Clinical trials: Post-Traumatic Stress Disorder (PTSD)
PTSD, Cognitive Function
Self-regulation of Prefrontal Cortex During Emotional Cognitive Control in PTSD
Deficits in emotional cognitive control are present in a number of clinical psychiatric populations including depression, anxiety, and PTSD.
- Trial name
- SPrC-PTSD (NCT04543513)
- Testing
- Real-time functional magnetic resonance neurofeedback (rtfMRI-nf)
- Where
- United States
- Sponsor
- Laureate Institute for Brain Research, Inc.
Post Traumatic Stress Disorder
Efficacy of Traumatic Memory Modification Using Memory Reconsolidation and Propranolol Among Adolescents With PTSD
The aim of this study is to demonstrate the effectiveness of propranolol in blocking reconsolidation by reducing PTSD symptoms in the short and long term in adolescents with PTSD for more than 3 months.
- Trial name
- PROPRADO (NCT04921982)
- Testing
- Propranolol
- Where
- 10 sites in France
- Sponsor
- Rennes University Hospital
Opioid-use Disorder, Addiction
Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
The purpose of this study is to develop and then test an enhanced version of the parent study's collaborative care intervention for co-occurring disorders (CC-COD) to reduce the risk of suicide and overdose among individuals with…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post Traumatic Stress Disorder
- Trial name
- NCT04634279
- Testing
- Collaborative care Plus
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- RAND
Posttraumatic Stress Disorder, Anger
Mobile Anger Reduction Intervention
Difficulty controlling anger is the most commonly reported reintegration concern among combat Veterans, especially those with a diagnosis of posttraumatic stress disorder (PTSD).
- Trial name
- MARI (NCT06094933)
- Testing
- Mobile Anger Reduction Intervention (MARI), Health Education Condition (HED)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Fear, GAD
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments.
- Conditions
- Fear, GAD, Emotional Memory, PTSD
- Trial name
- NCT05120635
- Testing
- Deep Brain Stimulation, Virtual and augmented reality tasks
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University
Post-Traumatic Stress Disorder
The Outcome of Treatment of Traumatised Refugees With Psychotherapy and/or Antidepressants
The purpose of the study is to investigate the effect of treatment of traumatized refugees with a diagnosis of Post-Traumatic Stress Disorder (PTSD).
- Trial name
- NCT00917397
- Testing
- Sertraline, trauma-focused cognitive behavioural therapy
- Where
- Denmark
- Volunteers
- 280 people
- Sponsor
- Caecilie Buhmann
Posttraumatic Stress Disorder, Depression
Yoga Breath Program and Client-Centered Exposure for Relief of PTSD in Tsunami Victims
Study hypothesis: that a standardized course of Eastern practices (Breath Water Sound Course -BWS) will significantly relieve PTSD and depression in tsunami victims.
- Trial name
- NCT00290225
- Testing
- Breath Water Sound Course and Traumatic Incident Reduction
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Victim Services Center, Miami
Combat Disorders, Stress Disorders, Post-Traumatic
A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD
The primary aim of this project is to examine whether administration of D-Cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) receptor agonist that has been shown to facilitate fear extinction, enhances the therapeutic…
- Trial name
- NCT00371176
- Testing
- Exposure therapy, D-Cycloserine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- US Department of Veterans Affairs
Pregnancy Loss
ACTRAMAT-D: Impact of Post-Traumatic Stress Disorder After Pregnancy Loss After 12 Weeks of Gestation
In France The prevalence of Pregnancy Loss after 12 weeks of gestation is around 3%. This situation is probably associated to a risk of post-traumatic stress disorder.
- Trial name
- ACTRAMAT-D (NCT03433989)
- Testing
- telephone interview
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Posttraumatic Stress Disorder (PTSD)
Cognition and Psychotherapy in PTSD
Posttraumatic stress disorder (PTSD) is prevalent among combat Veterans and is a substantial public health burden. Several psychotherapies, including cognitive processing therapy (CPT) and prolonged exposure therapy, have been…
- Trial name
- NCT03641924
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic
Fluoxetine vs EMDR to Treat Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to compare two treatments for post-traumatic stress disorder (PTSD): fluoxetine (an antidepressant) and Eye Movement Desensitization and Reprocessing (EMDR, a psychological treatment in which the…
- Trial name
- NCT00000379
- Testing
- Fluoxetine, EMDR
- Where
- United States
- Sponsor
- Boston University
Post Traumatic Stress Disorder
A Brief Intervention for PTSD - BWRT
The purpose of this study is to investigate if a novel brief intervention for Posttraumatic stress disorder (PTSD) is comparable to other traditional clinical interventions for symptom reduction.
- Trial name
- BWRT (NCT07460817)
- Testing
- BrainWorking Recursive Therapy, Treatment as usual
- Where
- Norway
- Volunteers
- 82 people
- Sponsor
- University of Bergen
Post Traumatic Stress Disorders
Post Traumatic Stress Disorder and Neural Mechanisms Involved in Its Treatment
The post traumatic stress disorder PTSD arises when the physiological response to stress does not come to its term. This study aims to explore the cognitive, psycho physiological and cerebral mechanisms involved in PTSD, in fear…
- Trial name
- NCT00893568
- Testing
- resonance magnetic imaging (fMRI),
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Post-traumatic Stress Disorder, Acute Stress Disorder
Feasibility Study of the Self-Care Immediate Stabilization Procedure (ISP) ® After a Traumatic Experience
The study aims to assess the feasibility of an online intervention platform based on the Immediate Stabilization Procedure (ISP®). This intervention targets early trauma reactions, aiming to reduce the risk of future PTSD.
- Trial name
- NCT06277973
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Stress
Coherence Training for Military Personnel
Military operations and training situations present many physical and psychological challenges for service members to adapt to and overcome.
- Trial name
- NCT01599598
- Testing
- Progressive Muscle Relaxation, Coherence Advantage
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- United States Naval Medical Center, San Diego
PTSD, Chronic Pain
Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Although most people recover from acute pain (such as pain caused by injury, surgery, repetitive motion, or unknown causes), many people do not fully recover and will experience chronic pain.
- Trial name
- NCT05700279
- Testing
- Stellate Ganglion Block, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- Rush University Medical Center
Substance Use Disorders, Posttraumatic Stress Disorder
Integrated Intervention Post-Sexual Assault
The primary objective of the proposed Stage IA/IB study is to establish feasibility of an integrated cognitive-behavioral intervention for reducing SUD and PTSD symptoms among women who experienced a sexual assault within the…
- Conditions
- Substance Use Disorders, Posttraumatic Stress Disorder, Sexual Assault
- Trial name
- NCT04724746
- Testing
- Written Exposure and Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorder
Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)
The investigators are testing novel treatments for combat PTSD: bright light exposure and negation ion exposure.
- Trial name
- NCT00701064
- Testing
- Bright Light Exposure, Negative Ion Generator
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder
Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance
The purpose of this study is to compare the effectiveness of two cognitive behavioral group psychotherapy interventions in controlling the subjective sleep disturbance in veterans with Post-traumatic Stress Disorder.
- Trial name
- NCT00108628
- Testing
- Imagery Rehearsal, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- US Department of Veterans Affairs
PTSD, Depression
Synchronized Transcranial Magnetic Stimulation for PTSD
The investigators propose a small, two-site, sham-controlled pilot study of synchronized Transcranial Magnetic Stimulation (sTMS) in patients with comorbid post-traumatic stress disorder (PTSD) and depression.
- Trial name
- sTMS (NCT02981381)
- Testing
- NEST-1, NEST-2
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Providence VA Medical Center