Clinical trials: Post-Prandial Hypoglycemia
Postprandial Hypoglycemia, Bariatric Surgery
Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study
The purpose of the study is to investigate whether hypoglycaemia observed after food intake in bariatric patients can be either influenced by an SGLT2 inhibitor, empagliflozin, or via inhibition of inflammation with an human…
- Conditions
- Postprandial Hypoglycemia, Bariatric Surgery, Late Dumping Syndrome
- Trial name
- Hypo-BEAR (NCT03200782)
- Testing
- Empagliflozin, Anakinra
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University Hospital, Basel, Switzerland
Hypoglycemia, Reactive
Pasireotide in the Treatment of Hypoglycemia Following Gastric Bypass Surgery
Postprandial hyperinsulinemic hypoglycemia is a well-known and potentially severe complication of Roux-en-Y gastric bypass (RYGB), and the treatment options are limited.
- Trial name
- NCT03514576
- Testing
- Pasireotide 0.3 MG/ML, Meal tolerance test (MTT)
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Zealand University Hospital
Type 1 Diabetes
Closed-loop Control of Glucose Levels After Meal Intake in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosage based on the sensor's…
- Trial name
- NCT01930097
- Testing
- 14 hours intervention
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Postprandial Hypoglycemia
Canagliflozin in Postprandial Hyperinsulinemic Hypoglycemia (CANA-PHH-RYGB)
Roux-en-Y gastric bypass (RYGB) is the most common surgical procedure for morbid obesity. However, it can present serious late complications, like postprandial hyperinsulinemic hypoglycemia (PHH).
- Trial name
- CANA-PHH-RYGB (NCT04720859)
- Testing
- Canagliflozin 300 MG Oral Tablet
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Polycystic Ovarian Syndrome
Compare Effects of Flax Seed Oil, and Fish Oil on Blood Sugar Levels
Flax seed oil, fish oil, and soy bean oil, are commonly recommended supplements for Polycystic Ovarian Syndrome (PCOS). These oils have different chemical structures and biological actions.
- Trial name
- PCOS (NCT00579540)
- Testing
- Flax Seed Oil, Fish Oil, Soybean Oil
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, Davis
Type 2 Diabetes Treated With Insulin
Novolog vs. Fiasp Insulin in Non-critically Ill Hospitalized Patients With Type 2 Diabetes Mellitus
Hyperglycemia affects 30-40% of hospitalized patients. Despite the fact that basal/bolus insulin therapy has been demonstrated to improve glycemic control and clinical outcomes in patients, achieving good glucose control remains…
- Trial name
- In-FI (NCT04460326)
- Testing
- Insulin glargine, NovoLog, Insulin Fiasp
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Boston Medical Center
Postprandial Hypoglycemia
Role of Glucagon-Like Peptide-1 in Postprandial Hypoglycemia
It has been proposed that the rapid gastric emptying of carbohydrate containing fluids into the intestine causes hyperglycemia followed by reactive hypoglycemia.
- Trial name
- NCT01162499
- Testing
- Exendin-(9-39), Vehicle
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Diva De Leon
Bariatric Surgery
Understanding Hypoglycaemia After Bariatric Surgery
Postprandial hyperinsulinaemic hypoglycaemia is an increasingly recognized adverse side effect of bariatric surgery. Affected individuals experience low glucose levels 1-3 hours after intake of meals, accompanied by symptoms such…
- Trial name
- HYPOBAR1 (NCT03609632)
- Testing
- Dietary Supplement: Glucose
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes
Regular physical activity is associated with many health benefits for individuals with type 1 diabetes including improved cardiovascular fitness and vascular health, decreased insulin requirements, improved body composition and…
- Trial name
- NCT02855307
- Testing
- 60-minute exercise, Insulin pump, Dexcom G4 Platinum glucose sensor
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Postbariatric Hypoglycemia
Effect of Mizagliflozin on Postprandial Glucose and Insulin in Post-Bariatric Hypoglycemia Subjects
This clinical study will examine the safety and tolerability, as well as the effects of orally administered mizagliflozin on post prandial glucose and insulin levels in subjects diagnosed with post-bariatric hypoglycemia (PBH).
- Trial name
- NCT05541939
- Testing
- Mizagliflozin
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Vogenx, Inc.
Diabetes Mellitus, Type 1
High-intensity Interval Exercise Compared With Continuous Moderate Exercise on Glycemia in Postabsorptive vs. Postprandial State in Adults With Type 1 Diabetes
This randomized crossover trial examined whether exercise modality (high-intensity interval exercise vs. moderate-intensity continuous exercise) and timing relative to meals (postprandial vs.
- Trial name
- Interdiab 1 (NCT07365176)
- Testing
- High-intensity interval exercise performed in postprandial phase, High-intensity interval exercise performed in postabsorptive phase, Moderate-intensity continuous exercise performed in postprandial phase
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Universite du Littoral Cote d'Opale
Type 1 Diabetes
Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation
In previous studies, investigators have studied if a pre-meal insulin bolus based on estimated carbohydrate meal size would alleviate the burden of carbohydrate counting without a significant degradation in postprandial glucose…
- Trial name
- NCT02626936
- Testing
- Dual-hormone closed-loop, Insulin, Glucagon
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Postprandial Hypotension, Hypoglycemia
Postprandial Hypotension and Insulin Levels
The goal of this observational study is to learn about the relationship between postprandial hypotension and insulin levels in adults.
- Trial name
- NCT06657287
- Testing
- Mixed meal test
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Hyperinsulinemic Hypoglycemia, Postprandial Hypoglycemia
Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass
The aim of this study is investigating the effect of a novel glucagon analogue administration in gastric bypass operated individuals, who are reactive hypoglycemic.
- Trial name
- NCT03984370
- Testing
- ZP4207
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen