Clinical trials: Post-Traumatic
Post-traumatic Stress Disorders
Pilot of Acupuncture to Improve Quality of Life in Veterans With TBI and PTSD
The purpose of this study is to examine if acupuncture improves Post-Traumatic Stress Disorder symptoms among veterans who participated in Operations Enduring Freedom and Iraqi Freedom.
- Trial name
- NCT01060553
- Testing
- Acupuncture treatment
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- US Department of Veterans Affairs
Post-traumatic
Exercise and PTSD in Older Veterans
The purpose of this study is to examine whether posttraumatic stress disorder (PTSD) symptoms impact adherence to a 12-week physical activity program and whether exercise can help improve PTSD symptoms and health outcomes in…
- Trial name
- NCT02295995
- Testing
- Exercise as an Adjuvant Therapy for Veterans with PTSD
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
Anxiety Disorders, Post Traumatic Stress Disorder
Increasing Treatment Efficacy Using SMART Methods for Personalizing Care
The proposed study will determine the feasibility, tolerability, and acceptability of a study that tests: 1) personalized treatment delivery (i.e., module sequencing and treatment discontinuation timing) aimed at increasing the…
- Conditions
- Anxiety Disorders, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT04642898
- Testing
- Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shannon E. Sauer-Zavala
Post-Traumatic Headaches
A Prospective Controlled Treatment Trial for Post-Traumatic Headaches
Post-traumatic headaches (PTH) are the most common complaint after traumatic brain injury, possibly generated by a number of stressors to the trigeminovascular and cervical plexus networks, including inflammation of the high…
- Trial name
- NCT03007420
- Testing
- Occipital Nerve Block (ONB) using lidocaine and dexamethosone, Cervical Medial Branch Block (CMBB) using lidocaine and dexamethosone
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
PTSD
Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD
The goal of this clinical trial is to learn if MDMA-assisted therapy is effective in U.S. military veterans with at least moderate chronic PTSD.
- Trial name
- MPVA6 (NCT04784143)
- Testing
- Midomafetamine, Psychotherapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Resilient Pharmaceuticals
Posttraumatic Stress Disorder
Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory
The purpose of the proposed study is to determine if pairing reactivation of a traumatic memory with a single administration of Rapamycin (e.g., Sirolimus) in men with combat-related Posttraumatic Stress Disorder leads to a…
- Trial name
- NCT01449955
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Texas Southwestern Medical Center
Substance Use Disorders, Posttraumatic Stress Disorder
SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)
This study proposes a prospective program of research that will identify feasible and inexpensive methods to detect and treat comorbid PTSD among VA SUD patients, thereby improving substance abuse treatment outcomes.
- Trial name
- NCT00265564
- Testing
- Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis, Post-traumatic Osteoarthritis
Translating Metabolic Responses to Mechanical Insult Into Early Interventions to Prevent PTOA
This is a small-scale proof-of concept clinical trial of amobarbital as a treatment to prevent post-traumatic osteoarthritis in fractured ankle joints.
- Trial name
- NCT04589611
- Testing
- amobarbital/Gel-One (one dose), amobarbital/Gel-One (two doses)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- J L Marsh
Post Traumatic Stress Disorder
A Pilot Dose-Response Biomarker Study of Brexpiprazole Treatment in PTSD
Determine if brexpiprazole treatment will be associated with a dose-dependent reduction in resting pupil diameter as a reflection of locus coeruleus (LC) norepinephrine (NE) neuron target engagement in a group of subjects with…
- Trial name
- NCT02934932
- Testing
- Brexpiprazole
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
PTSD
Service Dogs for Veterans With PTSD
The purpose of this study is to evaluate use of service dogs for individuals who have been diagnosed with Post Traumatic Stress Disorder (PTSD).
- Trial name
- NCT01329341
- Testing
- Service Dogs
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
PTSD
Cannabidiol and Prolonged Exposure
The trial will include a randomized control trial to evaluate the efficacy of using Cannabidiol (CBD), a non-intoxicating cannabinoid, as an adjunctive to Prolonged Exposure therapy (PE).
- Trial name
- CBD-PE (NCT03518801)
- Testing
- Prolonged Exposure, Cannabidiol
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Posttraumatic
Veteran Stress and Learning Study
This is a research study examining the use of two medications, Hydrocortisone and D-Cycloserine, compared to an inactive substance (placebo), on their ability to reduce fear responses and memory of fear in Veterans with symptoms…
- Trial name
- VSL (NCT00674570)
- Testing
- Hydrocortisone, D-Cycloserine
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Headache, Combat Disorders
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
The purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members…
- Conditions
- Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache
- Trial name
- NCT02266329
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- VA Office of Research and Development
Fever
Aggressive Fever Control With Intravenous Ibuprofen After Non-traumatic Brain Hemorrhage
Fever, defined as temperature higher than 38.3C (100.9 F), is common in patients with head injuries and is associated with poor recovery after injury.
- Trial name
- NCT01530880
- Testing
- Intravenous Ibuprofen, Acetaminophen (Standard of Care)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Columbia University
Grief, Post Traumatic Stress Disorder
Building and Sustaining Interventions for Children: Task-sharing Mental Health Care in Low-resource Settings
The BASIC study will take place in Kanduyi/Bungoma South Sub-County, in western Kenya, and focuses on children orphaned by one or two parents.
- Conditions
- Grief, Post Traumatic Stress Disorder, Depression
- Trial name
- BASIC (NCT03243396)
- Testing
- Trauma-Focused Cognitive Behavioral Therapy
- Where
- Kenya
- Volunteers
- 956 people
- Sponsor
- Duke University
Major Depressive Disorder, Posttraumatic Stress Disorder
Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders.
- Conditions
- Major Depressive Disorder, Posttraumatic Stress Disorder, Panic Disorder and Agoraphobia
- Trial name
- NCT04293341
- Testing
- Transdiagnostic Behavior Therapy, Cognitive Processing Therapy for PTSD, Cognitive Behavioral Therapy for MDD
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder, Generalized Anxiety Disorder
Primary Care Intervention Strategy for Anxiety Disorders
This study will compare the effectiveness of an intervention strategy for the treatment of people with post traumatic stress disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder in the primary care…
- Conditions
- Post-traumatic Stress Disorder, Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder
- Trial name
- NCT00347269
- Testing
- Cognitive-behavioral therapy, Psychotropic medication optimization, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 1,004 people
- Sponsor
- University of Washington
Cardiorespiratory Failure
Mobile Coping Skills Training to Improve Cardiorespiratory Failure Survivors' Psychological Distress
This is a pilot randomized clinical trial involving adult survivors of cardiorespiratory failure treated in intensive care units (ICUs) that is designed to test the acceptability, feasibility, and clinical impact of a coping…
- Trial name
- Blueprint (NCT04329702)
- Testing
- Coping skills training mobile app with call from CST therapist, Coping skills training mobile app only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Stress Disorders, Post-Traumatic, Concussion, Mild
Meditation in Veterans With PTSD and Mild TBI
The goal of this study is to learn more about how Inner Resources for Veterans (IRV), a mindfulness and mantra therapy, helps Veterans with Post Traumatic Stress Disorder (PTSD) and mild traumatic brain injury (mTBI).
- Trial name
- NCT02280304
- Testing
- Inner Resources for Veterans (IRV), Essential Skills therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- VA Office of Research and Development
PTSD
Veterans Telemedicine Outreach for PTSD Services
Post-Traumatic Stress Disorder (PTSD) is considered a major public health problem in the U.S. due to its high prevalence and high rates of disability associated with the disorder.
- Trial name
- VTOPS (NCT00645047)
- Testing
- Telemedicine CBT, In-Person CBT
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- VA Office of Research and Development