Clinical trials: Post-Stroke Spasticity
Upper Limb Spasticity
Efficacy and Safety Study of Botulinum Neurotoxin A With Rehabilitation Versus Botulinum Neurotoxin A Alone in Treatment of Post-stroke Spasticity
The purpose of this study is to determine if a combination of botulinum neurotoxin A and rehabilitation therapy is better than botulinum neurotoxin A alone for improvement in function based on the Fugl-Meyer and other validated…
- Trial name
- NCT00945295
- Testing
- Botulinum toxin type A, BoNT-A, Rehabilitation Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- JoAnn Harnar
Stroke, Spasticity, Muscle
Using Shear Wave Ultrasound Elastography for Follow up After Anti-spastic Intervention Among Stroke Patients
Spasticity of stroke patient, a very common complication in clinical practice, affects performance of hand function and gait pattern. It also interferes with quality of life of patients severely.
- Conditions
- Stroke, Spasticity, Muscle, Botulism, Ultrasound
- Trial name
- NCT04550793
- Testing
- Botulinum toxin injection
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Post-Stroke Chronic Upper Limb Spasticity
Effectiveness and Safety of SMART [Spastic Muscle Palpation by Anatomic Landscape for BoNT-A (Botulinumtoxin-A) Injection to Reduce Muscle Tone] BoNT-A Therapy With Dysport® in Patients With Post-stroke Chronic Upper Limb Spasticity (ULS) in Real-life Setting.
The purpose of this study is to collect data for Dysport® SMART BoNT-A therapy usage in an office-based setting in post-stroke participants with chronic (> 6 months) focal Upper Limb Spasticity who have been under stable oral…
- Trial name
- SMART-NIS (NCT05224349)
- Where
- 31 sites in Germany
- Volunteers
- 121 people
- Sponsor
- Ipsen
Ischemic Stroke, Hemorrhagic Stroke
Goal Attainment Scaling in Upper Limb Spasticity Treatment
Patients after stroke with upper limb spasticity treated with botulinum toxin-A (BTX-A) will be included in this two-part study.
- Trial name
- GASBTX (NCT04975646)
- Testing
- Prescribed exercise program
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Stroke, Muscle Spasticity
Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function
The purpose of this study is to evaluate the safety of injections of botulinum toxin Type A in patients with reduced lung function and focal upper limb poststroke spasticity
- Conditions
- Stroke, Muscle Spasticity, Motor Neuron Disease
- Trial name
- NCT00076687
- Testing
- botulinum toxin Type A, saline
- Where
- 4 sites in United States, Czechia and 2 more
- Volunteers
- 155 people
- Sponsor
- Allergan
Spasticity Post Stroke
Spinal Cord Stimulation for Poststroke Spasticity
The goal of this clinical trial is to learn whether spinal cord stimulation (SCS) is effective in treating post-stroke spasticity in adults. It will also evaluate the safety of the implanted SCS system.
- Trial name
- SCS-PSS (NCT07744659)
- Testing
- Active spinal cord stimulation
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Post-Stroke Upper Limb Spasticity
Comparing the Radial Extracorporeal Shock Waves and Botulinum Toxin Injection for Spasticity
Botulinum toxin type A (BoNT-A) is widely used in the clinics to reduce spasticity and improve upper limb function for post-stroke patients.
- Trial name
- NCT03131791
- Testing
- Shock Wave, Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Mackay Memorial Hospital
Stroke Gait Rehabilitation
The Effectiveness of Laser and Extracorporeal Shock Wave Therapy in Resolving Ankle Muscle Spasm in Stroke Patients.
Stroke is one of the leading causes of long-term disability worldwide. Spasticity (muscle spasm) is a common and disabling consequence of stroke.
- Trial name
- spasticity (NCT07364110)
- Testing
- Rehabilitation Protocol, Extracorporeal Shock Wave Therapy (ESWT), High-Intensity Laser Therapy (HILT)
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Necmettin Erbakan University
Stroke
Dry Needling in Patients Who Had Experience Stroke
Individuals who had experience a stroke usually suffer from spasticity at medium and long-terms. The presence of spasticity in the lower extremity implies several impairments for standing and walking inducing high disability.
- Trial name
- NCT02579291
- Testing
- Dry needling, Bobath
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Rey Juan Carlos
Stroke, Hemiplegia, Spastic
The Effect of Extracorporeal Shock Wave Therapy After Botulinum Toxin Type A Injection for Post-stroke Spasticity
There are few studies on whether botulinum toxin treatment and extracorporeal shock wave therapy are more effective than botulinum toxin alone treatment for post-stroke spasticity.
- Conditions
- Stroke, Hemiplegia, Spastic, Muscle Spasticity
- Trial name
- NCT05889026
- Testing
- Extracorporeal shock wave therapy, Botulinum toxin treatment
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Korea University Guro Hospital
Stroke, Post Stroke Upper Limb Spasticity
Effects of Focal Muscle Vibration Versus Whole Upper Limb Vibration in Post-Stroke Patients
This study contributes to the growing body of knowledge on rehabilitation strategies for post-stroke patients, specifically focusing on the efficacy of vibration therapy modalities.
- Trial name
- NCT07340034
- Testing
- Focal muscle vibration through focal muscle vibrator along with conventional neurorehabilitation, Upper limb vibration through whole body vibrator along with conventional neurorehabilitation
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Ischemic Stroke
Clinical Study on Huatuo Zaizao Pills for Post-stroke Treatment
The purpose of this study was to evaluate the improvement of limb motor function and nerve function of patients with HTZZ during stroke rehabilitation.
- Trial name
- NCT04910256
- Testing
- Huatuo Zaizao Pills, Basic treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Hemiplegia, Spastic
Inter-rater Reliability of the Australian Spasticity Assessment Scale (ASAS) in Post-stroke Spasticity
The reliability of the Australian Spasticity Assessment Scale (ASAS) has been reported to be not high enough in adult patients with acquired brain damage.
- Trial name
- NCT04613661
- Testing
- Australian Spasticity Assessment Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Izmir Katip Celebi University
Spasticity
Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Post-Stroke Spasticity
Spasticity is a common complication of stroke affecting quality of life. Spasticity involves exaggerated stretch reflexes that create stiffness in muscles with associated loss of motion and functional control.
- Trial name
- NCT02268461
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Spinal Cord Injured, Post-stroke
Effects of an Eccentric Muscle Strengthening Protocol on Force Moment, Muscle Activation and Plantar Flexor Structure of Patients With Central Nervous System Injuries.
Neurological disorders [such as Cerebral Vascular Accident (CVA) or Spinal Cord Injury (SCI)] are among the most costly health problems to society in industrialized countries.
- Trial name
- RenfExc (NCT06099340)
- Testing
- muscle-strengthening program
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Nantes University Hospital
Spasticity, Muscle
MEDITOXIN® Treatment in Subjects With Post-Stroke Upper Limb Spasticity
This study is "A Prospective, Multi-center, Single Arm, Open-label, Phase IV Clinical Trial to Evaluate the Efficacy and Safety of MEDITOXIN® in Treatment of Post Stroke Upper Limb Spasticity".
- Trial name
- NCT03908580
- Testing
- Meditoxin
- Volunteers
- 120 people
- Sponsor
- Medy-Tox
Severe Spasticity
SISTERS: Spasticity In Stroke Study - Randomized Study
To demonstrate that Intrathecal Baclofen (ITB) Therapy, compared to Best Medical Treatment (BMT), has superior efficacy in the treatment of severe spasticity in adult post-stroke patients with generalized spastic hypertonia who…
- Trial name
- SISTERS (NCT01032239)
- Testing
- intrathecal baclofen
- Where
- 25 sites in United States, Austria and 7 more
- Volunteers
- 61 people
- Sponsor
- MedtronicNeuro
Stroke, Spasticity
Efficacy of Shock Wave Therapy in Post-Stroke Muscle Spasticity Management
The goal of this clinical trial is to evaluate the efficacy and safety of shock wave therapy (SWT) in reducing muscle spasticity in patients who have suffered a stroke.
- Conditions
- Stroke, Spasticity, Post-stroke, Muscle Hypertonia
- Trial name
- SWT-PI (NCT06815328)
- Testing
- Shock Wave Therapy (SWT), Active Comparator - Conventional Therapy
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Stroke
Biofeedback After Stroke
Studies show that the use of electromyographic biofeedback combined with other therapies contributes to the reduction of upper limb spasticity after stroke.
- Trial name
- NCT07149129
- Testing
- Electromyographic Biofeedback
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Federal do Paraná
Spasticity, Muscle
Efficacy of Dry Needling in the Spasticity Post-stroke
Stroke is a serious clinical condition and one of the leading causes of long-term disability in the world. One of the most serious complications of this condition is spasticity.
- Trial name
- DNSpasticity (NCT04435561)
- Testing
- Standard physiotherapy rehabilitation and dry needling, Standard physiotherapy rehabilitation
- Volunteers
- 40 people
- Sponsor
- University of Malaga