Clinical trials: Post-Surgical Complication
Postoperative Pain
A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery
The purpose of this study is to compare the efficacy of pregabalin to placebo for postoperative pain control after photorefractive keratectomy.
- Trial name
- NCT01097577
- Testing
- pregabalin
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- 59th Medical Wing
Wound of Knee, Wound of Hip
Study to Compare Negative Pressure Wound Therapy or Standard Dressings After Orthopedic Surgery
The aim of this study is to assess the prevention of incision healing complications in patients undergoing Total Knee Arthroscopy (TKA) and Total Hip Arthroscopy (THA) treated with either Single-Use Incisional NPWT (Negative…
- Trial name
- PICO (NCT02064270)
- Testing
- Single-Use Negative Pressure Wound Therapy, Standard postsurgical dressings
- Where
- United States
- Volunteers
- 526 people
- Sponsor
- University of Missouri-Columbia
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Pain, Postoperative
Acetaminophen/Codeine vs Acetaminophen/Ibuprofen for Pain Control and Patient Satisfaction After Hand Surgery
The purpose of this research study is to find out if taking Acetaminophen with Ibuprofen (e.g. Tylenol + Advil), a non-opioid regimen, provides the same type of pain relief after hand surgery compared to Acetaminophen and codeine…
- Trial name
- NCT02647788
- Testing
- Acetaminophen/Ibuprofen, Acetaminophen/Codeine
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Pennsylvania
Post-Operative Nausea and Vomiting, Breast Cancer
Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)
The goal of this clinical research study is to learn if light electrical stimulation to the wrist area during surgery is feasible in women having breast surgery.
- Trial name
- NCT02473042
- Testing
- Electrical Stimulation, Zofran, Dexamethasone
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- M.D. Anderson Cancer Center
Kidney Failure, Acute
Effect of Erythropoietin (EPO) in Kidney After Cardiac Surgery
The purpose of this study is to determine whether erythropoietin is effective in preventing acute kidney dysfunction after coronary artery bypass grafting surgery.
- Trial name
- EPO-CABG (NCT00654992)
- Testing
- Erythropoietin-Beta, Normal Saline
- Where
- South Korea
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Laparoscopic Gastric Bypass, Obesity
Ketamine vs Hydromorphone
This study will help to determine if investigators can minimize narcotic use in laparoscopic gastric bypass patients while maintaining adequate pain control.
- Conditions
- Laparoscopic Gastric Bypass, Obesity, Pain, Postoperative
- Trial name
- NCT03001843
- Testing
- Ketamine, Narcotics, pain scale
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Florida
Bladder Cancer
FITBIT Study on Mobility and Readmissions After Radical Cystectomy
This is a two-arm randomized, controlled trial during the postoperative period after major abdominal surgery for cancer, including for example radical cystectomy, nephrectomy, colectomy, comparing a control group that uses a…
- Trial name
- FITBIT (NCT04314778)
- Testing
- social incentive-based gamification
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Pennsylvania
Surgical Site Infection
Use of 2% Chlorhexidine Cloths Reduce Surgical Site Infections
Use of 2% chlorhexidine gluconate cloths pre-operatively and daily post-operatively jaw line to toes will decrease surgical site infections (SSI) by 30% when compared to patients who receive routine standard of care (use of…
- Trial name
- NCT02385708
- Testing
- 2% Chlorohexidine Gluconate Standard of Care, 2% Chlorohexidine Gluconate Chin to Toe
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Vanderbilt University
Postoperative Pain, Surgery
Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery
The purpose of this study is to determine whether a continuous infusion of local anesthesia with a catheter in the surgical wound reduces patient consumption of opiates by 30% in the 48-hour postoperative period following surgery…
- Conditions
- Postoperative Pain, Surgery, Postoperative Complications
- Trial name
- CATROP-2007 (NCT01075646)
- Testing
- ropivacaine, saline solution
- Where
- Spain
- Volunteers
- 225 people
- Sponsor
- Hospital Universitari de Bellvitge
Surgical Site Infection, Colon Surgery
D-PLEX 311: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection
Phase III, Prospective, Multinational, Multicenter, Randomized, Controlled, Two-arm, Double Blind Study to assess Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SoC), compared to a SoC treated…
- Conditions
- Surgical Site Infection, Colon Surgery, Abdominal Surgery, Post-Op Infection
- Trial name
- NCT04233424
- Testing
- D-PLEX, Standard of Care (SoC)
- Where
- 62 sites in United States, Bulgaria and 8 more
- Volunteers
- 977 people
- Sponsor
- PolyPid Ltd.
Marginal Ulcers
Ulcer Prevention Study in Post Gastric Bypass Patients
This research is to determine which medication, Zegerid (Omeprazole/Sodium Bicarbonate) or Pepcid AC (Famotidine), works best at reducing the chance that a patient will get an ulcer after gastric bypass surgery.
- Trial name
- NCT00557349
- Testing
- Omeprazole, Famotidine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Missouri-Columbia
Neuropathic Pain
Donepezil Compared to Placebo in Patients With Chronic Neuropathic Pain
Based on laboratory studies, donepezil will improve pain relief more than placebo in patients with chronic neuropathic pain who are currently taking gabapentin or pregabalin.
- Trial name
- NCT01743976
- Testing
- Donepezil
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University
Postoperative Pain
Study to Evaluate Analgesic Effect of IV Administration of Kappa Agonist CR845 For Hysterectomy Surgery
The primary purpose of this study is to determine if CR845 is effective in treating the pain associated with a laparoscopic hysterectomy.
- Trial name
- NCT01361568
- Testing
- CR845
- Where
- 18 sites in United States
- Volunteers
- 203 people
- Sponsor
- Cara Therapeutics, Inc.
Chest Pain, Surgery
Assessment of Intercostal Block Scheduling in Preventing Acute Surgical and Post-surgical Pain in Thoracoscopic Surgery
It is well known that chest surgery patients suffer from high level pain in the perioperative period. The transition to thoracoscopic approaches reduced surgical pain.
- Trial name
- NCT02469610
- Testing
- Intercostal block Bupivacaine based
- Where
- Israel
- Volunteers
- 65 people
- Sponsor
- Carmel Medical Center
Postoperative Pain
Optimizing Recovery in Abdominoplasty
The overall purpose of this study is to evaluate the analgesic efficacy of liposomal bupivacaine in optimizing pain control, minimizing the risk of postoperative nausea and vomiting (PONV), and improving recovery after…
- Trial name
- NCT04254692
- Testing
- Liposomal bupivacaine, Standard of care
- Where
- 2 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Post Surgical Pain
Dose Response Study of Dexamethasone in Combination With Bupivacaine 0.25%
When used in conjunction with a local anesthetic, dexamethasone may prolong both the sensory and motor effects of high supraclavicular brachial plexus nerve block (SBP) in arthroscopic shoulder surgery.
- Trial name
- Dex Dose (NCT01690663)
- Testing
- Bupivacaine 0.25%, Dexamethasone, normal saline
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Pennsylvania
Clear Cell Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma
Carboplatin, Paclitaxel and Gemcitabine Hydrochloride With or Without Bevacizumab After Surgery in Treating Patients With Recurrent Ovarian, Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
This randomized phase III trial studies carboplatin, paclitaxel and gemcitabine hydrochloride when given together with or without bevacizumab after surgery to see how well it works in treating patients with ovarian, epithelial…
- Conditions
- Clear Cell Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma
- Trial name
- NCT00565851
- Testing
- Bevacizumab, Carboplatin, Docetaxel
- Where
- 709 sites in United States, Japan and 1 more
- Volunteers
- 1,052 people
- Sponsor
- National Cancer Institute (NCI)
Thyroidectomy, Parathyroidectomy
Opioid Use After Thyroid and Parathyroid Surgeries
Unnecessary opioid prescriptions for postoperative pain can increase the risk for new, persistent opioid use and dependence. Published literature suggests that most patients undergoing thyroid or parathyroid surgery can have…
- Conditions
- Thyroidectomy, Parathyroidectomy, Opioid Use, Pain, Postoperative
- Trial name
- NCT04955444
- Testing
- Quality improvement bundle
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- The Methodist Hospital Research Institute
Type 2 Diabetes Mellitus, Obesity
Resolution of Type 2 Diabetes Mellitus: Intensive vs. Conventional Glycaemic Control After Obesity Surgery
Obesity surgery is very effective in improving or even curing Type 2 Diabetes in patients with obesity. Many patients stop or reduce their medication after surgery and this can happen fairly quickly.
- Trial name
- GLUCOSURG1 (NCT01257087)
- Testing
- Insulin
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College London