Clinical trials: Post-operative
Pain, Postoperative
Effectiveness and Safety of Different Doses of BI 1026706 in Patients With Postoperative Dental Pain
To investigate the effectiveness of BI 1026706 powder for reconstitution of an oral solution compared to placebo and the relative effectiveness compared to Celecoxib.
- Trial name
- NCT02084511
- Testing
- BI 1026706, Celecoxib
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Boehringer Ingelheim
Corneal Endothelial Cell Loss
Comparative Study of Specular Microscopes for Measurements of Cell Density, Coefficient of Variation and Hexagonality
The primary objective of this clinical study is to collect clinical data to support an FDA 510(k) submission for the Nidek CEM-530 Center point method and Corner point method.
- Trial name
- NCT02276638
- Testing
- Specular Microscope Nidek CEM-530, Specular Microscope Konan CELLCHEK XL
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Nidek Co. LTD.
PONV
European Phase III Study of APD421 in PONV
A comparison of the efficacy of APD421 and placebo in the prevention of PONV in patients at moderate-to-high risk of PONV.
- Trial name
- NCT01991821
- Testing
- APD421
- Where
- 2 sites in France, Germany
- Volunteers
- 368 people
- Sponsor
- Acacia Pharma Ltd
Abdominal Surgery
Preoperative and Postoperative Incentive Spirometry in Patients Undergoing Major Abdominal Surgery
The goal of this study is to determine the efficacy of incentive spirometry (IS) to improve pulmonary function in the preoperative and postoperative surgical setting.
- Trial name
- NCT04887922
- Testing
- MIR Spirobank G, ZEPHYRx®, Conventional spirometer
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Amputation, Amputation; Postoperative, Sequelae
Evaluation of Closed Incision Negative Pressure Dressing (PREVENA) to Prevent Lower Extremity Amputation Wound Complications
This study is a prospective, multi-center, two-arm, unblinded, and randomized controlled trial with a goal of evaluating the impact of a closed incision negative pressure dressing (PREVENA) on incidence of post-operative wound…
- Conditions
- Amputation, Amputation; Postoperative, Sequelae, Wound Dehiscence, Seroma
- Trial name
- PREVENA-AMP (NCT03773575)
- Testing
- PREVENA™ PEEL & PLACE™ Dressing Kit
- Where
- 3 sites in United States, Italy
- Volunteers
- 272 people
- Sponsor
- Thomas Jefferson University
Pain Management
Regional Block for Postoperative Free Flap Care
The purpose of this protocol is to evaluate the safety and efficacy of regional anesthesia for head and neck patients undergoing microvascular free flap reconstruction.
- Trial name
- NCT04080739
- Testing
- ropivicaine 0.2%
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Post-operative Pain, Anesthesia
Methadone in Ambulatory Surgery
The μ-opioid receptor agonist methadone is frequently used in adult anesthesia and adult pain therapy. Methadone has an extremely long half-life, which confers therapeutic advantage by providing more stable plasma concentrations…
- Trial name
- NCT02300077
- Testing
- methadone, Control (Intra-operative administration of opioids, other than methadone)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Fractures, Bone, Nausea and Vomiting, Postoperative
Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration
The aim of this study is to evaluate not only the occurrence of side effects, but the quality of the recovery (QoR-40 Questionnaire) of patients submitted to spinal anesthesia with administration of low doses (0.1 mg) of…
- Conditions
- Fractures, Bone, Nausea and Vomiting, Postoperative, Pruritus, Morphine Adverse Reaction
- Trial name
- NCT03035942
- Testing
- Dexamethasone, Ondansetron, Saline
- Where
- Brazil
- Volunteers
- 135 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Pain, Postoperative, Chronic Postoperative Pain
Analgesia in Laparoscopic Cholecystectomy
The investigators hypothesis is that perioperative infusion of 0.75 ropivacaine in patients undergoing laparoscopic cholecystectomy may modify the intensity of postoperative pain or the analgesic consumption during the first 24…
- Trial name
- NCT01388946
- Testing
- Ropivacaine 0.75, Normal saline
- Where
- 2 sites in Greece
- Volunteers
- 110 people
- Sponsor
- University of Athens
Osteoarthritis, Knee
Efficacy and Safety of Single, Low-dose Dexamethasone in Patients After Total Knee Arthroplasty
This study was conducted to determine the efficacy of an additional preemptive, single, low-dose dexamethasone in terms of incidence and severity of postoperative nausea/vomiting (PONV), pain level, and the safety in terms of…
- Trial name
- NCT01612702
- Testing
- Dexamethasone
- Where
- South Korea
- Volunteers
- 291 people
- Sponsor
- Tae Kyun Kim
Post-Operative Pain, Acute Pain
Clinical Study to Evaluate the Effectiveness, Safety, and Tolerability of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects
The purpose of the study is to evaluate the efficacy, tolerability, safety and pharmacokinetics of Oxymorphone HCl as an analgesic for acute moderate to severe post-operative pain in pediatric subjects.
- Trial name
- NCT02687451
- Testing
- Oxymorphone HCl
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Ileus, Gastrointestinal Dysfunction
Alvimopan as a Rescue Treatment of Postoperative Ileus
This study aims to evaluate the cost effectiveness of Alvimopan as rescue therapy in patients undergoing colorectal or small bowel resection who develop POI, and its safety and effectiveness in reducing LOS and POI duration.
- Trial name
- NCT04405037
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Scott Steele
Acute Moderate-to-severe Pain
A Multicenter, Open-Label Trial to Evaluate the Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg in Patients With Post-Operative Pain
This is a multicenter, open-label study in patients 40 years and older who are undergoing a surgical procedure. Patients may receive one dose of ST 30 mcg as needed for pain management, but no more frequently than every 60…
- Trial name
- NCT02662556
- Testing
- sufentanil sublingual tablet 30 mcg
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Talphera, Inc
Postoperative Ecchymosis
DDAVP in the Reduction of Post-operative Ecchymosis in Rhinoplasty
This is study looking at the use of a medication, Desmopressin acetate (DDAVP), to reduce bleeding, swelling, and bruising in patients undergoing cosmetic nose surgery. DDAVP is a drug used in patients with bleeding disorders.
- Trial name
- NCT01982760
- Testing
- DDAVP
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University Hospitals Cleveland Medical Center
Pain, Postoperative
The Role of Quadratus Lumborum Blocks Following Minimally Invasive Hysterectomy
The purpose of this study is to compare quality of recovery as well as peri-operative systemic opiates use and pain scores in patients undergoing laparoscopic or robotic hysterectomy when local anesthetic versus Quadratus…
- Trial name
- NCT05480111
- Testing
- Local anesthesia at incision site, QL
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- The University of Texas Health Science Center, Houston
Short Bowel Syndrome
The Long-term Effect on Intestinal Absorption and Safety of Treatment With Glepaglutide in Patients With Short Bowel Syndrome
The purpose of this trial is to investigate the long-term effect of glepaglutide on the intestinal absorption, nutritional status of participants with Short Bowel Syndrome (SBS).
- Trial name
- EASE SBS 4 (NCT04991311)
- Testing
- Glepaglutide
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Zealand Pharma
Femoral Fracture
Analysis of the Relationship Between Early Postoperative Anemia and the Evolution of Autonomy at 6 Months in Patients 75 Years of Age and Older Operated on Following a Fracture of the Upper End of the Femur
Fracture of the upper extremity of the femur is a condition whose frequency increases with age. It is a serious disease, with multiple consequences such as a decrease in life expectancy, quality of life and patient autonomy.
- Trial name
- PAAF (NCT03810092)
- Where
- 5 sites in France
- Volunteers
- 255 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Postpartum Hemorrhage
Comparison Between Rectal & Sublingual Misoprostol Before Caesarian Section To Reduce Intra & Post-Operative Blood Loss
The aim of the work is to evaluate \& compare the effectiveness of rectally administered PGE1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before caesarean section to decrease blood…
- Trial name
- NCT02083107
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 636 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Shoulder Infection
Skin Prep to Reduce Postoperative Shoulder Infection
Propionibacterium acnes is the most common pathogen identified from a surgical site infection in the shoulder. Standard skin preps do not prevent this type of infection.
- Trial name
- NCT02510144
- Testing
- Skin Prep Chlorhexidine, Skin Prep Benzoyl Peroxide
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Maryland, Baltimore
Femoracetabular Impingement, Pain, Postoperative
Intra-articular Morphine and Clonidine Injections for Pain Management in Hip Arthroscopy
The purpose of this study is to determine whether intraoperative (during surgery) morphine and clonidine hip injections are effective in postoperative pain management for patients undergoing hip arthroscopy.
- Trial name
- NCT02530151
- Testing
- Morphine with clonidine, Normal saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
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