Clinical trials: Post-Prandial Hyperglycemia
Obesity, Pre-Diabetes
Effect of Food Order on Postprandial Glucose Excursions in Pre-Diabetes
The natural history of type 2 diabetes commonly follows a pattern of postprandial dysregulation followed by fasting hyperglycemia leading to overt type 2 diabetes.
- Trial name
- NCT03536364
- Testing
- Food Order, Carbohydrate Last, Vegetables first
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Weill Medical College of Cornell University
Type 2 Diabetes, Glycemic Control
Blood Glucose Homeostasis in Type 2 Diabetes: the Effects of Saccharose
Hyperglycemia forms a direct and independent risk factor for the development of cardiovascular co-morbidities in type 2 diabetes.
- Trial name
- NCT00821665
- Testing
- Sucrose consumption, water consumption
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Postprandial Hyperglycemia
Effects of Dairy- and Berry-based Snacks on Postprandial Glucose Metabolism in Older People
Malnutrition or its risk is common among older people. To maintain adequate nutrition, increased meal frequency is important. In addition to main meals, regular consumption of nutrient- and energy-dense snacks is recommended.
- Trial name
- MAVIRE2 (NCT04175353)
- Testing
- Dairy snack, Berry snack
- Where
- Finland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Diabetes Mellitus, Type 1, Type 1 Diabetes
Co-administration of Pramlintide and Insulin Via an Automated Dual-hormone Artificial Pancreas System in Adults With Type 1 Diabetes
One of the main challenges in maintaining tight glucose control in a closed-loop system occurs at meal times. Amylin is a gluco-regulatory beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli, and is…
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Postprandial Hyperglycemia
- Trial name
- NCT04243629
- Testing
- Rapid-Acting Insulin, Pramlintide Acetate, Artificial Pancreas
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McGill University
Insulin Resistance
Effects of Sourdough Fermentation Duration and Acid Development on Postprandial Blood Glucose in Prediabetic Adults
The primary intervention for management of prediabetes is lifestyle changes. Eating healthier and increasing physical activity was found to slow the progression of prediabetes into diabetes, reduce the risk of other diseases like…
- Trial name
- NCT06925451
- Testing
- sourdough bread 24, sourdough bread 48, sourdough bread 72
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Arizona State University
Type 2 Diabetes
Lifestyle Control of Postprandial Hyperglycemia
Large spikes in blood glucose experienced after meals in people with type 2 diabetes are known to damage blood vessels. Low carbohydrate high fat diets and exercise can improve blood glucose control in people with type 2 diabetes…
- Trial name
- NCT02683135
- Testing
- High-carbohydrate diet, Low-carbohydrate diet, Low-carbohydrate diet with post-meal walking
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of British Columbia
Postprandial Hyperglycemia, Type2 Diabetes
The Attenuating Effect of Soluble Fiber Consumption on Postprandial Glycemia in Humans
The main objective of the current study is to investigate whether consumption of soluble fibers (isomaltodextrin [IMD], partially digestible maltodextrin) and RS4 starch will lower postprandial glycemia as well as postprandial…
- Conditions
- Postprandial Hyperglycemia, Type2 Diabetes, Blood Sugar; High
- Trial name
- NCT05349916
- Testing
- Control, Isomaltodextrin Low Dose, Isomaltodextrin High Dose
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue University
Diabetes Mellitus, Type 2
Acute Study of Effect of Ultrasound Vagus Nerve Stimulation on Glycemia
This is an early feasibility study to evaluate the proof of concept of modulation of glycemia by non-invasive ultrasound vagus nerve stimulation.
- Trial name
- NCT04094649
- Testing
- Ultrasound Vagus Nerve Stimulation (DECIMA)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Aucta Technologies, Inc.
Cardiovascular Diseases, Endotoxemia
Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome
This study is focused on assessing potential health benefits of daily consumption of potatoes, specifically its resistant starch content (i.e.
- Conditions
- Cardiovascular Diseases, Endotoxemia, Endothelial Dysfunction, Postprandial Hyperglycemia
- Trial name
- NCT03624569
- Testing
- Bagel, Potato
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ohio State University
Postprandial Hyperglycemia, Overweight and Obesity
A Study of Biochemical Response to Alternative Proteins
The overall objective of this research is to determine the digestive faith and health impact of protein and fiber rich foods in different food matrices in type 2 diabetes risk population.
- Conditions
- Postprandial Hyperglycemia, Overweight and Obesity, Type2diabetes
- Trial name
- COBRA (NCT06253728)
- Testing
- High fiber and protein meal, Control
- Where
- Finland
- Volunteers
- 24 people
- Sponsor
- University of Eastern Finland
Prediabetes
Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Milk
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function and increase the risk of CVD.
- Trial name
- NCT02482675
- Testing
- Glucose, Glucose with Non-fat Milk, Glucose with Whey Protein Isolate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Pre Diabetes
Impact of Whey and Leucine on Glycaemia in Adults Without Diabetes
Higher than average blood sugar (glucose) levels are linked to an increased risk of developing type 2 diabetes. As such, there is interest in identifying dietary factors that could lower blood glucose to help reduce the number of…
- Trial name
- Whey2Glo (NCT03785951)
- Testing
- Whey Protein Isolate, Wheat Protein, Wheat Protein with Leucine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Postprandial Hyperglycemia
Metabolic Responses to Breakfast in Adolescent Girls
Breakfast consumption (BC) is frequently associated with a healthy lifestyle, healthy body weight and favourable cardiometabolic health.
- Trial name
- NCT04476693
- Testing
- Breakfast consumption, Breakfast Omission
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Bedfordshire
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Hyperglycemia, Postprandial, Vitamin D Status
Diabetes Risk in London and Its Association with Vitamin D by Ethnic Group (DELVE)
The goal of this study is to investigate the relationship between vitamin D status and a diabetes risk factor, postprandial glycaemic response in White, South Asian and Black African Caribbean populations in London.
- Trial name
- DELVE (NCT06241976)
- Testing
- Glucose drink, Pure orange juice
- Where
- United Kingdom
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- City, University of London
Type 2 Diabetes Mellitus
The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes
The purpose of this investigation is to evaluate whether exenatide, a type 2 diabetes medication, will improve the function of the innermost part of the arterial wall called the endothelium after a fat-enriched meal and to…
- Trial name
- NCT01181986
- Testing
- Exenatide SC, Exenatide IV, Exendin-9
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Carl T. Hayden VA Medical Center
PreDiabetes
Effect of Sea Weed (Ecklonia Cava Extract) on Blood Glucose and Insulin Level on Pre-diabetic Patients
Introduction: The inhibition of α-amylase and α-glucosidase enzymes is suggested strategy for glycemic control particularly in people with prediabetes and diabetes.
- Trial name
- NCT04864860
- Testing
- brown seaweed (ecklonia cava)
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- King Saud University
Parkinsonian Disorders
Post-prandial Hypotension and Sleepiness in Parkinson's Disease and Other Synucleinopathies
Excessive daytime sleepiness (EDS) is observed in 30 to 50 % of patients with Parkinson's disease (PD) patients, Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA).
- Trial name
- HYPOSOMNPARK (NCT02021903)
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Toulouse
Postprandial Hyperglycemia
Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia
The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).
- Trial name
- NCT02654301
- Testing
- Test 1, Test 2, Test 3
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Postprandial Glucose, Glucose Levels
Ultra-processed Food-reducing Intervention and Continuous Glucose Monitoring
The goal of this trial is to investigate whether reduction in ultra-processed food intake through dietary counseling and education can improve postprandial glucose responses and glycemic variability compared with a usual diet in…
- Conditions
- Postprandial Glucose, Glucose Levels, Hyperglycemias
- Trial name
- ULTRA-CGM (NCT07175701)
- Testing
- 40-minute one-on-one dietary counseling and nutrition education aimed at reducing ultra-processed food consumption, Standard dietary counseling and nutrition education based on national guidelines
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Korea University