Clinical trials: Post-Partum Hemorrhage
Post Partum Hemorrhage
Oxytocin vs Carbetocin at Cesarean Delivery in Women With Morbid Obesity
Postpartum hemorrhage (PPH) is a major cause of maternal death worldwide. Oxytocin is the most commonly used uterotonic drug for the active management of third stage labor, to reduce the risk of PPH and help deliver the placenta.
- Trial name
- NCT04902729
- Testing
- Carbetocin, Oxytocin
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Buccal Misoprostol During Cesarean Section for Preventing Postpartum Hemorrhage
Objective: to demonstrate that buccal misoprostol administration during cesarean delivery in women with risk factors for uterine atony decreases the need for additional uterotonic medications, uterine atony and postpartum…
- Trial name
- NCT01733329
- Testing
- Misoprostol, Folic Acid
- Where
- Mexico
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Placenta Accreta
Placenta Accreta Spectrum Disorders: A. Chohan Continuous Squeezing Suture (ACCSS)
Placenta Accreta Spectrum (PAS) disorders are rising in incidence due to increased rate of repeat caesarean sections. Peripartum hysterectomy remains the only definitive treatment of massive postpartum haemorrhage related to this…
- Trial name
- ACCSS (NCT05070689)
- Testing
- ACCSS
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Sharif Medical Research Center
Postpartum Hemorrhage, Postpartum Women
Prevalence of Psychological Disorders After Immediate Postpartum Hemorrhage
The objective of this cross-sectional study is to assess the prevalence of depression at 2 months, 6 months, and 1 year postpartum in women who had an immediate postpartum hemorrhage (immediate PPH defined as blood loss ≥ 500 mL…
- Conditions
- Postpartum Hemorrhage, Postpartum Women, Postpartum Depression, Postpartum Stress
- Trial name
- PSYCHE (NCT03120208)
- Testing
- • The Edinburgh postnatal depression scale (EPDS), validated in French, with a discrimination threshold ≥ 11., The GAD-7 with a discrimination threshold ≥10., • Spielberger's State-Trait anxiety inventory, Form Y (validated in French), with a STAI (form Y-A) discrimination threshold ≥ 46
- Where
- France
- Volunteers
- 1,298 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postpartum Hemorrhage
Balanced Crystalloids in Postpartum Hemorrhage
Introduction: Obstetric hemorrhage is the most feared complication that can occur during childbirth and continues to be the leading cause of death in pregnant women worldwide, about 7 women die every hour in the world.
- Trial name
- NCT03824743
- Testing
- Lactate Ringer, Plasma-lyte
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota
Postpartum Hemorrhage, Simulation Training
Hybrid Simulation in Postpartum Hemorrhage Training for Nursing Students
Abstract Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity worldwide, requiring nursing students to acquire both theoretical knowledge and clinical competence for safe and effective management.
- Conditions
- Postpartum Hemorrhage, Simulation Training, Nursing Education, Clinical Readiness
- Trial name
- NCT07854106
- Testing
- Hybrid Simulation-Based PPH Training, Standard Education
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Uludag University
Post Partum Hemorrhage
Intrauterine Misoprostol Versus Intravenous Oxytocin Infusion During Cesarean Delivery
Bleeding is still the major cause of mortality and morbidity in postpartum period. World health organization has reported 585000 deaths for pregnancy each year. Twenty five percent of cases die from post-partum bleeding.
- Trial name
- NCT03148574
- Testing
- Misoprostol, Oxytocin
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Assiut University
Cesarean Section Complications
Carbetocin Versus Buccal Misoprostol Plus IV Tranexamic Acid for Prevention of Postpartum Hemorrhage at Cesarean Section
The Millennium Development Goal of reducing the maternal mortality ratio by 75 % by 2015 will remain beyond our reach unless we prioritize the prevention and treatment of postpartum hemorrhage(PPH) in low-resource countries.
- Trial name
- NCT03710317
- Testing
- carbetocin, Tranexamic Acid, misoprostol
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Aswan University Hospital
Umbilical Cord
Timing of Umbilical Cord Clamping: One to Three Minutes vs. After Cessation of Cord Pulsation
The timing of umbilical cord clamping has been widely discussed in the scientific community. As part of the worldwide strategies to reduce childhood iron deficiency anemia, the incorporation of late clamping (at least one minute…
- Trial name
- CORD (NCT03844490)
- Testing
- CESSATION OF CORD PULSE, CONTROL
- Where
- Brazil
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Postpartum Hemorrhage
A Study of Self-administered Misoprostol to Prevent Bleeding After Childbirth in the Community (MamaMiso)
Postpartum hemorrhage (PPH) is a major cause of maternal death in the developing world. An important strategy in the prevention of deaths is the use of uterotonic drugs for PPH prophylaxis.
- Trial name
- NCT01510574
- Testing
- Misoprostol
- Where
- 4 sites in Uganda
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Placenta Previa, Post Partum Hemorrhage
Glove-loaded Foley's Catheter Tamponade for Cesarean Section for Placenta Previa
Objective: To investigate the effect of A glove-loaded Foley's catheter tamponade versus stepwise uterine devascularization on blood loss during cesarean section (CS) in patients with complete placenta previa.
- Trial name
- NCT03570723
- Testing
- A glove-loaded Foley's catheter tamponade, stepwise uterine devascularization
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Aswan University Hospital
PPH - Postpartum Hemorrhage
Post-Partum Haemorrhage (PPH) Improvement of Skills With Actor Simulations
Pre test and post test questionnaire for evaluation of skills and teamwork capacities in PPH management
- Trial name
- PPH (NCT06358768)
- Testing
- teamwork job improvement overall, teamwork job improvement in actor scenario vs mannequin scenario
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- G. d'Annunzio University
Postpartum Haemorrhage, Immediate Postpartum Hemorrhage
Prevention of Post-partum Haemorrhage
The primary purpose of the trial is to evaluate whether the management of placental delivery with controlled cord traction (CCT) reduces the incidence of postpartum haemorrhage, compared with management waiting for clinical signs…
- Trial name
- TRACOR (NCT01044082)
- Testing
- controlled cord traction, Clinical signs of placental separation
- Where
- France
- Volunteers
- 4,382 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Von Willebrand Diseases, Postpartum Hemorrhage
Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial
This is a single-center randomized phase III clinical trial, the VWD-Woman Trial, in which 20 pregnant subjects with von Willebrand disease (VWD), defined as VWF ristocetin co-factor activity (VWF:RCo) <0.50 IU/ml (historic) and…
- Trial name
- NCT04344860
- Testing
- Recombinant Von Willebrand factor, Tranexamic Acid Injection [Cyklokapron]
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nicoletta C Machin
Postpartum Hemorrhage
Management of the Third Stage of Labor
To compare the efficacy of three different protocols of third stage management in preventing PPH.
- Trial name
- NCT02319707
- Testing
- Oxytocin, Oxytocin in 100 ml NaCl 0.9%
- Volunteers
- 500 people
- Sponsor
- Yariv yogev
Postpartum Hemorrhage
Active Versus Expectant Management of the Third Stage of Labor
The purpose of this study is to determine if giving oxytocin immediately after delivery causes less bleeding, transfusion needs and hastens delivery of placenta.
- Trial name
- NCT00473707
- Testing
- Active management of the third stage of labor, Expectant management of the third stage of labor, Oxytocin and gentle cord traction with fundal massage
- Where
- United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Third Stage of Delivery
Maternal Outcomes Following Manual Lysis of the Placenta.
Comparison of maternal outcomes following manual lysis of placenta 15 vs 30 minutes after delivery. A primary outcome of the drop in hemoglobin will be compared between the two groups.
- Trial name
- NCT03626844
- Testing
- Manual Lysis of Placenta after 15 minutes (Intervention), Manual Lysis of Placenta after 30 minutes (Control)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Postpartum Hemorrhage (Primary)
Carbetocin Versus Oxytocin for the Prevention of Postpartum Hemorrhage in Emergency Caesarean Delivery
Postpartum haemorrhage keeps to be the leading cause of maternal mortality in middle and low-income countries, including Iraq. Much advancement had been made in the field of treatment for postpartum haemorrhage but no much…
- Trial name
- NCT03755531
- Testing
- Carbetocin, Oxytocin
- Where
- Iraq
- Volunteers
- 300 people
- Sponsor
- Al-Kindy College of Medicine
Postpartum Hemorrhage, Pregnancy Complications
High Or Low Dose pOstpartUm Oxytocin at the Time of Cesarean Birth
This is a study to investigate whether it is feasible to conduct a randomized controlled trial (RCT) of a high dose of oxytocin versus the standard low-dose oxytocin.
- Conditions
- Postpartum Hemorrhage, Pregnancy Complications, Cesarean Section Complications
- Trial name
- HOLDOUT (NCT06550089)
- Testing
- Oxytocin
- Sponsor
- University of Chicago