Clinical trials: Post-operative
Acute Kidney Injury, Post-Operative Delirium
Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery
Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that…
- Conditions
- Acute Kidney Injury, Post-Operative Delirium, Icu Delirium, Acute Renal Failure
- Trial name
- NCT00791648
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 653 people
- Sponsor
- Vanderbilt University Medical Center
Urinary Stone
A Study to Assess the Effect of Cannabidiol Oil on Pain After Ureteroscopy for Kidney Stones
The purpose of this study is to determine if CBD oil has any effect on decreasing postoperative pain control following ureteroscopy for urinary stone disease, and to determine if CBD oil has any effect in decreasing the amount of…
- Trial name
- NCT04387617
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Postoperative Pain
OxyNorm Capsules in Post-Operative Pain Study
The efficacy and safety of oxycodone capsules compared with morphine tablets in hospitalized patients with moderate to severe pain following surgery.
- Trial name
- NCT01675635
- Testing
- OxyNorm Capsules, Morphine tablet
- Volunteers
- 240 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Opioid Use, Pain, Postoperative
Standard Bupivacaine vs Liposomal Bupivacaine in Colorectal Patients
The transversus abdominis plane (TAP) block can be used to reduce pain in patients who get abdominal surgery. TAP blocks are given with a local anesthetic.
- Conditions
- Opioid Use, Pain, Postoperative, Colectomy, Colorectal Surgery
- Trial name
- NCT03638635
- Testing
- Bupivacaine, Bupivacaine liposome
- Where
- 6 sites in United States
- Volunteers
- 63 people
- Sponsor
- Inova Health Care Services
Short Bowel Syndrome
A One-Year, Open-Label Study With Teduglutide for Subjects Who Completed Study CL0600-021
This study is a 1-year open label extension study to collect long term efficacy and safety data from patients who have completed approximately 2 years of dosing in Study CL0600-021.
- Trial name
- STEPS3 (NCT01560403)
- Testing
- Teduglutide
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Shire
Bleeding, Surgical Blood Loss
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
The aim is to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing cardiac surgery at the…
- Trial name
- DEPOSITION (NCT03376061)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Population Health Research Institute
Rectal Cancer
5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer
The purpose of this Phase II study will be to investigate the antiangiogenic agent, aflibercept, in combination with chemoradiation as preoperative treatment for patients with stage II/III rectal cancer, followed by 4 months of…
- Trial name
- NCT01749956
- Testing
- Radiation, Aflibercept, Surgery
- Where
- 11 sites in United States
- Volunteers
- 39 people
- Sponsor
- SCRI Development Innovations, LLC
ACL Injury, Postoperative Pain
Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery
1. The investigators aim to examine the use of IV and oral ketorolac as an adjunctive agent to the standard of care pain protocol for postoperative pain control following ACL reconstruction surgery. 2.
- Trial name
- NCT04246554
- Testing
- Ketorolac, Oxycodone-Acetaminophen
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Endometriosis, Post Operative Pain
The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) Study
This is a randomized, single blinded, placebo-controlled trial to study the effectiveness of a subanesthetic dose (0.6 mg/kg) of ketamine versus placebo (saline) on postoperative pain and pain on adult female chronic pelvic pain…
- Trial name
- NCT05229653
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- NYU Langone Health
Tracheal Extubation
A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients
Tracheal extubation can be associated with hyperdynamic circulatory response. The investigators examined the effect of maintaining a remifentanil infusion on the cardiovascular response during extubation in propofol-remifentanil…
- Trial name
- NCT01152515
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Severance Hospital
Surgery
Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription
Currently there is a nationwide epidemic in opioid abuse and overdose deaths. While the opioid epidemic is multi-factorial one major source of excess opioids may be over-prescribing in the post-operative period.
- Trial name
- NCT03588910
- Testing
- Acetaminophen, Ibuprofen 600 mg, Oxycodone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Hypotension
Decision Support for Intraoperative Low Blood Pressure
The purpose of this study is to determine whether a decision support system can improve the adherence to thresholds for low blood pressure by anesthesia providers, which in turn prevents their patients from having organ injury.
- Trial name
- NCT02726620
- Testing
- Attending real-time decision support, In-room real-time decision support, Attending feedback emails
- Where
- United States
- Volunteers
- 22,435 people
- Sponsor
- Vanderbilt University Medical Center
Short Bowel Syndrome
Amino Acid-based Oral Rehydration Solution in Children With Short Bowel Syndrome
This study will assess the tolerability and palatability of an amino acid based oral rehydration solution (enterade®) compared to current oral rehydration solution among children with short bowel syndrome .
- Trial name
- NCT03105362
- Testing
- Enterade® oral rehydration solution
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Children's Hospital
Colonic Cancer, Rectal Cancer
Transversus Abdominis Plane (TAP) Block for Postoperative Analgesia After Laparoscopic Colonic Resection
Laparoscopic (key-hole) large bowel resection is a minimally invasive procedure when compared to open large bowel resection, but is still associated with a significant amount of pain and discomfort.
- Conditions
- Colonic Cancer, Rectal Cancer, Colonic Diverticulum, Ulcerative Colitis
- Trial name
- NCT01339273
- Testing
- Ultrasound guided Transversus Abdominis Plane (TAP) bock, Local anaesthetic infiltration of laparoscopic port sites
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- Oxford University Hospitals NHS Trust
Endometritis, Wound Infection
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
The Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) study is a large pragmatic multi-center randomized clinical trial designed to evaluate the comparative effectiveness and safety of azithromycin-based extended-spectrum…
- Conditions
- Endometritis, Wound Infection, Abscess, Surgical Site Infection
- Trial name
- C/SOAP (NCT01235546)
- Testing
- Azithromycin and standard of care
- Where
- 9 sites in United States
- Volunteers
- 2,013 people
- Sponsor
- Alan Tita
Laminectomy, Post-laminectomy Syndrome
Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase
Traditionally, pain relief through spinal cord stimulation has been associated with the appearance of paresthesia in the affected area.
- Conditions
- Laminectomy, Post-laminectomy Syndrome, Spinal Cord Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT03702010
- Testing
- spinal cord stimulation conventional, spinal cord stimulation experimental
- Where
- 2 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Postoperative Pain
Ropivacaine Transversus Abdominis Plane Blocks for Cesarean Section Analgesia
With this research the investigators hope to determine the lowest dose of ropivacaine used in transversus abdominis plane (TAP) blocks that can effectively treat pain in women after cesarean section (c-section).
- Trial name
- TAPROPI (NCT02893423)
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Maimonides Medical Center
Colorectal Carcinoma
Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum
58 patients undergoing surgery of the large bowel are divided into two groups. The control group will receive standard care. The intervention group will receive standard care plus optimization of the blood circulation based on…
- Trial name
- HOC (NCT01175317)
- Testing
- Goal-directed fluid optimization, Regimen based on expertise anaesthesist
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Maastricht University Medical Center
Pain, Acute Postoperative, Renal Stone
Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy
This is a randomized, triple-masked, placebo-controlled parallel-arm human subjects clinical trial investigating the addition of a continuous erector spinae plane nerve block to a single-injection erector spinae plane block to…
- Trial name
- NCT05121168
- Testing
- Active bupivacaine 0.25% via an erector spinae plane perineural catheter
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Breast Cancer Lymphedema, Compression Bandages
Effectiveness of Taping on Anastomotic Regions in Patients With Breast Cancer-Related Lymphoedema
One of the most common conservative treatments of lymphoedema is Complex Decongestive Physiotherapy (CDP). The bandage is one of the most important components of the treatment process.
- Conditions
- Breast Cancer Lymphedema, Compression Bandages, Manual Lymphatic Drainage
- Trial name
- NCT03765996
- Testing
- Decongestive Physiotherapy, Decongestive Physiotherapy plus taping
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Dokuz Eylul University
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