Clinical trials: Post-lumbar Puncture Headache
Post-Dural Puncture Headache
Contribution of Ondansetron to Preventing Post-Dural Puncture Headaches Following Spinal Anesthesia
A prospective, bicentric, randomized, double-blind controlled study including parturients scheduled for elective caesarean delivery under spinal anaesthesia and randomized and assigned to one of the two groups: Group O…
- Trial name
- OPDPH (NCT06444737)
- Testing
- Intravenous ondansetron, Intravenous normal saline
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- Mongi Slim Hospital
Post-Dural Puncture Headache
The Influence of Needle Diameter on Post Dural Puncture Headache
The purpose of this study is to determine whether injection needle pen point type 'PP Gauge 25' should be recommended as a primary choice of needle (in stead of 'PP Gauge 27') for healthy pregnant women who at delivery (vaginal…
- Trial name
- NCT02827058
- Testing
- G25 pencil point needle, G27 pencil point needle
- Where
- 3 sites in Norway
- Volunteers
- 65 people
- Sponsor
- Helse Nord-Trøndelag HF
Postdural Puncture Headache, Sphenopalatine Ganglion Block
Changes in Cerebral Blood Flow (CBF) in Prone and Sitting Position Before and After GSP-block and Before and After Epidural Blood-patch: A Substudy of NCT03652714
The purpose of this optional sub-study to GSPB-2018 (NCT03652714) is to evaluate the changes in cerebral blood flow (CBF) under different conditions to understand if postdural puncture headache is caused by changes in the…
- Trial name
- NCT03966547
- Testing
- Ganglion sphenopalatine block with local anesthetic administered on study GSPB-2018
- Where
- 2 sites in Denmark
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Leukemia, Lymphoma
Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH)
Headache following a lumbar puncture （post-lumbar-puncture headache,PLPH）is a common and often debilitating syndrome, which was reported to occur in about 40% patients who received lumbar puncture.
- Trial name
- NCT02347878
- Testing
- Aprepitant
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Sun Yat-sen University
Postdural Puncture Headache
Examination of Postdural Puncture Headache Frequency, Predisposing Factors and Treatment
Post-dural puncture headache (PDPH) is one of the most important complications of neuraxial blocks and lumbar interventions for cerebrospinal fluid (CSF) examination.
- Trial name
- PDPH (NCT06394024)
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Mustafa Soner Ozcan
Headache, Post-Dural Puncture
Sphenopalatine Blockade Versus Clinical Treatment
Post-dural puncture headache leads to high morbidity and cost to the health system. Pregnant women have a higher incidence than other population groups.
- Trial name
- NCT04148846
- Testing
- Dypirone, Sphenopalatine block, Ketoprofen
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo General Hospital
Cesarean Section Complications
Ultrasonographic ONSD as a Predictor of PDPH in Spinal Anesthesia for Cesarean Delivery
The Optic Nerve Sheath Diameter (ONSD), measured non-invasively by bedside ultrasound, is a well-established surrogate for intracranial pressure (ICP), as the optic nerve sheath is continuous with the intracranial dura mater and…
- Trial name
- NCT07360756
- Testing
- Study Cohort (Single Cohort)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Al-Azhar University
Post-Dural Puncture Headache
Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural Puncture Headache
Objectives: To compare the safety and efficacy of oral theophylline versus oral sumatriptan in the treatment of post-dural puncture headache (PDPH).
- Trial name
- NCT04257851
- Testing
- Theophylline Anhydrous Oral Tablet, Sumatriptan Succinate Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Post-Dural Puncture Headache
Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean
Postdural puncture headache (PDPH) is a common complication after spinal anesthesia. The role of pregabalin and hydrocortisone in the treatment of PDPH is unclear.
- Trial name
- PDPH (NCT03910088)
- Testing
- Pregabalin 100Mg Oral Cap, Hydrocortisone, Acetaminophen
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Post-Dural Puncture Headache
Intrathecal Neostigmine for Prevention of PDPH
Neuraxial blocks continue to be the cornerstone of anesthesia and postoperative analgesia for normal vaginal delivery and elective caesarean section due to its approved safety and efficiency for decades.
- Trial name
- NCT03587441
- Testing
- Neostigmine Methylsulfate, Dextrose 5% in water
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Fayoum University Hospital
Post Dural Puncture Headache
Effect of Intravenous Oxytocin on Post Dural Puncture Headache After Caesarean Sections
Spinal anesthesia is the preferred anesthetic technique for cesarean section because of its advantages over epidural and general anesthesia.
- Trial name
- NCT07853924
- Testing
- oxytocin, Normal Saline
- Volunteers
- 100 people
- Sponsor
- Assiut University
Leukemia, Lymphoma
A Randomized Study Evaluating the Incidence of Post Lumbar Puncture Headache With Atraumatic Needles in Hematology
Lumbar punctures are implemented for the diagnosis of patients with hematologic symptoms as well as for the intrathecal chemotherapy injections.
- Trial name
- SPPLAASH (NCT03126045)
- Testing
- Standard needle, Atraumatic needle
- Where
- 2 sites in France
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Post-Dural Puncture Headache
Two Fluid Strategies for Prevention of Post-dural Puncture Headache
Postdural puncture headache (PDPH) is a common complication after cesarean delivery (CD). The role of peri-operative fluid therapy in prophylaxis against PDPH is unclear.
- Trial name
- NCT03475784
- Testing
- Restrictive fluid therapy, Liberal fluid therapy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Post-Dural Puncture Headache
SGB in Management of Patients With PDPH Using TCD
This study aims to investigate the ability of SPGB in the management of PDPH. Transcranial Doppler is also used as an measure to assess the block success by detecting the variability in the cerebral hemodynamics before and after…
- Trial name
- NCT04401878
- Testing
- Sphenopalatine Ganglion Block using 2% lidocaine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Headache
Treatment of Post-dural Puncture Headache in Postpartum Patients: Sphenopalatine Ganglion Block to Epidural Blood Patch.
The purpose of this research study is to compare the effectiveness of a sphenopalatine ganglion block to an epidural blood patch for post-dural puncture headache relief in randomized postpartum parturients over a 48 hour period.
- Trial name
- NCT02962427
- Testing
- Sphenopalatine ganglion Block, Epidural blood patch
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Colorado, Denver
Postdural Puncture Headache, Lumbar Puncture
Effect of Anodal Transcranial Direct Current Stimulation on Postdural Puncture Headache
Post-dural puncture headache (PDPH) is the most prevalent complication in patients undergoing diagnostic or therapeutic lumbar puncture (LP).
- Trial name
- NCT06640634
- Testing
- active in therapeutic tDCS (Th-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS), active in preventive tDCS (Pr-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS)
- Where
- Italy
- Volunteers
- 97 people
- Sponsor
- Neuromed IRCCS
Preoperative Neutrophil-to-Lymphocyte Ratio (NLR), Postdural Puncture Headache
Neutrophil to Lymphocyte Ratio and Postdural Headache
This study will aim to investigate whether systemic inflammatory markers-especially the neutrophil-to-lymphocyte ratio (NLR)-obtained from preoperative complete blood counts can predict the development of post-dural puncture…
- Trial name
- NCT07075874
- Testing
- PDPH
- Where
- Turkey (Türkiye)
- Volunteers
- 821 people
- Sponsor
- Istinye University
Theophylline, Sumatriptan
Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache
The aim of this study is to compare the safety and efficacy of theophylline, sumatriptan, and gabapentin in the treatment of post-dural puncture headache.
- Conditions
- Theophylline, Sumatriptan, Gabapentin, Post-Dural Puncture Headache
- Trial name
- NCT07515456
- Testing
- Theophylline, Sumatriptan, Gabapentin
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Post Dural Puncture Headache
Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients
Some patients develop headache after spinal anesthesia used during cesarean section. This condition is called post-dural puncture headache (PDPH). Early identification of patients at risk may improve patient care.
- Trial name
- NCT07497945
- Testing
- Optic Nerve Sheath Diameter Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Kocaeli University
Sphenopalatine Ganglion Block, Adrenaline
Sphenopalatine Ganglion Block for Post-Dural Puncture Headache in Orthopedic Patients
The aim of this study is to assess the efficacy, onset and duration of analgesia of sphenopalatine ganglion bock (SPGB) using lidocaine 4% with adrenaline as a treatment of postoperative Post dural puncture headache (PDPH) of…
- Conditions
- Sphenopalatine Ganglion Block, Adrenaline, Post-Dural Puncture Headache, Orthopedic
- Trial name
- NCT04657952
- Testing
- Sphenopalatine Ganglion Block, Medical Treatment
- Volunteers
- 60 people
- Sponsor
- Tanta University