incidence of postoperative nausea and vomiting (PONV), which is reported to be as high as 60%.
- Trial name
- NCT02386059
- Testing
- Dexamethasone, Ondansetron, Dexamethasone + Ondansetron
- Where
- 4 sites in Italy
- Volunteers
- 1,200 people
- Sponsor
- University of Catania
Obesity, Morbid, Postoperative Pain
Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting
The purpose of this research study is to evaluate the drug gabapentin (Neurontin®) for its ability to reduce postoperative pain, the need for morphine-like pain medication, and the severity and frequency of postoperative nausea…
- Conditions
- Obesity, Morbid, Postoperative Pain, Postoperative Nausea and Vomiting
- Trial name
- NCT00886236
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina
Prevention
Intravenous Versus Intraperitoneal Instillation of Ondansetron for Decreasing Incidence of Nausea and Vomiting After Laparoscopic Gynecological Surgeries.
Study the effect of intraperitoneal instillation vs intravenous ondansetron on PONV added to intraperitoneal bupivacaine for enhanced recovery and to decrease incidence of PONV after laparoscopic surgeries.
- Trial name
- NCT05317611
- Testing
- Intraperitoneal instillation of ondansetron and bupivacaine, Intravenous ondansetron and intraperitoneal instillation of bupivacaine, Intraperitoneal instillation of bupivacaine
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Cardiac Disease, Cardiac Valve Disease
Optic Nerve Sheath After Extracorporeal Circulation
The purpose of this study is to assess the influence of extracorporeal circulation during cardiac surgery on the optic nerve sheath diameter (ONSD) after the surgery.
- Trial name
- NCT05335902
- Testing
- ultrasound measurement of the optic nerve sheath diameter, MoCA test
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Maribor
Penehyclidine, Postoperative Nausea and Vomiting
Penehyclidine and Postoperative Nausea and Vomiting After Bimaxillary Surgery
Postoperative nausea and vomiting (PONV) are common complications after surgery. Patients undergoing orthognathic surgery are reported to have a high rate of PONV, especially those undergoing bimaxillary surgery.
- Conditions
- Penehyclidine, Postoperative Nausea and Vomiting, Bimaxillar Surgery
- Trial name
- NCT04112771
- Testing
- Penehyclidine hydrochloride, No penehyclidine hydrochloride
- Where
- 2 sites in China
- Volunteers
- 243 people
- Sponsor
- Peking University First Hospital
Nausea, Vomiting
Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries
The combination of aprepitant and lower dose dexamethasone is superior to aprepitant alone with respect to the proportion of patients with a complete response (no vomiting and no use of rescue therapy) during 24 hours after the…
- Trial name
- NCT00835965
- Testing
- Dexamethasone, Aprepitant
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Main Line Health
Lumbar Degenerative Disease
Erector Spinae Plan Block (ESPB) with Dexmedetomidine and Dexamethasone in Lumbar Spine Fusion
This study wants to understand if using a pre-operative anesthetic injection could contribute to better pain relief after the surgery. This injection is referred to as an erector spinae plane block (ESPB, or "Block" for short).
- Trial name
- ESPB (NCT06658054)
- Testing
- Adjuvant analgesia, Control (Standard treatment)
- Volunteers
- 46 people
- Sponsor
- University of Southern California
Nausea and Vomiting, Laparoscopic Bariatric Surgery
Effect of Ultrasound-guided Transversus Abdominis Plane Block After Laparoscopic Bariatric Surgery
Purpose: To explore and compare Ultrasound-Guided Transversus Abdominis Plane Block on Postoperative nausea and vomiting and Early Outcome After Laparoscopic Bariatric Surgery To evaluate and examine TAPB can reduce the…
- Trial name
- NCT05016180
- Testing
- Ropivacaine
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University General Hospital
Post Operative Nausea and Vomiting
Association of 5-HT3 Receptor Gene Polymorphism With the Efficiency of Ondansetron for Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is a common and distressing complication in patients undergoing general anesthesia. However, although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced…
- Trial name
- NCT01657786
- Testing
- administration of ondanstron and screening of genomic DNA
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- Yonsei University
Post Operative Nausea and Vomiting (PONV), Adenotonsillectomy
Gabapentin Premedication and Adenotonsillectomy in Pediatric Patients
The frequent incidence of postoperative vomiting and severe pain in children undergoing adenotonsillectomy, may delay postoperative oral intake and increase the risk of dehydration.
- Trial name
- NCT02384187
- Testing
- Gabapentin as premedication
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Cairo University
Postoperative Nausea and Vomiting
Dose-ranging Study of APD405 in Post-operative Nausea and Vomiting (PONV)
To assess the efficacy and safety of different doses of APD405 in the prevention of post-operative nausea and vomiting (PONV) in adult patients at moderate to high-risk of PONV.
- Trial name
- NCT00895830
- Testing
- APD405
- Where
- 18 sites in United States, France and 2 more
- Volunteers
- 257 people
- Sponsor
- Acacia Pharma Ltd
Dexamethasone, Glucocorticoids
High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy
The aim of this study is to investigate the effect of a single preoperative high-dose steroid injection on complications in the immediate postoperative phase after breast cancer surgery, with removal of the breast (mastectomy).
- Conditions
- Dexamethasone, Glucocorticoids, Mastectomy, Breast Cancer
- Trial name
- DEX-MAS (NCT03125941)
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Nausea and Vomiting, Bariatric Surgery
Dual-dose Aprepitant to Reduce Postoperative Nausea and Vomiting After Laparoscopic Bariatric Surgery.
Postoperative nausea and vomiting (PONV) is unpleasant and increases health care costs. Despite modern techniques and prophylaxis, PONV rates remain high after laparoscopic bariatric surgery.
- Trial name
- DDA-PONV (NCT05189756)
- Testing
- Aprepitant 80 mg
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Surgical Wound Infection, Surgery, Colon
The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection
The investigators will test the hypotheses that mild hypercapnia and supplemental oxygen reduce wound infection risk in patients undergoing colon resection.
- Trial name
- NCT00273377
- Testing
- Mild intraoperative hypercapnia (50 mmHg vs. 30 mmHg), Supplemental oxygen (80% vs. 30%), Dexamethasone
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 2,000 people
- Sponsor
- The Cleveland Clinic
Post Operative Pain, Nausea and Vomiting, Postoperative
Preoperative Intravenous Fluid Type and Postoperative Nausea
In this study, it was aimed to investigate the relationship between postoperative nausea and vomiting, anxiety levels and pain scores in the postoperative period according to dosing and choosing of intravenous fluid type that the…
- Conditions
- Post Operative Pain, Nausea and Vomiting, Postoperative, Anxiety
- Trial name
- NCT05961722
- Testing
- preoperative IV 0.9% saline 400 ml, preoperative dextrose 5% 400 ml, preoperative and intraoperative dextrose 5% 400 ml
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara Etlik City Hospital
Postoperative Nausea and Vomiting
Transcutaneous Electrical Acupoint Stimulation of P6 to Prevent Postoperation Nausea and Vomiting
The purpose of this study is to access the effect of TEAS of P6 in the prevention of PONV in women scheduled for gynecologic laparoscopic surgery with general anesthesia.
- Trial name
- TEASP6PPONV (NCT02096835)
- Testing
- Transcutaneous electrical acupoint stimulation, Tropisetron, Dexamethasone
- Where
- China
- Volunteers
- 157 people
- Sponsor
- Huashan Hospital