Clinical trials: Post-acute COVID-19 Syndrome
Post-COVID Condition
Munich Long COVID Registry for Children, Adolescents, and Adults
The MLC-R aims to create a large-scale registry that provides data on epidemiology, phenotypes, and disease trajectories of and health care for Long COVID at any age in Germany, which can be used for future clinical trials.
- Trial name
- MLC-R (NCT05638724)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Technical University of Munich
Covid19, Post-COVID / Long-COVID
Characterizing Long-term Cognitive and Emotional Impairment in Post-COVID-19 Sequelae
Weeks and months after they have seemingly recovered from COVID-19, many patients continue to suffer from major long-term effects.
- Trial name
- NCT04881305
- Testing
- questionnaires and neuropsychological assessment
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Rabin Medical Center
Post-COVID, POST-Covid 19
sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19
Fatigue, cognitive problems, post-exertional malaise (PEM) and postural orthostatic tachycardia syndrome (POTS) are common and debilitating symptoms after COVID-19.
- Conditions
- Post-COVID, POST-Covid 19, Post-COVID Conditions
- Trial name
- ESPRIT (NCT07359482)
- Testing
- Fluvoxamine
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
COVID-19, Long COVID
A Six-Month Follow-Up Study of Participants With Coronavirus Disease 2019 (COVID-19) Previously Enrolled in a RO7496998 (AT-527) Study
This study will evaluate the long-term sequelae of COVID-19 in patients diagnosed with COVID-19 who previously enrolled in a RO7496998 (AT-527) study (i.e.
- Trial name
- MEADOWSPRING (NCT05059080)
- Where
- 35 sites in Argentina, Belgium and 8 more
- Volunteers
- 72 people
- Sponsor
- Hoffmann-La Roche
COVID-19
Follow-up of Patients With Previous SARS-CoV-2 Infection: Long-term Damage Assessment
People affected by SARS-CoV-2 infection, whether patients have developed mild forms or a severe form of the disease, complain of nonspecific and entirely new symptoms or complain about the persistence pf them.Investigators intend…
- Trial name
- NCT05359159
- Testing
- Data collection
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Long COVID, Post COVID Condition
RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine
The researchers propose to develop a Canada-wide, adaptive randomized clinical platform trial to assess the effectiveness of various interventions in patients with lingering symptoms of COVID-19 ("Long COVID").
- Conditions
- Long COVID, Post COVID Condition, Post Acute Sequelae of COVID-19
- Trial name
- RECLAIM (NCT05513560)
- Testing
- Ibudilast, Pentoxifylline
- Where
- 3 sites in Canada
- Volunteers
- 460 people
- Sponsor
- University Health Network, Toronto
Asthma, Chronic Obstructive Pulmonary Disease
Evaluation of the Efficacy of Respicure® (Resveratrol / Quercetin) in the Management of Respiratory Conditions Including Asthma,COPD and Long COVID.
Interventional, Prospective, National, Multicentre, Randomised, Open-label, Controlled Clinical Study Comparing Two Parallel Groups, One Control Arm (Standard Treatment) Versus Intervention Arm (Standard Treatment + Study…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Long COVID
- Trial name
- NCT05601180
- Testing
- Respicure®, Standard of care
- Where
- 8 sites in Algeria
- Volunteers
- 402 people
- Sponsor
- Beker Laboratories
Long COVID
Evaluation of the Effectiveness of Breathing Control Technique on Long COVID Symptoms at the Reunion University Hospital
Despite the controversy, on October 6, 2021, the World Health Organization (WHO) recognized Long Coronavirus disease (COVID) by officially defining it: " symptoms appeared 3 months after the onset of the primary infection by the…
- Trial name
- COCO-Long'Run (NCT05851859)
- Testing
- Cardiac coherence
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Post-COVID-19 Syndrome
Temelimab as a Disease Modifying Therapy in Patients With Neuropsychiatric Symptoms in Post-COVID 19 or PASC Syndrome
This study is a Phase 2, 24-week, randomized, prospective, double-blind, multicenter study in patients experiencing neuropsychiatric symptoms and functional impairment in the course of PASC.
- Trial name
- NCT05497089
- Testing
- Temelimab 54mg/kg
- Where
- 14 sites in Italy, Spain and 1 more
- Volunteers
- 203 people
- Sponsor
- GeNeuro SA
Long COVID, Post-Acute COVID-19 Syndrome
A Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid
Purpose: To decrease symptom burden, improve cognitive function, improve endurance, and decrease fatigue in subjects with post-acute sequelae of COVID-19 (PASC) or "long-hauler" COVID using amantadine.
- Trial name
- NCT06234462
- Testing
- Amantadine, Physical, Occupational, Speech Therapy, Provider Counseling
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Long COVID
Rehabilitation and Return to Everyday Life for Patients With Long COVID
This non-randomised controlled trial will investigate if patients with long COVID receiving a structured and group-based rehabilitation intervention (The Long COVID Rehabilitation Intervention) will report a difference in mean…
- Trial name
- NCT06544382
- Testing
- The Long COVID Rehabilitation Intervention, Usual care
- Where
- Denmark
- Volunteers
- 914 people
- Sponsor
- Defactum, Central Denmark Region
Post-acute COVID-19 (PACS), or "long COVID" Syndrome
Impact of Monoclonal Antibody Treatment on Post-Acute COVID-19 Syndrome
Use the Intermountain real-world MAb-treatment registry and control group to prospectively evaluate PACS symptoms at least 60 days after initial COVID-19 diagnosis.
- Trial name
- MAbPACs (NCT05013723)
- Testing
- Surveys
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Intermountain Health Care, Inc.
Long COVID, Long Covid19
RECOVER-AUTONOMIC Platform Protocol
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06305780
- Testing
- IVIG + Coordinated Care, Ivabradine + Coordinated Care, IVIG + Usual Care
- Where
- 50 sites in United States
- Volunteers
- 381 people
- Sponsor
- Kanecia Obie Zimmerman
Covid-19, Respiratory Complication
Effects of Inspiratory Muscle Training After Covid-19 (ReCOV)
Initially, it was suspected that Covid-19 would primarily affect the airways, but several studies have now shown that it is a disease with multisystem manifestations.
- Conditions
- Covid-19, Respiratory Complication, Post-Acute Covid-19 Syndrome
- Trial name
- IMT-ReCov (NCT05024474)
- Testing
- Inspiratory muscle training (IMT), Physical exercise
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Karolinska Institutet
COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
Quality of Life 1y and 2 y After VV-ECMO for COVID-19
This study aims to investigate the quality of life and the outcome after veno-venous extracoporeal membrane oxygenation (ECMO) support fir severe acute respiratory syndrome (ARDS) in COVID-19 patients.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication, Quality of Life, Death
- Trial name
- NCT05780255
- Testing
- VV-ECMO
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- University Hospital, Ghent
Postural Orthostatic Tachycardia Syndrome, COVID-19
Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized Controlled Study
Covid-19 has the potential to affect physical, cognitive and psychological functions in multiple ways. It has been clear that a significant proportion of patients with Covid-19 develop long-term symptoms.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, COVID-19, Post COVID-19 Condition, Post-Acute COVID-19 Syndrome
- Trial name
- NCT05877534
- Testing
- Individual tailored exercise
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Long COVID Fatigue
Fully Remote, Telehealth-based Ketogenic Metabolic Therapy for Long COVID
The goal of this clinical trial is to learn if a 12-week ketogenic diet program combined with lifestyle strategies (called KMT-LS) is practical and acceptable as a fully remote intervention for adults with Long COVID who also…
- Trial name
- NCT07745699
- Testing
- Ketogenic Metabolic Therapy, Lifestyle Intervention
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National University of Natural Medicine
Long COVID
A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID
The IMPACT Long Covid Treatment clinical study (IMPACT-LC) is testing two repurposed and previously approved drugs, Maraviroc and Atorvastatin, for the treatment of non-hospitalized subjects with Long COVID.
- Trial name
- IMPACT-LC (NCT06974084)
- Testing
- Maraviroc (MVC), Atorvastatin, 10mg, 20mg, 40mg
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- HealthBio, Inc.
Depressive Disorder, Post-Acute COVID-19 Syndrome
IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVID-19 Condition
This is a monocentric, randomized pilot study conducted at the Max Planck Institute of Psychiatry, Munich. The study investigates the effects of two different intermittent theta-burst stimulation (iTBS) schedules on biological…
- Trial name
- IMPACT-D+ (NCT07197138)
- Testing
- Intermittent theta-burst stimulation (iTBS) using PowerMAG 100 ppTMS
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Long COVID
tDCS in the Management of Post-COVID Disorders
Different physical and mental morbidities such as pain, fatigue, depressed mood and cognitive impairment can be triggered by coronavirus infection.
- Trial name
- tDCS (NCT06074848)
- Testing
- Transcranial Direct Current Stimulation (tDCS), Motor Training, Cognitive Training
- Where
- 2 sites in Brazil
- Volunteers
- 48 people
- Sponsor
- Universidade Federal de Pernambuco