Clinical trials: Post-Traumatic Stress Disorders
Stress Disorders, Post Traumatic, Trust
Neuroimaging the Impact of Treatment on Neural Substrates of Trust in Post-Traumatic Stress Disorder (PTSD)
Traumatic experiences can have a profound negative effect on the lives and well-being of both the people who experience them and their loved ones.
- Trial name
- NCT01244477
- Testing
- Group CPT-C
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- VA Office of Research and Development
Low Back Pain, PTSD
Care Outcomes for Chiropractic Outpatient Veterans
The primary objectives of this pilot trial are to evaluate the feasibility, safety and acceptability of an integrative care pathway that includes chiropractic care, for the coordinated care for Veterans Administration (VA)…
- Conditions
- Low Back Pain, PTSD, Depression, Anxiety
- Trial name
- COCOV (NCT03254719)
- Testing
- Study assessments
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Palmer College of Chiropractic
Post-Traumatic Stress Disorder
Vortioxetine for Posttraumatic Stress Disorder
Post-traumatic stress disorder (PTSD) can result from having experienced or witnessed a traumatic event. Patients with PTSD symptoms can sometimes experience symptom relief after treatment with antidepressants; however, few…
- Trial name
- NCT02637895
- Testing
- Vortioxetine
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Miami
Pharmacokinetic Study, Post Traumatic Stress Disorder
Pharmacokinetic Study for IV Allopregnanolone
About 6.4% of the U.S. population suffers from posttraumatic stress disorder (PTSD). Trauma-focused psychotherapies are generally effective in PTSD, but responses vary greatly across individuals and PTSD subpopulations.
- Trial name
- NCT04468360
- Testing
- PK-1 Good Manufacturing Practices (GMP) allopregnanolone (Allo) with Dexolve in 0.9% saline for infusion manufactured by the University of California, Davis, PK-2 GMP allopregnanolone (Allo) with Dexolve in 0.9% saline for infusion manufactured by the University of California, Davis.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston University
Posttraumatic Stress Disorders
Cognitive Behavioral Therapy to Improve Work and Wellness in Veterans With Mental Illness
Vocational instability in Veterans with serious mental illness (SMI) is pervasive, costly, and harmful. Over 75% of Veterans with SMI are unemployed, resulting in economic difficulties and trouble meeting basic needs.
- Trial name
- WORKWELL (NCT04504903)
- Testing
- Cognitive Behavioral Therapy For Work Success (CBTw), Psychoeducation
- Where
- 3 sites in United States
- Volunteers
- 294 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Opioid-use Disorder
Prolonged Exposure Therapy for PTSD and Opioid Use Disorder
Among patients with opioid use disorder (OUD), 90% report lifetime trauma exposure and 33% meet criteria for posttraumatic stress disorder (PTSD).
- Trial name
- NCT04104022
- Testing
- Prolonged Exposure Therapy, Attendance-based monetary incentives
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Vermont
PTSD, Cardiac Arrest
Stellate Ganglion Blockade to Reduce Cardiac Anxiety and PTSD Symptoms in Cardiac Arrest Survivors
This is a pilot randomized controlled trial (RCT) to gain preliminary evidence regarding the acceptability, tolerability, safety, and efficacy of a combined intervention of Stellate Ganglion Blockade (SGB) and psychoeducation on…
- Conditions
- PTSD, Cardiac Arrest, Anxiety and Fear, Sleep Disturbance
- Trial name
- SGB-PsychoED (NCT04582396)
- Testing
- stellate ganglion block injection, Normal saline injection, Psychoeducation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Stress, Psychological, Post-Traumatic Stress Disorder
Intervention to Reduce Stress in 0-5 Year Olds With Burns
The objectives of this study are to test and validate a simple, feasible intervention to reduce pediatric burn traumatic stress in 0-5 year old children and their parents.
- Conditions
- Stress, Psychological, Post-Traumatic Stress Disorder, Major Injury
- Trial name
- NCT00844896
- Testing
- DEF-only, DEF + COPE
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Massachusetts General Hospital
Post-Traumatic Stress Disorder, Depression
Evaluation of Two Community-based Mental Health Interventions for Violence-Displaced Afro-Descendants in Colombia.
This study is a community prevention randomized trial with three parallel groups: two intervention groups and one control group in Buenaventura and Quibdó.
- Conditions
- Post-Traumatic Stress Disorder, Depression, Anxiety, Violence
- Trial name
- ACOPLE (NCT01856673)
- Testing
- Common Elements Treatment Approach, Narrative Community Group Therapy, Standby group
- Where
- 2 sites in Colombia
- Volunteers
- 521 people
- Sponsor
- Universidad del Valle, Colombia
Post-Traumatic Stress Disorder
Cannabinoid Control of Fear Extinction Neural Circuits in Post-traumatic Stress Disorder
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT02069366
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Wayne State University
TBI, Anxiety
Cranial Electrotherapy Stimulation (CES) Therapy
The primary aim of this proposed study is to gather preliminary data for CES use in treating PTSD and anxiety symptoms in OEF/OIF Veterans with PTSD and a history of TBI.
- Conditions
- TBI, Anxiety, PTSD, Depression
- Trial name
- CES (NCT02453347)
- Testing
- CES Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Stress Disorder, Post Traumatic
Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)
The purpose of this study is to investigate a new use for a medication called levodopa (L-DOPA). L-DOPA has been approved for use in Parkinson 's disease, but not for Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT02560389
- Testing
- Levodopa
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Wisconsin, Madison
PTSD, Stress Disorders, Post-Traumatic
Memory and the Hippocampus in Twins
The purpose of this project is to measure brain markers and cognitive factors in twins with a history of military service with and without PTSD, and to follow them over time and measure changes in brain function and cognitive…
- Trial name
- NCT00638885
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- US Department of Veterans Affairs
Inflammatory Bowel Diseases, Depressive Episode
Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health
This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years…
- Conditions
- Inflammatory Bowel Diseases, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorder
- Trial name
- NCT05206734
- Testing
- No specific intervention
- Where
- United Kingdom
- Volunteers
- 19,469 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Post Traumatic Stress Disorder, Smoking
Computerized Tailored Intervention for Behavioral Sequelae of PTSD in Veterans
This project assesses the usability and feasibility of a multi-behavioral computerized, tailored intervention (CTI) or expert system delivered via the Internet for veterans with Post-Traumatic Stress symptoms.
- Conditions
- Post Traumatic Stress Disorder, Smoking, Anxiety, Depression
- Trial name
- CTI-PTSD (NCT01510834)
- Testing
- Multibehavioral, Computerized Tailored Intervention STR2IVE
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System
Posttraumatic Stress Disorder
Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)
The investigators are testing novel treatments for combat PTSD: bright light exposure and negation ion exposure.
- Trial name
- NCT00701064
- Testing
- Bright Light Exposure, Negative Ion Generator
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Insomnia
Treating Co-Morbid Sleep Difficulties in Veterans With Posttraumatic Stress Disorder (PTSD): A Pilot Study
A substantial number of US Veterans are suffering from Posttraumatic Stress Disorder (PTSD) following deployment in recent military conflicts, and sleep disturbance is a primary complaint of Veterans presenting to the VA with…
- Trial name
- NCT00734799
- Testing
- Sleep Intervention for PTSD (SIP).
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Durham VA Medical Center
Lung Diseases, Medication Compliance
Uncontrolled Lower Respiratory Symptoms in the WTC Survivor Program
The purpose of this study is to understand why patients in the World Trade Center program have continuing breathing problems. This study will improve investigators understanding of breathing problems among individuals with World…
- Trial name
- NCT02024204
- Testing
- Fluticasone propionate 230mcg for 3 Months, Current Treatment or no treatment, Salmeterol 21mcg for 3 Months
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Posttraumatic Stress Disorder
A Case Formulation Approach to Cognitive Processing Therapy
Recent estimates suggest that over 610,000 US Veterans treated by the Veterans Health Administration (VHA) suffer from PTSD, a disorder that can be chronic and debilitating.
- Trial name
- CF-CPT (NCT04407767)
- Testing
- Case Formulation plus Cognitive Processing Therapy, Cognitive Processing Therapy
- Where
- 8 sites in United States
- Volunteers
- 194 people
- Sponsor
- VA Office of Research and Development
Chronic Post-Traumatic Stress Disorder
Using Emotion Regulation to Decrease Aggression in Veterans With PTSD
Impulsive aggression (IA) is common among Veterans with posttraumatic stress disorder (PTSD), and PTSD is one of the most prevalent post deployment mental health conditions affecting Afghanistan and Iraq Veterans.
- Trial name
- (EMDA) (NCT02724787)
- Testing
- Manage Emotions to Reduce Aggression (MERA)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development