Clinical trials: Post-operative Atrial Fibrillation (POAF), open to volunteers
POAF, Atrial Fibrillation (AF)
Association of Lipoprotein(a) With Postoperative Atrial Fibrillation
About one in three patients who undergo open-heart surgery develop an irregular heart rhythm called postoperative atrial fibrillation (POAF).
- Trial name
- LPa and POAF (NCT07737444)
- Volunteers
- 20 people
- Sponsor
- Anthony Tang
Post-operative Atrial Fibrillation POAF
The DefiPace Study
Prospective, non-interventional, multi-center, international registry in two phases in consecutive patients undergoing elective cardiac surgery. The DefiPace registry is designed in two phases 1.
- Trial name
- Defipace (NCT04804748)
- Testing
- No intervention
- Where
- 10 sites in Austria, Germany
- Volunteers
- 450 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Atrial Fibrillation New Onset
Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot Trial
The START-POAF pilot study is a prospective, open-label two-arm, randomized controlled trial with blinded assessment of outcomes (PROBE).
- Trial name
- START-POAF (NCT05841056)
- Testing
- Amiodarone Hydrochloride 200 MG
- Where
- 2 sites in Canada
- Volunteers
- 400 people
- Sponsor
- Population Health Research Institute
Post-operative Atrial Fibrillation (POAF)
Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery and leads to worse outcomes. POAF is thought to be caused by the inflammatory state following cardiac surgery.
- Trial name
- NCT05991700
- Testing
- Freeze-Dried California Table Grape
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Michigan
Atrial Fibrillation, Post-Op Complication
Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone
The purpose of this study is to evaluate the combination of CardiaMend, with the addition of amiodarone in the prevention of postoperative atrial fibrillation (POAF) in patients undergoing cardiac arterial bypass grafting (CABG)…
- Trial name
- NCT06063538
- Testing
- CardiaMend in Combination with Amiodarone
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Chicago
Atrial Fibrillation, Postoperative
Amiodarone-Infused CardiaMend Patches for the Prevention of New-Onset POAF in Cardiac Surgery Subjects
The goal of this clinical trial is to is to test the safety of a new way to deliver a commonly used drug (amiodarone) used in heart surgery by placing a patch containing the drug directly on the heart instead of in an IV (vein).
- Trial name
- AMIOMEND (NCT06730828)
- Testing
- The intervention includes Amiodarone-Infused CardiaMend patches (70mg, 150mg and 300mg)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Helios Cardio Inc.
Coronary Arterial Disease (CAD), Valve Replacement
Prolonged Chest Tube Treatment to Reduce Rates of Atrial Fibrillation Following Cardiac Surgery
Evacuation of pericardial blood by posterior pericardiotomy or use of a posterior pericardial chest tube lowers postoperative atrial fibrillation (POAF) rates after cardiac surgery by 45-68%.
- Conditions
- Coronary Arterial Disease (CAD), Valve Replacement, Aortic Surgery
- Trial name
- PROPER (NCT06800781)
- Testing
- Prolonged treatment with posterior pericardial chest tube plus standard care
- Where
- Sweden
- Volunteers
- 624 people
- Sponsor
- Region Skane
Surgery, Cardiac, Atrial Fibrillation
Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Postoperative atrial fibrillation is quite common after cardiac surgery with up to 1 in 3 patients experiencing this abnormal heart rhythm.
- Trial name
- PATRONUS (NCT05543278)
- Testing
- Amiodarone
- Volunteers
- 242 people
- Sponsor
- Massachusetts General Hospital