Clinical trials: Post-cardiac Surgery Patients
Delirium, Postoperative
Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery
This study aims to clarify the preventive effect of perioperative liraglutide application on postoperative delirium in elderly patients with Type 2 diabetes undergoing cardiac surgery.
- Trial name
- NCT06361238
- Testing
- Liraglutide injection
- Where
- China
- Volunteers
- 260 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Acute Kidney Injury
Preop Digifab in CABG to Reduce Ouabain Levels and Prevent AKI
Acute kidney injury (AKI) occurs in up to 30% of patients undergoing coronary artery bypass graft (CABG) surgery, and often requires patients to go on dialysis.
- Trial name
- NCT03810417
- Testing
- Digoxin Antibodies Fab Fragments, Baseline EO > 360 pM, EO < 360 pM
- Where
- 2 sites in United States
- Volunteers
- 267 people
- Sponsor
- University of Maryland, Baltimore
Hypoxemic Respiratory Failure
Asymmetrical HFNCO vs Standard HFNCO Post Cardiac Surgery Patients
High-flow oxygen therapy has been applied after extubation in cardiac surgery patients with a well-known successful efficacy. The current authors plan to conduct a prospective, randomized, controlled study of the Asymmetrical…
- Trial name
- NCT06521489
- Testing
- Asymmetrical High Flow Nasal Cannula Oxygenation, Conventional High Flow Nasal Cannula Oxygenation
- Where
- Greece
- Volunteers
- 63 people
- Sponsor
- National and Kapodistrian University of Athens
Pulmonary Hypertension
Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery?
Post-operative pulmonary hypertension is a risk factor for right ventricular failure and an increasing cause of morbidity and mortality in patients undergoing high-risk cardiac surgery.
- Trial name
- NCT00334490
- Testing
- Sildenafil
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Cardiac Disease, Surgery
Patient-centered and Clinical Outcomes After Minimally Invasive Cardiothoracic Surgery
Nowadays, minimally invasive cardiothoracic surgery techniques are being performed to treat patients with coronary heart diseases.
- Trial name
- NCT03902717
- Testing
- Minimally invasive cardiac surgery
- Where
- 2 sites in Belgium
- Volunteers
- 209 people
- Sponsor
- Jessa Hospital
Coronary Artery Disease, Sleep Quality
Effect of Eye Mask Use on Sleep Quality and Delirium After CABG Surgery
Coronary artery bypass graft (CABG) surgery is an effective treatment for coronary artery disease; however, sleep disturbances and delirium are common during the postoperative period and may adversely affect recovery.
- Conditions
- Coronary Artery Disease, Sleep Quality, Postoperative Delirium (POD)
- Trial name
- EYE-CABG (NCT07768020)
- Testing
- Eye Mask
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Munzur University
Post-cardiac Surgery, Hyperlactatemia
Lactate Acidosis in Postoperative Hearts
This is a single-center, observational study. Investigators aim to characterize the metabolism of lactate in children over the first forty-eight hours following cardiac surgery. Blood samples will be obtained up to 12 timepoints.
- Trial name
- NCT03025659
- Testing
- Pyruvate levels
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Florida
Myocardial Injury After Non-cardiac Surgery
Preoperative BNP and MINS in AAA Open Repair
The aim of this study was to investigate whether preoperative B-type natriuretic peptides serves as an independent predictor of myocardial injury after non-cardiac surgery (MINS) in abdominal aortic aneurysm open repair.
- Trial name
- NCT06088641
- Testing
- preoperative BNP value
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- Gangnam Severance Hospital
Renal Failure Acute, Multiple Organ Failure
Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation
The purpose of this study is to assess the effectiveness and the safety of extracorporeal methods for removing mediators of systemic inflammation in patients with multiple organ dysfunction syndrome after heart and aorta surgery.
- Conditions
- Renal Failure Acute, Multiple Organ Failure, Cardiovascular Diseases
- Trial name
- NCT05182723
- Testing
- renal replacement therapy
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Respiratory Complication, Cardiac Disease
Active Cycle Breathing Technique (ACBT) on Respiratory Parameters, Dyspnea Related Kinesiophobia and Pain
This study aims to improve pulmonary function impairment is associated with a reduction in chest expansion, lung volume, pain perception and an impairment of the Post cardiac surgery patient's ability to cough effectively.
- Trial name
- (ACBT) (NCT06521346)
- Testing
- Active cycle breathing technique, Routine care
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Enhanced Recovery After Surgery, Open Heart Surgery
The Effect of Advanced Improvement Program (ERAS) on Postoperative Outcomes in Patients Undergoing Open Heart Surgery
Investigation of the effect of Enhanced Recovery After Surgery (ERAS) program on postoperative results of patients operated for open heart surgery.
- Trial name
- NCT03799965
- Testing
- ERAS (Enhanced Recovery After Surgery ) are evaluated, ERAS are not evaluated
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Kocaeli Derince Education and Research Hospital
Cardiac Complication, Postoperative Complications
Remote Electrocardiographic (ECG) ST-Monitoring (PROSE 3)in Post-op Patients
In moderate to high risk patients, cardiovascular complications after surgery account for almost 60% of death after surgery. This study will randomize 140 patients into routine postop care with Holter monitoring versus routine…
- Trial name
- PROSE 3 (NCT01423136)
- Testing
- Remote ECG monitoring Spacelab SL 1050
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- Ottawa Hospital Research Institute
Delirium in Old Age, Delirium
PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients
Our objective is to find an effective prophylactic intervention by evaluating IV acetaminophen's impact in reducing the frequency of postoperative delirium, one of the most common and detrimental complications of cardiac surgery…
- Conditions
- Delirium in Old Age, Delirium, Coronary Artery Disease
- Trial name
- PANDORA (NCT04093219)
- Testing
- IV acetaminophen
- Where
- 10 sites in United States
- Volunteers
- 901 people
- Sponsor
- Beth Israel Deaconess Medical Center
Heart Valve Disease
CopenHeartVR - Integrated Rehabilitation of Patients After Heart Valve Surgery
The aim of the study is to investigate the effect of an integrated rehabilitation programme, consisting of physical exercise training and psycho-educational consultations, for patients after heart valve surgery.
- Trial name
- CopenHeartVR (NCT01558765)
- Testing
- Integrated rehabilitation
- Where
- Denmark
- Volunteers
- 147 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
AKI - Acute Kidney Injury, Cardiac Surgery
Urine Output Response to Fluid and Diuretic Therapy in Cardiac ICU Patients Monitored With FIZE kUO®
This prospective observational study evaluates the real-time urine output response to fluid therapy and diuretics in cardiothoracic intensive care unit (CTICU) patients monitored with the FIZE kUO® device.
- Conditions
- AKI - Acute Kidney Injury, Cardiac Surgery, Fluid Therapy, Hemodynamic Instability
- Trial name
- NCT07022314
- Testing
- FIZE kUO®
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- FIZE Medical ltd
Cardiac Output
Total-body 13N-NH3 PET/CT to Study the Blood Perfusion in Severe AS Patients Pre- and Post-TAVR in Whole Body
The aim of our study is to analyze and quantitate whole-body blood perfusion by total-body 13N-NH3 PET/CT(uEXPLORER), and evaluate the influence to other organs in severe AS patients and the impact of TAVR surgery.
- Trial name
- NCT04941248
- Testing
- total-body PET/CT(uEXPLORER , United Imaging Healthcare, China)
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Neurological Injury, Stroke
Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms.
The objective of this study is to investigate the value of employing the aortic no-touch off-pump coronary artery bypass technique and the practice of carbon dioxide surgical field flooding for the prevention of type 1 and 2…
- Conditions
- Neurological Injury, Stroke, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- CANON (NCT03074604)
- Testing
- aortic no-touch OPCABG, OPCABG with partial clamp applying carbon dioxide, OPCABG with partial clamp
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Cardiac Surgery, Post-operative Pain
Reduce Nonsteroidal Antiinflammatory Drugs Doses for Analgesia After Sternotomy
Currently, the management of pain after cardiac surgery is based on the concept of multimodal analgesia: Combined use of non-opioid analgesics associated with morphine intravenous analgesia by a system controlled by the patient…
- Trial name
- LoDoNSAID (NCT02180087)
- Testing
- Ketoprofen
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Heart; Dysfunction Postoperative, Cardiac Surgery
Non-invasive Mechanical Ventilation After Cardiac Surgery
Non-invasive mechanical ventilation (NIV) has been used in hypoxic post-operative cardiac patients but more studies are necessary to clarify its respiratory and hemodynamic effects.
- Trial name
- NCT01457898
- Testing
- VPAP II®
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Irmandade Santa Casa de Misericórdia de Porto Alegre
Respiratory Failure, Mechanical Ventilation Complication
Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery
There is a direct relationship between the sedative agent and the duration of ventilation.
- Conditions
- Respiratory Failure, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- NCT05451121
- Testing
- Propofol, Dexmedetomidine, Propofol and dexmedetomidine
- Where
- Ukraine
- Volunteers
- 356 people
- Sponsor
- Anesthesia Research Group UA