Clinical trials: Post-operative Cardiac Surgery
Non-cardiac Surgery
Artificial Intelligence and Postoperative Acute Kidney Injury
The main objective of this study is to develop and validate an artificial intelligence model that predicts postoperative acute kidney injury.
- Trial name
- NCT04705064
- Testing
- Prediction of postoperative acute kidney injury using an artificial intelligence
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seoul National University Hospital
Patients Undergoing Elective Coronary Artery Bypass Graft
Lansoprazole Preventing Gastroduodenal Stress Ulcerations
The primary objective of this study is to determine whether lansoprazole, administered intravenously, can protect patients undergoing cardiac surgery from the development of and/or progression of previously undetected acid/peptic…
- Trial name
- NCT00220909
- Testing
- Lansoprazole
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Temple University
Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction
Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Function and Recovery in Children After Cardiac Surgery.
This study examines the effects of coughing exercises and incentive spirometry (IS) on lung function and recovery in children who undergo heart surgery.
- Conditions
- Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction, Postoperative Recovery After Cardiac Surgery
- Trial name
- CEXIS (NCT07405333)
- Testing
- Coughing Exercises, Incentive Spirometry, Standard Postoperative Care
- Where
- 4 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
Multiple Organ Dysfunction
Modulation of Microbiota Metabolism in Cardiac Surgery Patients
An imbalance in the microbiota (most often intestinal) largely determines the onset of a disease state, and often a critical state.
- Trial name
- MMMMODCS (NCT04921436)
- Testing
- cardiac surgery
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Non-convulsive Seizures
Seizures After Cardiac Surgery -- A Study With Continuous EEG Monitoring
The aim of this study is to determine the frequency of nonconvulsive seizures after cardiac surgery using an electroencephalogram or EEG, which records brainwaves through the scalp.
- Trial name
- NCT01291992
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
Excessive bleeding is common after cardiac surgery. This may result in patients receiving a blood transfusion or suffering the life-threatening complication of cardiac tamponade.
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Blood Platelet Disorders, Blood Coagulation Disorders
- Trial name
- NCT00359398
- Testing
- Platelet rich plasma sequestration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Hypotension
PeRsonalized Blood prEssure Management on Postoperative Complications and Mortality in hIgh-risk Patients Undergoing Major Non-cardiac Surgery
High-risk populations, particularly elderly individuals and patients with cardiovascular comorbidities, exhibit markedly elevated incidences of postoperative myocardial injury (MINS), acute kidney injury (AKI), and mortality.
- Trial name
- PREMIUM (NCT06952387)
- Testing
- Personalized blood pressure management, Routine blood pressure management
- Where
- 7 sites in China
- Volunteers
- 1,624 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Postoperative Pain Management
Additive Regional Fascial Plain Blocks to Pectointercostal Fascial Block for Postoperative Pain Management After Cardiac Surgery: a Randomized Controlled Trial
Acute postoperative pain is severe in cardiac patients undergoing sternotomy, and pain intensity is more severe than expected. Many patients referred to tube insertion as the most painful site after coronary artery bypass…
- Trial name
- NCT06865404
- Testing
- PIFPB block, PIRSB Block, PIEOB block
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Alexandria University
Sternal Closure
Montage-Enhanced Sternal Closure
Post-operative recovery after cardiac surgery is influenced by early sternal bone stability. Traditional sternal closure of median sternotomy usually entails the use of 6-10 stainless steel wires.
- Trial name
- NCT03365843
- Testing
- Montage bone putty, Conventional Sternal Closure
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University of Calgary
Coronary Arterial Disease (CAD), Surgery (Cardiac)
The Effect of Emotional FreedomTechnique on Postoperative Pain, Pain Belief and Anxiety in Coronary Artery Bypass Graft Planned Patients
When the literature is examined, there is almost no application of EFT on surgical patients. In a quasi-experimental study conducted by Kalroozi et al.
- Conditions
- Coronary Arterial Disease (CAD), Surgery (Cardiac), Emotional Freedom Technique
- Trial name
- NCT06839625
- Testing
- emotional freedom technıque
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ondokuz Mayıs University
Postoperative Pain, Cardiac Surgery
Dexmedetomidine Combined With Bupivacaine in Ultrasound-guided Pecto-Intercostal Fascial Block in Cardiac Surgery
Recent advancements in pain management techniques suggest that ultrasound-guided peripheral nerve blocks may significantly benefit patients undergoing cardiac surgery.
- Trial name
- NCT07023874
- Testing
- Bupivacaine group, bupivacaine + dexmedetomidine group
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Hematoma Intracranial, Hydrocephalus
Subgaleal Drains in Decompressive Craniectomies
This research is about the use of subgaleal drains to prevent accumulation of blood under the skin in patients undergoing surgery to remove part of the skull(craniectomy) and its associated complications.
- Conditions
- Hematoma Intracranial, Hydrocephalus, Surgical Site Infection, Wound Breakdown
- Trial name
- VADER (NCT03777774)
- Testing
- Passive Redon subgaleal drains, Vacuum Redon subgaleal drains, No Redon subgaleal drains
- Where
- 2 sites in Malaysia
- Volunteers
- 78 people
- Sponsor
- Universiti Sains Malaysia
Postoperative Pain, Opioid Use
Continuous Serratus Anterior Blockade for Sternotomy
This is a pilot study to assess the feasibility of a full study. The purpose is to assess the analgesic effectiveness of the serratus anterior plane (SAP) block following cardiac surgery.
- Conditions
- Postoperative Pain, Opioid Use, Quality of Life
- Trial name
- Cardiac-SAP (NCT04648774)
- Testing
- Serratus anterior plane (SAP) block
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Ventilator Lung
I-ASV in Cardiac Surgery
'POStoperative INTELLiVENT-adaptive support VEntilation in cardiac surgery patients II (POSITiVE II) is an investigator-initiated, international, multicenter, parallel, randomized clinical trial in patients after cardiac surgery.
- Trial name
- POSITiVE II (NCT06178510)
- Testing
- INTELLiVENT-ASV.
- Where
- Austria
- Volunteers
- 328 people
- Sponsor
- Medical University of Vienna
Postoperative Complications
The Relationship Between Anticholinergic Burden and Postoperative Complications After Cardiac Surgery in Older Adults
Drugs with anticholinergic properties are widely prescribed in the elderly population, despite increasing evidence in the literature regarding side effects and adverse outcomes.
- Trial name
- NCT05312684
- Testing
- cardiac surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Gulhane Training and Research Hospital
Heart; Dysfunction Postoperative, Cardiac Surgery, C.Surgical Procedure; Cardiac
Goal Directed Therapy Aiming to Optimise Oxygen Central Venous Saturation in Children Undergoing Cardiac Surgery
The purpose of this study is evaluate goal-directed therapy with continuous central venous saturation compared to standard therapy in children undergoing cardiac surgery.
- Trial name
- NCT03469440
- Testing
- Continuous central venous oxygenation monitoring, Standard protocol
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Instituto do Coracao
Sedation Complication
Influence of Sedation Strategies on Hospital LOS and ICU LOS in Patients Cardiac Surgery
Preoperative, intraoperative and postoperative management of the patient are some of the main stages that can affect the hospital LOS and ICU LOS.
- Trial name
- LOS (NCT05809518)
- Testing
- Propofol injection, Dexmedetomidine injection, Dexmedetomidine and Propofol
- Where
- Ukraine
- Volunteers
- 194 people
- Sponsor
- Anesthesia Research Group UA
Coronary Artery Bypass, Delirium
Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane
Background: Different anaesthetic agents have been shown to have different protective effects upon heart, brain and renal function under ischaemic conditions (oxygen starvation).
- Conditions
- Coronary Artery Bypass, Delirium, Dementia, Amnesia
- Trial name
- NCT00400790
- Testing
- propofol, desflurane
- Where
- Australia
- Volunteers
- 182 people
- Sponsor
- University of Melbourne
Ischemic Heart Disease, Aortic Stenosis, Severe
Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients
The goal of this interventional is to assess advantages of the ultrasound examination of the lungs in the early postoperative period in cardiac surgical patients after heart surgeries requiring cardiopulmonary bypass.
- Conditions
- Ischemic Heart Disease, Aortic Stenosis, Severe, Aortic Insufficiency, Mitral Stenosis
- Trial name
- NCT06377449
- Testing
- Ultrasound examination of the lungs
- Where
- Russia
- Volunteers
- 186 people
- Sponsor
- Saint Petersburg State University, Russia
Delirium Symptoms
Role of REM Sleep Alterations in Post Operative Delirium After Cardiac Surgery
Acute confusional states known as delirium frequently occur in Intensive Care Units (ICU), mostly after cardiac surgery, leading to serious consequences.
- Trial name
- NCT02801318
- Testing
- Polysomnography
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
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