Clinical trials: Post-Partum Hemorrhage
Postpartum Hemorrhage
Misoprostol as First Aid Measure to Address Excessive Postpartum Bleeding
The overall study purpose is to evaluate the safety, feasibility and acceptability of advance distribution of misoprostol to be used as 'first aid treatment' administered by the woman herself or her family to help treat excessive…
- Trial name
- NCT02853552
- Testing
- Misoprostol
- Volunteers
- 4,330 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Postpartum Hemorrhage
Retrospective Evaluation of the Impact of Epidural on the Risk of Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is a major complication of childbirth. Epidurals are often implicated in the onset of postpartum hemorrhages.
- Trial name
- NCT06816654
- Testing
- Data extraction from medical records
- Where
- Belgium
- Volunteers
- 5,753 people
- Sponsor
- Tatiana Besse-Hammer
Coagulation Defect; Puerperal, Post Partum Hemorrhage
Bedside Assessment of Coagulation in Post-partum Hemorrhage by Thromboelastography (TEG ®6S)
Postpartum hemorrhage (PPH) is one of the leading causes of maternal deaths. Its prognosis is directly influenced by the early diagnosis and treatment of the associated coagulopathy.
- Conditions
- Coagulation Defect; Puerperal, Post Partum Hemorrhage, Blood Protein Disorders, Pregnancy Hemorrhage
- Trial name
- HPPTEG6S (NCT03592303)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carbetocin, Oxytocic Drugs Causing Adverse Effects in Therapeutic Use
Comparison Of The Effects Of Carbetocin And Oxytocin In C-Sectıon
Obstetric hemorrhage is the most common cause of maternal mortality worldwide and its incidence is estimated to be approximately 24%.
- Trial name
- NCT05742854
- Testing
- C-sections operations, Oxytocin, Carbetocin
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ege University
Post Partum Hemorrhage
Tranexamic Acid Versus Sublingual Misoprostol in Reducing Blood Loss During Elective CS in High Risk Cases
The Efficacy and safety of Preoperative Intravenous Tranexamic acid versus Sublingual misoprostol in reducing blood loss during and after Elective Cesarean section among high risk pregnant cases.
- Trial name
- NCT04117243
- Testing
- Misoprostol, Tranexamic acid, Oxytocin
- Where
- Egypt
- Volunteers
- 345 people
- Sponsor
- Cairo University
Delayed and Secondary Postpartum Hemorrhage
Immediate vs Delayed Postpartum Implanon-NXT
This prospective observational cohort study aims to compare immediate postpartum insertion (within 72 hours after delivery) versus delayed insertion (4-6 weeks postpartum) of the etonogestrel subdermal implant (Implanon-NXT®️)…
- Trial name
- NCT07626502
- Testing
- Etonogestrel subdermal implant (Implanon-NXT®)
- Volunteers
- 90 people
- Sponsor
- Assiut University
Postpartum Hemorrhage
Efficacy of Four Different Treatment Regimes on Postpartum Hemorrhage
Postpartum hemorrhage is the most important cause of maternal morbidity and mortality worldwide and accounts for approximately 25% of deaths worldwide.
- Trial name
- NCT05467462
- Testing
- I.V carbetocin administration, I.V Oxytocin administration, I.V carbetocin and tranexamic acid administration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Hemorrhage, Postpartum
Haemorrhagia Postpartum: an Implementation Study on the NVOG Guidelines and MOET Instructions
The objectives of this study is first to asses to what extent the guidelines of the Dutch Society of Obstetrics and Gynaecology (NVOG) and the MOET (Management of Obstetric and Emergencies and Trauma) instructions for…
- Trial name
- Fluxim (NCT00928863)
- Testing
- implementation aids
- Where
- Netherlands
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Pregnancy Related, Post Partum Hemorrhage
Postpartum Ultrasound Evaluation to Assess Risk of Hemorrhage
Up to 5% of patients in the United States have a postpartum hemorrhage. "Postpartum hemorrhage" means excessive bleeding after delivery. The majority of these bleeds occur immediately with delivery.
- Trial name
- NCT06898034
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 1,725 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Post Partum Hemorrhage, Fibrinolysis; Hemorrhage
Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery
The investigators prepared a novel study of tranexamic acid (TXA) designed to estimate the quantity of blood loss in women undergoing elective repeat cesarean deliveries.
- Conditions
- Post Partum Hemorrhage, Fibrinolysis; Hemorrhage, Blood Loss
- Trial name
- TXA (NCT03856164)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
PPH
Postpartum Hemorrhage Reduction With Oral Tranexamic Acid: a Clinical Trial
This is a multicentre randomized placebo-controlled double-blinded phase IV study among 1000 women in Sweden and South Africa on the effect of oral tranexamic acid on PPH after vaginal delivery.
- Trial name
- PROTECT (NCT06025916)
- Testing
- Tranexamic acid
- Where
- Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Post Partum Haemorrhage
Severe Post Partum Haemorrhage (PPH): A Randomized Trial on Transversal Intervention in 6 French Perinatal Networks
Hypothesis A "multifaceted" intervention program aimed at increasing the responsiveness of care givers, the adequacy of care provided, and the efficacy of organisation of care, in presence of abnormal blood loss in the immediate…
- Trial name
- NCT00344929
- Where
- France
- Volunteers
- 6,500 people
- Sponsor
- Hospices Civils de Lyon
Post Partum Hemorrhage
Prevention of Postpartum Haemorrhage
Use of Tranexamic Acid for prevention of Postpartum hemorrhage in high risk patients: Randomized Control Trial
- Trial name
- NCT04463966
- Testing
- Tranexamic acid injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Post Partum Hemorrhage
Tranexamic Acid for Prevention of Postpartum Haemorrhage: a Dose-finding Study
Published trials on tranexamic acid (TxA) for prevention have used a variety of fixed (0.5gm or 1gm) and body-weight adjusted (10mg/kg or 15mg/kg) doses of TxA.
- Trial name
- NCT03565276
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Mount Sinai Hospital, Canada
Postpartum Hemorrhage
Oxytocin i.m./i.v. Versus Carbetocin i.v. in Elective Cesarean Sections
Objective is to proof non-inferiority of intramyometrial and intravenous oxytocin application compared to intravenous carbetocin for prevention of postpartum hemorrhage in planned, uncomplicated cesarean deliveries.
- Trial name
- NCT03651882
- Testing
- Oxytocin, Carbetocin
- Where
- Switzerland
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cesarean Section Complications, Tranexamic Acid
Comparing Intramyometrial Tranexamic Acid and Oxytocin for Blood Loss in Cesarean Section
Cesarean section is the most prevalent operation among women globally, 10-15% (1, 2). Recent research has shown Egypt to be the third-largest country globally, with an estimated 52% cesarean sections (3).
- Conditions
- Cesarean Section Complications, Tranexamic Acid, Oxytocin, Post Partum Hemorrhage
- Trial name
- NCT06010368
- Testing
- Tranexamic acid injection, Oxytocin
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Prevention of Post Partum Hemorrhage After Labor Induction
Effect of Misoprostol in Reducing Post Partum Hemorrhage After Labor Induction by Oxytocin
The use of Oxytocin for labor induction may cause receptor exhaustion and thus making its use in the third stage of labor ineffective in reducing post partum blood loss as compared to other uterotonics.So, we studied the effect…
- Trial name
- NCT02983591
- Testing
- Misoprostol after delivery, Oxytocin after delivery, Oxytocin before delivery
- Where
- Lebanon
- Volunteers
- 300 people
- Sponsor
- Makassed General Hospital
Post Partum Hemorrhage
S-Condom Uterine Tamponade in Controlling Atraumatic Postpartum Haemorrhage (PPH) - RCT
A Randomized Controlled Non inferiority Trial will be conducted to see the feasibility, acceptability and efficacy of S-Condom Uterine Tamponade in women with atraumatic PPH and not responding to first line of treatment.
- Trial name
- NCT05559840
- Testing
- S-Condom Uterine Tamponade, Traditional condom catheter
- Volunteers
- 82 people
- Sponsor
- Mamms Institute of Fistula and Womens Health
High Risk Postpartum Hemorrhage (PPH)
ROTEM® Obstetric Hemorrhage Pilot Study
This is a prospective observational study among women at high-risk of postpartum hemorrhage, in their third trimester who are admitted to Labor \&Delivery in spontaneous labor, for induction of labor, or for scheduled cesarean…
- Trial name
- NCT04409015
- Testing
- ROTEM - rotation thromboelastometry testing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Postpartum Hemorrhage, Blood Loss
Carbetocin Versus Syntometrine for Prevention of Postpartum Hemorrhage After Cesarean Section
to compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of Postpartum hemorrhage after cesarean section
- Trial name
- NCT02044549
- Testing
- carbetocin, Syntometrine
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Cairo University