Clinical trials: Post-ischemic Stroke
Ischemic Stroke, Intracranial Haemorrhage
Prospective, Randomized, Parallel-Controlled Study of Brain Computer Interface Integrated Robotic Mirror Therapy for Post-Stroke Upper Limb Motor Function Disorder
This study aims to utilize non-invasive brain-computer interface technology in conjunction with mirror therapy to design a new paradigm for rehabilitation robots to induce compensatory movements on the healthy side in stroke…
- Conditions
- Ischemic Stroke, Intracranial Haemorrhage, Brain-Computer Interfaces, Rehabilitation Exercise
- Trial name
- BCI-RMT (NCT07553416)
- Testing
- Brain computer interface-robotic mirror therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Tiantan Hospital
Large Vessel Occlusion, Stroke
Head of Bed After Ischemic Stroke Thrombectomy (HoBIT)
Endovascular thrombectomy (EVT), also known as clot retrieval, is a procedure that improves recovery for people who suffer a stroke by removing blood clots from large blood vessels in the brain.
- Conditions
- Large Vessel Occlusion, Stroke, Ischemic Stroke
- Trial name
- HoBIT (NCT07367633)
- Testing
- Head of bed position of 0-degrees, Head of bed position of 30-degrees or greater
- Where
- 2 sites in Canada
- Volunteers
- 2,240 people
- Sponsor
- Population Health Research Institute
Ischemic Stroke, Atrial Fibrillation
Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation 2
This study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation who develop hemorrhagic transformation…
- Trial name
- TIMERS-2 (NCT07139314)
- Testing
- Early anticoagulation, Delayed anticoagulation
- Where
- 37 sites in China
- Volunteers
- 240 people
- Sponsor
- Capital Medical University
Basilar Artery Occlusion
Extending the Time Window for Tenecteplase by Recanalization of Basilar Artery Occlusion in Posterior Circulation Stroke
Patients presenting to the emergency department with an acute ischemic stroke due to basilar artery occlusion within 24 hours of stroke onset will be assessed to determine their eligibility for randomization into the trial.
- Trial name
- POST-ETERNAL (NCT05105633)
- Testing
- Tenecteplase, Standard Care (which may include intravenous Alteplase)
- Where
- 17 sites in Australia, Brazil and 1 more
- Volunteers
- 688 people
- Sponsor
- University of Melbourne
Hormone Deficiency
Hormone Treatment in Growth Hormone and Testosterone Deficient Patients
Growth hormone and gonadotropin deficiency after brain injury (traumatic brain injury, ischemic stroke, subarachnoidal hemorrhage): the effects of hormone replacement on cognition, quality of life and body composition Randomized…
- Trial name
- NCT01397500
- Testing
- Genotropin, Testosterone undecannoate
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Ischemic Stroke
Early Mobilization of Ischemic Stroke Patients Within 24-hours After Intravenous-Tissue Plasminogen Activator (IV-tPA)
The purpose of this study is to study the safety and feasibility of mobilization of acute ischemic stroke patients treated with IV-tPA between 12-24 hours of treatment.
- Trial name
- EMISTPA (NCT01331200)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Cardiovascular Events, MACE
Tezspire Cardiac Events PASS
The aim of this study is to evaluate the risk of serious adverse cardiovascular events in adolescent and adult patients with severe asthma taking tezepelumab compared to a population receiving standard of care treatment for…
- Trial name
- TRESPASS (NCT06951867)
- Testing
- Tezepelumab
- Where
- 4 sites in United States, Denmark and 2 more
- Volunteers
- 16,640 people
- Sponsor
- AstraZeneca
Hemorrhagic Stroke, Ischemic Stroke
Telerehabilitation to Improve Balance and Mobility in Patients After Stroke
Telerehabilitation is an effective rehabilitation method that allows patients to receive physiotherapy remotely in their homes. The purpose of this study was to investigate the effects of home-based remote group training for…
- Trial name
- TeleHome (NCT06365463)
- Testing
- Telerehabilitation
- Where
- Slovenia
- Volunteers
- 13 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Stroke, Brain Infarction
Critical Periods After Stroke Study (CPASS)
To perform an exploratory single center randomized study that will form the basis for a larger scale, more definitive randomized clinical trial to determine the optimal time after stroke for intensive motor training.
- Conditions
- Stroke, Brain Infarction, Brain Ischemia, Cerebral Infarction
- Trial name
- CPASS (NCT02235974)
- Testing
- Early Intensive upper extremity motor training, Sub-acute intensive upper extremity motor training, Chronic intensive upper extremity motor training
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- MedStar National Rehabilitation Network
Ischemia, Stroke
Intravenous Stem Cells After Ischemic Stroke
The main objective of the study is to evaluate feasibility and tolerance of the intravenous injection of autologous mesenchymal stem cells for patients presenting an ischemic stroke (less than 6 weeks).
- Trial name
- ISIS (NCT00875654)
- Testing
- Autologous mesenchymal stem cells
- Where
- 3 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Grenoble
Stroke, Ischemic
DELTA (Detecting and Predicting Atrial Fibrillation in Post-Stroke Patients)
Atrial Fibrillation (AF) is an abnormal heart rhythm. Because AF is often asymptomatic, it often remains undiagnosed in the early stages. Anticoagulant therapy greatly reduces the risks of stroke in patients diagnosed with AF.
- Trial name
- NCT05795842
- Testing
- wearable wristband model, Samsung Galaxy Watch 6, Standard of care extended ECG monitoring
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Emory University
Acute Stroke
Early Administration of PCSK9 Inhibitors After Thrombectomy for Atherosclerotic Acute Ischemic Stroke: A Randomized Controlled Trial
This study (EPOCH-TECT) was a single-center, randomized, open-label, blinded, endpoint-assessing controlled trial conducted at the Affiliated Hospital of Xuzhou Medical University.
- Trial name
- EPOCH-TECT (NCT07295366)
- Testing
- Evolocumab(420 mg injections)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Acute Ischemic Stroke, Arterial Thrombosis
Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)
The CHOICE study suggested that the use of adjunct intra-arterial alteplase after successful endovascular reperfusion in large vessel occlusion acute ischemic strokes may result in a greater likelihood of excellent neurological…
- Conditions
- Acute Ischemic Stroke, Arterial Thrombosis, Posterior Circulation Brain Infarction
- Trial name
- NCT05897554
- Testing
- intra-arterial alteplase
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke
Colchicine for Secondary Prevention After Ischemic Stroke (CHANCE-3 EX)
The role of colchicine in the secondary prevention of ischemic stroke has not been determinded. This multicenter, randomized, double-blind, placebo-controlled, event-driven clinical trial of CHANCE-3 EX was aimed to assess the…
- Trial name
- NCT07035405
- Testing
- Colchicine 0.5 mg
- Volunteers
- 7,500 people
- Sponsor
- Beijing Tiantan Hospital
Arterial Ischemic Stroke
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also…
- Trial name
- DOP-MOBILIZE (NCT07232498)
- Testing
- Doppler-guided early mobilization
- Where
- 7 sites in Croatia, Portugal
- Volunteers
- 1,300 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Acute Ischemic Stroke
Mesenchymal Stem Cells for The Treatment of Acute Ischemic Stroke
The clinical study with UMC119-06 is designed to investigate the safety in patients with acute ischemic stroke ("AIS"). This will be a dose escalation, open-label, single-center study in adult with acute ischemic stroke.
- Trial name
- NCT04097652
- Testing
- UMC119-06
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- Meridigen Biotech Co., Ltd.
Stroke, Acute
Establishment and Validation of a Predictive Model for Hemorrhage
Background: Patients with acute ischemic stroke (AIS) are at risk of hemorrhagic transformation (HT) after intravenous thrombolysis.
- Trial name
- NCT04745052
- Testing
- Clinical observation index
- Where
- 2 sites in China
- Volunteers
- 240 people
- Sponsor
- Shenzhen Second People's Hospital
Cerebral Ischemia
Study on the Role of Human Serum Albumin in Large Acute Ischemic Stroke of Anterior Circulation After Thrombectomy
This project intends to explore the therapeutic efficacy of human serum albumin in mitigating postoperative cerebral edema and enhancing clinical outcomes following mechanical thrombectomy in patients with acute anterior…
- Trial name
- NCT06629116
- Testing
- Patients with AIS receive intravascular therapy, and within 10 minutes after the surgery, they are administered 100ml of 20% human albumin intravenously (infused within 30 minutes).
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tingyu-Yi
Ischemic Stroke
Transmission Electron Microscopy Images for Platelet Ultrastructural Criteria Before and After the Onset of an Antiplatelet Agent
The aim of the pilot study is to collect all the ultrastructural platelet characteristics by transmission electron microscopy before and after the onset of an antiplatelet treatment in patients hospitalized for an ischemic stroke…
- Trial name
- ELECTROSTROKE (NCT05004233)
- Testing
- Blood collection before antiplatelet treatment, Blood collection after antiplatelet treatment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Ischemic Stroke, Vessel Occlusion
Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA)
Endovascular thrombectomy (EVT) improves outcomes in patients with acute large vessel occlusion (LVO). However, despite successful recanalization rates exceeding 80%, fewer than 50% of patients achieve favorable functional…
- Conditions
- Acute Ischemic Stroke, Vessel Occlusion, Endovascular Thrombectomy, Anterior Circulation Brain Infarction
- Trial name
- NCT07594314
- Testing
- Minocycline hydrochloride capsule
- Where
- China
- Volunteers
- 860 people
- Sponsor
- Xiang Luo